arXiv subjects

G. Petringa

Publications and source records attributed to G. Petringa.

14 recordsLinked to original sources

arXiv2026

Relative and absolute dosimetric commissioning of the ELIMAIA--ELIMED laser-driven proton beamline at 23.4 MeV

The development of laser-driven proton beamlines for biomedical and radiobiological applications requires traceable dosimetry and reliable online monitoring at the irradiation point. In this work, we report the relative and absolute dosimetric commissioning of the ELIMAIA--ELIMED laser-driven proton beamline at ELI Beamlines using an energy-selected proton beam with an average energy of about 24~MeV. Radiochromic-film measurements were used to characterize the transverse dose distribution, the depth--dose profile, and the proton energy spectrum at the irradiation point. The reconstructed spectrum was centred at $23.45~\mathrm{MeV}$ with a FWHM of $2.60~\mathrm{MeV}$, while the transverse dose distribution showed an approximately $5.5~\mathrm{mm}$ field size with a millimetre-scale homogeneous region. The Faraday Cup was used as the absolute reference detector for dose to water determination and for cross-calibrating the Dual-Gap Ionization Chamber, which was operated as the primary online dose monitor. The Integrating Current Transformer and Secondary Electron Monitor were evaluated as upstream relative beam monitors. An independent RCF--FC dose comparison performed over fifty consecutive shots yielded $30.45 \pm 3.5~\mathrm{cGy}$ from the FC and $36.46 \pm 1.8~\mathrm{cGy}$ from the EBT3 film. Dedicated G4ELIMED Monte Carlo simulations showed that the RCF positioned upstream of the FC perturbs the FC measurement through proton losses outside the FC acceptance and through an increase in the effective beam area at the FC entrance. Applying the resulting correction factor, $C_{\mathrm{MC}}=1.109$, reduced the residual difference between the FC- and RCF-derived doses to about $7\%$. These results establish the dosimetric chain of the ELIMAIA--ELIMED beamline under the present low-fluence commissioning conditions and identify the operational limits of the online monitoring system.

physics.acc-ph↗

arXiv2025

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigues et al. [1]). The experimental proton energy distribution recorded on a shot-to-shot basis and confirmed in a follow up experiment (K. Batani et al. [2]), allowed us to derive the number of nuclear reactions taking place in different targets on a single shot. From this analysis, using the ratio of the yields 11C/7Be, we obtained an effective "single shot" temperature of the TNSA plasma. We used this value to evaluate the yield of alpha particles from the reaction p + 11B -> 3 alpha which may reach (1.6 +/- 0.5) x 10^9 alpha particles in 2pi. From the fluctuations of the protons and the fusion yields, we derived a "TNSA-Equation of State" (EoS), The deviation of such "EoS" from the classical ideal gas limit is well reproduced by the soliton solution of the Korteweg-de Vries (KdV) equation for each shot.

physics.plasm-ph↗

arXiv2025

HASPIDE-SPACE: a new concept of a radiation-resistant instrument for solar energetic particles

Galactic cosmic rays and solar energetic particles (SEPs) affect the performance of instruments carried on board space missions and are the source of the absorbed dose to astronauts. Particles above 100 MeV are the most penetrating. The overall particle flux impacting spacecraft increases by several orders of magnitude during the most intense SEP events and gamma-ray bursts, compared to the galactic cosmic-ray background. Unfortunately, most detectors dedicated to the monitoring of solar particles in space do not allow measurements above 200 MeV. Space agencies and the space and heliospheric weather communities are interested in improving this scenario. We propose a new, compact, low-power, and radiation-resistant instrument, intended for long-duration missions to monitor solar X-rays, electrons, and protons up to energies of tens of keV, MeV, and 600 MeV, respectively. Intense long and short gamma-ray bursts would be observed in the absence of solar activity.

hep-ex↗

arXiv2024

Proton irradiation on Hydrogenated Amorphous Silicon flexible devices

Radiation damage tests in hydrogenated amorphous silicon (a-Si:H) flexible flux and dose-measuring devices have been performed with a 3 MeV proton beam, to evaluate combined displacement and total ionizing dose damage. The tested devices had two different configurations and thicknesses. The first device was a 2 um thick n-i-p diode having a 5 mm x 5 mm area. The second device was a 5 um thick charge selective contact detector having the same area. Both the devices were deposited on a flexible polyimide substrate and were irradiated up to the fluence of 1016 neq/cm2. The response to different proton fluxes has been measured before irradiation and after irradiation at 1016 neq/cm2 for charge-selective contacts and n-i-p devices. The effect of annealing for partial performance recovery at 100{\deg}C for 12 hours was also studied and a final characterization on annealed devices was performed. This test is the first combined displacement and total ionizing dose test on flexible a-Si:H devices.

physics.ins-det↗

arXiv2024

Laser initiated p-11B fusion reactions in petawatt high-repetition-rates laser facilities

Driving the nuclear fusion reaction p+11B -> 3 alpha + 8.7 MeV in laboratory conditions, by interaction between high-power laser pulses and matter, has become a popular field of research, due to numerous applications that it can potentially allow: an alternative to deuterium-tritium (DT) for fusion energy production, astrophysics studies and alpha-particle generation for medical treatments. A possible scheme for laser-driven p-11B reactions is to direct a beam of laser-accelerated protons onto a boron sample (the so-called 'pitcher-catcher' scheme). This technique was successfully implemented on large, energetic lasers, yielding hundreds of joules per shot at low repetition. We present here a complementary approach, exploiting the high-repetition rate of the VEGA III petawatt laser at CLPU (Spain), aiming at accumulating results from many interactions at much lower energy, for better controlling the parameters and the statistics of the measurements. Despite a moderate energy per pulse, our experiment allowed exploring the laser-driven fusion process with tens (up to hundreds) of laser shots. The experiment provided a clear signature of the produced reactions and of the fusion products, accumulated over many shots, leading to an improved optimization of the diagnostic for these experimental campaigns In this paper we discuss the effectiveness of the laser-driven p-11B fusion in the pitcher-catcher scheme, at high-repetition rate, addressing the challenges of this experimental scheme and highlighting its critical aspects. Our proposed methodologies allow evaluating the performance of this scheme for laser-driven alpha particle production and can be adapted to high-repetition rate laser facilities with higher energy and intensity.

physics.plasm-ph↗

arXiv2023

Radioisotopes production using lasers: from basic science to applications

Laser technologies improved after the understanding of the Chirped Pulse Amplification (CPA) which allows energetic laser beams to be compressed to tens of femtosecond (fs) pulse durations and focused to few $\mu$m. Protons of tens of MeV can be accelerated using for instance the Target Normal Sheath Acceleration (TNSA) method and focused on secondary targets. In such conditions, nuclear reactions can occur and radioisotopes relevant for medical purposes be produced. High repetition lasers can be used to produce enough isotopes for medical applications. This route is competitive to conventional methods mostly based on accelerators. In this paper we study the production of $^{67}$Cu, $^{63}$Zn, $^{18}$F and $^{11}$C currently used in positron emission tomography (PET) and other applications. At the same time, we study the reaction $^{10}$B(p,$\alpha$)$^{7}$Be and $^{70}$Zn(p,4n)$^{67}$Ga to put further constraints to the proton distributions at different angles and to the reaction $^{11}$B(p,$\alpha$)$^{8}$Be relevant for energy production. The experiment was performed at the 1 petawatt (PW) laser facility at Vega III located in Salamanca-Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a High Purity Germanium Detector (HPGE). Our results are reasonably reproduced by the numerical estimates following the approach of Kimura et al. (NIMA637(2011)167)

nucl-ex↗

arXiv2023

Characterization of hydrogenated amorphous silicon sensors on polyimide flexible substrate

Hydrogenated amorphous silicon (a-Si:H) is a material having an intrinsically high radiation hardness that can be deposited on flexible substrates like Polyimide. For these properties a-Si:H can be used for the production of flexible sensors. a-Si:H sensors can be successfully utilized in dosimetry, beam monitoring for particle physics (x-ray, electron, gamma-ray and proton detection) and radiotherapy, radiation flux measurement for space applications (study of solar energetic particles and stellar events) and neutron flux measurements. In this paper we have studied the dosimetric x-ray response of n-i-p diodes deposited on Polyimide. We measured the linearity of the photocurrent response to x-rays versus dose-rate from which we have extracted the dosimetric x-ray sensitivity at various bias voltages. In particular low bias voltage operation has been studied to assess the high energy efficiency of these kind of sensor. A measurement of stability of x-ray response versus time has been shown. The effect of detectors annealing has been studied. Operation under bending at various bending radii is also shown.

physics.ins-det↗

arXiv2022

Development of thin hydrogenated amorphous silicon detectors on a flexible substrate

The HASPIDE (Hydrogenated Amorphous Silicon PIxels DEtectors) project aims at the development of thin hydrogenated amorphous silicon (a-Si:H) detectors on flexible substrates (mostly Polyimide) for beam monitoring, neutron detection and space applications. Since a-Si:H is a material with superior radiation hardness, the benefit for the above-mentioned applications can be appreciated mostly in radiation harsh environments. Furthermore, the possibility to deposit this material on flexible substrates like Polyimide (PI), polyethylene naphthalate (PEN) or polyethylene terephthalate (PET) facilitates the usage of these detectors in medical dosimetry, beam flux and beam profile measurements. Particularly interesting is its use when positioned directly on the flange of the vacuum-to-air separation interface in a beam line, as well as other applications where a thin self-standing radiation flux detector is envisaged. In this paper, the HASPIDE project will be described and some preliminary results on PI and glass substrates will be reported.

physics.ins-det↗

arXiv2022

Testing of planar hydrogenated amorphous silicon sensors with charge selective contacts for the construction of 3D- detectors

Hydrogenated Amorphous Silicon (a-Si:H) is a material well known for its intrinsic radiation hardness and is primarily utilized in solar cells as well as for particle detection and dosimetry. Planar p-i-n diode detectors are fabricated entirely by means of intrinsic and doped PECVD of a mixture of Silane (SiH4) and molecular Hydrogen. In order to develop 3D detector geometries using a-Si:H, two options for the junction fabrication have been considered: ion implantation and charge selective contacts through atomic layer deposition. In order to test the functionality of the charge selective contact electrodes, planar detectors have been fabricated utilizing this technique. In this paper, we provide a general overview of the 3D fabrication project followed by the results of leakage current measurements and x-ray dosimetric tests performed on planar diodes containing charge selective contacts to investigate the feasibility of the charge selective contact methodology for integration with the proposed 3D detector architectures.

physics.ins-det↗

arXiv2021

Feasibility Study and Perspectives of proton Dielectric Laser Accelerators (p-DLA): from nanosource to accelerator scheme

In this paper we discuss the possibility to generate and accelerate proton nanobeams in fully dielectric laser-driven accelerators (p-DLAs). High gradient on-chip optical-power dielectric laser accelerators (DLAs) could represent one of the most promising way towards future miniaturized particle accelerator. A primary challenge for DLAs are small beam apertures having a size of the order of the driving laser wavelength where low charge high-repetition (or also CW) ultralow emittance nanobeams have to be transported. For electrons beams generation and acceleration, intense research activities are ongoing, and several demonstrations have been already obtained by using electrons nanotip (or flat photocathode) sources feeding dielectric microstructures. In this article we aim at the possibility to integrate a nanosource for the generation of a light ion or proton nano-beams suitable for the subsequent acceleration into sub-relativistic (low-beta) p-DLA stages. Such integration includes the idea to use a proton dielectric radiofrequency quadrupole (p-DRFQ) for bridging the gap between the accelerator front-end and the drift-tube and high-beta sections. The paper has been prepared as a white book including state-of-art technologies and new solutions that now put the ambitious frontier of a fully nanostructured proton accelerator into reach. Conceptual studies of p-DLAs here presented could enable table-top proton nano-beams for several applications: proton beam writing, nuclear reaction analysis at sub-micrometer scales, the construction of miniaturized Proton-Boron Nuclear Fusion based Reactors, biological analysis at the micrometer scale, ion beam analysis at the sub-cellular level, mini-beams ion therapy to spare the shallow tissues, proton irradiation of transistors, compact proton linac for neutron generation.

physics.acc-ph↗

arXiv2018

A new energy spectrum reconstruction method for Time-Of-Flight diagnostics of high-energy laser-driven protons

The Time-of-Flight (ToF) technique coupled with semiconductor-like detectors, as silicon carbide and diamond, is one of the most promising diagnostic methods for high-energy, high repetition rate, laser-accelerated ions allowing a full on-line beam spectral characterization. A new analysis method for reconstructing the energy spectrum of high-energy laser-driven ion beams from TOF signals is hereby presented and discussed. The proposed method takes into account the detector's working principle, through the accurate calculation of the energy loss in the detector active layer, using Monte Carlo simulations. The analysis method was validated against well-established diagnostics, such as the Thomson Parabola Spectrometer, during an experimental campaign carried out at the Rutherford Appleton Laboratory (RAL, UK) with the high-energy laser-driven protons accelerated by the VULCAN Petawatt laser.

physics.acc-ph↗

arXiv2018

Discussing the discrepancy between analytical calculations and the observed biological effectiveness in proton boron capture therapy (pbct)

A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the potential role of the p+11B to 3α (for brevity, p-B) reaction in the biological enhancement of proton therapy effectiveness. The work reports robust experimental data in terms of clonogenic cell survival and chromosomal aberrations and unambiguously shows the presence of an enhancement when cells were exposed to a clinical proton beam subject to treatment with sodium boroncaptate (BSH). Moreover, the greater occurrence of complex-type chromosomal exchanges points to the effect as due radiation of a LET (Linear Energy Transfer) greater than that of protons alone, possibly the alpha particles generated by the reaction. At the same time, we emphasized that analytical calculations, performed on the basis of the well-known total production cross section data, are not able to explain the effect in a macroscopic way, i.e. solely in terms of a trivial increase in the total dose released in the cells by the alpha-particles. In this paper, thanks to simulations and analytical calculations, we will discuss the theoretically expected alpha particle yield and the corresponding LET and RBE (Relative Biological Effectiveness) increase related to the 11B presence. We conclude that a mere calculation based on the classical concepts of integral Dose, and average LET and RBE cannot be used to justify the observed radiobiological phenomena. We, therefore, suggest that micro- and nano-dosimetric aspects must be taken into account.

physics.med-ph↗

arXiv2018

Geant4 simulation of the ELIMED transport and dosimetry beam line for high-energy laser-driven ion beam multidisciplinary applications

The ELIMED (MEDical and multidisciplinary application at ELI Beamlines) beam line is being developed at INFN-LNS with the aim of transporting and selecting in energy proton and ion beams accelerated by laser-matter interaction at ELI Beamlines in Prague. It will be a section of the ELIMAIA (ELI Multidisciplinary Applications of laser-Ions Acceleration) beam line, dedicated to applications, including the medical one, of laser-accelerated ion beams [1,2]. A Monte Carlo model has been developed to support the design of the beam line in terms of particle transport efficiency, to optimize the transport parameters at the irradiation point in air and, furthermore, to predict beam parameters in order to deliver dose distributions of clinical relevance. The application has been developed using the Geant4 [3] Monte Carlo toolkit and has been designed in a modular way in order to easily switch on/off geometrical components according to different experimental setups and users requirements, as reported in [4], describing the early-stage code and simulations. The application has been delivered to ELI Beamlines and will be available for future ELIMAIA's users as ready-to-use tool useful during experiment preparation and analysis. The final version of the developed application will be described in detail in this contribution, together with the final results, in terms of energy spectra and transmission efficiency along the in-vacuum beam line, obtained by performing end-to-end simulations.

physics.acc-ph↗

arXiv2017

Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model

Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) $^{12}$C ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper $^{12}$C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + $^{11}$B $\rightarrow$3$α$ reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses $^{10}$B-enriched BSH for neutron irradiation-triggered alpha-particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy ballistic precision with the higher RBE promised by BNCT and $^{12}$C-ion therapy is thus demonstrated.

physics.med-ph↗