arXiv subjects

Gerhard Glatting

Publications and source records attributed to Gerhard Glatting.

2 recordsLinked to original sources

arXiv2025

Mathematical and Computational Nuclear Oncology: Toward Optimized Radiopharmaceutical Therapy via Digital Twins

This article presents the general framework of theranostic digital twins (TDTs) in computational nuclear medicine, designed to support clinical decision-making and improve cancer patient prognosis through personalized radiopharmaceutical therapies (RPTs). It outlines potential clinical applications of TDTs and proposes a roadmap for successful implementation. Additionally, the chapter provides a conceptual overview of the current state of the art in the mathematical and computational modeling of RPTs, highlighting key challenges and the strategies being pursued to address them.

q-bio.OT↗

arXiv2025

An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models

This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiological and drug parameter information, whereas PopPK models leverage population data to enhance individual dose estimation accuracy. Future directions include developing hybrid models, incorporating artificial intelligence, and establishing regulatory guidelines to promote their clinical adoption. Ultimately, these modeling strategies aim to enable precise, personalized RPT dosing, thereby improving therapeutic outcomes and safety.

physics.med-ph↗