arXiv subjects

François Charest

Publications and source records attributed to François Charest.

5 recordsLinked to original sources

arXiv2026

AI-assisted Protocol Information Extraction For Improved Accuracy and Efficiency in Clinical Trial Workflows

Increasing clinical trial protocol complexity, amendments, and challenges around knowledge management create significant burden for trial teams. Structuring protocol content into standard formats has the potential to improve efficiency, support documentation quality, and strengthen compliance. We evaluate an Artificial Intelligence (AI) system using generative LLMs with Retrieval-Augmented Generation (RAG) for automated clinical trial protocol information extraction. We compare the extraction accuracy of our clinical-trial-specific RAG process against that of publicly available (standalone) LLMs. We also assess the operational impact of AI-assistance on simulated extraction Clinical Research Coordinator (CRC) workflows. Our RAG process shows higher extraction accuracy (89.0%) than standalone LLMs with fine-tuned prompts (62.6%) against expert-supported reference annotations. In simulated extraction workflows, AI-assisted tasks are completed 40% faster, are rated as less cognitively demanding and are strongly preferred by users. While expert oversight remains essential, this suggests that AI-assisted extraction can enable protocol intelligence at scale, motivating the integration of similar methodologies into real-world clinical workflows to further validate its impact on feasibility, study start-up, and post-activation monitoring.

cs.IR↗

arXiv2022

Floer theory and flips

We show that blow-ups or reverse flips (in the sense of the minimal model program) of rational symplectic manifolds with point centers create Floer-non-trivial Lagrangian tori. As applications, we demonstrate the existence of Hamiltonian non-displaceable Lagrangian tori in, for example, small symplectic blow-ups of compact symplectic manifolds and moduli spaces of polygons. These results are part of a conjectural description of generators for the Fukaya category of a compact symplectic manifold with a singularity-free running of the minimal model program.

math.SG↗

arXiv2017

Floer trajectories and stabilizing divisors

We incorporate pearly Floer trajectories into the transversality scheme for pseudoholomorphic maps introduced by Cieliebak-Mohnke. By choosing generic domain-dependent almost complex structures we obtain zero and one-dimensional moduli spaces with the structure of cell complexes with rational fundamental classes. This gives a definition of Floer cohomology over Novikov rings via stabilizing divisors for compact symplectic manifolds with rational symplectic classes and Lagrangians that are fixed point sets of anti-symplectic involutions satisfying certain Maslov index conditions, in particular, Hamiltonian Floer cohomology.

math.SG↗

arXiv2017

Fukaya algebras via stabilizing divisors

We use the technique of stabilizing divisors introduced by Cieliebak-Mohnke to construct finite dimensional, strictly unital Fukaya algebras of compact, oriented, relatively spin Lagrangians in compact symplectic manifolds with rational symplectic classes. The homotopy type of the algebra and the moduli space of solutions to the weak Maurer-Cartan equation are shown to be independent of the choice of perturbation data. The Floer cohomology is the cohomology of a complex of vector bundles over the space of solutions to the weak Maurer-Cartan equation and is shown to be independent of the choice of perturbation data up to gauge equivalence.

math.SG↗

arXiv2012

Source Spaces and Perturbations for Cluster Complexes

We define objects made of marked complex disks connected by metric line segments and construct nonsymmetric and symmetric moduli spaces of these objects. This allows choices of coherent perturbations over the corresponding versions of the Floer trajectories proposed by Cornea and Lalonde. These perturbations are intended to lead to an alternative description of the (obstructed) $A_\infty$-structures studied by Fukaya, Oh, Ohta and Ono. Given a $Pin_{\pm}$ monotone lagrangian submanifold $L \subset (M,ω)$ with minimal Maslov number $N_L \geq 2$, we define an $A_\infty$-algebra (resp. differential graded algebra) structure from the critical points of a generic Morse function on $L$. It is written as a cochain (resp. chain) complex extending the pearl complex introduced by Oh and further explicited by Biran and Cornea, equipped with its quantum product. We verify that the construction is homotopy invariant, defining a functor from a homotopy category of $Pin_{\pm}$ monotone lagrangian submanifolds $h\mathcal{L}^{mono, \pm}(M,ω)$ to the homotopy category of cochain (resp. chain) complexes $hK(Λ\text{-mod})$ where $Λ$ is a Novikov ring with coefficients in $\mathbb{Z}$.

math.SG↗