Searcharxiv⌕ Search

arXiv subjects

G. Ortenzi

Publications and source records attributed to G. Ortenzi.

42 records · Page 3Linked to original sources

Universal features of cell polarization processes

Cell polarization plays a central role in the development of complex organisms. It has been recently shown that cell polarization may follow from the proximity to a phase separation instability in a bistable network of chemical reactions. An example which has been thoroughly studied is the formation of signaling domains during eukaryotic chemotaxis. In this case, the process of domain growth may be described by the use of a constrained time-dependent Landau-Ginzburg equation, admitting scale-invariant solutions {\textit{à la}} Lifshitz and Slyozov. The constraint results here from a mechanism of fast cycling of molecules between a cytosolic, inactive state and a membrane-bound, active state, which dynamically tunes the chemical potential for membrane binding to a value corresponding to the coexistence of different phases on the cell membrane. We provide here a universal description of this process both in the presence and absence of a gradient in the external activation field. Universal power laws are derived for the time needed for the cell to polarize in a chemotactic gradient, and for the value of the smallest detectable gradient. We also describe a concrete realization of our scheme based on the analysis of available biochemical and biophysical data.

cond-mat.stat-mech↗

Patch coalescence as a mechanism for eukaryotic directional sensing

Eukaryotic cells possess a sensible chemical compass allowing them to orient toward sources of soluble chemicals. The extracellular chemical signal triggers separation of the cell membrane into two domains populated by different phospholipid molecules and oriented along the signal anisotropy. We propose a theory of this polarization process, which is articulated into subsequent stages of germ nucleation, patch coarsening and merging into a single domain. We find that the polarization time, $t_ε$, depends on the anisotropy degree $ε$ through the power law $t_ε\propto ε^{-2}$, and that in a cell of radius $R$ there should exist a threshold value $ε_\mathrm{th}\propto R^{-1}$ for the smallest detectable anisotropy.

cond-mat.stat-mech↗

Plane waves from double extended spacetimes

We study exact string backgrounds (WZW models) generated by nonsemisimple algebras which are obtained as double extensions of generic D--dimensional semisimple algebras. We prove that a suitable change of coordinates always exists which reduces these backgrounds to be the product of the nontrivial background associated to the original algebra and two dimensional Minkowski. However, under suitable contraction, the algebra reduces to a Nappi--Witten algebra and the corresponding spacetime geometry, no more factorized, can be interpreted as the Penrose limit of the original background. For both configurations we construct D--brane solutions and prove that {\em all} the branes survive the Penrose limit. Therefore, the limit procedure can be used to extract informations about Nappi--Witten plane wave backgrounds in arbitrary dimensions.

hep-th↗

Zeta function regularization for a scalar field in a compact domain

We express the zeta function associated to the Laplacian operator on $S^1_r\times M$ in terms of the zeta function associated to the Laplacian on $M$, where $M$ is a compact connected Riemannian manifold. This gives formulas for the partition function of the associated physical model at low and high temperature for any compact domain $M$. Furthermore, we provide an exact formula for the zeta function at any value of $r$ when $M$ is a $D$-dimensional box or a $D$-dimensional torus; this allows a rigorous calculation of the zeta invariants and the analysis of the main thermodynamic functions associated to the physical models at finite temperature.

math-ph↗