arXiv subjects

Giovanni Toto

Publications and source records attributed to Giovanni Toto.

3 recordsLinked to original sources

arXiv2026

Bayesian Semiparametric Multivariate Density Regression with Coordinate-Wise Predictor Selection

We propose a flexible Bayesian approach for estimating the joint density of a multivariate outcome of interest in the presence of categorical covariates. Leveraging a Gaussian copula framework, our method effectively captures the dependence structure across different coordinates of the multivariate response. The conditional (on covariates) marginal (across outcomes) distributions are modeled as flexible mixtures with shared atoms across coordinates, while the mixture weights are allowed to vary with covariates through a novel Tucker tensor factorization-based structure, which enables the identification of coordinate-specific subsets of influential covariates. In particular, we replace the traditional mode matrices with coordinate-specific random partition models on the covariate levels, offering a flexible mechanism to aggregate covariate levels that exhibit similar effects on the response. Additionally, to handle settings with many covariates, we introduce a Markov chain Monte Carlo algorithm that scales with the number of aggregated levels rather than the original levels, significantly reducing memory requirements and improving computational efficiency. We demonstrate the method's numerical performance through simulation experiments and its practical applicability through the analysis of NHANES dietary data.

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arXiv2025

Bayesian local clustering of functional data via semi-Markovian random partitions

We introduce a Bayesian framework for indirect local clustering of functional data, leveraging B-spline basis expansions and a novel dependent random partition model. By exploiting the local support properties of B-splines, our approach allows partially coincident functional behaviors, achieved when shared basis coefficients span sufficiently contiguous regions. This is accomplished through a cutting-edge dependent random partition model that enforces semi-Markovian dependence across a sequence of partitions. By matching the order of the B-spline basis with the semi-Markovian dependence structure, the proposed model serves as a highly flexible prior, enabling efficient modeling of localized features in functional data. Furthermore, we extend the utility of the dependent random partition model beyond functional data, demonstrating its applicability to a broad class of problems where sequences of dependent partitions are central, and standard Markovian assumptions prove overly restrictive. Empirical illustrations, including analyses of simulated data and tide level measurements from the Venice Lagoon, showcase the effectiveness and versatility of the proposed methodology.

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arXiv2023

Structured factorization for single-cell gene expression data

Single-cell gene expression data are often characterized by large matrices, where the number of cells may be lower than the number of genes of interest. Factorization models have emerged as powerful tools to condense the available information through a sparse decomposition into lower rank matrices. In this work, we adapt and implement a recent Bayesian class of generalized factor models to count data and, specifically, to model the covariance between genes. The developed methodology also allows one to include exogenous information within the prior, such that recognition of covariance structures between genes is favoured. In this work, we use biological pathways as external information to induce sparsity patterns within the loadings matrix. This approach facilitates the interpretation of loadings columns and the corresponding latent factors, which can be regarded as unobserved cell covariates. We demonstrate the effectiveness of our model on single-cell RNA sequencing data obtained from lung adenocarcinoma cell lines, revealing promising insights into the role of pathways in characterizing gene relationships and extracting valuable information about unobserved cell traits.

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