arXiv subjects

Grace Cai

Publications and source records attributed to Grace Cai.

5 recordsLinked to original sources

arXiv2026

Intracellular Measurement-Informed Multiscale Modeling for Scalable iPSC Manufacturing

Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D aggregate cultures used in manufacturing exhibit substantial spatial and metabolic heterogeneity compared with the relatively homogeneous monolayer systems used in laboratory studies, complicating mechanistic understanding and predictive metabolic modeling across culture scales. To address this challenge, we developed a modular multiscale mechanistic foundation model that links molecular, cellular, and macroscopic processes while accounting for spatial and metabolic heterogeneity. The framework integrates extracellular culture dynamics, intracellular metabolic fluxes, and cellular redox states by extending a previously established monolayer kinetic network and coupling it with a biological systems-of-systems (Bio-SoS) multiscale model for aggregate cultures, incorporating explicit redox interactions. Systematic monolayer and aggregate experiments (including multiple isotopic tracers, extracellular metabolite profiling, and two-photon optical redox imaging) were used to improve and validate the model. This integrated framework unifies heterogeneous datasets across culture configurations and enables mechanistic interpretation of metabolic and redox responses across heterogeneous culture scales, providing a quantitative foundation for scalable iPSC biomanufacturing.

q-bio.CB↗

arXiv2025

GM3: A General Physical Model for Micro-Mobility Vehicles

Modeling the dynamics of micro-mobility vehicles (MMV) is becoming increasingly important for training autonomous vehicle systems and building urban traffic simulations. However, mainstream tools rely on variants of the Kinematic Bicycle Model (KBM) or mode-specific physics that miss tire slip, load transfer, and rider/vehicle lean. To our knowledge, no unified, physics-based model captures these dynamics across the full range of common MMVs and wheel layouts. We propose the "Generalized Micro-mobility Model" (GM3), a tire-level formulation based on the tire brush representation that supports arbitrary wheel configurations, including single/double track and multi-wheel platforms. We introduce an interactive model-agnostic simulation framework that decouples vehicle/layout specification from dynamics to compare the GM3 with the KBM and other models, consisting of fixed step RK4 integration, human-in-the-loop and scripted control, real-time trajectory traces and logging for analysis. We also empirically validate the GM3 on the Stanford Drone Dataset's deathCircle (roundabout) scene for biker, skater, and cart classes.

cs.RO↗

arXiv2022

A Comparison of New Swarm Task Allocation Algorithms in Unknown Environments with Varying Task Density

Task allocation is an important problem for robot swarms to solve, allowing agents to reduce task completion time by performing tasks in a distributed fashion. Existing task allocation algorithms often assume prior knowledge of task location and demand or fail to consider the effects of the geometric distribution of tasks on the completion time and communication cost of the algorithms. In this paper, we examine an environment where agents must explore and discover tasks with positive demand and successfully assign themselves to complete all such tasks. We first provide a new discrete general model for modeling swarms. Operating within this theoretical framework, we propose two new task allocation algorithms for initially unknown environments -- one based on N-site selection and the other on virtual pheromones. We analyze each algorithm separately and also evaluate the effectiveness of the two algorithms in dense vs. sparse task distributions. Compared to the Levy walk, which has been theorized to be optimal for foraging, our virtual pheromone inspired algorithm is much faster in sparse to medium task densities but is communication and agent intensive. Our site selection inspired algorithm also outperforms Levy walk in sparse task densities and is a less resource-intensive option than our virtual pheromone algorithm for this case. Because the performance of both algorithms relative to random walk is dependent on task density, our results shed light on how task density is important in choosing a task allocation algorithm in initially unknown environments.

cs.MA↗

arXiv2022

A Geometry-Sensitive Quorum Sensing Algorithm for the Best-of-N Site Selection Problem

The house hunting behavior of the Temnothorax albipennis ant allows the colony to explore several nest choices and agree on the best one. Their behavior serves as the basis for many bio-inspired swarm models to solve the same problem. However, many of the existing site selection models in both insect colony and swarm literature test the model's accuracy and decision time only on setups where all potential site choices are equidistant from the swarm's starting location. These models do not account for the geographic challenges that result from site choices with different geometry. For example, although actual ant colonies are capable of consistently choosing a higher quality, further site instead of a lower quality, closer site, existing models are much less accurate in this scenario. Existing models are also more prone to committing to a low quality site if it is on the path between the agents' starting site and a higher quality site. We present a new model for the site selection problem and verify via simulation that is able to better handle these geographic challenges. Our results provide insight into the types of challenges site selection models face when distance is taken into account. Our work will allow swarms to be robust to more realistic situations where sites could be distributed in the environment in many different ways.

cs.MA↗

arXiv2021

A Spatially Dependent Probabilistic Model for House Hunting in Ant Colonies

Ant species such as Temnothorax albipennis select a new nest site in a distributed fashion that, if modeled correctly, can serve as useful information for site selection algorithms for robotic swarms and other applications. Studying and replicating the ants' house hunting behavior will also illuminate useful distributed strategies that have evolved in nature. Many of the existing models of househunting behaviour for T. albipennis make the assumption that all candidate nest sites are equally distant from the ants' home nest, or that an ant has an equal probability of finding each candidate nest site. However, realistically this is not the case, as nests that are further away from the home nest and nests that are difficult to access are less likely to be found, even if they are of higher quality. We extend previous house-hunting models to account for a pairwise distance metric between nests, compare our results to those of real colonies, and use our results to examine the effects of house hunting in nests of different spatial orientations. Our incorporation of distances in the ant model appear to match empirical data in situations where a distance-quality tradeoff between nests is relevant. Furthermore, the model continues to be on par with previous house-hunting models in experiments where all candidate nests are equidistant from the home nest, as is typically assumed.

cs.MA↗