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Gabriel Balaban

Publications and source records attributed to Gabriel Balaban.

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Latent PDE mapping for efficient physics-informed learning across geometries with limited data

In this study, we introduce latent PDE mapping, a broadly applicable physics-informed learning technique designed to enable efficient geometric generalization with sparse training data. Latent PDE mapping pulls back geometry-specific PDE residuals and boundary conditions to a predefined latent geometry via the deformation gradient, thereby enabling the automated calculation of geometry-consistent shape gradients that are missing in conventional physics-informed machine learning formulations. We demonstrate the utility of latent PDE mapping in solving the anisotropic Aliev-Panfilov PDE of cardiac electrophysiology using both physics-informed neural networks and physics-informed deep operator networks. The Aliev-Panfilov PDE serves as a challenging exemplar: a nonlinear, time-dependent PDE benchmark with sharp gradients that are expensive to capture using traditional numerical solvers. To represent the limited data regime, we train the networks using just fifteen geometric samples drawn from parameterized distributions in two and three spatial dimensions. While modest improvements appear for geometries parameterized by affine and shear deformations, latent PDE mapping demonstrates significant benefits on select geometric families, achieving a factor ~4-6 reduction in mean relative L2 error. Furthermore, our results show that the computational cost of applying latent PDE mapping was modest during network training, and negligible at inference. Taken together, our study highlights how latent PDE mapping facilitates the creation of generalizable physics-informed machine learning models from limited sets of training geometries.

cs.LG

Physics-Informed Symbolic Regression for Elasticity Modeling in Cardiac Digital Twins

Cardiac digital twins hold great promise for personalized medicine, but they currently depend on complex constitutive models of tissue mechanics that are often over-parameterized for the clinical context. To address this, we introduce CHESRA (Cardiac Hyperelastic Evolutionary Symbolic Regression Algorithm), a physics-informed machine learning framework that automatically derives simple strain energy functions from multiple experimental data sources. Using a normalizing loss function, CHESRA identified two new functions with only three and four parameters, respectively. These functions achieve high data fitting accuracy in experimental scenarios while enabling more consistent parameter estimation than state-of-the-art approaches, both in tissue benchmarks and 3D simulations. By combining biophysical constraints with data-driven discovery, CHESRA demonstrates how physics-informed learning can generate accurate, personalizable models for advancing cardiac digital twins and clinical decision-making.

q-bio.TO

Adjoint Multi-Start Based Estimation of Cardiac Hyperelastic Material Parameters using Shear Data

Cardiac muscle tissue during relaxation is commonly modelled as a hyperelastic material with strongly nonlinear and anisotropic stress response. Adapting the behavior of such a model to experimental or patient data gives rise to a parameter estimation problem which involves a significant number of parameters. Gradient-based optimization algorithms provide a way to solve such nonlinear parameter estimation problems with relatively few iterations, but require the gradient of the objective functional with respect to the model parameters. This gradient has traditionally been obtained using finite differences, the calculation of which scales linearly with the number of model parameters, and introduces a differencing error. By using an automatically derived adjoint equation, we are able to calculate this gradient more efficiently, and with minimal implementation effort. We test this adjoint framework on a least squares fitting problem involving data from simple shear tests on cardiac tissue samples. A second challenge which arises in gradient-based optimization is the dependency of the algorithm on a suitable initial guess. We show how a multi-start procedure can alleviate this dependency. Finally, we provide estimates for the material parameters of the Holzapfel and Ogden strain energy law using finite element models together with experimental shear data.

q-bio.TO