arXiv subjects

Fredrik Strand

Publications and source records attributed to Fredrik Strand.

15 recordsLinked to original sources

arXiv2026

Dense Temporal Contrast Synthesis via Conditioned Latent Transport

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer management, but reliance on gadolinium-based contrast agents (GBCAs) restricts use in contraindicated populations, prolongs scan protocols, and presents environmental toxicity concerns. Contrast synthesis offers a non-invasive alternative; however, existing approaches struggle to balance spatial realism with temporal continuity, suffer from slow iterative sampling, underutilize structural priors, and lack clinical validation. We propose a novel conditioned latent transport framework that predicts contrast enhancement in a single forward pass. By anchoring the latent trajectory to the pre-contrast anatomy and applying continuous time conditioning, the model synthesizes patient-specific contrast evolution at any acquisition time. The proposed approach outperforms baseline and the state-of-the-art models across spatial, perceptual, temporal, and distributional metrics. Evaluated on an independent external cohort, the method demonstrates robustness to domain shifts induced by scanner noise as well as differing acquisition protocol. Furthermore, our synthetic contrast enhancement significantly improved downstream tumor segmentation performance, yielding a 22.4% relative increase in Dice coefficient (0.60 vs. 0.49 baseline pre-contrast, p < 0.01), reducing boundary segmentation error by over 39%, while outperforming all other generative model baselines. Finally, a reader study involving four breast radiologists evaluated the image quality, kinetic fidelity, and diagnostic viability of our synthesized sequences across 40 randomly selected cases. The results demonstrated that in 70% of cases, synthesized images provided sufficient clinical information to support the same management decisions as real DCE-MRI, suggesting a path toward safer and faster contrast-free or contrast-reduced imaging workflows.

cs.CV↗

arXiv2026

A theory of ROC analysis of rule-out and rule-in diagnostics with applications to mammography data

Multiple diagnostic tests are frequently used to determine the presence of a disease condition in patients. In this paper, we use bivariate copulas to examine the properties of receiver operating characteristic (ROC) curves formed when two correlated diagnostic tests are used together to rule-out ("believe the negative") and rule-in ("believe the positive") patients for disease. We use this theory to analyze three mammography data sets where AI devices are applied to reduce radiologists' workload or improve diagnostic performance. Our analysis shows with generality that increasing the radiologist-AI correlation for diseased cases enhances the area under the ROC curve (AUC) of a radiologist-AI rule-out curve, whereas decreasing correlation for non-diseased cases has a similar effect. The opposite trends hold for rule-in scenarios. Applications to clinical mammography data show that projected empirical radiologist performance under a rule-out or rule-in scenario is consistent with the theory.

stat.ME↗

arXiv2025

Learning What Helps: Task-Aligned Context Selection for Vision Tasks

Humans often resolve visual uncertainty by comparing an image with relevant examples, but ViTs lack the ability to identify which examples would improve their predictions. We present Task-Aligned Context Selection (TACS), a framework that learns to select paired examples which truly improve task performance rather than those that merely appear similar. TACS jointly trains a selector network with the task model through a hybrid optimization scheme combining gradient-based supervision and reinforcement learning, making retrieval part of the learning objective. By aligning selection with task rewards, TACS enables discriminative models to discover which contextual examples genuinely help. Across 18 datasets covering fine-grained recognition, medical image classification, and medical image segmentation, TACS consistently outperforms similarity-based retrieval, particularly in challenging or data-limited settings.

cs.CV↗

arXiv2024

A new Time-decay Radiomics Integrated Network (TRINet) for short-term breast cancer risk prediction

To facilitate early detection of breast cancer, there is a need to develop short-term risk prediction schemes that can prescribe personalized/individualized screening mammography regimens for women. In this study, we propose a new deep learning architecture called TRINet that implements time-decay attention to focus on recent mammographic screenings, as current models do not account for the relevance of newer images. We integrate radiomic features with an Attention-based Multiple Instance Learning (AMIL) framework to weigh and combine multiple views for better risk estimation. In addition, we introduce a continual learning approach with a new label assignment strategy based on bilateral asymmetry to make the model more adaptable to asymmetrical cancer indicators. Finally, we add a time-embedded additive hazard layer to perform dynamic, multi-year risk forecasting based on individualized screening intervals. We used two public datasets, namely 8,528 patients from the American EMBED dataset and 8,723 patients from the Swedish CSAW dataset in our experiments. Evaluation results on the EMBED test set show that our approach significantly outperforms state-of-the-art models, achieving AUC scores of 0.851, 0.811, 0.796, 0.793, and 0.789 across 1-, 2-, to 5-year intervals, respectively. Our results underscore the importance of integrating temporal attention, radiomic features, time embeddings, bilateral asymmetry, and continual learning strategies, providing a more adaptive and precise tool for short-term breast cancer risk prediction.

eess.IV↗

arXiv2024

Artificial Intelligence-Informed Handheld Breast Ultrasound for Screening: A Systematic Review of Diagnostic Test Accuracy

Background. Breast cancer screening programs using mammography have led to significant mortality reduction in high-income countries. However, many low- and middle-income countries lack resources for mammographic screening. Handheld breast ultrasound (BUS) is a low-cost alternative but requires substantial training. Artificial intelligence (AI) enabled BUS may aid in both the detection (perception) and classification (interpretation) of breast cancer. Materials and Methods. This review (CRD42023493053) is reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) and SWiM (Synthesis Without Meta-analysis) guidelines. PubMed and Google Scholar were searched from January 1, 2016 to December 12, 2023. A meta-analysis was not attempted. Studies are grouped according to their AI task type, application time, and AI task. Study quality is assessed using the QUality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Results. Of 763 candidate studies, 314 total full texts were reviewed. 34 studies are included. The AI tasks of included studies are as follows: 1 frame selection, 6 detection, 11 segmentation, and 16 classification. In total, 5.7 million BUS images from over 185,000 patients were used for AI training or validation. A single study included a prospective testing set. 79% of studies were at high or unclear risk of bias. Conclusion. There has been encouraging development of AI for BUS. Despite studies demonstrating high performance across all identified tasks, the evidence supporting AI-enhanced BUS generally lacks robustness. High-quality model validation will be key to realizing the potential for AI-enhanced BUS in increasing access to screening in resource-limited environments.

eess.IV↗

arXiv2024

Random Token Fusion for Multi-View Medical Diagnosis

In multi-view medical diagnosis, deep learning-based models often fuse information from different imaging perspectives to improve diagnostic performance. However, existing approaches are prone to overfitting and rely heavily on view-specific features, which can lead to trivial solutions. In this work, we introduce Random Token Fusion (RTF), a novel technique designed to enhance multi-view medical image analysis using vision transformers. By integrating randomness into the feature fusion process during training, RTF addresses the issue of overfitting and enhances the robustness and accuracy of diagnostic models without incurring any additional cost at inference. We validate our approach on standard mammography and chest X-ray benchmark datasets. Through extensive experiments, we demonstrate that RTF consistently improves the performance of existing fusion methods, paving the way for a new generation of multi-view medical foundation models.

cs.CV↗

arXiv2024

A large-scale multicenter breast cancer DCE-MRI benchmark dataset with expert segmentations

Artificial Intelligence (AI) research in breast cancer Magnetic Resonance Imaging (MRI) faces challenges due to limited expert-labeled segmentations. To address this, we present a multicenter dataset of 1506 pre-treatment T1-weighted dynamic contrast-enhanced MRI cases, including expert annotations of primary tumors and non-mass-enhanced regions. The dataset integrates imaging data from four collections in The Cancer Imaging Archive (TCIA), where only 163 cases with expert segmentations were initially available. To facilitate the annotation process, a deep learning model was trained to produce preliminary segmentations for the remaining cases. These were subsequently corrected and verified by 16 breast cancer experts (averaging 9 years of experience), creating a fully annotated dataset. Additionally, the dataset includes 49 harmonized clinical and demographic variables, as well as pre-trained weights for a baseline nnU-Net model trained on the annotated data. This resource addresses a critical gap in publicly available breast cancer datasets, enabling the development, validation, and benchmarking of advanced deep learning models, thus driving progress in breast cancer diagnostics, treatment response prediction, and personalized care.

cs.CV↗

arXiv2023

RADIFUSION: A multi-radiomics deep learning based breast cancer risk prediction model using sequential mammographic images with image attention and bilateral asymmetry refinement

Breast cancer is a significant public health concern and early detection is critical for triaging high risk patients. Sequential screening mammograms can provide important spatiotemporal information about changes in breast tissue over time. In this study, we propose a deep learning architecture called RADIFUSION that utilizes sequential mammograms and incorporates a linear image attention mechanism, radiomic features, a new gating mechanism to combine different mammographic views, and bilateral asymmetry-based finetuning for breast cancer risk assessment. We evaluate our model on a screening dataset called Cohort of Screen-Aged Women (CSAW) dataset. Based on results obtained on the independent testing set consisting of 1,749 women, our approach achieved superior performance compared to other state-of-the-art models with area under the receiver operating characteristic curves (AUCs) of 0.905, 0.872 and 0.866 in the three respective metrics of 1-year AUC, 2-year AUC and > 2-year AUC. Our study highlights the importance of incorporating various deep learning mechanisms, such as image attention, radiomic features, gating mechanism, and bilateral asymmetry-based fine-tuning, to improve the accuracy of breast cancer risk assessment. We also demonstrate that our model's performance was enhanced by leveraging spatiotemporal information from sequential mammograms. Our findings suggest that RADIFUSION can provide clinicians with a powerful tool for breast cancer risk assessment.

eess.IV↗

arXiv2022

Visual Detection of Personal Protective Equipment and Safety Gear on Industry Workers

Workplace injuries are common in today's society due to a lack of adequately worn safety equipment. A system that only admits appropriately equipped personnel can be created to improve working conditions. The goal is thus to develop a system that will improve workers' safety using a camera that will detect the usage of Personal Protective Equipment (PPE). To this end, we collected and labeled appropriate data from several public sources, which have been used to train and evaluate several models based on the popular YOLOv4 object detector. Our focus, driven by a collaborating industrial partner, is to implement our system into an entry control point where workers must present themselves to obtain access to a restricted area. Combined with facial identity recognition, the system would ensure that only authorized people wearing appropriate equipment are granted access. A novelty of this work is that we increase the number of classes to five objects (hardhat, safety vest, safety gloves, safety glasses, and hearing protection), whereas most existing works only focus on one or two classes, usually hardhats or vests. The AI model developed provides good detection accuracy at a distance of 3 and 5 meters in the collaborative environment where we aim at operating (mAP of 99/89%, respectively). The small size of some objects or the potential occlusion by body parts have been identified as potential factors that are detrimental to accuracy, which we have counteracted via data augmentation and cropping of the body before applying PPE detection.

cs.CV↗

arXiv2022

High-resolution synthesis of high-density breast mammograms: Application to improved fairness in deep learning based mass detection

Computer-aided detection systems based on deep learning have shown good performance in breast cancer detection. However, high-density breasts show poorer detection performance since dense tissues can mask or even simulate masses. Therefore, the sensitivity of mammography for breast cancer detection can be reduced by more than 20% in dense breasts. Additionally, extremely dense cases reported an increased risk of cancer compared to low-density breasts. This study aims to improve the mass detection performance in highdensity breasts using synthetic high-density full-field digital mammograms (FFDM) as data augmentation during breast mass detection model training. To this end, a total of five cycle-consistent GAN (CycleGAN) models using three FFDM datasets were trained for low-to-high-density image translation in highresolution mammograms. The training images were split by breast density BIRADS categories, being BI-RADS A almost entirely fatty and BI-RADS D extremely dense breasts. Our results showed that the proposed data augmentation technique improved the sensitivity and precision of mass detection in models trained with small datasets and improved the domain generalization of the models trained with large databases. In addition, the clinical realism of the synthetic images was evaluated in a reader study involving two expert radiologists and one surgical oncologist.

eess.IV↗

arXiv2022

PatchDropout: Economizing Vision Transformers Using Patch Dropout

Vision transformers have demonstrated the potential to outperform CNNs in a variety of vision tasks. But the computational and memory requirements of these models prohibit their use in many applications, especially those that depend on high-resolution images, such as medical image classification. Efforts to train ViTs more efficiently are overly complicated, necessitating architectural changes or intricate training schemes. In this work, we show that standard ViT models can be efficiently trained at high resolution by randomly dropping input image patches. This simple approach, PatchDropout, reduces FLOPs and memory by at least 50% in standard natural image datasets such as ImageNet, and those savings only increase with image size. On CSAW, a high-resolution medical dataset, we observe a 5 times savings in computation and memory using PatchDropout, along with a boost in performance. For practitioners with a fixed computational or memory budget, PatchDropout makes it possible to choose image resolution, hyperparameters, or model size to get the most performance out of their model.

cs.CV↗

arXiv2021

CSAW-M: An Ordinal Classification Dataset for Benchmarking Mammographic Masking of Cancer

Interval and large invasive breast cancers, which are associated with worse prognosis than other cancers, are usually detected at a late stage due to false negative assessments of screening mammograms. The missed screening-time detection is commonly caused by the tumor being obscured by its surrounding breast tissues, a phenomenon called masking. To study and benchmark mammographic masking of cancer, in this work we introduce CSAW-M, the largest public mammographic dataset, collected from over 10,000 individuals and annotated with potential masking. In contrast to the previous approaches which measure breast image density as a proxy, our dataset directly provides annotations of masking potential assessments from five specialists. We also trained deep learning models on CSAW-M to estimate the masking level and showed that the estimated masking is significantly more predictive of screening participants diagnosed with interval and large invasive cancers -- without being explicitly trained for these tasks -- than its breast density counterparts.

cs.CV↗

arXiv2020

Development and evaluation of a 3D annotation software for interactive COVID-19 lesion segmentation in chest CT

Segmentation of COVID-19 lesions from chest CT scans is of great importance for better diagnosing the disease and investigating its extent. However, manual segmentation can be very time consuming and subjective, given the lesions' large variation in shape, size and position. On the other hand, we still lack large manually segmented datasets that could be used for training machine learning-based models for fully automatic segmentation. In this work, we propose a new interactive and user-friendly tool for COVID-19 lesion segmentation, which works by alternating automatic steps (based on level-set segmentation and statistical shape modeling) with manual correction steps. The present software was tested by two different expertise groups: one group of three radiologists and one of three users with an engineering background. Promising segmentation results were obtained by both groups, which achieved satisfactory agreement both between- and within-group. Moreover, our interactive tool was shown to significantly speed up the lesion segmentation process, when compared to fully manual segmentation. Finally, we investigated inter-observer variability and how it is strongly influenced by several subjective factors, showing the importance for AI researchers and clinical doctors to be aware of the uncertainty in lesion segmentation results.

eess.IV↗

arXiv2020

Adding Seemingly Uninformative Labels Helps in Low Data Regimes

Evidence suggests that networks trained on large datasets generalize well not solely because of the numerous training examples, but also class diversity which encourages learning of enriched features. This raises the question of whether this remains true when data is scarce - is there an advantage to learning with additional labels in low-data regimes? In this work, we consider a task that requires difficult-to-obtain expert annotations: tumor segmentation in mammography images. We show that, in low-data settings, performance can be improved by complementing the expert annotations with seemingly uninformative labels from non-expert annotators, turning the task into a multi-class problem. We reveal that these gains increase when less expert data is available, and uncover several interesting properties through further studies. We demonstrate our findings on CSAW-S, a new dataset that we introduce here, and confirm them on two public datasets.

cs.CV↗

arXiv2020

Decoupling Inherent Risk and Early Cancer Signs in Image-based Breast Cancer Risk Models

The ability to accurately estimate risk of developing breast cancer would be invaluable for clinical decision-making. One promising new approach is to integrate image-based risk models based on deep neural networks. However, one must take care when using such models, as selection of training data influences the patterns the network will learn to identify. With this in mind, we trained networks using three different criteria to select the positive training data (i.e. images from patients that will develop cancer): an inherent risk model trained on images with no visible signs of cancer, a cancer signs model trained on images containing cancer or early signs of cancer, and a conflated model trained on all images from patients with a cancer diagnosis. We find that these three models learn distinctive features that focus on different patterns, which translates to contrasts in performance. Short-term risk is best estimated by the cancer signs model, whilst long-term risk is best estimated by the inherent risk model. Carelessly training with all images conflates inherent risk with early cancer signs, and yields sub-optimal estimates in both regimes. As a consequence, conflated models may lead physicians to recommend preventative action when early cancer signs are already visible.

eess.IV↗