Gregor Gorjanc | Searcharxiv

arXiv2026

Population-scale Ancestral Recombination Graphs with tskit 1.0

Ancestral recombination graphs (ARGs) are an increasingly important component of population and statistical genetics. The tskit library has become key infrastructure for the field, providing an expressive and general representation of ARGs together with a suite of efficient fundamental operations. In this note, we announce tskit version 1.0, describe its underlying rationale, and document its stability guarantees. These guarantees provide a foundation for durable computational artefacts and support long-term reproducibility of code and analyses.

q-bio.PE↗

arXiv2024

Robust Optimal Contribution Selection

Optimal contribution selection (OCS) is a selective breeding method that manages the conversion of genetic variation into genetic gain to facilitate short-term competitiveness and long-term sustainability in breeding programmes. Traditional approaches to OCS do not account for uncertainty in input data, which is always present and challenges optimization and practical decision making. Here we use concepts from robust optimization to derive a robust OCS problem and develop two ways to solve the problem using either conic optimization or sequential quadratic programming. We have developed the open-source Python package 'robustocs' that leverages the Gurobi and HiGHS solvers to carry out these methods. Our testing shows favourable performance when solving the robust OCS problem using sequential quadratic programming and the HiGHS solver.

math.OC↗