arXiv subjects

Florian Kamp

Publications and source records attributed to Florian Kamp.

3 recordsLinked to original sources

arXiv2026

COBRA2026: a large-scale multicenter pelvic cone-beam computed tomography projection dataset

The COBRA2026 dataset is a large-scale, multicenter resource of raw radiotherapy cone-beam computed tomography (CBCT) acquisitions created for the development and evaluation of conventional and learning-based reconstruction and image-correction methods. It contains data from 867 patients undergoing pelvic radiotherapy at six European centers, acquired using Elekta and Varian imaging systems. For each case, the dataset includes raw projection data, acquisition geometry, calibration and correction information, clinically reconstructed CBCT images, and corresponding planning CT images. Vendor-specific files were anonymized and converted into open formats. Planning CT images were deformably registered to the daily CBCT anatomy, and matched projections were simulated using the corresponding acquisition geometry. All cases underwent visual quality control, and cases with substantial processing or registration errors were excluded. The approximately 950 GB dataset is divided into training, validation, and test sets containing 692, 52, and 123 cases, respectively. Projection stacks and volumetric images are provided as compressed MetaImage files, with geometry and metadata supplied in XML and YAML formats. COBRA2026 supports research on full- and sparse-view reconstruction, low-dose imaging, artifact and scatter correction, motion compensation, and synthetic CT generation. The dataset is released under the CC BY-NC 4.0 license, indexed on Zenodo (doi:10.5281/zenodo.21322350), and accompanied by openly available preprocessing and baseline reconstruction code. It also forms the basis of the COBRA2026 reconstruction challenge.

physics.med-ph↗

arXiv2026

Generating synthetic computed tomography for radiotherapy: SynthRAD2025 challenge report

Radiation therapy (RT) requires precise dose delivery over multiple fractions, with CT fundamental for treatment planning due to its electron density information. Repeated CT acquisitions impose radiation exposure and logistical burdens, MRI lacks electron density, and cone-beam CT (CBCT) requires correction for dose calculation. Synthetic CT (sCT) generation addresses these by converting MRI or CBCT into CT-equivalent images with accurate Hounsfield Unit (HU) values, enabling MRI-only RT and CBCT-based adaptive workflows. Building on SynthRAD2023, SynthRAD2025 benchmarked sCT methods on 2,362 patients from five European centers across head and neck, thorax, and abdomen. Two tasks: MRI-to-CT (890 cases) and CBCT-to-CT (1,472 cases), evaluated via image similarity (MAE, PSNR, MS-SSIM), segmentation (Dice, HD95), and dosimetric metrics from photon and proton plans. With 803 participants and 12/13 valid submissions, Task 1 top performance reached MAE $64.8\pm21.3$ HU, PSNR $\sim$30 dB, MS-SSIM $\sim$0.936, Dice 0.79, photon $\gamma_{2\%/2\text{mm}}>98\%$, proton $\gamma\approx85\%$. Task 2 improved: MAE $48.3\pm13.4$ HU, PSNR 32.6 dB, MS-SSIM 0.968, Dice 0.86, photon $\gamma>99\%$, proton $\gamma\approx89\%$. Strong image--segmentation correlations ($\rho=0.78$--$0.79$) but moderate dose correlations confirmed image quality is insufficient as a dosimetric surrogate. Head-and-neck cases were most consistent; thoracic and abdominal cases showed greater variability. Residual errors at tissue interfaces propagate along beam paths, affecting proton dose more than photon. SynthRAD2025 demonstrates that deep learning yields clinically relevant sCTs, especially for CBCT-to-CT, while identifying persistent MRI-to-CT challenges and underscoring dose-based evaluation as essential for clinical validation.

physics.med-ph↗

arXiv2025

SynthRAD2025 Grand Challenge dataset: generating synthetic CTs for radiotherapy

Medical imaging is essential in modern radiotherapy, supporting diagnosis, treatment planning, and monitoring. Synthetic imaging, particularly synthetic computed tomography (sCT), is gaining traction in radiotherapy. The SynthRAD2025 dataset and Grand Challenge promote advancements in sCT generation by providing a benchmarking platform for algorithms using cone-beam CT (CBCT) and magnetic resonance imaging (MRI). The dataset includes 2362 cases: 890 MRI-CT and 1472 CBCT-CT pairs from head-and-neck, thoracic, and abdominal cancer patients treated at five European university medical centers (UMC Groningen, UMC Utrecht, Radboud UMC, LMU University Hospital Munich, and University Hospital of Cologne). Data were acquired with diverse scanners and protocols. Pre-processing, including rigid and deformable image registration, ensures high-quality, modality-aligned images. Extensive quality assurance validates image consistency and usability. All imaging data is provided in MetaImage (.mha) format, ensuring compatibility with medical image processing tools. Metadata, including acquisition parameters and registration details, is available in structured CSV files. To maintain dataset integrity, SynthRAD2025 is divided into training (65%), validation (10%), and test (25%) sets. The dataset is accessible at https://doi.org/10.5281/zenodo.14918089 under the SynthRAD2025 collection. This dataset supports benchmarking and the development of synthetic imaging techniques for radiotherapy applications. Use cases include sCT generation for MRI-only and MR-guided photon/proton therapy, CBCT-based dose calculations, and adaptive radiotherapy workflows. By integrating diverse acquisition settings, SynthRAD2025 fosters robust, generalizable image synthesis algorithms, advancing personalized cancer care and adaptive radiotherapy.

physics.med-ph↗