arXiv subjects

Guangxin Li

Publications and source records attributed to Guangxin Li.

2 recordsLinked to original sources

arXiv2026

Towards Precision Therapy in Hepatocellular Carcinoma: A Clinical-Reasoning LLM for Risk Stratification and Treatment Guidance

Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of cancer-related mortality. Current guidelines and staging systems provide coarse categories, but often miss within-stage heterogeneity and the clinical context in electronic medical records (EMRs). We present HCC-STAR (Hepatocellular Carcinoma Staging, Treatment And pRognosis), a clinically aligned large language model that reads routine EMR narratives and jointly outputs risk score-based staging, ranked guideline-consistent treatments with evidence-based rationales, and individualized survival estimates. We curated about 30,000 HCC cases from SEER and expanded them into EMR-style narrative training data using a clinician-validated, prompt-based augmentation workflow. On this corpus, we developed a knowledge-aligned reasoning framework optimized with a step-verifiable composite reward, moving beyond text-level memorization of clinical guidelines. In a multi-center cohort of 6,668 patients from 12 hospitals in China, HCC-STAR achieved state-of-the-art performance in treatment recommendation and risk stratification compared with clinical guidelines and competitive models, including GPT-5 and Gemini-2.5 Pro. Hypothetical overall-survival analysis showed a median survival of 51 months under adherence to HCC-STAR recommendations, compared with 29 and 32 months under BCLC and CNLC. In clinician-centric evaluations, blinded hepatobiliary specialists rated HCC-STAR's reasoning and evidence-based justifications as trustworthy. The model surpassed resident and attending physicians in treatment accuracy and helped physicians make more accurate decisions faster when used as an assistant. These findings support HCC-STAR as a reliable and verifiable decision-support system for risk stratification and precision therapy in HCC.

cs.AI↗

arXiv2024

Diagnosis Assistant for Liver Cancer Utilizing a Large Language Model with Three Types of Knowledge

Liver cancer has a high incidence rate, but primary healthcare settings often lack experienced doctors. Advances in large models and AI technologies offer potential assistance. This work aims to address limitations in liver cancer diagnosis models, such as poor understanding of medical images, insufficient consideration of liver blood vessels, and ensuring accurate medical information. We propose a specialized diagnostic assistant to improve the diagnostic capabilities of less experienced doctors. Our framework combines large and small models, using optimized small models for precise patient image perception. Specifically, a segmentation network iteratively removes ambiguous pixels for liver tumor segmentation, and a multi-scale, multi-level differential network segments liver vessels. Features from these segmentations and medical records form a patient's personalized knowledge base. For diagnosis, Chain of Thought (COT) technology designs prompts mimicking experienced doctors' thought patterns, and Retrieval-Augmented Generation (RAG) technology provides answers based on reliable domain knowledge and trusted cases. Our small model methods improve liver tumor and vessel segmentation performance, resulting in more accurate information extraction. The large model component scores over 1 point higher on a 10-point scale in evaluations by doctors compared to control methods. Our method enhances semantic perception of medical images, improves classification of ambiguous pixels, and optimizes small object perception. It considers blood vessel positions for specific treatments and improves response credibility and interpretability by mimicking experienced doctors' thought processes using reliable resources. This approach has been recognized by doctors and benefits liver cancer auxiliary diagnosis.

physics.med-ph↗