arXiv subjects

Francesco Tudisco

Publications and source records attributed to Francesco Tudisco.

At least 19 recordsLinked to original sources

arXiv2026

From Raw Segmentations to Simulation-Ready Cardiac Meshes: An Automated Framework for Anatomical Reconstruction and Virtual Cohort Generation

Computational models of the human heart are widely used to study electromechanical and fluid-dynamical cardiac function and to support applications such as in silico clinical trials. However, most studies remain limited to single or patient-specific anatomies, restricting the inclusion of population-level variability required for uncertainty quantification. A key challenge is translating medical-image segmentations, which may contain artifacts, mesh defects or disjoint domains, into topologically coherent geometries suitable for multiphysics simulations. In this work, we present a semi-automatic pipeline that converts CT-based segmentations into simulation-ready cardiac meshes within a few minutes while preserving anatomical and topological consistency. Building on modern deep learning segmentation methods, the framework incorporates a template-based registration stage to regularize artifacts and enforce mesh-quality constraints. A Chamfer-distance morphing strategy deforms a high-quality template toward each segmented heart, matching individual chambers while preserving topology. The resulting meshes are watertight, isotopological, and endowed with consistent point-to-point correspondence. The pipeline is validated on 58 healthy cardiac CT scans, including all cardiac chambers and proximal vessel segments. The resulting meshes can be represented in a unified shape space, enabling the construction of a statistical shape model of the heart and major vessels. Principal Component Analysis shows that a low-dimensional latent space efficiently captures population variability, while Gaussian Mixture Modeling enables synthetic anatomy generation. Overall, the proposed framework (released open-source) provides a pathway from raw segmentations to simulation-ready cardiac geometries, enabling anatomically consistent virtual cohorts for large-scale in silico studies.

cs.CV↗

arXiv2026

Constrained Variable Projection for Structured Problems

Variable projection is a classical technique for separable nonlinear least-squares problems, in which variables that enter linearly are eliminated exactly, yielding a reduced nonlinear problem. By expressing this framework as a particular instance of a broader class of bilevel optimization problems, we develop a constrained variable-projection framework for data-science models, where the remaining variables are subject to convex constraints and the eliminated variables arise from a lower-level least-squares problem. In particular, by interpreting variable projection as a collapsed bilevel optimization problem, we derive exact reduced-gradient formulas compatible with automatic differentiation and propose a conditional-gradient algorithm for the resulting constrained reduced problem. We establish convergence guarantees under standard smoothness and compactness assumptions, and discuss extensions to structured lower-level variables. Numerical experiments on sparse autoencoding, dictionary learning, blind deconvolution, and few-shot learning suggest that the method can improve wall-clock efficiency and data efficiency relative to natural joint-optimization baselines.

math.OC↗

arXiv2026

Emergency hub placement with a neutral-atom quantum computer

We study the problem of emergency operation center placement in disaster response, where a minimal number of hubs must be selected to ensure timely coverage of all affected locations. This task can be formulated as a minimum dominating set problem on a graph encoding reachability within a target response time. We propose a hybrid quantum-classical approximation framework that leverages neutral-atom quantum computers as independent set samplers. Candidate dominating sets are constructed from both small maximal independent sets and complements of large independent sets, and are subsequently refined via a lightweight classical procedure. We benchmark the approach on synthetic instances and realistic case studies, and implement it on the Fresnel quantum processor by Pasqal, solving instances of up to 100 nodes. Our results show that quantum-generated samples, despite hardware noise, enable near-optimal solutions of the placement problem. Overall, our results demonstrate that neutral-atom devices operating in analog mode can already be used to tackle graph optimization problems for real-world applications.

quant-ph↗

arXiv2026

Neural-HSS: Hierarchical Semi-Separable Neural PDE Solver

Deep learning-based methods have shown remarkable effectiveness in solving PDEs, largely due to their ability to enable fast simulations once trained. However, despite the availability of high-performance computing infrastructure, many critical applications remain constrained by the substantial computational costs associated with generating large-scale, high-quality datasets and training models. In this work, inspired by studies on the structure of Green's functions for elliptic PDEs, we introduce Neural-HSS, a parameter-efficient architecture built upon the Hierarchical Semi-Separable (HSS) matrix structure that is provably data-efficient for a broad class of PDEs. We theoretically analyze the proposed architecture, proving that it satisfies exactness properties even in very low-data regimes. We also investigate its connections with other architectural primitives, such as the Fourier neural operator layer and convolutional layers. We experimentally validate the data efficiency of Neural-HSS on the three-dimensional Poisson equation over a grid of two million points, demonstrating its superior ability to learn from data generated by elliptic PDEs in the low-data regime while outperforming baseline methods. Finally, we demonstrate its capability to learn from data arising from a broad class of PDEs in diverse domains, including electromagnetism, fluid dynamics, and biology.

cs.LG↗

arXiv2026

Drone delivery packing problem on a neutral-atom quantum computer

Quantum architectures based on neutral atoms have gained significant attention in recent years as specialized computational machines due to their ability to directly encode the independent set constraint on graphs, exploiting the Rydberg blockade mechanism. In this work, we address the Drone Delivery Packing Problem via a hybrid quantum-classical framework leveraging a neutral-atom quantum processing unit (QPU). We reformulate the optimization task as a graph-partitioning problem based on the independent sets (ISs) of a scheduling graph that encodes delivery incompatibilities. Each partition corresponds to deliveries assigned to a single drone, with the objective of minimizing the total number of partitions. While the ISs represent time-feasible schedules, battery-duration constraints are enforced through a classical post-processing routine. This methodology enables the recovery of optimal delivery schedules, provided a sufficient number of samples is collected from the QPU to resolve the solution space. We benchmark the hybrid workflow through numerical emulations and demonstrate its effectiveness on Pasqal's Fresnel QPU, reporting hardware experiments with configurations of up to 100 atoms.

quant-ph↗

arXiv2026

Ambient Physics: Training Neural PDE Solvers with Partial Observations

In many scientific settings, acquiring complete observations of PDE coefficients and solutions can be expensive, hazardous, or impossible. Recent diffusion-based methods can reconstruct fields given partial observations, but require complete observations for training. We introduce Ambient Physics, a framework for learning the joint distribution of coefficient-solution pairs directly from partial observations, without requiring a single complete observation. The key idea is to randomly mask a subset of already-observed measurements and supervise on them, so the model cannot distinguish "truly unobserved" from "artificially unobserved", and must produce plausible predictions everywhere. Ambient Physics achieves state-of-the-art reconstruction performance. Compared with prior diffusion-based methods, it achieves a 62.51$\%$ reduction in average overall error while using 125$\times$ fewer function evaluations. We also identify a "one-point transition": masking a single already-observed point enables learning from partial observations across architectures and measurement patterns. Ambient Physics thus enables scientific progress in settings where complete observations are unavailable.

cs.AI↗

arXiv2025

Low-Rank Compression of Language Models via Differentiable Rank Selection

Approaches for compressing large-language models using low-rank decomposition have made strides, particularly with the introduction of activation and loss-aware SVD, which improves the trade-off between decomposition rank and downstream task performance. Despite these advancements, a persistent challenge remains--selecting the optimal ranks for each layer to jointly optimise compression rate and downstream task accuracy. Current methods either rely on heuristics that can yield sub-optimal results due to their limited discrete search space or are gradient-based but are not as performant as heuristic approaches without post-compression fine-tuning. To address these issues, we propose Learning to Low-Rank Compress (LLRC), a gradient-based approach which directly learns the weights of masks that select singular values in a fine-tuning-free setting. Using a calibration dataset, we train only the mask weights to select fewer and fewer singular values while minimising the divergence of intermediate activations from the original model. Our approach outperforms competing ranking selection methods that similarly require no post-compression fine-tuning across various compression rates on common-sense reasoning and open-domain question-answering tasks. For instance, with a compression rate of 20% on Llama-2-13B, LLRC outperforms the competitive Sensitivity-based Truncation Rank Searching (STRS) on MMLU, BoolQ, and OpenbookQA by 12%, 3.5%, and 4.4%, respectively. Compared to other compression techniques, our approach consistently outperforms fine-tuning-free variants of SVD-LLM and LLM-Pruner across datasets and compression rates. Our fine-tuning-free approach also performs competitively with the fine-tuning variant of LLM-Pruner.

cs.LG↗

arXiv2025

The Effects of Remote Working on Scientific Collaboration and Impact

The COVID-19 pandemic shifted academic collaboration from in-person to remote interactions. This study explores, for the first time, the effects on scientific collaborations and impact of such a shift, comparing research output before, during, and after the pandemic. Using large-scale bibliometric data, we track the evolution of collaboration networks and the resulting impact of research over time. Our findings are twofold: first, the geographic distribution of collaborations significantly shifted, with a notable increase in cross-border partnerships after 2020, indicating a reduction in the constraints of geographic proximity. Second, despite the expansion of collaboration networks, there was a concerning decline in citation impact, suggesting that the absence of spontaneous in-person interactions-which traditionally foster deep discussions and idea exchange-negatively affected research quality. As hybrid work models in academia gain traction, this study highlights the need for universities and research organizations to carefully consider the balance between remote and in-person engagement.

physics.soc-ph↗

arXiv2025

Algebraformer: A Neural Approach to Linear Systems

Recent work in deep learning has opened new possibilities for solving classical algorithmic tasks using end-to-end learned models. In this work, we investigate the fundamental task of solving linear systems, particularly those that are ill-conditioned. Existing numerical methods for ill-conditioned systems often require careful parameter tuning, preconditioning, or domain-specific expertise to ensure accuracy and stability. In this work, we propose Algebraformer, a Transformer-based architecture that learns to solve linear systems end-to-end, even in the presence of severe ill-conditioning. Our model leverages a novel encoding scheme that enables efficient representation of matrix and vector inputs, with a memory complexity of $O(n^2)$, supporting scalable inference. We demonstrate its effectiveness on application-driven linear problems, including interpolation tasks from spectral methods for boundary value problems and acceleration of the Newton method. Algebraformer achieves competitive accuracy with significantly lower computational overhead at test time, demonstrating that general-purpose neural architectures can effectively reduce complexity in traditional scientific computing pipelines.

cs.LG↗

arXiv2025

Generalized Friendship Paradoxes in Network Science

Generalized friendship paradoxes occur when, on average, our friends have more of some attribute than us. These paradoxes are relevant to many aspects of human interaction, notably in social science and epidemiology. Here, we derive new theoretical results concerning the inevitability of a paradox arising, using a linear algebra perspective. Following the seminal 1991 work of Scott L. Feld, we consider two distinct ways to measure and compare averages, which may be regarded as global and local. For global averaging, we show that a generalized friendship paradox holds for a large family of walk-based centralities, including Katz centrality and total subgraph communicability, and also for nonbacktracking eigenvector centrality. However, we also find counterexamples for centralities based on walks of even length. For local averaging we establish a paradox for nonbacktracking eigenvector centrality and we characterize the cases where the paradox holds with equality for the walk-based case. Defining loneliness as the reciprocal of the number of friends, we show that for this attribute the generalized and local friendship paradoxes always hold in reverse. In this sense, we are always more lonely, on average, than our friends. We also derive global and local averaging paradoxes for the case where the arithmetic mean is replaced by the geometric mean. As well as unifying and adding to the literature in this area, we highlight some open questions.

physics.soc-ph↗

arXiv2025

Stuart-Landau Oscillatory Graph Neural Network

Oscillatory Graph Neural Networks (OGNNs) are an emerging class of physics-inspired architectures designed to mitigate oversmoothing and vanishing gradient problems in deep GNNs. In this work, we introduce the Complex-Valued Stuart-Landau Graph Neural Network (SLGNN), a novel architecture grounded in Stuart-Landau oscillator dynamics. Stuart-Landau oscillators are canonical models of limit-cycle behavior near Hopf bifurcations, which are fundamental to synchronization theory and are widely used in e.g. neuroscience for mesoscopic brain modeling. Unlike harmonic oscillators and phase-only Kuramoto models, Stuart-Landau oscillators retain both amplitude and phase dynamics, enabling rich phenomena such as amplitude regulation and multistable synchronization. The proposed SLGNN generalizes existing phase-centric Kuramoto-based OGNNs by allowing node feature amplitudes to evolve dynamically according to Stuart-Landau dynamics, with explicit tunable hyperparameters (such as the Hopf-parameter and the coupling strength) providing additional control over the interplay between feature amplitudes and network structure. We conduct extensive experiments across node classification, graph classification, and graph regression tasks, demonstrating that SLGNN outperforms existing OGNNs and establishes a novel, expressive, and theoretically grounded framework for deep oscillatory architectures on graphs.

cs.LG↗

arXiv2025

Efficient Sparsification of Simplicial Complexes via Local Densities of States

Simplicial complexes (SCs) have become a popular abstraction for analyzing complex data using tools from topological data analysis or topological signal processing. However, the analysis of many real-world datasets often leads to dense SCs, with many higher-order simplicies, which results in prohibitive computational requirements in terms of time and memory consumption. The sparsification of such complexes is thus of broad interest, i.e., the approximation of an original SC with a sparser surrogate SC (with typically only a log-linear number of simplices) that maintains the spectrum of the original SC as closely as possible. In this work, we develop a novel method for a probabilistic sparsification of SCs that uses so-called local densities of states. Using this local densities of states, we can efficiently approximate so-called generalized effective resistance of each simplex, which is proportional to the required sampling probability for the sparsification of the SC. To avoid degenerate structures in the spectrum of the corresponding Hodge Laplacian operators, we suggest a ``kernel-ignoring'' decomposition to approximate the sampling probability. Additionally, we utilize certain error estimates to characterize the asymptotic algorithmic complexity of the developed method. We demonstrate the performance of our framework on a family of Vietoris--Rips filtered simplicial complexes.

stat.ML↗

arXiv2025

Synchronization of coupled Stuart-Landau oscillators: How heterogeneity can facilitate synchronization

We study the collective dynamics of coupled Stuart--Landau oscillators, which model limit-cycle behavior near a Hopf bifurcation and serve as the amplitude-phase analogue of the Kuramoto model. Unlike the well-studied phase-reduced systems, the full Stuart--Landau model retains amplitude dynamics, enabling the emergence of rich phenomena such as amplitude death, quenching, and multistable synchronization. We provide a complete analytical classification of asymptotic behaviors for identical natural frequencies, but heterogeneous inherent amplitudes in the finite-$N$ setting. In the two-oscillator case, we classify the asymptotic behavior in all possible regimes including heterogeneous natural frequencies and inherent amplitudes, and in particular we identify and characterize a novel regime of \emph{leader-driven synchronization}, wherein one active oscillator can entrain another regardless of frequency mismatch. For general $N$, we prove exponential phase synchronization under sectorial initial data and establish sharp conditions for global amplitude death. Finally, we analyze a real-valued reduction of the model, connecting the dynamics to nonlinear opinion formation and consensus processes. Our results highlight the fundamental differences between amplitude-phase and phase-only Kuramoto models, and provide a new framework for understanding synchronization in heterogeneous oscillator networks.

math.DS↗

arXiv2025

An Efficient Network-aware Direct Search Method for Influence Maximization

Influence Maximization (IM) is a pivotal concept in social network analysis, involving the identification of influential nodes within a network to maximize the number of influenced nodes, and has a wide variety of applications that range from viral marketing and information dissemination to public health campaigns. IM can be modeled as a combinatorial optimization problem with a black-box objective function, where the goal is to select $B$ seed nodes that maximize the expected influence spread. Direct search methods, which do not require gradient information, are well-suited for such problems. Unlike gradient-based approaches, direct search algorithms, in fact, only evaluate the objective function at a suitably chosen set of trial points around the current solution to guide the search process. However, these methods often suffer from scalability issues due to the high cost of function evaluations, especially when applied to combinatorial problems like IM. This work, therefore, proposes the Network-aware Direct Search (NaDS) method, an innovative direct search approach that integrates the network structure into its neighborhood formulation and is used to tackle a mixed-integer programming formulation of the IM problem, the so-called General Information Propagation model. We tested our method on large-scale networks, comparing it to existing state-of-the-art approaches for the IM problem, including direct search methods and various greedy techniques and heuristics. The results of the experiments empirically confirm the assumptions underlying NaDS, demonstrating that exploiting the graph structure of the IM problem in the algorithmic framework can significantly improve its computational efficiency in the considered context.

cs.SI↗

arXiv2025

Improving the robustness of neural ODEs with minimal weight perturbation

We propose a method to enhance the stability of a neural ordinary differential equation (neural ODE) by reducing the maximum error growth subsequent to a perturbation of the initial value. Since the stability depends on the logarithmic norm of the Jacobian matrix associated with the neural ODE, we control the logarithmic norm by perturbing the weight matrices of the neural ODE by a smallest possible perturbation (in Frobenius norm). We do so by engaging an eigenvalue optimisation problem, for which we propose a nested two-level algorithm. For a given perturbation size of the weight matrix, the inner level computes optimal perturbations of that size, while - at the outer level - we tune the perturbation amplitude until we reach the desired uniform stability bound. We embed the proposed algorithm in the training of the neural ODE to improve its robustness to perturbations of the initial value, as adversarial attacks. Numerical experiments on classical image datasets show that an image classifier including a neural ODE in its architecture trained according to our strategy is more stable than the same classifier trained in the classical way, and therefore, it is more robust and less vulnerable to adversarial attacks.

math.NA↗

arXiv2025

The graph $\infty$-Laplacian eigenvalue problem

We analyze various formulations of the $\infty$-Laplacian eigenvalue problem on graphs, comparing their properties and highlighting their respective advantages and limitations. First, we investigate the graph $\infty$-eigenpairs arising as limits of $p$-Laplacian eigenpairs, extending key results from the continuous setting to the discrete domain. We prove that every limit of $p$-Laplacian eigenpair, for $p$ going to $\infty$, satisfies a limit eigenvalue equation and establish that the corresponding eigenvalue can be bounded from below by the packing radius of the graph, indexed by the number of nodal domains induced by the eigenfunction. Additionally, we show that the limits, for $p$ going to $\infty$, of the variational $p$-Laplacian eigenvalues are bounded both from above and from below by the packing radii, achieving equality for the smallest two variational eigenvalues and corresponding packing radii of the graph. In the second part of the paper, we introduce generalized $\infty$-Laplacian eigenpairs as generalized critical points and values of the $\infty$-Rayleigh quotient. We prove that the generalized variational $\infty$-eigenvalues equal the limit of the $p$-Laplacian variational eigenvalues and so satisfy the same upper bounds in terms of packing radii. Finally, we establish that any solution to the limit eigenvalue equation is also a generalized eigenpair, while any generalized eigenpair satisfies the limit eigenvalue equation on a suitable subgraph.

math.SP↗

arXiv2025

Nonlinear Joint Spectral Radius

We introduce a nonlinear extension of the joint spectral radius (JSR) for switched discrete-time dynamical systems governed by sub-homogeneous and order-preserving maps acting on cones. We show that this nonlinear JSR characterizes both the asymptotic stability of the system and the divergence or convergence rate of trajectories originating from different points within the cone. Our analysis establishes upper and lower bounds on the nonlinear JSR of a sub-homogeneous family via the JSRs of two associated homogeneous families obtained through asymptotic scaling. In the homogeneous case, we develop a dual formulation of the JSR and investigate the equality between the joint spectral radius and the generalized joint spectral radius, extending classical results from linear theory to the nonlinear setting. We also propose a polytopal-type algorithm to approximate the nonlinear JSR and provide conditions ensuring its finite-time convergence. The proposed framework is motivated by applications such as the analysis of deep neural networks, which can be modeled as switched systems with structured nonlinear layers. Our results offer new theoretical tools for studying the stability, robustness, and convergence behavior of such models.

math.DS↗

arXiv2025

Graph-Convolutional-Beta-VAE for Synthetic Abdominal Aorta Aneurysm Generation

Synthetic data generation plays a crucial role in medical research by mitigating privacy concerns and enabling large-scale patient data analysis. This study presents a beta-Variational Autoencoder Graph Convolutional Neural Network framework for generating synthetic Abdominal Aorta Aneurysms (AAA). Using a small real-world dataset, our approach extracts key anatomical features and captures complex statistical relationships within a compact disentangled latent space. To address data limitations, low-impact data augmentation based on Procrustes analysis was employed, preserving anatomical integrity. The generation strategies, both deterministic and stochastic, manage to enhance data diversity while ensuring realism. Compared to PCA-based approaches, our model performs more robustly on unseen data by capturing complex, nonlinear anatomical variations. This enables more comprehensive clinical and statistical analyses than the original dataset alone. The resulting synthetic AAA dataset preserves patient privacy while providing a scalable foundation for medical research, device testing, and computational modeling.

cs.LG↗