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Emma Horton

Publications and source records attributed to Emma Horton.

At least 19 recordsLinked to original sources

Convergence to the Brownian CRT for critical branching Markov processe

We prove an invariance principle for a general class of continuous time critical branching processes with finite variance (non-local) branching mechanism. We show that the genealogical trees, viewed as random compact metric measure spaces, converge under rescaling to the Brownian continuum random tree in the Gromov-Hausdorff-weak topology, establishing a universal scaling limit for critical finite variance branching processes.

math.PR

A moment approach to the law of large numbers for supercritical branching Markov processes

We offer a new proof of the classical law of large numbers for a general class of branching Markov processes based on the asymptotic behaviour of the moments developed in \cite{bmoments, gonzalez2022erratum}. Moreover, we show that the law of the limiting random variable, that is the almost sure limit of the classical additive martingale, is completely determined by its moments.

math.PR

SDE-based Monte Carlo dose calculation for proton therapy validated against Geant4

Objective: To assess the accuracy and computational performance of a stochastic differential equation (SDE)--based model for proton beam dose calculation by benchmarking against Geant4 in simplified phantom geometries. Approach: Building on Crossley et al. (2025), we implemented the SDE model using standard approximations to interaction cross sections and mean excitation energies, enabling straightforward adaptation to new materials and configurations. The model was benchmarked against Geant4 in homogeneous, longitudinally heterogeneous and laterally heterogeneous phantoms to assess depth--dose behaviour, lateral transport and material heterogeneities. Main results: Across all phantoms and beam energies, the SDE model reproduced the main depth--dose characteristics predicted by Geant4, with proton range agreement within 0.2 mm for 100 MeV beams and 0.6 mm for 150 MeV beams. Voxel--wise comparisons yielded gamma pass rates exceeding 95% under 2%/0.5 mm criteria with a 1% dose threshold. Differences were localised to steep dose gradients or material interfaces, while overall lateral beam dispersion was well reproduced. The SDE model achieved speed-up factors of about 2.5--3 relative to single-threaded Geant4. Significance: The SDE approach reproduces key dosimetric features with good accuracy at lower computational cost and is amenable to parallel and GPU implementations, supporting fast proton therapy dose calculations.

physics.med-ph

Consistent estimation in subcritical birth-and-death processes

We investigate parameter estimation in subcritical continuous-time birth-and-death processes with multiple births. We show that the classical maximum likelihood estimators for the model parameters, based on the continuous observation of a single non-extinct trajectory, are not consistent in the usual sense: conditional on survival up to time $t$, they converge as $t \to \infty$ to the corresponding quantities in the associated $Q$-process, namely the process conditioned to survive in the distant future. We develop the first $C$-consistent estimators in this setting, which converge to the true parameter values when conditioning on survival up to time $t$, and establish their asymptotic normality. The analysis relies on spine decompositions and coupling techniques.

math.ST

Functional central limit theorems for non-local branching Markov processes

The aim of this paper is to study the fluctuations of a general class of supercritical branching Markov processes with non-local branching mechanisms. We establish functional central limit theorems and show that the limiting behaviour falls into three regimes, determined by the size of the spectral gap associated with the first-moment semigroup of the branching process. The main novelty is to develop a unified functional fluctuation theory for spatial branching Markov processes with non-local reproduction, allowing a general finite-dimensional spectral structure for the first-moment semigroup, including non-simple leading eigenvalues and nilpotent Jordan-type components. In doing so, we extend the classical small, critical and large fluctuation trichotomy beyond the finite-type and local spatial settings, and obtain limiting processes that capture the covariance structure induced by non-local offspring displacement.

math.PR

More on the asymptotic behaviour of moments of branching Markov processes

Consider a branching Markov process, $X = (X(t), t \ge 0)$, with non-local branching mechanism. Studying the asymptotic behaviour of the moments of X has recently received attention in the literature [6, 7] due to the importance of these results in understanding the underlying genealogical structure of $X$. In this article, we generalise the results of [7] to allow for a non-simple leading eigenvalue and to also study the higher order fluctuations of the moments of $X$. These results will be useful for proving central limit theorems and extending well-known LLN results.

math.PR

Jump stochastic differential equations for the characterisation of the Bragg peak in proton beam radiotherapy

Proton beam radiotherapy stands at the forefront of precision cancer treatment, leveraging the unique physical interactions of proton beams with human tissue to deliver minimal dose upon entry and deposit the therapeutic dose precisely at the so-called Bragg peak, with no residual dose beyond this point. The Bragg peak is the characteristic maximum that occurs when plotting the curve describing the rate of energy deposition along the length of the proton beam. Moreover, as a natural phenomenon, it is caused by an increase in the rate of nuclear interactions of protons as their energy decreases. From an analytical perspective, Bortfeld proposed a parametric family of curves that can be accurately calibrated to data replicating the Bragg peak in one dimension. We build, from first principles, the very first mathematical model describing the energy deposition of protons. Our approach uses stochastic differential equations and affords us the luxury of defining the natural analogue of the Bragg curve in two or three dimensions. This work is purely theoretical and provides a new mathematical framework which is capable of encompassing models built using Geant4 Monte Carlo, at one extreme, to pencil beam calculations with Bortfeld curves at the other.

physics.med-ph

Stochastic branching models for the telomeres dynamics in a model including telomerase activity

Telomeres are repetitive sequences of nucleotides at the end of chromosomes, whose evolution over time is intrinsically related to biological ageing. In most cells, with each cell division, telomeres shorten due to the so-called end replication problem, which can lead to replicative senescence and a variety of age-related diseases. On the other hand, in certain cells, the presence of the enzyme telomerase can lead to the lengthening of telomeres, which may delay or prevent the onset of such diseases but can also increase the risk of cancer. In this article, we propose a stochastic representation of this biological model, which takes into account multiple chromosomes per cell, the effect of telomerase, different cell types and the dependence of the distribution of telomere length on the dynamics of the process. We study theoretical properties of this model, including its long-term behaviour. In addition, we investigate numerically the impact of the model parameters on biologically relevant quantities, such as the Hayflick limit and the Malthusian parameter of the population of cells.

q-bio.CB

Stability of (sub)critical non-local spatial branching processes with and without immigration

We consider the setting of either a general non-local branching particle process or a general non-local superprocess, in both cases, with and without immigration. Under the assumption that the mean semigroup has a Perron-Frobenious type behaviour for the immigrated mass, as well as the existence of second moments, we consider necessary and sufficient conditions that ensure limiting distributional stability. More precisely, our first main contribution pertains to proving the asymptotic Kolmogorov survival probability and Yaglom limit for critical non-local branching particle systems and superprocesses under a second moment assumption on the offspring distribution. Our results improve on existing literature by removing the requirement of bounded offspring in the particle setting [21] and generalising [43] to allow for non-local branching mechanisms. Our second main contribution pertains to the stability of both critical and sub-critical non-local branching particle systems and superprocesses with immigration. At criticality, we show that the scaled process converges to a Gamma distribution under a necessary and sufficient integral test. At subcriticality we show stability of the process, also subject to an integral test. In these cases, our results complement classical results for (continuous-time) Galton-Watson processes with immigration and continuous-state branching processes with immigration; see [22,40,42,48,51], among others. In the setting of superprocesses, the only work we know of at this level of generality is summarised in [34]. The proofs of our results, both with and without immigration, appeal to similar technical approaches and accordingly, we include the results together in this paper.

math.PR

Limit theorems for the neutron transport equation

Over the last decade, ingenuous developments in Monte Carlo methods have enabled the unbiased estimation of adjoint-weighted reactor parameters expressed as bilinear forms, such as kinetics parameters and sensitivity coefficients. A prominent example is the Iterated Fission Probability method, which relies on the simulation of the fission chains descending from an ancestor neutron: the neutron population at an asymptotic fission generation yields an estimate of the importance function (and hence of the adjoint fundamental eigenmode) at the phase-space coordinates of the ancestor neutron. In this paper we first establish rigorous results concerning the moments of the asymptotic neutron population stemming from a single initial particle, with special focus on the average and the variance. Then, we propose a simple benchmark configuration where exact solutions are derived for these moments, which can be used for the verification of new functionalities of production Monte Carlo codes involving the Iterated Fission Probability method.

physics.comp-ph

Many-to-few for non-local branching Markov process

We provide a many-to-few formula in the general setting of non-local branching Markov processes. This formula allows one to compute expectations of k-fold sums over functions of the population at k different times. The result generalises [14] to the non-local setting, as introduced in [11] and [8]. As an application, we consider the case when the branching process is critical, and conditioned to survive for a large time. In this setting, we prove a general formula for the limiting law of the death time of the most recent common ancestor of two particles selected uniformly from the population at two different times, as t tends to infinity. Moreover, we describe the limiting law of the population sizes at two different times, in the same asymptotic regime.

math.PR

Binary branching processes with Moran type interactions

The aim of this paper is to study the large population limit of a binary branching particle system with Moran type interactions: we introduce a new model where particles evolve, reproduce and die independently and, with a probability that may depend on the configuration of the whole system, the death of a particle may trigger the reproduction of another particle, while a branching event may trigger the death of an other one. We study the occupation measure of the new model, explicitly relating it to the Feynman-Kac semigroup of the underlying Markov evolution and quantifying the L2 distance between their normalisations. This model extends the fixed size Moran type interacting particle system discussed in [18, 19, 6, 7, 57] and we will indeed show that our model outperforms the latter when used to approximate a birth and death process. We discuss several other applications of our model including the neutron transport equation [36, 15] and population size dynamics.

math.PR

Yaglom limit for critical neutron transport

We consider the classical Yaglom limit theorem for a branching Markov process $X = (X_t, t \ge 0)$, with non-local branching mechanism in the setting that the mean semigroup is critical, i.e. its leading eigenvalue is zero. In particular, we show that there exists a constant $c(f)$ such that \[ {\rm Law}\left(\frac{\langle f, X_t\rangle}{t} \bigg| \langle 1, X_t\rangle > 0 \right) \to {\mathbf e}_{c(f)}, \qquad t \to \infty, \] where ${\mathbf e}_{c(f)}$ is an exponential random variable with rate $c(f)$ and the convergence is in distribution. As part of the proof, we also show that the probability of survival decays inversely proportionally to time. Although Yaglom limit theorems have recently been handled in the setting of branching Brownian motion in a bounded domain and superprocesses, \cite{Ellen, Yanxia}, these results do not allow for non-local branching, which complicates the analysis. Our approach and the main novelty of this work is based around a precise result for the scaled asymptotics for the $k$-th martingale moments of $X$ (rather than the Yaglom limit itself). We then illustrate our results in the setting of neutron transport, for which the non-locality is essential, complementing recent developments in this domain \cite{SNTE, SNTEII, SNTEIII, MCNTE, MultiNTE}.

math.PR

On the Stability of Positive Semigroups

The stability and contraction properties of positive integral semigroups on Polish spaces are investigated. Our novel analysis is based on the extension of V-norm contraction methods, associated to functionally weighted Banach spaces for Markov semigroups, to positive semigroups. This methodology is applied to a general class of positive and possibly time-inhomogeneous bounded integral semigroups and their normalised versions. The spectral theorems that we develop are an extension of Perron-Frobenius and Krein-Rutman theorems for positive operators to a class of time-varying positive semigroups. In the context of time-homogeneous models, the regularity conditions discussed in the present article appear to be necessary and sufficient condition for the existence of leading eigenvalues. We review and illustrate the impact of these results in the context of positive semigroups arising in transport theory, physics, mathematical biology and signal processing.

math.PR

A note on Riccati matrix difference equations

Discrete algebraic Riccati equations and their fixed points are well understood and arise in a variety of applications, however, the time-varying equations have not yet been fully explored in the literature. In this article we provide a self-contained study of discrete time Riccati matrix difference equations. In particular, we provide a novel Riccati semigroup duality formula and a new Floquet-type representation for these equations. Due to the aperiodicity of the underlying flow of the solution matrix, conventional Floquet theory does not apply in this setting and thus further analysis is required. We illustrate the impact of these formulae with an explicit description of the solution of time-varying Riccati difference equations and its fundamental-type solution in terms of the fixed point of the equation and an invertible linear matrix map, as well as uniform upper and lower bounds on the Riccati maps. These are the first results of this type for time varying Riccati matrix difference equations.

math.DS

A theoretical analysis of one-dimensional discrete generation ensemble Kalman particle filters

Despite the widespread usage of discrete generation Ensemble Kalman particle filtering methodology to solve nonlinear and high dimensional filtering and inverse problems, little is known about their mathematical foundations. As genetic-type particle filters (a.k.a. sequential Monte Carlo), this ensemble-type methodology can also be interpreted as mean-field particle approximations of the Kalman-Bucy filtering equation. In contrast with conventional mean-field type interacting particle methods equipped with a globally Lipschitz interacting drift-type function, Ensemble Kalman filters depend on a nonlinear and quadratic-type interaction function defined in terms of the sample covariance of the particles. Most of the literature in applied mathematics and computer science on these sophisticated interacting particle methods amounts to designing different classes of useable observer-type particle methods. These methods are based on a variety of inconsistent but judicious ensemble auxiliary transformations or include additional inflation/localisationtype algorithmic innovations, in order to avoid the inherent time-degeneracy of an insufficient particle ensemble size when solving a filtering problem with an unstable signal. To the best of our knowledge, the first and the only rigorous mathematical analysis of these sophisticated discrete generation particle filters is developed in the pioneering articles by Le Gland-Monbet-Tran and by Mandel-Cobb-Beezley, which were published in the early 2010s. Nevertheless, besides the fact that these studies prove the asymptotic consistency of the Ensemble Kalman filter, they provide exceedingly pessimistic meanerror estimates that grow exponentially fast with respect to the time horizon, even for linear Gaussian filtering problems with stable one dimensional signals. In the present article we develop a novel self-contained and complete stochastic perturbation analysis of the fluctuations, the stability, and the long-time performance of these discrete generation ensemble Kalman particle filters, including time-uniform and non-asymptotic mean-error estimates that apply to possibly unstable signals. To the best of our knowledge, these are the first results of this type in the literature on discrete generation particle filters, including the class of genetic-type particle filters and discrete generation ensemble Kalman filters. The stochastic Riccati difference equations considered in this work are also of interest in their own right, as a prototype of a new class of stochastic rational difference equation.

math.PR

Quantum harmonic oscillators and Feynman-Kac path integrals for linear diffusive particles

We propose a new solvable class of multidimensional quantum harmonic oscillators for a linear diffusive particle and a quadratic energy absorbing well associated with a semi-definite positive matrix force. Under natural and easily checked controllability conditions, the ground state and the zero-point energy are explicitly computed in terms of a positive fixed point of a continuous time algebraic Riccati matrix equation. We also present an explicit solution of normalized and time dependent Feynman-Kac measures in terms of a time varying linear dynamical system coupled with a differential Riccati matrix equation. A refined non asymptotic analysis of the stability of these models is developed based on a recently developed Floquet-type representation of time varying exponential semigroups of Riccati matrices. We provide explicit and non asymptotic estimates of the exponential decays to equilibrium of Feynman-Kac semigroups in terms of Wasserstein distances or Boltzmann-relative entropy. For reversible models we develop a series of functional inequalities including de Bruijn identity, Fisher's information decays, log-Sobolev inequalities, and entropy contraction estimates. In this context, we also provide a complete and explicit description of all the spectrum and the excited states of the Hamiltonian, yielding what seems to be the first result of this type for this class of models. We illustrate these formulae with the traditional harmonic oscillator associated with real time Brownian particles and Mehler's formula. The analysis developed in this article can also be extended to solve time dependent Schrodinger equations equipped with time varying linear diffusions and quadratic potential functions.

math.PR

Strong laws of large numbers for a growth-fragmentation process with bounded cell sizes

Growth-fragmentation processes model systems of cells that grow continuously over time and then fragment into smaller pieces. Typically, on average, the number of cells in the system exhibits asynchronous exponential growth and, upon compensating for this, the distribution of cell sizes converges to an asymptotic profile. However, the long-term stochastic behaviour of the system is more delicate, and its almost sure asymptotics have been so far largely unexplored. In this article, we study a growth-fragmentation process whose cell sizes are bounded above, and prove the existence of regimes with differing almost sure long-term behaviour.

math.PR