arXiv subjects

Felix Schwock

Publications and source records attributed to Felix Schwock.

5 recordsLinked to original sources

arXiv2026

Robust Neural Stimulation Response Modeling Through Meta-Learning and Pretraining

Objective: Model-based closed-loop neural stimulation holds promise for therapeutic applications ranging from Parkinson's disease to sensory restoration, but deployment has been limited by two obstacles: 1) forecasting models for predicting the consequences of stimulation fail catastrophically on a meaningful fraction of sessions, and 2) per-session calibration requirements are often incompatible with clinical constraints. We address both by demonstrating, for the first time, that meta-learning and pretraining can be applied to neural stimulation response modeling. Methods: Temporal basis function models (TBFMs) forecast state-dependent neural responses to stimulation. We extend TBFMs with cross-session pretraining using a novel architecture and algorithm based on model-agnostic meta-learning (MAML), evaluating them on 40 sessions of optogenetic stimulation in primary sensorimotor cortex of two non-human primates. Results: Meta-learning substantially reduces catastrophic forecast failure: for a 1k calibration set size, sessions with test R-squared < 0.05 drop from 16 of 40 (single-session training) to 1 (MAML-pretrained), and prediction intervals become significantly narrower (p < 0.05). Calibration requirements are reduced by 50-90% at matched accuracy, enabling experiments otherwise infeasible within clinical session-time constraints. Conclusion: Our results demonstrate that cross-session structure in stimulation responses is consistent enough to support pretraining, providing the first empirical evidence that meta-learning approaches are viable for neural stimulation. Significance: The robustness and sample efficiency gains directly address known obstacles to deploying model-based stimulation controllers. Our results motivate community efforts to assemble standardized multi-site stimulation datasets and to further explore meta-learning for robust closed-loop stimulation.

cs.LG↗

arXiv2025

Temporal Basis Function Models for Closed-Loop Neural Stimulation

Closed-loop neural stimulation provides novel therapies for neurological diseases such as Parkinson's disease (PD), but it is not yet clear whether artificial intelligence (AI) techniques can tailor closed-loop stimulation to individual patients or identify new therapies. Progress requires us to address a number of translational issues, including sample efficiency, training time, and minimizing loop latency such that stimulation may be shaped in response to changing brain activity. We propose temporal basis function models (TBFMs) to address these difficulties, and explore this approach in the context of excitatory optogenetic stimulation. We demonstrate the ability of TBF models to provide a single-trial, spatiotemporal forward prediction of the effect of optogenetic stimulation on local field potentials (LFPs) measured in two non-human primates. We further use simulations to demonstrate the use of TBF models for closed-loop stimulation, driving neural activity towards target patterns. The simplicity of TBF models allow them to be sample efficient, rapid to train (2-4min), and low latency (0.2ms) on desktop CPUs. We demonstrate the model on 40 sessions of previously published excitatory optogenetic stimulation data. For each session, the model required 15-20min of data collection to successfully model the remainder of the session. It achieved a prediction accuracy comparable to a baseline nonlinear dynamical systems model that requires hours to train, and superior accuracy to a linear state-space model. In our simulations, it also successfully allowed a closed-loop stimulator to control a neural circuit. Our approach begins to bridge the translational gap between complex AI-based approaches to modeling dynamical systems and the vision of using such forward prediction models to develop novel, clinically useful closed-loop stimulation protocols.

cs.LG↗

arXiv2023

Estimating and Analyzing Neural Information Flow Using Signal Processing on Graphs

Correlating neural communication in brain networks with behavior and cognition can provide fundamental insights into the functionality of both healthy and diseased brains. We demonstrate how communication in the brain can be estimated from recorded neural activity using concepts from graph signal processing. The communication is modeled as a flow signals on the edges of a graph and naturally arises from a graph diffusion process. We apply the diffusion model to micro-electrocorticography (ECoG) recordings from sensorimotor cortex of two non-human primates to estimate the neural communication flow during excitatory optogenetics. Comparisons with a baseline model demonstrate that adding the neural flow can improve ECoG predictions. Finally, we demonstrate how the neural flow can be decomposed into a gradient and rotational component and show that the gradient component depends on the location of stimulation. This technique, for the first time, offers the opportunity to study neural communication on an unprecedented spatiotemporal scale.

eess.SP↗

arXiv2023

Complex Clipping for Improved Generalization in Machine Learning

For many machine learning applications, a common input representation is a spectrogram. The underlying representation for a spectrogram is a short time Fourier transform (STFT) which gives complex values. The spectrogram uses the magnitude of these complex values, a commonly used detector. Modern machine learning systems are commonly overparameterized, where possible ill-conditioning problems are ameliorated by regularization. The common use of rectified linear unit (ReLU) activation functions between layers of a deep net has been shown to help this regularization, improving system performance. We extend this idea of ReLU activation to detection for the complex STFT, providing a simple-to-compute modified and regularized spectrogram, which potentially results in better behaved training. We then confirmed the benefit of this approach on a noisy acoustic data set used for a real-world application. Generalization performance improved substantially. This approach might benefit other applications which use time-frequency mappings, for acoustic, audio, and other applications.

eess.AS↗

arXiv2021

Statistical Properties of a Modified Welch Method That Uses Sample Percentiles

We present and analyze an alternative, more robust approach to the Welch's overlapped segment averaging (WOSA) spectral estimator. Our method computes sample percentiles instead of averaging over multiple periodograms to estimate power spectral densities (PSDs). Bias and variance of the proposed estimator are derived for varying sample sizes and arbitrary percentiles. We have found excellent agreement between our expressions and data sampled from a white Gaussian noise process.

eess.SP↗