Correlation Matters! Streamlining the Sample Size Procedure with Hierarchical Time-to-event Endpoints
Composite endpoints are widely used in cardiovascular clinical trials to improve statistical efficiency while preserving clinical relevance. The win ratio (WR) measure and more general frameworks of win statistics have emerged as popular alternatives to traditional time-to-first-event analyses. Although analytic sample size formulas for WR have been developed, they rely on design parameters that are often not straightforward to specify. Consequently, sample size determination in clinical trials with WR for the primary analysis is most often based on simulations, which, however, can be computationally intensive. To address this challenge, we derive refined formulas to calculate the proportions of wins, losses, and ties for multiple prioritized time-to-event endpoints to assist with study planning. These formulas rely on familiar design inputs and become directly applicable when integrated with existing sample size methods. We conduct a comprehensive assessment of how correlation among endpoints affects sample size requirements across varying design features, and demonstrate the role of correlations through case studies to generate further insights.