arXiv subjects

Gazendra Shakya

Publications and source records attributed to Gazendra Shakya.

5 recordsLinked to original sources

arXiv2026

Bubble jetting in acoustic microdroplet vaporization

Acoustic droplet vaporization denotes the phase-change of micron- and sub-micron-sized droplets upon the application of high-amplitude ultrasound. The asymmetric collapse of the incepted vapor bubbles within the droplets can give rise to high-speed liquid microjets. Here, we describe acoustically-driven and bubble-pair jetting arising within the vaporizing droplet, observed experimentally with ultra-high-speed imaging at the microscale. The existence of complex pressure fields due to the continued acoustic wave-droplet interaction and the nucleation of multiple bubbles within the droplet leads to rich dynamics, with the jets presenting behavioral self-similarity to millimetric bubbles under comparable conditions. Evaporative instabilities that develop during bubble growth impede jet formation during bubble collapse. Furthermore, the ability of the jets to pierce the droplet interface and penetrate into the surrounding fluid is discussed. These powerful microjets could be harnessed to induce cell permeabilization for targeted drug delivery and treatment of cancerous tissue.

physics.flu-dyn↗

arXiv2025

Shape modes and jet formation on ultrasound-driven wall-attached bubbles

Understanding how substrate-attached bubbles respond to ultrasound is important for applications from industrial cleaning to biomedical therapy. Under ultrasonic excitation, bubbles can deform through Faraday instability and periodically emit high-speed jets. Although this behavior is increasingly well understood for free bubbles, the dynamics of wall-attached bubbles remain largely unexplored. In particular, the three-dimensional selection and evolution of non-spherical modes and their relation to jetting have not been resolved. We investigate micrometric air bubbles in contact with a rigid substrate and driven by ultrasound, using a dual-view imaging setup combining top-view bright-field microscopy with side-view phase-contrast X-ray imaging. This approach reveals a stepwise evolution of bubble shape through four regimes: spherical oscillations, harmonic axisymmetric meniscus waves, half-harmonic axisymmetric Faraday waves, and the superposition of half-harmonic sectoral Faraday waves. This contrasts with free bubbles, which jump directly to their final Faraday pattern at instability onset. For the chosen substrate, the observed shape-mode spectrum is degenerate and spans a continuous range of mode degrees, consistent with theoretical predictions based on kinematic arguments. Free bubbles, although also degenerate, remain limited to discrete spherical harmonics. Measured ultrasound pressure thresholds for Faraday instability agree with classical interface-stability theory modified for a rigid boundary. Complementary 3D boundary-element simulations reproduce the observed shape evolution. Finally, we identify the acceleration threshold for cyclic jetting: unlike free bubbles, wall-attached bubbles always jet from the side not constrained by the substrate.

physics.flu-dyn↗

arXiv2025

Cyclic jetting enables microbubble-mediated drug delivery

The pursuit of targeted therapies capable of overcoming biological barriers, including the tenacious blood-brain barrier, has spurred the investigation into stimuli-responsive microagents. This approach could improve therapeutic efficacy, reduce undesirable side effects, and open avenues for treating previously incurable diseases. Intravenously-administered ultrasound-responsive microbubbles are one of the most promising agents, having demonstrated potential in several clinical trials. However, the mechanism by which microbubbles enhance drug absorption remains unclear. Here, we reveal through unprecedented time-resolved side-view visualisations that single microbubbles, upon microsecond-long ultrasound driving, puncture the cell membrane and induce drug uptake via stable cyclic microjets. Our theoretical models successfully reproduce the observed bubble and cell dynamic responses. We find that cyclic jets arise from shape instabilities, warranting recognition as a novel class of jets in bubbles, distinct from classical inertial jets driven by pressure gradients. We also establish a threshold for bubble radial expansion beyond which microjets form and facilitate cellular permeation. Remarkably, these microjets occur at ultrasound pressures below 100kPa due to their unique formation mechanism. We show that the stress generated by microjetting surpasses all previously suggested mechanisms by at least an order of magnitude. In summary, this work elucidates the physics behind microbubble-mediated targeted drug delivery and provides criteria for its effective yet safe application.

physics.flu-dyn↗

arXiv2024

Positive pressure matters in acoustic droplet vaporization

Acoustically vaporizable droplets are phase-change agents that can improve the effectiveness of ultrasound-based therapies. In this study, we demonstrate that the compression part of an acoustic wave can generate tension that initiates the vaporization. This counter-intuitive process is explained by the occurrence of Gouy phase shift due to the focusing of the acoustic wave inside the droplet. Our analysis unifies the existing theories for acoustic droplet vaporization under a single framework and is supported by experiments and simulations. We use our theory to identify governing parameters that allow to vaporize droplets using predominantly compression waves, which are safer in medical use.

physics.flu-dyn↗

arXiv2021

Acoustically Manipulating Internal Structure of Disk-in-Sphere Endoskeletal Droplets

Manipulation of micro/nano particles has been well studied and demonstrated by optical, electromagnetic, and acoustic approaches, or their combinations. Manipulation of internal structure of droplet/particle is rarely explored and remains challenging due to its complicated nature. Here we demonstrated the manipulation of internal structure of disk-in-sphere endoskeletal droplets using acoustic wave for the first time. We developed a model to investigate the physical mechanisms behind this novel phenomenon. Theoretical analysis of the acoustic interactions indicated that these assembly dynamics arise from a balance of the primary and secondary radiation forces. Additionally, the disk orientation was found to change with acoustic driving frequency, which allowed on-demand, reversible adjusting disk orientations with respect to the substrate. This novel dynamic behavior leads to unique reversible arrangements of the endoskeletal droplets and their internal architecture, which may provide a new avenue for directed assembly of novel hierarchical colloidal architectures and intracellular organelles or intra-organoid structures.

physics.app-ph↗