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Francisco J. Perez-Reche

Publications and source records attributed to Francisco J. Perez-Reche.

11 recordsLinked to original sources

The elbow statistic: Multiscale clustering statistical significance

Selecting the number of clusters remains a fundamental challenge in unsupervised learning. Existing approaches typically focus on identifying a single "optimal" partition, often overlooking statistically meaningful structure present across multiple resolutions. We introduce ElbowSig, a general inferential framework for assessing clustering structure over a range of resolutions. The method formalizes the elbow heuristic by defining a normalized discrete curvature statistic based on the sequence of within-cluster heterogeneity values, and evaluates its significance relative to a null distribution of unstructured data. This yields hypothesis tests across resolutions, enabling simultaneous inference at multiple clustering scales. We derive the asymptotic behavior of the null statistic in both large-sample and high-dimensional regimes, characterizing its limiting form and variability. Because it depends only on the heterogeneity sequence, ElbowSig is compatible with a wide range of clustering algorithms, including hard, fuzzy, and model-based methods. Experiments on synthetic and real datasets show that the procedure controls Type-I error under unstructured data while providing power to detect multiscale organization, revealing structure that is often missed by single-resolution selection criteria.

stat.ML↗

Multistability and High Codimension Bifurcations in Synergistic Epidemics on Heterogeneous Networks

We investigate the impact of network heterogeneity on synergistic contagion dynamics. By extending a synergistic contagion model to diverse heterogeneous network topologies, we uncover the emergence of novel dynamical regimes characterized by multiple stable states, separated by a rich set of bifurcations reaching up to codimension 4. Additionally, we demonstrate how synergy fundamentally reshapes the influence of nodes based on their degree. Unlike in non-synergistic epidemics, low-degree nodes can play a pivotal role in enabling network invasion at the onset of spread, while high-degree nodes can trigger explosive contagion. These findings challenge conventional control strategies, highlighting the need for new approaches to enhance or suppress synergistic contagion.

physics.soc-ph↗

Impact of heterogeneity on infection probability: Insights from single-hit dose-response models

The process of infection of a host is complex, influenced by factors such as microbial variation within and between hosts as well as differences in dose across hosts. This study uses dose-response and within-host microbial infection models to delve into the impact of these factors on infection probability. It is rigorously demonstrated that within-host heterogeneity in microbial infectivity enhances the probability of infection. The effect of infectivity and dose variation between hosts is studied in terms of the expected value of the probability of infection. General analytical findings, derived under the assumption of small infectivity, reveal that both types of heterogeneity reduce the expected infection probability. Interestingly, this trend appears consistent across specific dose-response models, suggesting a limited role for the small infectivity condition. Additionally, the vital dynamics behind heterogeneous infectivity are investigated with a within-host microbial growth model which enhances the biological significance of single-hit dose-response models. Testing these mathematical predictions inspire new and challenging laboratory experiments that could deepen our understanding of infections.

q-bio.PE↗

Immunization and targeted destruction of networks using explosive percolation

A new method (`explosive immunization' (EI)) is proposed for immunization and targeted destruction of networks. It combines the explosive percolation (EP) paradigm with the idea of maintaining a fragmented distribution of clusters. The ability of each node to block the spread of an infection (or to prevent the existence of a large cluster of connected nodes) is estimated by a score. The algorithm proceeds by first identifying low score nodes that should not be vaccinated/destroyed, analogously to the links selected in EP if they do not lead to large clusters. As in EP, this is done by selecting the worst node (weakest blocker) from a finite set of randomly chosen `candidates'. Tests on several real-world and model networks suggest that the method is more efficient and faster than any existing immunization strategy. Due to the latter property it can deal with very large networks.

physics.soc-ph↗

Modelling avalanches in martensites

Solids subject to continuous changes of temperature or mechanical load often exhibit discontinuous avalanche-like responses. For instance, avalanche dynamics have been observed during plastic deformation, fracture, domain switching in ferroic materials or martensitic transformations. The statistical analysis of avalanches reveals a very complex scenario with a distinctive lack of characteristic scales. Much effort has been devoted in the last decades to understand the origin and ubiquity of scale-free behaviour in solids and many other systems. This chapter reviews some efforts to understand the characteristics of avalanches in martensites through mathematical modelling.

cond-mat.stat-mech↗

Origin of scale-free intermittency in structural first-order phase transitions

A salient feature of cyclically driven first-order phase transformations in crystals is their scale-free avalanche dynamics. This behavior has been linked to the presence of a classical critical point but the mechanism leading to criticality without extrinsic tuning remains unexplained. Here we show that the source of scaling in such systems is an annealed disorder associated with transformation-induced slip which co-evolves with the phase transformation, thus ensuring the crossing of a critical manifold. Our conclusions are based on a model where annealed disorder emerges in the form of a random field induced by the phase transition. Such disorder exhibits super-transient chaotic behavior under thermal loading, obeys a heavy-tailed distribution and exhibits long-range spatial correlations. We show that the universality class is affected by the long-range character of elastic interactions. In contrast, it is not influenced by the heavy-tailed distribution and spatial correlations of disorder.

cond-mat.dis-nn↗

Capillary condensation in one-dimensional irregular confinement

A lattice-gas model with heterogeneity is developed for the description of fluid condensation in finite sized one-dimensional pores of arbitrary shape. An exact solution of the model is presented for zero-temperature that reproduces the experimentally observed dependence of the amount of fluid adsorbed in the pore on external pressure. Finite-temperature Metropolis dynamics simulations support analytical findings in the limit of low temperatures. The proposed framework is viewed as a fundamental building block of the theory of capillary condensation necessary for reliable structural analysis of complex porous media from adsorption-desorption data.

cond-mat.stat-mech↗

Prediction of invasion from the early stage of an epidemic

Predictability of undesired events is a question of great interest in many scientific disciplines including seismology, economy, and epidemiology. Here, we focus on the predictability of invasion of a broad class of epidemics caused by diseases that lead to permanent immunity of infected hosts after recovery or death. We approach the problem from the perspective of the science of complexity by proposing and testing several strategies for the estimation of important characteristics of epidemics, such as the probability of invasion. Our results suggest that parsimonious approximate methodologies may lead to the most reliable and robust predictions. The proposed methodologies are first applied to analysis of experimentally observed epidemics: invasion of the fungal plant pathogen \emph{Rhizoctonia solani} in replicated host microcosms. We then consider numerical experiments of the SIR (susceptible-infected-removed) model to investigate the performance of the proposed methods in further detail. The suggested framework can be used as a valuable tool for quick assessment of epidemic threat at the stage when epidemics only start developing. Moreover, our work amplifies the significance of the small-scale and finite-time microcosm realizations of epidemics revealing their predictive power.

q-bio.PE↗

Synergy in spreading processes: from exploitative to explorative foraging strategies

An epidemiological model which incorporates synergistic effects that allow the infectivity and/or susceptibility of hosts to be dependent on the number of infected neighbours is proposed. Constructive synergy induces an exploitative behaviour which results in a rapid invasion that infects a large number of hosts. Interfering synergy leads to a slower and sparser explorative foraging strategy that traverses larger distances by infecting fewer hosts. The model can be mapped to a dynamical bond-percolation with spatial correlations that affect the mechanism of spread but do not influence the critical behaviour of epidemics.

q-bio.PE↗

Complexity and anisotropy in host morphology make populations safer against epidemic outbreaks

One of the challenges in epidemiology is to account for the complex morphological structure of hosts such as plant roots, crop fields, farms, cells, animal habitats and social networks, when the transmission of infection occurs between contiguous hosts. Morphological complexity brings an inherent heterogeneity in populations and affects the dynamics of pathogen spread in such systems. We have analysed the influence of realistically complex host morphology on the threshold for invasion and epidemic outbreak in an SIR (susceptible-infected-recovered) epidemiological model. We show that disorder expressed in the host morphology and anisotropy reduces the probability of epidemic outbreak and thus makes the system more resistant to epidemic outbreaks. We obtain general analytical estimates for minimally safe bounds for an invasion threshold and then illustrate their validity by considering an example of host data for branching hosts (salamander retinal ganglion cells). Several spatial arrangements of hosts with different degrees of heterogeneity have been considered in order to analyse separately the role of shape complexity and anisotropy in the host population. The estimates for invasion threshold are linked to morphological characteristics of the hosts that can be used for determining the threshold for invasion in practical applications.

q-bio.PE↗

On the athermal character of structural phase transitions

The significance of thermal fluctuations on nucleation in structural first-order phase transitions has been examined. The prototype case of martensitic transitions has been experimentally investigated by means of acoustic emission techniques. We propose a model based on the mean first-passage time to account for the experimental observations. Our study provides a unified framework to establish the conditions for isothermal and athermal transitions to be observed.

cond-mat.mtrl-sci↗