Fengran Wang | Searcharxiv

arXiv2026

A Guideline-Grounded Multi-Agent Framework for Personalized Exercise Prescription from Clinical and Wearable Data

Translating population-level exercise guidance into individualized prescriptions requires integrating clinical and wearable data, including diagnoses, medications, functional limitations, and baseline activity, with condition-specific recommendations, a process difficult to scale beyond specialist rehabilitation settings. We developed FITTER, a multi-agent framework that integrates these data with condition-specific guidance to generate personalized FITT-VP prescriptions and applies deterministic safety audit and repair to correct rule-checkable violations. We evaluated FITTER using data from 400 All of Us participants (300 cancer, 100 stroke) against five LLM comparators through computational evaluation, ablation, and structured clinician review. FITTER achieved 98.5% safety-constraint compliance versus 75.8-85.8% for comparators and showed greater quantitative dosing precision and guideline alignment. Cancer-cohort ablation identified safety audit and repair as the largest contributor to safety-constraint compliance. Clinicians reviewed 80 prescriptions across safety, personalization, instruction concreteness, anticipated effectiveness, and clinical acceptability. FITTER provides a clinician-facing approach integrating clinical and wearable data, guidance, and explicit safety constraints.

cs.AI↗

arXiv2025

Towards Synthesizing Normative Data for Cognitive Assessments Using Generative Multimodal Large Language Models

Cognitive assessments require normative data as essential benchmarks for evaluating individual performance. Hence, developing new cognitive tests based on novel image stimuli is challenging due to the lack of readily available normative data. Traditional data collection methods are costly, time-consuming, and infrequently updated, limiting their practical utility. Recent advancements in generative multimodal large language models (MLLMs) offer a new approach to generate synthetic normative data from existing cognitive test images. We investigated the feasibility of using MLLMs, specifically GPT-4o and GPT-4o-mini, to synthesize normative textual responses for established image-based cognitive assessments, such as the "Cookie Theft" picture description task. Two distinct prompting strategies-naive prompts with basic instructions and advanced prompts enriched with contextual guidance-were evaluated. Responses were analyzed using embeddings to assess their capacity to distinguish diagnostic groups and demographic variations. Performance metrics included BLEU, ROUGE, BERTScore, and an LLM-as-a-judge evaluation. Advanced prompting strategies produced synthetic responses that more effectively distinguished between diagnostic groups and captured demographic diversity compared to naive prompts. Superior models generated responses exhibiting higher realism and diversity. BERTScore emerged as the most reliable metric for contextual similarity assessment, while BLEU was less effective for evaluating creative outputs. The LLM-as-a-judge approach provided promising preliminary validation results. Our study demonstrates that generative multimodal LLMs, guided by refined prompting methods, can feasibly generate robust synthetic normative data for existing cognitive tests, thereby laying the groundwork for developing novel image-based cognitive assessments without the traditional limitations.

cs.LG↗