arXiv subjects

G. Elisabeta Marai

Publications and source records attributed to G. Elisabeta Marai.

16 recordsLinked to original sources

arXiv2026

Healthy skepticism in AI: a data visualization research agenda

Research in data visualization of artificial intelligence (AI) models has historically focused on enhancing trust through visual explanations of AI. The trustworthiness line of work was built at least partially on an assumption that humans were critical users unlikely to adopt AI technology. It is increasingly clear that human trust levels in AI span, in fact, a wide range from critical to over-reliant. There is an urgent need to support both trust and healthy skepticism in AI solutions. We argue that it is healthy for humans to adopt a skeptical view both on the results of AI models and on the use of such AI models. We share our thoughts on the rising phenomenon of over-reliance on AI models, the risks and opportunities in using AI models, and the role of data visualization in over-reliance situations where humans are not motivated to engage in critical thinking.

cs.HC↗

arXiv2026

Loom: Multi-Region Analysis of Spatial Transcriptomics with Local Neighborhoods and Global Trajectories

We present Loom, a spatial transcriptomics (ST) visual computing system to support the analysis of pseudo-temporal trajectories, comparative investigation across samples and regions of interest, and the examination of spatially structured processes within local microenvironments. ST is a molecular profiling technology that measures gene expression directly within a thin tissue section while preserving its spatial organization. For practical application-driven analyses, the ST local microenvironment data needs to be integrated with cell reference datasets and temporal simulations of cell behavior. This integration is challenging due to multi-modal registration issues and the complexity of the pseudo-temporal patterns, spatial enrichment data, and gene expression dynamics. Loom leverages a novel glyph coupled with a computational backbone to facilitate the detailed pseudo-temporal exploration of local microenvironments, cross-sample comparisons, and investigation of spatiotemporal biological mechanisms. We evaluate Loom through two case studies developed with experts in tissue pathology and oncologists and through an external usability study. The results demonstrate that Loom supports effectively the discovery of cellular transitions and spatiotemporal expression dynamics.

q-bio.QM↗

arXiv2026

Dysphagia Risk Stratification in Head and Neck Cancer via Two-Stage PRO-Clinical Stacking

Dysphagia is a debilitating late effect of head and neck cancer (HNC) treatment, yet timely identification of at-risk patients remains challenging in survivorship care. Definitive assessment relies on videofluoroscopic imaging, as captured by the Dynamic Imaging Grade of Swallowing Toxicity (CTCAE-DIGEST), which, while validated, requires specialized equipment, trained personnel, and significant patient burden, limiting its routine use in surveillance. Patient-reported outcomes (PROs), by contrast, are low-cost, scalable, and easily collected at any clinical encounter, making them an attractive alternative signal for identifying patients who may warrant further evaluation. However, a clear clinical framework for translating PRO responses into actionable interventions is still evolving. In particular, uncertainty remains regarding when a patient's self-reported symptom burden should prompt escalation of care. This study addresses this gap by formulating a single-visit PRO-clinical prediction framework and introducing a clinically interpretable two-stage stacking model to predict swallowing impairment risk using PRO responses and structured clinical variables, without requiring videofluoroscopic imaging. The proposed framework quantifies the independent contributions of patient-reported symptoms and clinical factors within a unified and interpretable risk assessment model. Our findings demonstrate that individual MDADI responses contain predictive information beyond that captured by composite or global summary scores, while interpretability analyses reveal symptom patterns and clinical risk factors associated with swallowing impairment. Together, these results support the use of structured PRO-clinical integration as a practical, imaging-free approach for dysphagia risk stratification in HNC survivorship.

cs.LG↗

arXiv2025

Attention-based ROI Discovery in 3D Tissue Images

High-dimensional tissue imaging generates highly complex 3D data containing multiple biomarkers, making it challenging to identify biologically relevant regions without an expert user specifying manual labels for regions of interest. We introduce an approach to automatically identifying regions of interest (ROIs) in the 3D microscopy data. Our approach is based on a novel self-supervised multi-layer graph attention network (SSGAT), coupled with a React interactive interface wrapped around Vitessce. SSGAT employs an adversarial self-supervised learning objective to identify meaningful immune microenvironments through marker interactions. Our method reveals complex spatial bioreactions that can be visually assessed to assess their distribution across tissue. Index Terms: Biomedical visualization, graph attention networks,self-supervised learning, spatial interaction analysis.

q-bio.QM↗

arXiv2025

StreetWeave: A Declarative Grammar for Street-Overlaid Visualization of Multivariate Data

The visualization and analysis of street and pedestrian networks are important to various domain experts, including urban planners, climate researchers, and health experts. This has led to the development of new techniques for street and pedestrian network visualization, expanding how data can be shown and understood more effectively. Despite their increasing adoption, there is no established design framework to guide the creation of these visualizations while addressing the diverse requirements of various domains. When exploring a feature of interest, domain experts often need to transform, integrate, and visualize a combination of thematic data (e.g., demographic, socioeconomic, pollution) and physical data (e.g., zip codes, street networks), often spanning multiple spatial and temporal scales. This not only complicates the process of visual data exploration and system implementation for developers but also creates significant entry barriers for experts who lack a background in programming. With this in mind, in this paper, we reviewed 45 studies utilizing street-overlaid visualizations to understand how they are used. Through qualitative coding of these visualizations, we analyzed three key aspects of street and pedestrian network visualization usage: the analytical purpose they serve, the visualization approaches employed, and the data sources used in their creation. Building on this design space, we introduce StreetWeave, a declarative grammar for designing custom visualizations of multivariate spatial network data across multiple resolutions. We demonstrate how StreetWeave can be used to create various street-overlaid visualizations, enabling effective exploration and analysis of spatial data. StreetWeave is available at https://urbantk.org/streetweave.

cs.HC↗

arXiv2024

A Part-to-Whole Circular Cell Explorer

Spatial transcriptomics methods capture cellular measurements such as gene expression and cell types at specific locations in a cell, helping provide a localized picture of tissue health. Traditional visualization techniques superimpose the tissue image with pie charts for the cell distribution. We design an interactive visual analysis system that addresses perceptual problems in the state of the art, while adding filtering, drilling, and clustering analysis capabilities. Our approach can help researchers gain deeper insights into the molecular mechanisms underlying complex biological processes within tissues.

q-bio.QM↗

arXiv2024

DITTO: A Visual Digital Twin for Interventions and Temporal Treatment Outcomes in Head and Neck Cancer

Digital twin models are of high interest to Head and Neck Cancer (HNC) oncologists, who have to navigate a series of complex treatment decisions that weigh the efficacy of tumor control against toxicity and mortality risks. Evaluating individual risk profiles necessitates a deeper understanding of the interplay between different factors such as patient health, spatial tumor location and spread, and risk of subsequent toxicities that can not be adequately captured through simple heuristics. To support clinicians in better understanding tradeoffs when deciding on treatment courses, we developed DITTO, a digital-twin and visual computing system that allows clinicians to analyze detailed risk profiles for each patient, and decide on a treatment plan. DITTO relies on a sequential Deep Reinforcement Learning digital twin (DT) to deliver personalized risk of both long-term and short-term disease outcome and toxicity risk for HNC patients. Based on a participatory collaborative design alongside oncologists, we also implement several visual explainability methods to promote clinical trust and encourage healthy skepticism when using our system. We evaluate the efficacy of DITTO through quantitative evaluation of performance and case studies with qualitative feedback. Finally, we discuss design lessons for developing clinical visual XAI applications for clinical end users.

cs.HC↗

arXiv2024

MOTIV: Visual Exploration of Moral Framing in Social Media

We present a visual computing framework for analyzing moral rhetoric on social media around controversial topics. Using Moral Foundation Theory, we propose a methodology for deconstructing and visualizing the \textit{when}, \textit{where}, and \textit{who} behind each of these moral dimensions as expressed in microblog data. We characterize the design of this framework, developed in collaboration with experts from language processing, communications, and causal inference. Our approach integrates microblog data with multiple sources of geospatial and temporal data, and leverages unsupervised machine learning (generalized additive models) to support collaborative hypothesis discovery and testing. We implement this approach in a system named MOTIV. We illustrate this approach on two problems, one related to Stay-at-home policies during the COVID-19 pandemic, and the other related to the Black Lives Matter movement. Through detailed case studies and discussions with collaborators, we identify several insights discovered regarding the different drivers of moral sentiment in social media. Our results indicate that this visual approach supports rapid, collaborative hypothesis testing, and can help give insights into the underlying moral values behind controversial political issues. Supplemental Material: https://osf.io/ygkzn/?view_only=6310c0886938415391d977b8aae8b749

cs.CY↗

arXiv2023

Roses Have Thorns: Understanding the Downside of Oncological Care Delivery Through Visual Analytics and Sequential Rule Mining

Personalized head and neck cancer therapeutics have greatly improved survival rates for patients, but are often leading to understudied long-lasting symptoms which affect quality of life. Sequential rule mining (SRM) is a promising unsupervised machine learning method for predicting longitudinal patterns in temporal data which, however, can output many repetitive patterns that are difficult to interpret without the assistance of visual analytics. We present a data-driven, human-machine analysis visual system developed in collaboration with SRM model builders in cancer symptom research, which facilitates mechanistic knowledge discovery in large scale, multivariate cohort symptom data. Our system supports multivariate predictive modeling of post-treatment symptoms based on during-treatment symptoms. It supports this goal through an SRM, clustering, and aggregation back end, and a custom front end to help develop and tune the predictive models. The system also explains the resulting predictions in the context of therapeutic decisions typical in personalized care delivery. We evaluate the resulting models and system with an interdisciplinary group of modelers and head and neck oncology researchers. The results demonstrate that our system effectively supports clinical and symptom research.

cs.HC↗

arXiv2023

A Lens to Pandemic Stay at Home Attitudes

We describe the design process and the challenges we met during a rapid multi-disciplinary pandemic project related to stay-at-home orders and social media moral frames. Unlike our typical design experience, we had to handle a steeper learning curve, emerging and continually changing datasets, as well as under-specified design requirements, persistent low visual literacy, and an extremely fast turnaround for new data ingestion, prototyping, testing and deployment. We describe the lessons learned through this experience.

cs.HC↗

arXiv2023

BI-LAVA: Biocuration with Hierarchical Image Labeling through Active Learning and Visual Analysis

In the biomedical domain, taxonomies organize the acquisition modalities of scientific images in hierarchical structures. Such taxonomies leverage large sets of correct image labels and provide essential information about the importance of a scientific publication, which could then be used in biocuration tasks. However, the hierarchical nature of the labels, the overhead of processing images, the absence or incompleteness of labeled data, and the expertise required to label this type of data impede the creation of useful datasets for biocuration. From a multi-year collaboration with biocurators and text-mining researchers, we derive an iterative visual analytics and active learning strategy to address these challenges. We implement this strategy in a system called BI-LAVA Biocuration with Hierarchical Image Labeling through Active Learning and Visual Analysis. BI-LAVA leverages a small set of image labels, a hierarchical set of image classifiers, and active learning to help model builders deal with incomplete ground-truth labels, target a hierarchical taxonomy of image modalities, and classify a large pool of unlabeled images. BI-LAVA's front end uses custom encodings to represent data distributions, taxonomies, image projections, and neighborhoods of image thumbnails, which help model builders explore an unfamiliar image dataset and taxonomy and correct and generate labels. An evaluation with machine learning practitioners shows that our mixed human-machine approach successfully supports domain experts in understanding the characteristics of classes within the taxonomy, as well as validating and improving data quality in labeled and unlabeled collections.

cs.HC↗

arXiv2023

DASS Good: Explainable Data Mining of Spatial Cohort Data

Developing applicable clinical machine learning models is a difficult task when the data includes spatial information, for example, radiation dose distributions across adjacent organs at risk. We describe the co-design of a modeling system, DASS, to support the hybrid human-machine development and validation of predictive models for estimating long-term toxicities related to radiotherapy doses in head and neck cancer patients. Developed in collaboration with domain experts in oncology and data mining, DASS incorporates human-in-the-loop visual steering, spatial data, and explainable AI to augment domain knowledge with automatic data mining. We demonstrate DASS with the development of two practical clinical stratification models and report feedback from domain experts. Finally, we describe the design lessons learned from this collaborative experience.

cs.HC↗

arXiv2022

Understanding Stay-at-home Attitudes through Framing Analysis of Tweets

With the onset of the COVID-19 pandemic, a number of public policy measures have been developed to curb the spread of the virus. However, little is known about the attitudes towards stay-at-home orders expressed on social media despite the fact that social media are central platforms for expressing and debating personal attitudes. To address this gap, we analyze the prevalence and framing of attitudes towards stay-at-home policies, as expressed on Twitter in the early months of the pandemic. We focus on three aspects of tweets: whether they contain an attitude towards stay-at-home measures, whether the attitude was for or against, and the moral justification for the attitude, if any. We collect and annotate a dataset of stay-at-home tweets and create classifiers that enable large-scale analysis of the relationship between moral frames and stay-at-home attitudes and their temporal evolution. Our findings suggest that frames of care are correlated with a supportive stance, whereas freedom and oppression signify an attitude against stay-at-home directives. There was widespread support for stay-at-home orders in the early weeks of lockdowns, followed by increased resistance toward the end of May and the beginning of June 2020. The resistance was associated with moral judgment that mapped to political divisions.

cs.SI↗

arXiv2022

Visual Analysis and Detection of Contrails in Aircraft Engine Simulations

Contrails are condensation trails generated from emitted particles by aircraft engines, which perturb Earth's radiation budget. Simulation modeling is used to interpret the formation and development of contrails. These simulations are computationally intensive and rely on high-performance computing solutions, and the contrail structures are not well defined. We propose a visual computing system to assist in defining contrails and their characteristics, as well as in the analysis of parameters for computer-generated aircraft engine simulations. The back-end of our system leverages a contrail-formation criterion and clustering methods to detect contrails' shape and evolution and identify similar simulation runs. The front-end system helps analyze contrails and their parameters across multiple simulation runs. The evaluation with domain experts shows this approach successfully aids in contrail data investigation.

cs.HC↗

arXiv2021

THALIS: Human-Machine Analysis of Longitudinal Symptoms in Cancer Therapy

Although cancer patients survive years after oncologic therapy, they are plagued with long-lasting or permanent residual symptoms, whose severity, rate of development, and resolution after treatment vary largely between survivors. The analysis and interpretation of symptoms is complicated by their partial co-occurrence, variability across populations and across time, and, in the case of cancers that use radiotherapy, by further symptom dependency on the tumor location and prescribed treatment. We describe THALIS, an environment for visual analysis and knowledge discovery from cancer therapy symptom data, developed in close collaboration with oncology experts. Our approach leverages unsupervised machine learning methodology over cohorts of patients, and, in conjunction with custom visual encodings and interactions, provides context for new patients based on patients with similar diagnostic features and symptom evolution. We evaluate this approach on data collected from a cohort of head and neck cancer patients. Feedback from our clinician collaborators indicates that THALIS supports knowledge discovery beyond the limits of machines or humans alone, and that it serves as a valuable tool in both the clinic and symptom research.

cs.HC↗

arXiv2020

Explainable Spatial Clustering: Leveraging Spatial Data in Radiation Oncology

Advances in data collection in radiation therapy have led to an abundance of opportunities for applying data mining and machine learning techniques to promote new data-driven insights. In light of these advances, supporting collaboration between machine learning experts and clinicians is important for facilitating better development and adoption of these models. Although many medical use-cases rely on spatial data, where understanding and visualizing the underlying structure of the data is important, little is known about the interpretability of spatial clustering results by clinical audiences. In this work, we reflect on the design of visualizations for explaining novel approaches to clustering complex anatomical data from head and neck cancer patients. These visualizations were developed, through participatory design, for clinical audiences during a multi-year collaboration with radiation oncologists and statisticians. We distill this collaboration into a set of lessons learned for creating visual and explainable spatial clustering for clinical users.

cs.HC↗