Persistent Homology as a Morphological Signature of Fibrin Networks
We present an investigation of the applicability of topological data analysis (TDA) to the study of high-resolution confocal microscopy images of fibrin network structures from patients with oesophageal cancer undergoing intended curative surgery. Investigation of clot structure brings new knowledge about blood coagulation, risk of bleeding, and thrombosis in this group of patients. Images of fibrin network formation in the collected blood samples were captured by confocal microscopy and three-dimensional z-stacks were analysed. Each z-stack was cropped to a centre region for analysis, the validity of which is assessed in detail. Overall, we found no significant differences in fibrin network topology across the perioperative period, and no consistent differences in network structure between the standard and intervention groups.