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Gerson C. Duarte-Filho

Publications and source records attributed to Gerson C. Duarte-Filho.

2 recordsLinked to original sources

Consecutive-gap ratio distribution for crossover ensembles

The study of spectrum statistics, such as the consecutive-gap ratio distribution, has revealed many interesting properties of many-body complex systems. Here we propose a two-parameter surmise expression for such distribution to describe the crossover between the Gaussian orthogonal ensemble (GOE) and Poisson statistics. This crossover is observed in the isotropic Heisenberg spin-$1/2$ chain with disordered local field, exhibiting the Many-Body Localization (MBL) transition. Inspired by the analysis of stability in dynamical systems, this crossover is presented as a flow pattern in the parameter space, with the Poisson statistics being the fixed point of the system, which represents the MBL phase. We also analyze an isotropic Heisenberg spin-$1/2$ chain with disordered local exchange coupling and a zero magnetic field. In this case, the system never achieves the MBL phase because of the spin rotation symmetry. This case is more sensitive to finite-size effects than the previous one, and thus the flow pattern resembles a two-dimensional random walk close to its fixed point. We propose a system of linearized stochastic differential equations to estimate this fixed point. We study the continuous-state Markov process that governs the probability of finding the system close to this fixed point as the disorder strength increases. In addition, we discuss the conditions under which the stationary probability distribution is given by a bivariate normal distribution.

cond-mat.dis-nn

Intermediate time scale in the first product formation time distribution of Michaelis-Menten kinetics with inhibitors

Michaelis-Menten kinetics is one of the most recognized models in enzyme kinetics, crucial for the understanding of biochemical reactions in several metabolic processes. In this study, we perform a stochastic analysis of the Michaelis-Menten kinetics with the introduction of inhibitory mechanisms, which significantly diversifies the study of the reaction. We apply the Fock space formalism to reformulate the master equation, transforming it into a Schrödinger-type equation. We investigate reversible inhibitions and analyze the behavior of the averaged number of substances involved, identifying a stiffness behavior in all scenarios. In a specific case of partial inhibition, we observe that the inhibitor can act as an activator that favors product formation. We calculate the first product formation time (FPFT), which characterizes the time statistic of the first product formation. We observe the emergence of an intermediate time scale in addition to the two known time scales typical in first-passage problems. This intermediate time scale is closely aligned with the slow-binding kinetics observed in experimentally observed enzymatic reactions that involve inhibitors. This intermediate time scale is related to the new pathways introduced by the presence of inhibitors. This study offers a new perspective on inhibited enzymatic reactions, and demonstrates the usefulness of the Fock space formalism in the analysis of complex chemical systems.

physics.bio-ph