F. Davoodian | Searcharxiv

arXiv2026

Effects of PLGA coating on biological and mechanical behaviors of tissue engineering scaffolds

Scaffolds have a key role in the clinical success of tissue engineering for the regeneration of damaged tissues. Their bio-performance is often described as the extent to which they can provide an extracellular matrix-like environment for cells embedded where their function and growth can effectively continue. For this purpose, tissue engineering scaffolds should exhibit biodegradability, biocompatibility, bioactivity, delivery, and mechanical performance. The use of polymer coatings, especially poly(lactic-co-glycolic acid) (PLGA), on tissue engineering scaffolds has been found to be one of the most effective methods to improve the scaffold properties. This paper reviews the techniques used to coat tissue engineering scaffolds with PLGA and its effects on the mechanical characteristics, biodegradability, biocompatibility, Molecular delivery, and osteointegration of the scaffolds. It is concluded that apart from apatite-formation ability, all bio-functionalities can be tuned through PLGA coatings. This reflects the great potential of this modification approach to be used in tissue regeneration and therapeutic delivery applications.

physics.bio-ph↗

arXiv2025

Eliminating the irregular surface layer of anodically-grown Ni-Ti-O nanopore arrays in a two-stage anodization

Nanopores (NPs) grown by anodizing can be partially hidden beneath a relatively compact surface oxide layer, which limits the volumetric surface area of these nanostructures. In this work, nitinol (NiTi) alloy was anodized in an electrolyte containing ethylene glycol, water, and sodium chloride in static and stirred electrolyte stages with the aim of removing the irregular surface array while achieving a thick NP layer. Electron micrographs showed that anodization in the static electrolyte provides a controlled thickness of NP layers covered by an irregular surface layer. In contrast, anodizing in the stirred electrolyte reduced the thickness and the degree of irregularity, which were controlled by the different kinetics of dissolution at the tops, perimeters and bottoms of NPs. To benefit simultaneously from the thickness and regularity of the oxide layers, two-stage anodizing under static and then stirred electrolyte conditions was found to be effective. Following a 30 min anodization in the static electrolyte, anodizing for 30 min under the stirred conditions provided the highest regularity in the oxide array, resulting in NPs of almost 40 nm and 11 μm in diameter and layer thickness, respectively. Two-stage anodizing under static then stirred electrolyte conditions is proposed in order to promote NP structures for applications demanding higher surface areas.

cond-mat.mtrl-sci↗