arXiv subjects

F. Fang

Publications and source records attributed to F. Fang.

At least 19 recordsLinked to original sources

arXiv2026

Parenclitic hypergraphs and their application in personalized cancer therapy

Understanding the differences between individual instances of the same complex system remains a central challenge, particularly in biological contexts. Parenclitic networks constitute a suitable means to detect deviations in correlations with respect to reference populations. Here, we introduce parenclitic hypergraphs, a general framework for identifying anomalies in higher-order correlations across arbitrary interaction orders. After validating the method on synthetic datasets and benchmark ones, we apply it to patient-derived cancer organoids, capturing temporal changes in gene expression between healthy and cancerous tissues as the disease progresses. Our approach not only reproduces known oncogenic signatures, but also reveals a previously unrecognized candidate therapeutic target. Since organoids are generated from individual patients, our method provides, for the first time, a viable protocol for personalized cancer therapy based on higher-order correlation patterns. These findings offer a novel, systems-level strategy for precision oncology grounded in complex systems theory.

q-bio.QM↗

arXiv2026

Search for Light-Mass Fractionally Charged Particles in Space with DAMPE Experiment

Free Fractionally Charged Particles (FCPs) are predicted by some theories beyond or extended to the standard model. FCPs have been widely searched for by underground and space-based experiments based on the assumption of heavy lepton-like particles. However, there is a paucity of research focusing on light-mass FCPs (LFCPs) in the sub-MeV mass range. In this work, we report the LFCPs in primary high energy cosmic rays, based on observational data from the Dark Matter Particle Explorer (DAMPE) satellite. This study utilized ten years on-orbit data of DAMPE to search for LFCPs with a charge of $\frac{2}{3}~e$. No LFCP candidate was observed. Upper flux limit of LFCPs with a mass of 0.511 MeV$/c^{2}$ and a charge of $\frac{2}{3}~e$ is determined to be $\rm 5.0 \times 10^{-11}\,cm^{-2}sr^{-1}s^{-1}$ at the $\rm 90\%$ confidence level.

astro-ph.HE↗

arXiv2026

Diverse properties of electron Forbush decreases revealed by the Dark Matter Particle Explorer

The Forbush decrease (FD) of cosmic rays is an important probe of the interplanetary environment disturbed by solar activities. In this work, we study the properties of 8 FDs electrons (including positrons) between 2 GeV and 20 GeV from January, 2016 to March, 2024, with the Dark Matter Particle Explorer. The maximum decrease amplitudes of these events are about 30% - 15%, and the amplitudes reduce with energy. The recovery time of these events shows diverse behaviors of their energy-dependence. Some of them show strong energy-dependence, while some have a nearly constant recovery time. It has been shown that such diverse behaviors could be related with the geometry of the disturbed regions of the interplanetary space by coronal mass ejections (CME), represented by the combined effect of the CME velocity, angular spread, and ejection direction.

astro-ph.HE↗

arXiv2025

Observations of the Fermi bubbles and the Galactic center excess with the DArk Matter Particle Explorer

The DArk Matter Particle Explorer (DAMPE) is a space-borne high-energy particle detector that surveys the $\gamma$-ray sky above$\sim 2~\rm GeV$ with a peak acceptance of $\sim 0.2~\rm m^2\,sr$. With the 102 months of data collected by DAMPE, we show that the Fermi bubbles are detected at a significance of $\sim 26\sigma$ and identify a GeV excess in the direction of Galactic center at $\sim 7 \sigma$ confidence. Both spectra and morphology are consistent with those observed by Fermi-LAT and the GeV excess component can be interpreted by the dark matter annihilation with a mass of $\sim 50$ GeV and a velocity-averaged cross section of $\sim 10^{-26}~{\rm cm^{3}~s^{-1}}$ for the $\chi \chi \rightarrow b\bar{b}$ channel. Our results thus provide the first independent detection of these two intriguing diffuse gamma-ray sources besides Fermi-LAT.

astro-ph.HE↗

arXiv2025

Measurement of the cosmic ray nickel energy spectrum from 10 GeV/n to 2 TeV/n with the DAMPE

Nickel, one of the most tightly bound nuclei alongside iron, is the most abundant heavy element beyond iron in cosmic rays. With DAMPE's excellent charge resolution and broad energy range, a high-precision energy spectrum provides valuable insights into the acceleration sources of heavy nuclei and their propagation through the interstellar medium. In this analysis, we report the direct measurement of cosmic-ray nickel spectrum from 10 GeV/n to 2 TeV/n with nine years of flight data. The nickel spectrum is consistent with a single power law with spectral index -2.60 +/- 0.03 from 40 GeV/n to 1 TeV/n. This work provides an accurate measurement of differential flux of nickel with kinetic energy extending to TeV/n for the first time.

astro-ph.HE↗

arXiv2025

Investigation of hadronic cross sections of cosmic ray carbon and oxygen on BGO from 200 GeV to 10 TeV energy at the DAMPE experiment

The Dark Matter Particle Explorer (DAMPE) has made significant progress in measuring the fluxes of cosmic rays. These new measurements are pivotal in advancing our understanding of the origins and propagation mechanisms of cosmic rays. The bismuth germanium oxide (BGO) calorimeter plays a crucial role in these measurements, particularly in the precise determination of cosmic ray fluxes. However, for a calorimetric experiment like DAMPE, uncertainties in hadronic models persist as a major barrier in achieving more accurate measurements of fluxes of cosmic ray nuclei. This study centers on the measurement of the inelastic hadronic cross sections of carbon and oxygen nuclei interacting with BGO crystals target over an extensive energy range, spanning from 200 GeV to 10 TeV. For carbon nuclei interacting with the BGO target, the measurements of the cross sections have achieved a total relative uncertainty of less than 10% below 8 TeV for carbon, and below 3 TeV for oxygen. For oxygen nuclei, the same level of precision was attained below 3 TeV. Additionally, we compare the experimental results with Geant4 and FLUKA simulations to validate the accuracy and consistency of these simulation tools. Through comprehensive analysis of the inelastic hadronic interaction cross sections, this research provides validation for the hadronic interaction models used in DAMPE's cosmic-ray flux measurements.

hep-ex↗

arXiv2025

A high-lying isomer in ^{92}Zr with lifetime modulated by the atomic charge states: a proposed approach for a nuclear gamma-ray laser

The nuclides ^{92}Zr are produced and transported by using a radioactive beam line to a lowbackground detection station. After a flight time of about 1.14 {\mu}s, the ions are implanted into a carbon foil, and four {\gamma} rays deexciting the 8+ state in ^{92}Zr are observed in coincidence with the implantation signals within a few nanoseconds. We conjecture that there exists an isomer located slightly above the 8^{+} state in ^{92}Zr. The isomeric lifetime in highly charged states is extended significantly due to the blocking of internal conversion decay channels, enabling its survival over the transportation. During the slowing-down process in the carbon foil, the ^{92}Zr ions capture electron and evolve toward neutral atoms, and consequently the lifetime is restored to a normal short value. Such a high-lying isomer depopulated by a low-energy transition may provide unique opportunity to develop nuclear {\gamma} laser.

nucl-ex↗

arXiv2025

Measurement of separate electron and positron spectra from 10 GeV to 20GeV with the geomagnetic field on DAMPE

The cosmic-ray (CR) electrons and positrons in space are of great significance for studying the origin and propagation of cosmic-rays. The satellite-borne experiment DArk Matter Particle Explorer (DAMPE) has been used to measure the separate electron and positron spectra, as well as the positron fraction. In this work, the Earth's magnetic field is used to distinguish CR electrons and positrons, as the DAMPE detector does not carry an onboard magnet. The energy range for the measurements is from 10 to 20 GeV, being currently limited at high energy by the zenith pointing orientation of DAMPE. The results are consistent with previous measurements based on the magnetic spectrometer by AMS-02 and PAMELA, while the results of Fermi-LAT seem then to be systematically shifted to larger values.

astro-ph.HE↗

arXiv2025

Nanoindentation responses of Fe-Cr alloys from room temperature to 600 {\deg}C

In this work, the evolution of nanomechanical properties was studied systematically as a function of temperature, chemical, and microstructural complexity of different Fe-based alloys. Experiments were performed at different temperatures (room temperature, 200 C, 400 C, 600 C) using the nanoindentation technique on low activation Fe9Cr-1WVTa (Eurofer97), model Fe-9Cr-NiSiP, Fe-9Cr alloys, and pure iron samples, followed by microstructural observations. The results show varying softening and hardening effects depending on the experimental temperature, demonstrating Portevin-Le-Chatelier effect, i.e., dynamic strain aging phenomenon in model alloys. Sources of the dynamic strain aging instabilities were traced back to the interaction between dislocations and alloying elements such as interstitial carbon and substitutional chromium. The materials undergo dynamic recovery and recrystallization below the regions of high-temperature indentation depending on the pre-indentation dislocation density and the alloy composition. Our findings help in the understanding of the structure and mechanical property relationship in complex Eurofer97 alloy at high-temperatures for potential nuclear applications as structural materials.

cond-mat.mtrl-sci↗

arXiv2024

Observation of a spectral hardening in cosmic ray boron spectrum with the DAMPE space mission

Secondary cosmic ray fluxes are important probes of the propagation and interaction of high-energy particles in the Galaxy. Recent measurements of primary and secondary cosmic ray nuclei have revealed unexpected spectral features that demand a deeper understanding. In this work we report the direct measurement of the cosmic ray boron spectrum from 10 GeV/n to 8 TeV/n with eight years of data collected by the Dark Matter Particle Explorer (DAMPE) mission. The measured spectrum shows an evident hardening at $182\pm24$ GeV/n with a spectral power index of $\gamma_1 = 3.02 \pm 0.01$ before the break and an index change of $\Delta \gamma = 0.31 \pm 0.05$ after the break. A simple power law model is disfavored at a confidence level of 8$\sigma$. Compared with the hardenings measured in the DAMPE proton and helium spectra, the secondary boron spectrum hardens roughly twice as much as these primaries, which is consistent with a propagation related mechanism to interpret the spectral hardenings of cosmic rays observed at hundreds of GeV/n.

astro-ph.HE↗

arXiv2024

Hadronic cross section measurements with the DAMPE space mission using 20GeV-10TeV cosmic-ray protons and $^4$He

Precise direct cosmic-ray (CR) measurements provide an important probe to study the energetic particle sources in our Galaxy, and the interstellar environment through which these particles propagate. Uncertainties on hadronic models, ion-nucleon cross sections in particular, are currently the limiting factor towards obtaining more accurate CR ion flux measurements with calorimetric space-based experiments. We present an energy-dependent measurement of the inelastic cross section of protons and helium-4 nuclei (alpha particles) on a Bi$_4$Ge$_3$O$_{12}$ target, using 88 months of data collected by the DAMPE space mission. The kinetic energy range per nucleon of the measurement points ranges from 18 GeV to 9 TeV for protons, and from 5 GeV/n to 3 TeV/n for helium-4 nuclei. Our results lead to a significant improvement of the CR flux normalisation. In the case of helium-4, these results correspond to the first cross section measurements on a heavy target material at energies above 10 GeV/n.

hep-ex↗

arXiv2024

Data discovery of low dimensional fluid dynamics of turbulent flows

Discovering governing equations from data, in particular high dimensional data, is challenging in various fields of science and engineering, and it has potential to revolutionise the science and technology in this big data era. This paper combines sparse identification and deep learning with non-linear fluid dynamics, in particular the turbulent flows, to discover governing equations of nonlinear fluid dynamics in the lower nonlinear manifold space. The autoencoder deep neural network is used to project the high dimensional space into a lower dimensional nonlinear manifold space. The Proper Orthogonal Decomposition (POD) is then used to stabilise the nonlinear manifold space in order to guarantee a stable manifold space for pattern or equations discovery for the highly nonlinear problems such as turbulent flows. Sparse regression is then used to discover the lower dimensional governing equations of fluid dynamics in the lower dimensional nonlinear manifold space. What distinguishes this approach is its ability to discover a lower dimensional governing equations of fluid dynamics in the nonlinear manifold space. We demonstrate this method on a number of high-dimensional fluid dynamic systems such as lock exchange, flow past one and two cylinders. The results demonstrate that the resulting method is capable of discovering lower dimensional governing equations that took researchers in this community many decades years to resolve. In addition, this model discovers dynamics in a lower dimensional manifold space, thus leading to great computational efficiency, model complexity and avoiding overfitting. It also provides a new insight for our understanding of sciences such as turbulent flows.

physics.flu-dyn↗

arXiv2023

Roadmap towards the redefinition of the second

This paper outlines the roadmap towards the redefinition of the second, which was recently updated by the CCTF Task Force created by the CCTF in 2020. The main achievements and the open challenges related to the status of the optical frequency standards, their contribution to time scales and UTC, the possibility of their comparison and the knowledge of the Earth's gravitational potential at the necessary level of uncertainty are discussed. In addition, the mandatory criteria to be achieved before redefinition and their current fulfilment level, together with the redefinition options based on a single or on a set of transitions are described.

physics.atom-ph↗

arXiv2023

Microstructure and mechanical properties of mechanically-alloyed CoCrFeNi high-entropy alloys using low ball-to-powder ratio

High-entropy alloys are extensively studied due to their very promising properties. However manufacturing methods currently used to prepare HEAs are complicated, costly, and likely non-industrially scalable processes. This limits their evolution and poses questions regarding the material's applicability in the future. Considering the abovementioned point, we developed a novel methodology for efficient HEA production using a low ball-to-powder ratio (BPR). Using different milling times, we manufactured four HEA powder precursors using a BPR of 5:1, which were later sintered via the Spark Plasma Sintering technique and heat treated. Microstructural characterization was performed by optical microscopy, Scanning Electron Microscopy equipped with EDS and EBSD detectors, and X-ray diffraction. Mechanical properties were measured using nano and microhardness techniques. In this work, we follow the structural evolution of the material and connect it with the strengthening effect as a function of milling time. Furthermore, we discuss the impact of different sintering and annealing conditions, proving that HEAs characterized by high mechanical properties may be manufactured using low BPR.

cond-mat.mtrl-sci↗

arXiv2023

Measurement of the cosmic p+He energy spectrum from 50 GeV to 0.5 PeV with the DAMPE space mission

Recent observations of the light component of the cosmic-ray spectrum have revealed unexpected features that motivate further and more precise measurements up to the highest energies. The Dark Matter Particle Explorer is a satellite-based cosmic-ray experiment that has been operational since December 2015, continuously collecting data on high-energy cosmic particles with very good statistics, energy resolution, and particle identification capabilities. In this work, the latest measurements of the energy spectrum of proton+helium in the energy range from 46 GeV to 464 TeV are presented. Among the most distinctive features of the spectrum, a spectral hardening at 600 GeV has been observed, along with a softening at 29 TeV measured with a 6.6{\sigma} significance. Moreover, the detector features and the analysis approach allowed for the extension of the spectral measurement up to the sub-PeV region. Even if with small statistical significance due to the low number of events, data suggest a new spectral hardening at about 150 TeV.

astro-ph.HE↗

arXiv2022

Search for relativistic fractionally charged particles in space

More than a century after the performance of the oil drop experiment, the possible existence of fractionally charged particles FCP still remains unsettled. The search for FCPs is crucial for some extensions of the Standard Model in particle physics. Most of the previously conducted searches for FCPs in cosmic rays were based on experiments underground or at high altitudes. However, there have been few searches for FCPs in cosmic rays carried out in orbit other than AMS-01 flown by a space shuttle and BESS by a balloon at the top of the atmosphere. In this study, we conduct an FCP search in space based on on-orbit data obtained using the DArk Matter Particle Explorer (DAMPE) satellite over a period of five years. Unlike underground experiments, which require an FCP energy of the order of hundreds of GeV, our FCP search starts at only a few GeV. An upper limit of $6.2\times 10^{-10}~~\mathrm{cm^{-2}sr^{-1} s^{-1}}$ is obtained for the flux. Our results demonstrate that DAMPE exhibits higher sensitivity than experiments of similar types by three orders of magnitude that more stringently restricts the conditions for the existence of FCP in primary cosmic rays.

astro-ph.HE↗

arXiv2021

Measurement of the cosmic ray helium energy spectrum from 70 GeV to 80 TeV with the DAMPE space mission

The measurement of the energy spectrum of cosmic ray helium nuclei from 70 GeV to 80 TeV using 4.5 years of data recorded by the DArk Matter Particle Explorer (DAMPE) is reported in this work. A hardening of the spectrum is observed at an energy of about 1.3 TeV, similar to previous observations. In addition, a spectral softening at about 34 TeV is revealed for the first time with large statistics and well controlled systematic uncertainties, with an overall significance of $4.3\sigma$. The DAMPE spectral measurements of both cosmic protons and helium nuclei suggest a particle charge dependent softening energy, although with current uncertainties a dependence on the number of nucleons cannot be ruled out.

astro-ph.HE↗

arXiv2021

Numerical study of COVID-19 spatial-temporal spreading in London

Recent study reported that an aerosolised virus (COVID-19) can survive in the air for a few hours. It is highly possible that people get infected with the disease by breathing and contact with items contaminated by the aerosolised virus. However, the aerosolised virus transmission and trajectories in various meteorological environments remain unclear. This paper has investigated the movement of aerosolised viruses from a high concentration source across a dense urban area. The case study looks at the highly air polluted areas of London: University College Hospital (UCH) and King Cross and St Pancras International Station (KCSPI). We explored the spread and decay of COVID-19 released from the hospital and railway stations with the prescribed meteorological conditions. The study has three key findings: the primary result is that it is possible for the virus to travel from meters up to hundred meters from the source location. The secondary finding shows viruses released into the atmosphere from entry and exit points at KCSPI remain trapped within a small radial distance of < 50m. This strengthens the case for the use of face coverings to reduce the infection rate. The final finding shows that there are different levels of risk at various door locations for UCH, depending on which door is used there can be a higher concentration of COVID-19. Although our results are based on London, since the fundamental knowledge processes are the same, our study can be further extended to other locations (especially the highly air polluted areas) in the world.

physics.med-ph↗