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Gerwin Osnabrugge

Publications and source records attributed to Gerwin Osnabrugge.

7 recordsLinked to original sources

3D scanning microscopy through scattering surfaces using the optical memory effect

Wavefront shaping allows light to be focused through scattering objects. However, the wavefront correction found is only valid in a small region called the isoplanatic patch. Here we present a simple approach to extend this isoplanatic patch by shifting and scaling the corrected wavefront appropriately, demonstrating an 8.6-fold increase in the lateral scanning range and a 1.5-fold increase in the axial range through a scattering layer without the need to perform additional wavefront shaping measurements. Our findings agree well with a simple geometrical model that also allows us to extract the effective position of the scattering layer from the measurements.

physics.optics↗

Mirror Symmetry in three-dimensional Multiple-Scattering Media

We investigate the effect of a mirror-symmetry plane in multiple-scattering media under plane-wave illumination along the symmetry plane. Designed and fabricated samples' optical transport properties are compared quantitatively with three-dimensional modeling. Strong polarization-dependent deviations of the bulk speckle-averaged intensity distribution at the symmetry plane are observed, showing either up to a factor two enhancement or complete suppression of the ensemble-averaged intensities. We derive analytical expressions for the ensemble-averaged intensity profiles near the symmetry plane. Apart from their interest in fundamental light propagation studies, applications of mirror-symmetric scattering media are envisioned in anti-counterfeiting.

physics.optics↗

Generative adversarial network for super-resolution imaging through a fiber

A multimode fiber represents the ultimate limit in miniaturization of imaging endoscopes. Here we propose a fiber imaging approach employing compressive sensing with a data-driven machine learning framework. We implement a generative adversarial network for image reconstruction without relying on a sample sparsity constraint. The proposed method outperforms the conventional compressive imaging algorithms in terms of image quality and noise robustness. We experimentally demonstrate speckle-based imaging below the diffraction limit at a sub-Nyquist speed through a multimode fiber.

eess.IV↗

Model-based wavefront shaping microscopy

Wavefront shaping is increasingly being used in modern microscopy to obtain distortion-free, high-resolution images deep inside inhomogeneous media. Wavefront shaping methods typically rely on the presence of a 'guidestar' in order to find the optimal wavefront to mitigate the scattering of light. However, this condition cannot be satisfied in most biomedical applications. Here, we introduce a novel, guidestar-free wavefront shaping method in which the optimal wavefront is computed using a digital model of the sample. The refractive index model of the sample, that serves as the input for the computation, is constructed in-situ by the microscope itself. In a proof of principle imaging experiment, we demonstrate a large improvement in the two-photon fluorescence signal through a diffuse medium, outperforming the state-of-the-art wavefront shaping techniques by a factor of 21.

physics.optics↗

Blind focusing through strongly scattering media using wavefront shaping with nonlinear feedback

Scattering prevents light from being focused in turbid media. The effect of scattering can be negated through wavefront shaping techniques when a localized form of feedback is available. Even in the absence of such a localized reporter, wavefront shaping can blindly form a single diffraction-limited focus when the feedback response is nonlinear. We developed and experimentally validated a model that accurately describes the statistics of this blind focusing process. We show that maximizing the nonlinear feedback signal does not always result in the formation of a focus. Using our model, we can calculate the minimal requirements to blindly focus light through strongly scattering media.

physics.optics↗

The generalized optical memory effect

The optical memory effect is a well-known type of wave correlation that is observed in coherent fields that scatter through thin and diffusive materials, like biological tissue. It is a fundamental physical property of scattering media that can be harnessed for deep-tissue microscopy or 'through-the-wall' imaging applications. Here we show that the optical memory effect is a special case of a far more general class of wave correlation. Our new theoretical framework explains how waves remain correlated over both space and angle when they are jointly shifted and tilted inside scattering media of arbitrary geometry. We experimentally demonstrate the existence of such coupled correlations and describe how they can be used to optimize the scanning range in adaptive optics microscopes.

physics.optics↗

A convergent Born series for solving the inhomogeneous Helmholtz equation in arbitrarily large media

We present a fast method for numerically solving the inhomogeneous Helmholtz equation. Our iterative method is based on the Born series, which we modified to achieve convergence for scattering media of arbitrary size and scattering strength. Compared to pseudospectral time-domain simulations, our modified Born approach is two orders of magnitude faster and nine orders of magnitude more accurate in benchmark tests in 1-dimensional and 2-dimensional systems.

physics.comp-ph↗