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Florian Thomas-Odenthal

Publications and source records attributed to Florian Thomas-Odenthal.

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Roleplaying with Structure: Synthetic Therapist-Client Conversation Generation from Questionnaires

Large Language Models (LLMs) are promising tools for synthetic data generation in mental health. However, privacy policies and restrictions forced previous work to rely mainly on generic information. We present a comprehensive corpus of synthetic therapist-client conversations generated through LLMs. We construct our generation pipeline, SQPsych (Structured Questionnaire-based Psychotherapy), which uses real structured client profiles and psychological questionnaires without leaking any sensitive data. We fine-tune various open-weight LLMs on our generated corpus, SQPsychConv , and test them through both automatic benchmarks and human evaluation with trained psychotherapists. We find that standard benchmarks do not adequately capture the strengths of our dataset, but expert judgment shows that SQPsych makes LLMs significantly better at therapist roleplaying. Experts also consistently prefer therapy sessions generated by our models compared to other mental-health-oriented LLMs. We release our code, fine-tuned models SQPsychLLM, and corpora at https://ai-mh.github.io/SQPsych.html.

cs.CL

deepmriprep: Voxel-based Morphometry (VBM) Preprocessing via Deep Neural Networks

Voxel-based Morphometry (VBM) has emerged as a powerful approach in neuroimaging research, utilized in over 7,000 studies since the year 2000. Using Magnetic Resonance Imaging (MRI) data, VBM assesses variations in the local density of brain tissue and examines its associations with biological and psychometric variables. Here, we present deepmriprep, a neural network-based pipeline that performs all necessary preprocessing steps for VBM analysis of T1-weighted MR images using deep neural networks. Utilizing the Graphics Processing Unit (GPU), deepmriprep is 37 times faster than CAT12, the leading VBM preprocessing toolbox. The proposed method matches CAT12 in accuracy for tissue segmentation and image registration across more than 100 datasets and shows strong correlations in VBM results. Tissue segmentation maps from deepmriprep have over 95% agreement with ground truth maps, and its non-linear registration, using supervised SYMNet, predicts smooth deformation fields comparable to CAT12. The high processing speed of deepmriprep enables rapid preprocessing of extensive datasets and thereby fosters the application of VBM analysis to large-scale neuroimaging studies and opens the door to real-time applications. Finally, deepmripreps straightforward, modular design enables researchers to easily understand, reuse, and advance the underlying methods, fostering further advancements in neuroimaging research. deepmriprep can be conveniently installed as a Python package and is publicly accessible at https://github.com/wwu-mmll/deepmriprep.

eess.IV