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Guang Gao

Publications and source records attributed to Guang Gao.

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SmoothRL: Online Reinforcement Learning During Asynchronous Execution

Deploying robot policies in the physical world requires satisfying two fundamental desiderata: reliability and smooth real-time execution. However, deploying state-of-the-art generalist models presents challenges on both fronts. Achieving the precision and robustness required for real-world deployment necessitates sample-efficient online reinforcement learning (RL) to adapt pretrained models. Meanwhile, the increasing scale of robot foundation models has led to higher inference latency. To satisfy real-time constraints under high latency, modern systems adopt asynchronous inference with action chunking, overlapping policy computation with chunk execution to hide latency and enable smooth control. Despite their complementary roles, integrating asynchronous execution with gradient-based online RL remains underexplored. We present SmoothRL, an online RL framework that fine-tunes a pretrained policy within an asynchronous inference loop. SmoothRL follows a value-gradient paradigm, directly updating policy parameters using gradients of the action-value function with respect to policy actions. To enable correct optimization under asynchronous execution, SmoothRL explicitly models the asynchronous inference process during training. Specifically, each generated action chunk is partitioned by frame index into three regions: a committed region, consisting of actions committed by the previous inference cycle; an execution region, containing newly generated actions executed by the robot; and a discarded region, containing actions superseded by the next inference cycle. Gradients are propagated only through the execution region, ensuring policy optimization aligns with the trajectory distribution induced by asynchronous execution. We evaluate SmoothRL on real-world robotic tasks requiring high precision, as well as highly dynamic tasks that necessitate asynchronous execution.

cs.RO

Towards Human-level Intelligence via Human-like Whole-Body Manipulation

Building general-purpose intelligent robots has long been a fundamental goal of robotics. A promising approach is to mirror the evolutionary trajectory of humans: learning through continuous interaction with the environment, with early progress driven by the imitation of human behaviors. Achieving this goal presents three core challenges: (1) designing safe robotic hardware with human-level physical capabilities; (2) developing an intuitive and scalable whole-body teleoperation interface for data collection; and (3) creating algorithms capable of learning whole-body visuomotor policies from human demonstrations. To address these challenges in a unified framework, we propose Astribot Suite, a robot learning suite for whole-body manipulation aimed at general daily tasks across diverse environments. We demonstrate the effectiveness of our system on a wide range of activities that require whole-body coordination, extensive reachability, human-level dexterity, and agility. Our results show that Astribot's cohesive integration of embodiment, teleoperation interface, and learning pipeline marks a significant step towards real-world, general-purpose whole-body robotic manipulation, laying the groundwork for the next generation of intelligent robots.

cs.RO

AI-based analysis of super-resolution microscopy: Biological discovery in the absence of ground truth

Super-resolution microscopy, or nanoscopy, enables the use of fluorescent-based molecular localization tools to study molecular structure at the nanoscale level in the intact cell, bridging the mesoscale gap to classical structural biology methodologies. Analysis of super-resolution data by artificial intelligence (AI), such as machine learning, offers tremendous potential for discovery of new biology, that, by definition, is not known and lacks ground truth. Herein, we describe the application of weakly supervised paradigms to super-resolution microscopy and its potential to enable the accelerated exploration of the nanoscale architecture of subcellular macromolecules and organelles.

q-bio.SC

A windowed local fdr estimator providing higher resolution and robust thresholds

Motivation: In microarray analysis, special consideration must be given to the issues of multiple statistical tests and typically p-values are adjusted to control family-wise error rate (FWER) or false discovery rate (FDR). FDR metrics have been suggested for controlling false positives, however, genes with p-values close to the threshold typically have a higher chance of being false positives than genes with very low p-values. The local FDR (fdr) metric gives the number of false positives in the vicinity of a test statistic. We propose a new fdr estimator that uses windows instead of binsand define heuristics that use the fluctuations in the estimator to determine robust thresholds for classifying differential expression. Results: Our fdr approach estimates the false discovery rate within a window of p-values. We present heuristics that derive robust fdr thresholds such that a significant change in the fdr threshold yields a small change in the number of rejected hypotheses. We compare these thresholds with thresholds from other approaches using two simulated datasets and one cancer microarray dataset. In the latter, our estimator finds two robust thresholds. Since our fdr estimator is an extension of the FDR metric, it can be used with many FDR estimation methods. Availability: An R function implementing the proposed estimator is available at http://www.dbi.tju.edu/dbi/tools/fdr Contact: james.schwaber@jefferson.edu Supplementary Information: Supplementary figures and code are available at http://www.dbi.tju.edu/dbi/tools/fdr

q-bio.QM