arXiv subjects

Eric Jakobsson

Publications and source records attributed to Eric Jakobsson.

4 recordsLinked to original sources

arXiv2024

A Generalised Theory of Interactions -- II. The Theoretical Construction

After discussing the significance of interactions to understand complex multiscale stochastic systems (CMSS), we turn our attention to the construction of a Generalised Theory of Interactions (GToI). We define interactions as discrete, localised events where the thermodynamically irreversible exchange of degrees of freedom involves signal propagation and relaxation phenomena. We proceed to define the mechanics of such space, as well as how these approximately map onto dynamical manifolds. By characterising various systems through the effect of transformations across interaction space, we develop a view of systems where features such as emergence and information representation become apparent. Our theory appears to capture structural and dynamical features of CMSS efficiently by making explicit the extent of the dynamical range of action in them; we identify the boundaries of such range with statistical limits corresponding to physical laws, and derive a generalised form of the Correspondence Principle.

physics.soc-ph↗

arXiv2024

A Generalized Theory of Interactions -- I. The General Problem

Understanding realistic complex systems requires confronting significant conceptual, theoretical and experimental limitations rooted in the persistence of views that originated in the mechanics of simple moving bodies. We define the category of complex multiscale stochastic systems as a useful device for capturing the minimally required complexity of many types of phenomena. In doing so, we provide evidence indicating that determinism, continuity and reversibility can lead to theoretical inadequacies that manifest as intractability, inaccuracies or non-representativeness when applied to complex systems. We take the view that interactions are fundamental and summarize their portrayal across many disciplines. Despite their centrality, interactions remain largely neglected as subjects of research interest of their own. We hypothesize that a generalized theory of interactions may help organize evidence from multiple scientific domains towards a more unified realistic view of systems.

physics.soc-ph↗

arXiv2013

Genome wide identification of regulatory networks associated with general cognitive ability using a normalized alignment free similarity measure of promoter regions

We show that a normalized alignment free similarity measure, called D2z, can be used to detect potential regulatory relations for gene sets when little is known about the regulatory elements involved. One scenario where such gene sets arise is genome wide association studies (GWAS). In this work we consider a gene set from a GWAS on childhood general cognitive ability. We build a co-regulation network for the GWAS genes based on the D2z scores, which shows potential co-regulatory relationships between the genes as well as predict additional genes that are likely to be part of the network. We found that the set of the predicted genes is enriched in genes associated with mental retardation and GO terms such as synapse and neuron development. In particular, we found strong evidence of regulatory connection between the GWAS genes and CHL1, a gene known to be involved in mental retardation.

q-bio.GN↗

arXiv2009

Evolutionary Analysis of Biological Excitability

Excitability is an attribute of life, and is a driving force in the descent of complexity. Cellular electrical activity as realized by membrane proteins that act as either channels or transporters is the basis of excitability. Electrical signaling is mediated by a wave of action potentials, which consist of synchronous redistribution of ionic gradients down ion channels. Ion channels select for the passage of a particular ion species. Potassium ion channels are gated by a variety of stimuli, including membrane voltage. Sodium and calcium channels are gated only by membrane voltage, suggesting the conservative argument that voltage-gated potassium channels are the founding members of the voltage-gated ion channel superfamily. The principal focus of this work is the investigation of the complement of potassium ion channels in our genome and its generalizabilty. An array of issues relevant to excitability is addressed, and a range of engagement in questions regarding the unity of life is proffered.

q-bio.BM↗