arXiv subjects

G. Landi

Publications and source records attributed to G. Landi.

13 recordsLinked to original sources

arXiv2026

Spreading of pathological proteins through brain networks: a case study for Alzheimers disease

Mathematical modeling offers a valuable approach to understanding Alzheimers disease (AD) given its complexity, unknown causes, and lack of effective treatments. Models, once validated, offer a powerful tool to test medical hypotheses that are otherwise difficult to verify directly. Our focus here is on elucidating the spread of misfolded tau protein, a critical hallmark of AD alongside Abeta protein, taking also into account the synergistic interaction between the two proteins. We consider distinct modelling choices, all employing network frameworks for protein evolution, differentiated by their network architecture and diffusion operators. By carefully comparing these models against clinical tau concentration data, gathered through advanced multimodal analysis techniques, we show that certain models replicate better the proteins dynamics. This investigation underscores a crucial insight: in modeling complex pathologies, the precision with which the mathematical framework is chosen is crucial, especially when validation against clinical data is considered decisive.

math.AP↗

arXiv2018

Reconciliation of quantum local master equations with thermodynamics

The study of open quantum systems often relies on approximate master equations derived under the assumptions of weak coupling to the environment. However when the system is made of several interacting subsystems such a derivation is in many cases very hard. An alternative method, employed especially in the modelling of transport in mesoscopic systems, consists in using {\it local} master equations containing Lindblad operators acting locally only on the corresponding subsystem. It has been shown that this approach however generates inconsistencies with the laws of thermodynamics. In this paper we demonstrate that using a microscopic model of local master equations based on repeated collisions all thermodynamic inconsistencies can be resolved by correctly taking into account the breaking of global detailed balance related to the work cost of maintaining the collisions. We provide examples based on a chain of quantum harmonic oscillators whose ends are connected to thermal reservoirs at different temperatures. We prove that this system behaves precisely as a quantum heat engine or refrigerator, with properties that are fully consistent with basic thermodynamics.

quant-ph↗

arXiv2018

Experimental determination of irreversible entropy production in out-of-equilibrium mesoscopic quantum systems

By making use of a recently proposed framework for the inference of thermodynamic irreversibility in bosonic quantum systems, we experimentally measure and characterize the entropy production rates in the non-equilibrium steady state of two different physical systems -- a micro-mechanical resonator and a Bose-Einstein condensate -- each coupled to a high finesse cavity and hence also subject to optical loss. Key features of our setups, such as cooling of the mechanical resonator and signatures of a structural quantum phase transition in the condensate are reflected in the entropy production rates. Our work demonstrates the possibility to explore irreversibility in driven mesoscopic quantum systems and paves the way to a systematic experimental assessment of entropy production beyond the microscopic limit.

quant-ph↗

arXiv2016

Uniform Penalty inversion of two-dimensional NMR Relaxation data

The inversion of two-dimensional NMR data is an ill-posed problem related to the numerical computation of the inverse Laplace transform. In this paper we present the 2DUPEN algorithm that extends the Uniform Penalty (UPEN) algorithm [Borgia, Brown, Fantazzini, {\em Journal of Magnetic Resonance}, 1998] to two-dimensional data. The UPEN algorithm, defined for the inversion of one-dimensional NMR relaxation data, uses Tikhonov-like regularization and optionally non-negativity constraints in order to implement locally adapted regularization. In this paper, we analyze the regularization properties of this approach. Moreover, we extend the one-dimensional UPEN algorithm to the two-dimensional case and present an efficient implementation based on the Newton Projection method. Without any a-priori information on the noise norm, 2DUPEN automatically computes the locally adapted regularization parameters and the distribution of the unknown NMR parameters by using variable smoothing. Results of numerical experiments on simulated and real data are presented in order to illustrate the potential of the proposed method in reconstructing peaks and flat regions with the same accuracy.

math.NA↗

arXiv1999

From Large N Matrices to the Noncommutative Torus

We describe how and to what extent the noncommutative two-torus can be approximated by a tower of finite-dimensional matrix geometries. The approximation is carried out for both irrational and rational deformation parameters by embedding the algebra of the noncommutative torus into an approximately finite algebra. The construction is a rigorous derivation of the recent discretizations of noncommutative gauge theories using finite dimensional matrix models, and it shows precisely how the continuum limits of these models must be taken. We clarify various aspects of Morita equivalence using this formalism and describe some applications to noncommutative Yang-Mills theory.

hep-th↗

arXiv1999

String Geometry and the Noncommutative Torus

We construct a new gauge theory on a pair of d-dimensional noncommutative tori. The latter comes from an intimate relationship between the noncommutative geometry associated with a lattice vertex operator algebra A and the noncommutative torus. We show that the (truncated) tachyon subalgebra of A is naturally isomorphic to a class of twisted modules representing quantum deformations of the algebra of functions on the torus. We construct the corresponding even real spectral triples and determine their Morita equivalence classes using string duality arguments. These constructions yield simple proofs of the O(d,d;Z) Morita equivalences between $d$-dimensional noncommutative tori and give a natural physical interpretation of them in terms of the target space duality group of toroidally compactified string theory. We classify the automorphisms of the twisted modules and construct the most general gauge theory which is invariant under the automorphism group. We compute bosonic and fermionic actions associated with these gauge theories and show that they are explicitly duality-symmetric. The duality-invariant gauge theory is manifestly covariant but contains highly non-local interactions. We show that it also admits a new sort of particle-antiparticle duality which enables the construction of instanton field configurations in any dimension. The duality non-symmetric on-shell projection of the field theory is shown to coincide with the standard non-abelian Yang-Mills gauge theory minimally coupled to massive Dirac fermion fields.

hep-th↗

arXiv1996

Lattice Gauge Fields and Noncommutative Geometry

Conventional approaches to lattice gauge theories do not properly consider the topology of spacetime or of its fields. In this paper, we develop a formulation which tries to remedy this defect. It starts from a cubical decomposition of the supporting manifold (compactified spacetime or spatial slice) interpreting it as a finite topological approximation in the sense of Sorkin. This finite space is entirely described by the algebra of cochains with the cup product. The methods of Connes and Lott are then used to develop gauge theories on this algebra and to derive Wilson's actions for the gauge and Dirac fields therefrom which can now be given geometrical meaning. We also describe very natural candidates for the QCD theta term and Chern-Simons action suggested by this algebraic formulation. Some of these formulations are simpler than currently available alternatives. The paper treats both the functional integral and Hamiltonian approaches.

hep-lat↗

arXiv1996

Metrics and Pairs of Left and Right Connections on Bimodules

Properties of metrics and pairs consisting of left and right connections are studied on the bimodules of differential 1-forms. Those bimodules are obtained from the derivation based calculus of an algebra of matrix valued functions, and an $SL\sb q(2,\IC)$-covariant calculus of the quantum plane plane at a generic $q$ and the cubic root of unity. It is shown that, in the aforementioned examples, giving up the middle-linearity of metrics significantly enlarges the space of metrics. A~metric compatibility condition for the pairs of left and right connections is defined. Also, a compatibility condition between a left and right connection is discussed. Consequences entailed by reducing to the centre of a bimodule the domain of those conditions are investigated in detail. Alternative ways of relating left and right connections are considered.

q-alg↗

arXiv1995

Noncommutative Lattices as Finite Approximations and Their Noncommutative Geometries

Lattice discretizations of continuous manifolds are common tools used in a variety of physical contexts. Conventional discrete approximations, however, cannot capture all aspects of the original manifold, notably its topology. In this paper we discuss an approximation scheme due to Sorkin which correctly reproduces important topological aspects of continuum physics. The approximating topological spaces are partially ordered sets (posets), the partial order encoding the topology. Now, the topology of a manifold $M$ can be reconstructed from the commutative C*-algebra $\cc(M)$ of continuous functions defined on it. In turn, this algebra is generated by continuous probability densities in ordinary quantum physics on $M$. The latter also serve to specify the domains of observables like the Hamiltonian. For a poset, the role of this algebra is assumed by a noncommutative C$^*$-algebra $\ca $. This fact makes any poset a genuine `noncommutative' (`quantum') space, in the sense that the algebra of its `continuous functions' is a noncommutative C$^*$-algebra. We therefore also have a remarkable connection between finite approximations to quantum physics and noncommutative geometries. We use this connection to develop various approximation methods for doing quantum physics using $\ca$.

hep-th↗

arXiv1995

Lattices and Their Continuum Limits

We address the problem of the continuum limit for a system of Hausdorff lattices (namely lattices of isolated points) approximating a topological space $M$. The correct framework is that of projective systems. The projective limit is a universal space from which $M$ can be recovered as a quotient. We dualize the construction to approximate the algebra ${\cal C}(M)$ of continuous functions on $M$. In a companion paper we shall extend this analysis to systems of noncommutative lattices (non Hausdorff lattices).

hep-th↗

arXiv1995

Noncommutative Lattices and Their Continuum Limits

We consider finite approximations of a topological space $M$ by noncommutative lattices of points. These lattices are structure spaces of noncommutative $C^*$-algebras which in turn approximate the algebra $\cc(M)$ of continuous functions on $M$. We show how to recover the space $M$ and the algebra $\cc(M)$ from a projective system of noncommutative lattices and an inductive system of noncommutative $C^*$-algebras, respectively.

hep-th↗

arXiv1994

Finite Quantum Physics and Noncommutative Geometry

Conventional discrete approximations of a manifold do not preserve its nontrivial topological features. In this article we describe an approximation scheme due to Sorkin which reproduces physically important aspects of manifold topology with striking fidelity. The approximating topological spaces in this scheme are partially ordered sets (posets). Now, in ordinary quantum physics on a manifold $M$, continuous probability densities generate the commutative C*-algebra $\cc(M)$ of continuous functions on $M$. It has a fundamental physical significance, containing the information to reconstruct the topology of $M$, and serving to specify the domains of observables like the Hamiltonian. For a poset, the role of this algebra is assumed by a noncommutative C*-algebra $\ca $. As noncommutative geometries are based on noncommutative C*-algebras, we therefore have a remarkable connection between finite approximations to quantum physics and noncommutative geometries. Various methods for doing quantum physics using $\ca $ are explored. Particular attention is paid to developing numerically viable approximation schemes which at the same time preserve important topological features of continuum physics.

hep-th↗

arXiv1993

Generalized Reduction Procedure: Symplectic and Poisson Formalism

We present a generalized reduction procedure which encompasses the one based on the momentum map and the projection method. By using the duality between manifolds and ring of functions defined on them, we have cast our procedure in an algebraic context. In this framework we give a simple example of reduction in the non-commutative setting.

hep-th↗