arXiv subjects

Francesco Fontani

Publications and source records attributed to Francesco Fontani.

At least 19 recordsLinked to original sources

arXiv2026

FAUST XXXII. Chemically layered structures and ionisation in the disk and envelope of NGC 1333 IRAS 4C

Recent molecular line observations with high spatial resolutions have revealed vertical chemical stratification in Class I/II disks (i.e. chemical composition changing with height in the vertical direction of the disk), as well as a radial variation of ionisation rates. However, such chemical layered structures in Class 0 disk and envelope systems have been investigated only for limited objects, such as L1527. In the context of the ALMA Large Program FAUST, we report the results of molecular line observations toward the disk and envelope around the low-mass Class 0 protostar NGC 1333 IRAS 4C in the Perseus Molecular Cloud. Previous observations have shown that the disk rotation axis of this object is largely tilted to the line of sight, making it suitable for studying the molecular abundance distribution as a function of disk height. We found that the molecules known as gas density tracers such as C18O and H2CO are distributed around the disk midplane. In addition, molecules known as tracers of photochemical reactions such as CCH and c-C3H2 are distributed in the low-density upper layers of the disk, unlike the distribution in L1527. Moreover, the column density ratio of HCO+/CO derived from the H13CO+ and C18O line emission suggests that the ionisation degree and the ionisation rate vary with the disk radius and they are larger in the outer region of the disk and envelope.

astro-ph.EP↗

arXiv2026

Unveiling star formation at sub-solar metallicity with ALMA2040

A fundamental question in astrophysics is whether the processes governing star formation are universal or depend on the physical conditions of their local galactic environment. The Milky Way and the Magellanic clouds offer ideal laboratories to explore this question, as the gas conditions in them span up to orders of magnitude in metallicity, gas surface density, ambient pressure, dust abundance, radiation field, and cosmic-ray flux. In particular, both the outer Milky Way and the Magellanic clouds provide the closest low-metallicity environments with conditions similar to those of metal-poor galaxies, while remaining sufficiently close to soon allow spatial resolution of individual star-forming cores and disks. Recent observations with ALMA and other facilities have begun to unveil the physical and chemical properties of star-forming regions in low-metallicity environments. Yet, their distances from the Sun still require transformational gains in current ALMA capabilities to address fundamental open questions: (1) Are the properties of prestellar cores universal? (2) Does cloud fragmentation, and the resulting stellar IMF, depend critically on metallicity? (3) How does dust evolution depend on metallicity, and what is the impact in the survival of protoplanetary disks? (4) Is the reduced amount of metals and dust shielding at low metallicity critical for the formation and survival of molecules? ALMA2040 will identify similarities and differences between solar- and sub-solar-metallicity star-forming regions, and answer the question: how do different environmental conditions influence the physical and chemical pathways leading to star formation?

astro-ph.IM↗

arXiv2026

From local chemistry to galactic evolution: unlocking the power of interstellar isotopes with ALMA2040

Molecular isotopic ratios provide a unique window into the chemical evolution of the interstellar medium, linking stellar nucleosynthesis and Galactic chemical evolution to the physical and chemical processes shaping molecular clouds, star-forming regions, and planetary systems. However, molecular isotopic ratios do not necessarily trace the underlying elemental composition, as chemical isotopic fractionation, isotope-selective photodissociation, grain chemistry, and radiative-transfer effects can significantly alter the observed values. Disentangling these effects requires simultaneous observations of multiple transitions, isotope systems and molecular families, including rare, doubly, and multiply substituted isotopologues involving D, $^{13}$C, $^{15}$N, $^{17,18}$O, $^{29,30}$Si, and $^{33,34,36}$S (e.g., $^{13}$C$^{15}$N, $^{13}$C$^{34}$S, and $^{13}$C$^{18}$O). ALMA2040, with an order-of-magnitude improvement in sensitivity and at least 512 GHz of instantaneous bandwidth, will make these species accessible across statistically significant samples of Galactic and nearby extragalactic sources. By enabling systematic isotopic inventories from molecular clouds and prestellar cores to protoplanetary systems, across the Milky Way and in external galaxies, ALMA2040 will establish molecular isotopes as quantitative probes of chemical inheritance, stellar nucleosynthesis, and galaxy evolution, disentangling local chemical processing from the large-scale evolution of matter from stars to new planetary systems.

astro-ph.IM↗

arXiv2026

Frontiers of chemical complexity in the interstellar medium: unveiling the cosmic origins of life

The interstellar medium (ISM) contains a rich molecular inventory that provides a unique window into the chemistry operating during star and planet formation and its connection to prebiotic chemistry. More than 350 interstellar molecules are currently known, including increasingly complex organic molecules and species containing elements beyond the second row of the periodic table. Yet the limits that interstellar chemical complexity can reach, its evolution from molecular clouds to planetary systems, and its contribution to the molecular feedstock of life remain poorly constrained. Addressing these questions requires sensitive, broadband observations capable of detecting multiple weak rotational transitions of molecular species, such as amino acids, nucleobases, sugars and lipids, towards star- and planet-forming environments. Current facilities, including ALMA, are limited by instantaneous spectral coverage, sensitivity (especially on extended spatial scales), and the trade-off between total bandwidth and integration time. The proposed ALMA2040 facility would overcome these limitations through at least a tenfold improvement in spectral-line sensitivity, high-fidelity imaging from sub-arcsecond to tens-of-arcsecond scales, and ultra-broad instantaneous frequency coverage from 35 to 950 GHz at high spectral resolution. These capabilities would allow systematic detections of species with molecular abundances with respect to H$_2$ below 10$^{-11}$, facilitating the identification of new complex and heavy-element-bearing species through multiple transitions, and providing complete molecular inventories across evolutionary stages. ALMA2040 would thus make it possible to comprehensively investigate the emergence and evolution of chemical complexity, and to determine whether molecular precursors of prebiotic chemistry are widespread throughout the Galaxy.

astro-ph.IM↗

arXiv2026

Star Formation across the Galaxy

Star formation is both a multi-scale and highly dynamic process. It is regulated by the combination of gravity, turbulence, feedback and magnetic fields, which connect more than six orders of magnitude in scale: from large molecular clouds (several 10s to 100s pc in size) down to protoplanetary disks (a few 10s to 100s of astronomical units in size, or 10^{-5} to 10^{-4} pc). Resolving the processes of fragmentation, accretion, and feedback that result in the formation of stellar systems throughout all relevant scales, from clouds to disks, and across the entire range of different environments in the Milky Way is key to constructing a comprehensive understanding and a predictive model of the formation process of stars of all masses that populate not only our Galaxy but the wider Universe across cosmic times. With current astronomical facilities, we are only able to grasp the details of star formation in <5% of Galactic star-forming regions, being heavily biased towards those close to us. Thus, characterizing this multi-scale phenomenon at the necessary sensitivity and resolution across all Galactic environments requires the next generation (sub)millimeter-wavelength facility: ALMA2040.

astro-ph.IM↗

arXiv2026

The environments forming stellar and planetary systems

How does a star's birth environment set the mass, angular momentum and chemical complexity delivered to its planet-forming disk, and thereby whether it builds planets, brown dwarfs or stellar companions? This requires following material from the cloud to the sub-au to few-au scales where infalling gas, magnetized winds and the disk interact, across all star-forming environments. At frequencies where young disks are optically thin, current facilities, even ALMA after its Wideband Sensitivity Upgrade, fall short by a factor of a few in angular resolution and an order of magnitude in sensitivity. Likewise, resolving how disks around distant high-mass stars fragment into tight multiples requires a linear resolution of a few to a few tens of au, currently out of reach. Yet the disks characterized so far lie almost exclusively in nearby, isolated clouds at near-solar metallicity, although the environment (radiation field, ionization rate, gas and stellar density, pressure and metallicity) varies by orders of magnitude across the Galaxy. Most stars, probably including the Sun, form in clustered regions at kpc distances, and the widest metallicity range lies farther still, in the outer Galaxy, the Central Molecular Zone and the Magellanic Clouds. With three times finer angular resolution and ten times the sensitivity, ALMA2040 will follow the path of material from cloud to disk across the full stellar-mass spectrum and, for the first time, measure how this path changes with environment: resolving the sub-au infall-impact and wind-launching zones nearby, disk fragmentation and the onset of multiplicity in distant high-mass regions, and disk formation at a few tenths of solar metallicity. It will thereby reveal the dust-obscured, embedded origins of planetary systems that optical and infrared facilities, including the ELT, see only once they emerge, and show how the birth environment shapes them.

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arXiv2026

Observations of non complex organic molecules in the gas phase of the interstellar medium

The field of astrochemistry has seen major advances triggered by the completion of new powerful radio telescopes, with gains in sensitivity of receivers and in bandwidth. As of June 2026, about 347 molecular species have been detected, in interstellar clouds, circumstellar shells and even extragalactic sources. The first interstellar molecules were first discovered through their electronic transitions in the visual and near UV regions of the spectra in the 1930s. Then the discovery of (pure) rotational transitions of interstellar molecules dates back to the late 1960s. The improvement of detectors and the increase in telescope sizes really opened up the submillimeter sky. The radio and submillimeter ranges cover the lowest rotational lines of molecular species. The bigger the molecule, the more spectral lines at different frequencies it produces, with weaker line intensities. Over the past 30 years, we have discovered that we live in a molecular universe, where molecules are abundant and widespread, probing the structure and evolution of galaxies, as well as the temperature and density of the observed medium, opening a new field called astrochemistry. The progress has been dramatic, since the discovery of the first molecules about 100 years ago. We present in this review, the detection techniques that led to the discovery of the simple molecules in the gas phase and the methodology that lead to the abundances determinations and the comparison with chemical modelling.

astro-ph.GA↗

arXiv2026

Low cosmic-ray ionisation at parsec scales in G035.39-00.33

Cosmic rays (CRs) regulate the chemical evolution of the gas and its coupling to the magnetic field in the densest and coldest regions of the interstellar medium (ISM). However, the CR ionisation rate of H$_2$ ($ζ_2$) is one of the most debated parameters characterising molecular clouds due to the uncertainties in its estimation. We developed a new analytical framework based on the chemistry of N$_2$H$^+$, N$_2$D$^+$ and DCO$^+$ to overcome observational limitations in current estimates of $ζ_2$ and to probe the latter and the electron fraction, $x(e)$, in the gas across multiple density regimes. We applied this method towards the parsec-scale filament of the infrared dark cloud (IRDC) G035.39-00.33 with new observations from the NOrthern Extended Array (NOEMA) at a resolution of $3''$ (or $\sim9000$ au). Ancillary observations of C$^{18}$O complete this survey to measure $x(e)$ and $ζ_2$ in G035.39-00.33. CO depletion is widespread in G035.39-00.33 with factors, $f_\mathrm{D}$, positively correlated with column and number densities of H$_2$ in the cloud. The deuterium fractions ($R_\mathrm{D}$) are enhanced towards these same sites in which the corresponding electron fraction values cluster below $\lesssim10^{-8}$. $ζ_2$ varies by three orders of magnitude in G035.39-00.33 ($\sim10^{-18}-10^{-15}$ s$^{-1}$) with a median of $\sim2.3\times10^{-18}$ s$^{-1}$, consistent with those reported for other IRDCs and giant filaments, but on average lower than the typical $ζ_2$ for the ISM. $ζ_2$ shows a functional dependence on $N(\mathrm{H_2})$, but with absolute values lower compared to those predicted by theoretical models. This behaviour suggests the presence of an overall attenuation of the CR flux taking place in G035.39-00.33. The CR flux appears to be reduced by the change in magnetic field strength and morphology previously reported in the region.

astro-ph.GA↗

arXiv2026

Chemical Complexity in the Early Stages of Star Formation in the SKAO Era

About 350 molecules have been identified in the interstellar medium (ISM), including complex molecules relevant to prebiotic chemistry. A remarkable level of molecular diversity has been observed from the earliest stages of star formation, providing the initial chemical inventory inherited by planetary systems. Radio observations have played a pivotal role in these discoveries, starting with the identification of the first polyatomic molecule, $\text{NH}_3$ (Cheung et al. 1968). (Sub-)millimeter observations have revealed complex organic molecules of prebiotic relevance, including formamide ($\text{NH}_2\text{CHO}$), glycolaldehyde ($\text{CH}_2\text{OHCHO}$), and even urea ($(\text{NH}_2)_2\text{CO}$), and hydroxylamine ($\text{NH}_2\text{OH}$), which are possible precursors of RNA nucleotides (Ceccarelli et al. 2023; Jiménez-Serra et al. 2020). However, in dense protostellar regions, dust opacity hampers the detection of molecular emission. Additionally, large molecules and those containing heavy atoms, which have rotational transitions at lower frequencies, often remain inaccessible to current instruments. The Square Kilometre Array Observatory (SKAO) will provide an unprecedented combination of sensitivity and angular resolution at radio wavelengths. This will allow for the detection of prebiotic species and offer new insights into the chemical pathways that shape emerging planetary systems (Jiménez-Serra et al. 2022). This chapter details the scientific questions and advancements that the SKAO, and more specifically, SKA-Mid equipped with the Band 5 receivers, will pursue in the field of astrochemistry, focusing on the chemical complexity in both high-mass and solar-type star-forming regions.

astro-ph.SR↗

arXiv2025

SiO emission in the filamentary Infrared Dark Cloud G035.39-00.33: An ALMA view

Filamentary infrared dark clouds (IRDCs) are believed to represent the initial conditions for massive star and cluster formation. We investigate the IRDC G035.39-00.33 using SiO, H13CO+, CH3OH, and CS emission observed with ALMA at 3.5\arcsec\ resolution (0.05 pc). The SiO emission traces shock activity within the cloud, providing insights into current star formation and cloud formation mechanisms. We identify several regions with broad SiO emission clearly associated with outflows, pinpointing the locations of ongoing star formation across the cloud. The ALMA images also reveal a series of spatially extended SiO emission spots with narrow line profiles, aligned along an arc-like path that is also seen in CS and CH3OH emission. While the broad SiO emission is mainly associated with the main cloud filament, as seen in visual extinction, the narrow SiO arch is located at the edge of the cloud, far from the identified sites of star formation activity. The presence of these arc-like morphologies suggests that large-scale shocks may have compressed the gas in the surroundings of the G035.39-00.33 cloud, shaping its filamentary structure. By inspecting the large-scale radio continuum emission around G035.39-00.33, we find that this IRDC is part of a larger star-forming complex where the densest and coolest material appears at the interacting regions between a Supernova Remnant (SNR) and an expanding HII region. In particular, we hypothesize that this IRDC may be spatially coincident with the ionized expanding gas associated with the previously identified SNR G35.6-0.4. We suggest that collisions between giant molecular clouds and expanding gas flows from interacting SNRs and HII regions may be responsible for the observed arc-like structures. Such shock compressions could play an important role in the formation of IRDCs and in the potential triggering of star formation.

astro-ph.GA↗

arXiv2025

The Emergence of Prebiotic Chemistry in the ISM

Contrary to popular belief, the interstellar medium (ISM) is not empty; it is filled with atoms, dust particles, and molecules. Some of these molecules may have been the very building blocks of life that, delivered to Earth via comets and meteorites, could have given rise to Life itself. A large-area single-dish telescope with superb sensitivity, field-of-view and multi-band instruments will allow us to explore the limits of chemical complexity in the interstellar medium, across our Galaxy and in external galaxies, determining whether amino acids, sugars, or RNA/DNA nucleobases can form in space.

astro-ph.IM↗

arXiv2025

Chemical evolution in high-mass star-forming regions

Growing evidence shows that most stars in the Milky Way, including the Sun, are born in high-mass star-forming regions, but due to both observational and theoretical challenges, our understanding of their chemical evolution is much less clear than that of their low-mass counterparts. Thanks to the capabilities of new generation telescopes and computers, a growing amount of observational and theoretical results have been recently obtained, which have important implications not only for our understanding of the (still mysterious) formation process of high-mass stars, but also for the chemistry that the primordial Solar System might have inherited from its birth environment. In this review, we summarise the main observational and theoretical results achieved in the last decades in the study of chemistry evolution in high-mass star-forming regions, and in the identification of chemical evolutionary indicators. Emphasis is especially given to observational studies, for which most of the work has been carried out so far. A comparison with the chemical evolution occurring in other astrophysical environments, in particular in low-mass star-forming cores and extragalactic cores, is also briefly presented. Current open questions and future perspectives are discussed.

astro-ph.GA↗

arXiv2025

Understanding molecular ratios in the carbon and oxygen poor outer Milky Way with interpretable machine learning

Context. The outer Milky Way has a lower metallicity than our solar neighbourhood, but still many molecules are detected in the region. Molecular line ratios can serve as probes to better understand the chemistry and physics in these regions. Aims. We use interpretable machine learning to study 9 different molecular ratios, helping us understand the forward connection between the physics of these environments and the carbon and oxygen chemistries. Methods. Using a large grid of astrochemical models generated using UCLCHEM, we study the properties of molecular clouds of low oxygen and carbon initial abundance. We first try to understand the line ratios using a classical analysis. We then move on to using interpretable machine learning, namely Shapley Additive Explanations (SHAP), to understand the higher order dependencies of the ratios over the entire parameter grid. Lastly we use the Uniform Manifold Approximation and Projection technique (UMAP) as a reduction method to create intuitive groupings of models. Results. We find that the parameter space is well covered by the line ratios, allowing us to investigate all input parameters. SHAP analysis shows that the temperature and density are the most important features, but the carbon and oxygen abundances are important in parts of the parameter space. Lastly, we find that we can group different types of ratios using UMAP. Conclusions. We show the chosen ratios are mostly sensitive to changes in the carbon initial abundance, together with the temperature and density. Especially the CN/HCN and HNC/HCN ratio are shown to be sensitive to the initial carbon abundance, making them excellent probes for this parameter. Out of the ratios, only CS/SO shows a sensitivity to the oxygen abundance.

astro-ph.GA↗

arXiv2024

Observations of phosphorus-bearing molecules in the interstellar medium

The chemistry of phosphorus (31P) in space is particularly significant due to the key role it plays in biochemistry on Earth. Utilising radio and infrared spectroscopic observations, several key phosphorus-containing molecules have been detected in interstellar clouds, circumstellar shells, and even extragalactic sources. Among these, phosphorus nitride (PN) was the first P-bearing molecule detected in space, and still is the species detected in the largest number of sources. Phosphorus oxide (PO) and phosphine (PH3) were also crucial species due to their role both in chemical networks and in forming biogenic compounds. The still limited high-angular resolution observations performed so far are shading light on the geometrical distribution of these molecules, which represent crucial insights on their formation processes. Observations have also highlighted the challenges and complexities associated with detecting and understanding phosphorus chemistry in space, owing to the low elemental abundance of P relative to other elements. This review article provides a state-of-art picture of the observational results obtained so far on phosphorus compounds in the interstellar medium. Special attention is given to star-forming regions, and to their implications for our understanding of prebiotic chemistry and the potential for life beyond Earth. Our knowledge of the dominant formation and destruction pathways of the most abundant species has improved, but critical questions remain open, among which: what is (are) the main phosphorus carrier(s) in space? Upcoming facilities will offer new opportunities to both detect new phosphorus-bearing molecules and enlarge the number of sources in which the chemistry of P can be studied. The synergy between observations, models, laboratory experiments, and computational works is mandatory to progress in this field.

astro-ph.GA↗

arXiv2024

Multiple chemical tracers finally unveil the intricate NGC\,1333 IRAS\,4A outflow system. FAUST XVI

The exploration of outflows in protobinary systems presents a challenging yet crucial endeavour, offering valuable insights into the dynamic interplay between protostars and their evolution. In this study, we examine the morphology and dynamics of jets and outflows within the IRAS\,4A protobinary system. This analysis is based on ALMA observations of SiO(5--4), H$_2$CO(3$_{0,3}$--2$_{0,3}$), and HDCO(4$_{1,4}$--3$_{1,3}$) with a spatial resolution of $\sim$150\,au. Leveraging an astrochemical approach involving the use of diverse tracers beyond traditional ones has enabled the identification of novel features and a comprehensive understanding of the broader outflow dynamics. Our analysis reveals the presence of two jets in the redshifted emission, emanating from IRAS\,4A1 and IRAS\,4A2, respectively. Furthermore, we identify four distinct outflows in the region for the first time, with each protostar, 4A1 and 4A2, contributing to two of them. We characterise the morphology and orientation of each outflow, challenging previous suggestions of bends in their trajectories. The outflow cavities of IRAS\,4A1 exhibit extensions of 10$''$ and 13$''$ with position angles (PA) of 0$^{\circ}$ and -12$^{\circ}$, respectively, while those of IRAS\,4A2 are more extended, spanning 18$''$ and 25$''$ with PAs of 29$^{\circ}$ and 26$^{\circ}$. We propose that the misalignment of the cavities is due to a jet precession in each protostar, a notion supported by the observation that the more extended cavities of the same source exhibit lower velocities, indicating they may stem from older ejection events.

astro-ph.GA↗

arXiv2024

The Wide-field Spectroscopic Telescope (WST) Science White Paper

The Wide-field Spectroscopic Telescope (WST) is proposed as a new facility dedicated to the efficient delivery of spectroscopic surveys. This white paper summarises the initial concept as well as the corresponding science cases. WST will feature simultaneous operation of a large field-of-view (3 sq. degree), a high multiplex (20,000) multi-object spectrograph (MOS) and a giant 3x3 sq. arcmin integral field spectrograph (IFS). In scientific capability these requirements place WST far ahead of existing and planned facilities. Given the current investment in deep imaging surveys and noting the diagnostic power of spectroscopy, WST will fill a crucial gap in astronomical capability and work synergistically with future ground and space-based facilities. This white paper shows that WST can address outstanding scientific questions in the areas of cosmology; galaxy assembly, evolution, and enrichment, including our own Milky Way; origin of stars and planets; time domain and multi-messenger astrophysics. WST's uniquely rich dataset will deliver unforeseen discoveries in many of these areas. The WST Science Team (already including more than 500 scientists worldwide) is open to the all astronomical community. To register in the WST Science Team please visit https://www.wstelescope.com/for-scientists/participate

astro-ph.IM↗

arXiv2024

Polarized Light from Massive Protoclusters (POLIMAP). I. Dissecting the role of magnetic fields in the massive infrared dark cloud G28.37+0.07

Magnetic fields may play a crucial role in setting the initial conditions of massive star and star cluster formation. To investigate this, we report SOFIA-HAWC+ $214\:μ$m observations of polarized thermal dust emission and high-resolution GBT-Argus C$^{18}$O(1-0) observations toward the massive Infrared Dark Cloud (IRDC) G28.37+0.07. Considering the local dispersion of $B$-field orientations, we produce a map of $B$-field strength of the IRDC, which exhibits values between $\sim0.03 - 1\:$mG based on a refined Davis-Chandrasekhar-Fermi (r-DCF) method proposed by Skalidis \& Tassis. Comparing to a map of inferred density, the IRDC exhibits a $B-n$ relation with a power law index of $0.51\pm0.02$, which is consistent with a scenario of magnetically-regulated anisotropic collapse. Consideration of the mass-to-flux ratio map indicates that magnetic fields are dynamically important in most regions of the IRDC. A virial analysis of a sample of massive, dense cores in the IRDC, including evaluation of magnetic and kinetic internal and surface terms, indicates consistency with virial equilibrium, sub-Alfvénic conditions and a dominant role for $B-$fields in regulating collapse. A clear alignment of magnetic field morphology with direction of steepest column density gradient is also detected. However, there is no preferred orientation of protostellar outflow directions with the $B-$field. Overall, these results indicate that magnetic fields play a crucial role in regulating massive star and star cluster formation and so need to be accounted for in theoretical models of these processes.

astro-ph.GA↗

arXiv2022

Astrochemical modelling of infrared dark clouds

Infrared dark clouds (IRDCs) are cold, dense regions of the interstellar medium (ISM) that are likely to represent the initial conditions for massive star formation. It is thus important to study the physical and chemical conditions of IRDCs to provide constraints and inputs for theoretical models of these processes. We aim to determine the astrochemical conditions, especially cosmic ray ionisation rate (CRIR) and chemical age, in different regions of the massive IRDC G28.37+00.07 by comparing observed abundances of multiple molecules and molecular ions with the predictions of astrochemical models. We have computed a series of single-zone astrochemical models with a gas-grain network that systematically explores the parameter space of density, temperature, CRIR, and visual extinction. We have also investigated the effects of choices of CO ice binding energy and temperatures achieved in transient heating of grains when struck by cosmic rays. We selected 10 positions across the IRDC that are known to have a variety of star formation activity. We utilised mid-infrared (MIR) extinction maps and sub-mm emission maps to measure the mass surface densities of these regions, needed for abundance and volume density estimates. The sub-mm emission maps were also used to measure temperatures. We then used IRAM-30m observations of various tracers to estimate column densities and thus abundances. Using estimates of the abundances of CO, HCO$^+$ and N$_2$H$^+$ we find consistency with astrochemical models that have relatively low CRIRs of $ζ\sim10^{-18}$ to $\sim10^{-17}\:{\rm s}^{-1}$, with no evidence for systematic variation with the level of star formation activity. Astrochemical ages are found to be < 1 Myr. We discuss potential sources of systematic uncertainties in these results and the overall implications for IRDC evolutionary history and astrochemical models.(abridged for arXiv)

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