arXiv subjects

Emmanuel Lwele

Publications and source records attributed to Emmanuel Lwele.

3 recordsLinked to original sources

arXiv2026

Cardiovascular Digital Twins from Physics Based to Data Driven Approaches

Cardiovascular digital twins aim to create patient-specific computational models that evolve with clinical data to support diagnosis, prognosis, and therapy optimisation. Mechanistic models provide physiological interpretability but remain computationally demanding, whereas data-driven approaches improve scalability yet risk limited robustness. Emerging physics-informed, graph-based, and hybrid methods integrate physical constraints with relational learning across vascular networks. We review modelling paradigms, data assimilation frameworks, validation challenges, and translational pathways toward clinically deployable cardiovascular digital twins.

physics.med-ph↗

arXiv2025

Risk-Aware Deep Reinforcement Learning for Dynamic Portfolio Optimization

This paper presents a deep reinforcement learning (DRL) framework for dynamic portfolio optimization under market uncertainty and risk. The proposed model integrates a Sharpe ratio-based reward function with direct risk control mechanisms, including maximum drawdown and volatility constraints. Proximal Policy Optimization (PPO) is employed to learn adaptive asset allocation strategies over historical financial time series. Model performance is benchmarked against mean-variance and equal-weight portfolio strategies using backtesting on high-performing equities. Results indicate that the DRL agent stabilizes volatility successfully but suffers from degraded risk-adjusted returns due to over-conservative policy convergence, highlighting the challenge of balancing exploration, return maximization, and risk mitigation. The study underscores the need for improved reward shaping and hybrid risk-aware strategies to enhance the practical deployment of DRL-based portfolio allocation models.

q-fin.PM↗

arXiv2025

Can audio recordings be used to detect leaks and coughs during mechanical insufflation exsufflation (MI-E) treatment?

This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by SofTMech and Innovate UK, Business Connect. The BIOREME network hosts events, including this study group, to bring together multi-disciplinary researchers, clinicians, companies and charities to catalyse research in the applications of mathematical modelling for respiratory medicine. The goal of this study group was to provide an interface between companies, clinicians, and mathematicians to develop mathematical tools to the problems presented. The study group was held at The University of Glasgow on the 17 - 21 June 2024 and was attended by 16 participants from 8 different institutions. Below details the technical report of one of the challenges and the methods developed by the team of researchers who worked on this challenge.

physics.med-ph↗