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Gaetana Spedalieri

Publications and source records attributed to Gaetana Spedalieri.

At least 19 recordsLinked to original sources

Quantum-enhanced biosensing enables earlier detection of bacterial growth

Rapid detection of bacterial growth is crucial in clinical, food safety, and environmental contexts, yet conventional optical methods are limited by noise and require hours of incubation. Here, we present the first experimental demonstration of a quantum-enhanced photometric measurement for early bacterial detection using squeezed light. By monitoring the optical absorbance of an Escherichia coli culture with a quantum probe, we achieve a sensitivity beyond the shot-noise limit, enabling identification of growth onset up to 30 minutes earlier than with a classical sensor. The noise reduction is validated through statistical modeling with a truncated Gaussian distribution and hypothesis testing, confirming earlier detection with low false-alarm rates. This work illustrates how quantum resources can improve real-time, non-invasive diagnostics. Our results pave the way for quantum-enhanced biosensors that accelerate detection of microbial growth and other biological processes without increasing photodamage.

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An Overview of CV-MDI-QKD

As quantum key distribution (QKD) emerges as a robust defense against quantum computer threats, significant advancements have been realized by researchers. A pivotal focus has been the development of protocols that not only simplify hardware implementation like the use of continuous-variable (CV) systems, but also negate the necessity for trusted nodes, as seen with the measurement-device independent (MDI) approach. This paper delves into the integration of these methodologies in the CV-MDI-QKD protocol, offering an in-depth exploration of its evolution, primary characteristics, and the latest advancements in both theory and experiment.

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Quantum Illumination and Quantum Radar: A Brief Overview

Quantum illumination (QI) and quantum radar have emerged as potentially groundbreaking technologies, leveraging the principles of quantum mechanics to revolutionise the field of remote sensing and target detection. The protocol, particularly in the context of quantum radar, has been subject to a great deal of aspirational conjecture as well as criticism with respect to its realistic potential. In this review, we present a broad overview of the field of quantum target detection focusing on QI and its potential as an underlying scheme for a quantum radar operating at microwave frequencies. We provide context for the field by considering its historical development and fundamental principles. Our aim is to provide a balanced discussion on the state of theoretical and experimental progress towards realising a working QI-based quantum radar, and draw conclusions about its current outlook and future directions.

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Optimal squeezing for quantum target detection

It is not clear if the performance of a quantum lidar or radar, without an idler and only using Gaussian resources, could exceed the performance of a semiclassical setup based on coherent states and homodyne detection. Here we prove this is indeed the case by showing that an idler-free squeezed-based setup can beat this semiclassical benchmark. More generally, we show that probes whose displacement and squeezing are jointly optimized can strictly outperform coherent states with the same mean number of input photons for both the problems of quantum illumination and reading.

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Performance of coherent-state quantum target detection in the context of asymmetric hypothesis testing

Due to the difficulties of implementing joint measurements, quantum illumination schemes that are based on signal-idler entanglement are difficult to implement in practice. For this reason, one may consider quantum-inspired designs of quantum lidar/radar where the input sources are semiclassical (coherent states) while retaining the quantum aspects of the detection. The performance of these designs could be studied in the context of asymmetric hypothesis testing by resorting to the quantum Stein's lemma. However, here we discuss that, for typical finite-size regimes, the second- and third-order expansions associated with this approach are not sufficient to prove quantum advantage.

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Detecting and tracking bacteria with quantum light

The field of quantum sensing aims at improving the detection and estimation of classical parameters that are encoded in physical systems by resorting to quantum sources of light and quantum detection strategies. The same approach can be used to improve the current classical measurements that are performed on biological systems. Here we consider the scenario of two bacteria (E. coli and Salmonella) growing in a Luria Bertani broth and monitored by classical spectrophotometers. Their concentration can be related to the optical transmissivity via the Beer-Lambert-Bouguer's law and their growth curves can be described by means of Gompertz functions. Starting from experimental data points, we extrapolate the growth curves of the two bacteria and we study the theoretical performance that would be achieved with a quantum setup. In particular, we discuss how the bacterial growth can, in principle, be tracked by irradiating the samples with orders of magnitude fewer photons, identifying the clear superiority of quantum light in the early stages of growth. We then show the superiority and the limits of quantum resources in two basic tasks: (i) the early detection of bacterial growth and (ii) the early discrimination between two bacteria species.

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Quantum Illumination with a generic Gaussian source

With the aim to loosen the entanglement requirements of quantum illumination, we study the performance of a family of Gaussian states at the transmitter, combined with an optimal and joint quantum measurement at the receiver. We find that maximal entanglement is not strictly necessary to achieve quantum advantage over the classical benchmark of a coherent-state transmitter, in both settings of symmetric and asymmetric hypothesis testing. While performing this quantum-classical comparison, we also investigate a suitable regime of parameters for potential short-range radar (or scanner) applications.

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Environment-assisted bosonic quantum communications

We consider a quantum relay which is used by two parties to perform several continuous-variable protocols of quantum communication, from entanglement distribution (swapping and distillation), to quantum teleportation, and quantum key distribution. The theory of these protocols is suitably extended to a non-Markovian model of decoherence characterized by correlated Gaussian noise in the bosonic environment. In the worst case scenario where bipartite entanglement is completely lost at the relay, we show that the various protocols can be reactivated by the assistance of classical (separable) correlations in the environment. In fact, above a critical amount, these correlations are able to guarantee the distribution of a weaker form of entanglement (quadripartite), which can be localized by the relay into a stronger form (bipartite) that is exploitable by the parties. Our findings are confirmed by a proof-of-principle experiment where we show, for the first time, that memory effects in the environment can drastically enhance the performance of a quantum relay, well beyond the single-repeater bound for quantum and private communications.

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Symmetric and asymmetric discrimination of bosonic loss: Toy applications to biological samples and photo-degradable materials

We consider quantum discrimination of bosonic loss based on both symmetric and asymmetric hypothesis testing. In both approaches, an entangled resource is able to outperform any classical strategy based on coherent-state transmitters in the regime of low photon numbers. In the symmetric case, we then consider the low energy detection of bacterial growth in culture media. Assuming an exponential growth law for the bacterial concentration and the Beer-Lambert law for the optical transmissivity of the sample, we find that the use of entanglement allows one to achieve a much faster detection of growth with respect to the use of coherent states. This performance is also studied by assuming an exponential photo-degradable model, where the concentration is reduced by increasing the number of photons irradiated over the sample. This investigation is then extended to the readout of classical information from suitably-designed photo-degradable optical memories.

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Discrimination of discord in separable Gaussian states

Consider two bosonic modes which are prepared in one of two possible Gaussian states with the same local energy: either a tensor-product thermal state (with zero correlations) or a separable Gaussian state with maximal correlations (with both classical and quantum correlations, the latter being quantified by quantum discord). For the discrimination of these states, we compare the optimal joint coherent measurement with the best local measurement based on single-mode Gaussian detections. We show how the coherent measurement always strictly outperforms the local detection strategy for both single- and multi-copy discrimination. This means that using local Gaussian measurements (assisted by classical communication) is strictly suboptimal in detecting discord. A better performance may only be achieved by either using non Gaussian measurements (non linear optics) or coherent non-local measurements.

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Theory of channel simulation and bounds for private communication

We review recent results on the simulation of quantum channels, the reduction of adaptive protocols (teleportation stretching), and the derivation of converse bounds for quantum and private communication, as established in PLOB [Pirandola, Laurenza, Ottaviani, Banchi, arXiv:1510.08863]. We start by introducing a general weak converse bound for private communication based on the relative entropy of entanglement. We discuss how combining this bound with channel simulation and teleportation stretching, PLOB established the two-way quantum and private capacities of several fundamental channels, including the bosonic lossy channel. We then provide a rigorous proof of the strong converse property of these bounds by adopting a correct use of the Braunstein-Kimble teleportation protocol for the simulation of bosonic Gaussian channels. This analysis provides a full justification of claims presented in the follow-up paper WTB [Wilde, Tomamichel, Berta, arXiv:1602.08898] whose upper bounds for Gaussian channels would be otherwise infinitely large. Besides clarifying contributions in the area of channel simulation and protocol reduction, we also present some generalizations of the tools to other entanglement measures and novel results on the maximum excess noise which is tolerable in quantum key distribution.

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Thermal quantum metrology in memoryless and correlated environments

In bosonic quantum metrology, the estimate of a loss parameter is typically performed by means of pure states, such as coherent, squeezed or entangled states, while mixed thermal probes are discarded for their inferior performance. Here we show that thermal sources with suitable correlations can be engineered in such a way to approach, or even surpass, the error scaling of coherent states in the presence of general Gaussian decoherence. Our findings pave the way for practical quantum metrology with thermal sources in optical instruments (e.g., photometers) or at different wavelengths (e.g., far infrared, microwave or X-ray) where the generation of quantum features, such as coherence, squeezing or entanglement, may be extremely challenging.

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Channel Simulation in Quantum Metrology

In this review we discuss how channel simulation can be used to simplify the most general protocols of quantum parameter estimation, where unlimited entanglement and adaptive joint operations may be employed. Whenever the unknown parameter encoded in a quantum channel is completely transferred in an environmental program state simulating the channel, the optimal adaptive estimation cannot beat the standard quantum limit. In this setting, we elucidate the crucial role of quantum teleportation as a primitive operation which allows one to completely reduce adaptive protocols over suitable teleportation-covariant channels and derive matching upper and lower bounds for parameter estimation. For these channels, we may express the quantum Cramér Rao bound directly in terms of their Choi matrices. Our review considers both discrete- and continuous-variable systems, also presenting some new results for bosonic Gaussian channels using an alternative sub-optimal simulation. It is an open problem to design simulations for quantum channels that achieve the Heisenberg limit.

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Secret key capacity of the thermal-loss channel: Improving the lower bound

We consider the secret key capacity of the thermal loss channel, which is modeled by a beam splitter mixing an input signal mode with an environmental thermal mode. This capacity is the maximum value of secret bits that two remote parties can generate by means of the most general adaptive protocols assisted by unlimited and two-way classical communication. To date, only upper and lower bounds are known. The present work improves the lower bound by resorting to Gaussian protocols based on suitable trusted-noise detectors.

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CV-MDI-QKD: One-mode Gaussian attacks are not enough

The security proof of continuous variable (CV) measurement device independent (MDI) quantum key distribution (QKD) cannot be reduced to the analysis of one-mode Gaussian attacks (in particular, independent entangling-cloner attacks). To stress this point, the present note provides a very simple (almost trivial) argument, showing that there are an infinite number of two-mode Gaussian attacks which cannot be reduced to or simulated by one-mode Gaussian attacks. This result further confirms that the security analysis of CV-MDI-QKD must involve a careful minimization over two-mode attacks as originally performed in [S. Pirandola et al., Nature Photon. 9, 397-402 (2015)].

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Restoring broken entanglement by separable correlations

We consider two bosonic Gaussian channels whose thermal noise is strong enough to break bipartite entanglement. In this scenario, we show how the presence of separable correlations between the two channels is able to restore the broken entanglement. This reactivation occurs not only in a scheme of direct distribution, where a third party (Charlie) broadcasts entangled states to remote parties (Alice and Bob), but also in a configuration of indirect distribution which is based on entanglement swapping. In both schemes, the amount of entanglement remotely activated can be large enough to be distilled by one-way distillation protocols.

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Nonclassical readout of optical memories under local energy constraint

Nonclassical states of light play a central role in many quantum information protocols. Their quantum features have been exploited to improve the readout of information from digital memories, modelled as arrays of microscopic beam splitters [S. Pirandola, Phys. Rev. Lett. 106, 090504 (2011)]. In this model of "quantum reading", a nonclassical source of light with Einstein-Podolski-Rosen correlations has been proven to retrieve more information than any classical source. In particular, the quantum-classical comparison has been performed under a global energy constraint, i.e., by fixing the mean total number of photons irradiated over each memory cell. In this paper we provide an alternative analysis which is based on a local energy constraint, meaning that we fix the mean number of photons per signal mode irradiated over the memory cell. Under this assumption, we investigate the critical number of signal modes after which a nonclassical source of light is able to beat any classical source irradiating the same number of signals.

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Quantum reading under a local energy constraint

Nonclassical states of light play a central role in many quantum information protocols. Their quantum features have been exploited to improve the readout of information from digital memories, modelled as arrays of microscopic beam splitters [S. Pirandola, Phys. Rev. Lett. 106, 090504 (2011)]. In this model of quantum reading, a nonclassical source of light with Einstein-Podolski-Rosen correlations has been proven to retrieve more information than any classical source. In particular, the quantum-classical comparison has been performed under a global energy constraint, i.e., by fixing the mean total number of photons irradiated over each memory cell. In this paper we provide an alternative analysis which is based on a local energy constraint, meaning that we fix the mean number of photons per signal mode irradiated over the memory cell. Under this assumption, we investigate the critical number of signal modes after which a nonclassical source of light is able to beat any classical source irradiating the same number of signals.

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