arXiv subjects

F. Pennazio

Publications and source records attributed to F. Pennazio.

4 recordsLinked to original sources

arXiv2026

Toward High-Resolution Detection of Target Fragmentation: TEA-Sensitized NIT for Proton Therapy Applications

Nano Imaging Trackers (NIT) are fine-grained nuclear emulsions capable of tracking charged particles with sub-micrometric spatial resolution. The DAMON (Direct Measurement of Target Fragmentation) experiment recently employed NIT to detect target-fragmentation events relevant to proton therapy in direct kinematics. These measurements showed that the small crystal size, while providing high spatial resolution, limits the reconstruction efficiency for primary proton tracks and high-energy secondary protons. This work reports an enhancement of NIT sensitivity achieved through alternative chemical sensitization methods, namely gold-plus-sulfur (Au-S) and triethanolamine (TEA), together with the use of the GR-1 developer. The detector response was evaluated with gamma-ray, carbon-ion and proton exposures, including clinically relevant proton energies.

physics.ins-det↗

arXiv2025

Cross Section Measurements of Large Angle Fragments Production in the Interaction of Carbon Ion Beams with Thin Targets

The fragmentation cross sections of carbon ion beams with kinetic energies of $115 - 353~\text{MeV/u}$ impinging on thin targets of graphite (C), polyvinyl-toluene (C$_9$H$_{10}$) and PMMA (C$_2$O$_5$H$_8$) have been measured at 90$^{\text{o}}$ and 60$^{\text{o}}$ at the CNAO particle therapy center (Pavia, Italy). The presented measurements are a complete reanalysis by the FOOT collaboration of already published elemental cross section on composite targets, in order to refine the analysis, improve the systematic uncertainties and show the comparison with the FLUKA Monte Carlo code calculations. In this work, the kinetic energy at production of measured fragments has been completely redefined, together with the efficiencies computation. The new analysis strategy has been successfully validated against the Monte Carlo cross sections. Two detection arms were positioned at two different angles to perform the measurement at 90$^{\text{o}}$ and 60$^{\text{o}}$. The fragment species have been identified in charge (Z$_{id}$ = H) and mass (M$_{id}$ = $^1$H, $^2$H, $^3$H) combining the information of the deposited energy in thin plastic scintillators, of the deposited energy in a thick LYSO crystal and of the fragments Time of Flight (ToF) measurement. The ToF was also used to compute the fragments measured kinetic energy. The cross sections are presented as a function of the fragments kinetic energy at production thanks to an unfolding technique applied to the data.

nucl-ex↗

arXiv2024

Angular differential and elemental fragmentation cross sections of a $400\,\text{MeV/nucleon}$ $^{16}\text{O}$ beam on a graphite target with the FOOT experiment

This paper presents the measurements of the angular differential cross sections for the forward production of He, Li, Be, B, C and N nuclei in the fragmentation process of a 400$\text{MeV/nucleon}$ $^{16}\text{O}$ beam interacting with a graphite target. Due to the limited data available in this energy regime, these measurements of nuclear fragmentation cross sections are relevant to improve nuclear interaction models for Particle Therapy and space radioprotection applications. The data analyzed in this paper were collected during a measurement campaign carried out at the GSI Helmholtz Center for Heavy Ion Research facility in Darmstadt (Germany) by the FOOT collaboration. The results are compared with similar results found in the literature and with a previous FOOT measurement of the same process, using the same setup, from a previous pilot run performed at GSI. The pilot run data, however, had limited statistics and only allowed for the measurement of elemental fragmentation cross sections integrated in the setup acceptance. This data set, with statistics more than 100 times larger compared to the data collected in the previous run, enabled the measurement of angular differential cross sections, fully exploiting the granularity of the FOOT $\Delta \text{E}$-TOF system. Furthermore, a better comprehension of the FOOT apparatus allowed to improve the analysis techniques, leading to a reduction in the final systematic uncertainties.

nucl-ex↗

arXiv2022

Analysis methods for in-beam PET images in proton therapy treatment verification: a comparison based on Monte Carlo simulations

Background and purpose: In-beam Positron Emission Tomography (PET) is one of the modalities that can be used for in-vivo non-invasive treatment monitoring in proton therapy. PET distributions obtained during various treatment sessions can be compared in order to identify regions that have anatomical changes. The purpose of this work is to test and compare different analysis methods in the context of inter-fractional PET image comparison for proton treatment verification. Methods: For our study we used the FLUKA Monte Carlo code and artificially generated CT scans to simulate in-beam PET distributions at different stages during proton therapy treatment. We compared the Beam-Eye-View method, the Most-Likely-Shift method, the Voxel-Based-Morphology method and the gamma evaluation method to compare PET images at the start of treatment, and after a few weeks of treatment. The results were compared to the CT scan. Results and conclusions: Three-dimensional methods like VBM and gamma are preferred above two-dimensional methods like MLS and BEV if much statistics is available, since the these methods allow to identify the regions with anomalous activity. The VBM approach has as disadvantage that a larger number of MC simulations is needed. The gamma analysis has the disadvantage that no clinical indication exist on tolerance criteria. In terms of calculation time, the BEV and MLS method are preferred. We recommend to use the four methods together, in order to best identify the location and cause of the activity changes.

physics.med-ph↗