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Gianluca Manzo

Publications and source records attributed to Gianluca Manzo.

2 recordsLinked to original sources

Hesitation is defeat? Connecting Linguistic and Predictive Uncertainty

Automating chest radiograph interpretation using Deep Learning (DL) models has the potential to significantly improve clinical workflows, decision-making, and large-scale health screening. However, in medical settings, merely optimising predictive performance is insufficient, as the quantification of uncertainty is equally crucial. This paper investigates the relationship between predictive uncertainty, derived from Bayesian Deep Learning approximations, and human/linguistic uncertainty, as estimated from free-text radiology reports labelled by rule-based labellers. Utilising BERT as the model of choice, this study evaluates different binarisation methods for uncertainty labels and explores the efficacy of Monte Carlo Dropout and Deep Ensembles in estimating predictive uncertainty. The results demonstrate good model performance, but also a modest correlation between predictive and linguistic uncertainty, highlighting the challenges in aligning machine uncertainty with human interpretation nuances. Our findings suggest that while Bayesian approximations provide valuable uncertainty estimates, further refinement is necessary to fully capture and utilise the subtleties of human uncertainty in clinical applications.

cs.CL

Halting SARS-CoV-2 by Targeting High-Contact Individuals

Network scientists have proposed that infectious diseases involving person-to-person transmission may be effectively halted by targeting interventions at a minority of highly connected individuals. Can this strategy be effective in combating a virus partly transmitted in close-range contact, as many believe SARS-CoV-2 to be? Effectiveness critically depends on high between-person variability in the number of close-range contacts. We analyze population survey data showing that indeed the distribution of close-range contacts across individuals is characterized by a small fraction of individuals reporting very high frequencies. Strikingly, we find that the average duration of contact is mostly invariant in the number of contacts, reinforcing the criticality of hubs. We simulate a population embedded in a network with empirically observed contact frequencies. Simulations show that targeting hubs robustly improves containment.

cs.SI