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Grace V. Ringlein

Publications and source records attributed to Grace V. Ringlein.

3 recordsLinked to original sources

Proximal causal inference through cross-proxy balancing

Proximal causal inference identifies causal effects in the presence of unmeasured confounding by drawing on two sets of proxy variables. Identification typically utilizes bridge functions, defined as solutions to integral equations. However, the mechanism by which fitted bridge functions correct for confounding bias remains opaque, offering little to interpret, inspect or stress-test. We show that the defining equation of a treatment bridge function is already a balance condition, with a cross-proxy form: the weights are functions of the treatment confounding proxies and covariates, and they balance the outcome confounding proxies and covariates (i.e., reweighting the distribution in a particular treatment arm to match the distribution across treatment arms). Several existing identification paths via a treatment bridge function can then be interpreted as providing conditions under which balance on the outcome proxies implies balance on the unobserved confounders, which we call balance propagation. Leveraging this framing, we show that estimation of the treatment bridge function is a type of balancing weight estimation. Finally, we show that an outcome-weighted estimator form can also be obtained for a large class of proximal estimators, including those that utilize an outcome bridge function. Using this framing, we provide conditions under which common estimators are numerically equivalent.

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Self-separated and self-connected models for mediator and outcome missingness in mediation analysis

Missing data is a common challenge in studying treatment effects. In the context of mediation analysis, this paper addresses missingness in the mediator and outcome, focusing on identification. We first consider self-separated missingness models where identification is achieved by conditional independence assumptions. This model class is somewhat limited as it is constrained by the need to remove a certain number of connections from the model. We then turn to self-connected missingness models where identification relies on information from shadow variables. This model class turns out to contain substantial variation, allowing models with built-in shadow variables (mediator, outcome or covariates) and models with auxiliary shadow variables at different positions in the causal structure. To improve the practical value of the missingness mechanisms, we allow where possible for dependencies due to unobserved causes of the missingness, a feature often neglected. In this exploration, we review existing models, connect to new models, and develop theory where needed. This results in templates for identification in the mediation setting, generally useful identification techniques, and perhaps most importantly a synthesis and substantial extension of shadow variable theory. Two examples relate the models to practical considerations.

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Demystifying Proximal Causal Inference

Proximal causal inference (PCI) has emerged as a promising framework for identifying and estimating causal effects in the presence of unobserved confounders. While many traditional causal inference methods rely on the assumption of no unobserved confounding, this assumption is likely often violated. PCI addresses this challenge by relying on an alternative set of assumptions regarding the relationships between treatment, outcome, and auxiliary variables that serve as proxies for unmeasured confounders. We review existing identification results, discuss the assumptions necessary for valid causal effect estimation via PCI, and compare different PCI estimation methods. We offer practical guidance on operationalizing PCI, with a focus on selecting and evaluating proxy variables using domain knowledge, measurement error perspectives, and negative control analogies. Through conceptual examples, we demonstrate tensions in proxy selection and discuss the importance of clearly defining the unobserved confounding mechanism. By bridging formal results with applied considerations, this work aims to demystify PCI, encourage thoughtful use in practice, and identify open directions for methodological development and empirical research.

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