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Guo Zhang

Publications and source records attributed to Guo Zhang.

At least 19 recordsLinked to original sources
arXiv2025

A dispersal recolonisation 3D biofilm in vitro model based on co-assembled peptide amphiphiles and clinical wound fluid

Chronic wound infections are sustained by dynamic 3D biofilm cycles involving maturation, dispersal, and recolonisation, yet existing in vitro models fail to reproduce these temporal and structural complexities. Here, we report a strategy that co-assembles a designed protease-inhibitory peptide amphiphile (PA-GF) with patient-derived wound fluid (WF) to reconstruct the complete biofilm life cycle in vitro. The PA-GF sequence incorporates an HWGF motif capable of binding and inhibiting matrix metalloproteinase-9 (MMP-9), thereby preserving the integrity of recolonised biofilms under proteolytic stress. Co-assembling with WF generated a living material that faithfully mimicked the biochemical and mechanical microenvironment of chronic wounds, supporting the formation of stable 3D biofilms capable of dispersal and recolonisation. Furthermore, we established a controllable polymicrobial infection model and validated its translational relevance through antibiotic susceptibility profiling and spatial microbiological analyses. Notably, the antibiotic response patterns of the PA/WF-derived biofilms closely mirrored those observed in a rat wound infection in vivo model. Collectively, our findings demonstrate that co-assembling living materials can recapitulate the nutritional composition, 3D architecture, and recolonisation dynamics of in vivo infectious biofilms, offering a physiologically relevant and customisable platform for investigating chronic wound infections and accelerating anti-biofilm drug discovery.

physics.med-ph↗
arXiv2025

Accelerating Fault-Tolerant Quantum Computation with Good qLDPC Codes

We propose a fault-tolerant quantum computation scheme that is broadly applicable to quantum low-density parity-check (qLDPC) codes. The scheme achieves constant qubit overhead and a time overhead of $O(d^{a+o(1)})$ for any $[[n,k,d]]$ qLDPC code with constant encoding rate and distance $d = \Omega(n^{1/a})$. For good qLDPC codes, the time overhead is minimized and reaches $O(d^{1+o(1)})$. In contrast, code surgery based on gauging measurement and brute-force branching requires a time overhead of $O(dw^{1+o(1)})$, where $d\leq w\leq n$. Thus, our scheme is asymptotically faster for all codes with $a < 2$. This speedup is achieved by developing techniques that enable parallelized code surgery under constant qubit overhead and leverage classical locally testable codes for efficient resource state preparation. These results establish a new paradigm for accelerating fault-tolerant quantum computation on qLDPC codes, while maintaining low overhead and broad applicability.

quant-ph↗
arXiv2025

STANCE: Motion Coherent Video Generation Via Sparse-to-Dense Anchored Encoding

Video generation has recently made striking visual progress, but maintaining coherent object motion and interactions remains difficult. We trace two practical bottlenecks: (i) human-provided motion hints (e.g., small 2D maps) often collapse to too few effective tokens after encoding, weakening guidance; and (ii) optimizing for appearance and motion in a single head can favor texture over temporal consistency. We present STANCE, an image-to-video framework that addresses both issues with two simple components. First, we introduce Instance Cues -- a pixel-aligned control signal that turns sparse, user-editable hints into a dense 2.5D (camera-relative) motion field by averaging per-instance flow and augmenting with monocular depth over the instance mask. This reduces depth ambiguity compared to 2D arrow inputs while remaining easy to use. Second, we preserve the salience of these cues in token space with Dense RoPE, which tags a small set of motion tokens (anchored on the first frame) with spatial-addressable rotary embeddings. Paired with joint RGB \(+\) auxiliary-map prediction (segmentation or depth), our model anchors structure while RGB handles appearance, stabilizing optimization and improving temporal coherence without requiring per-frame trajectory scripts.

cs.CV↗
arXiv2025

SDPose: Exploiting Diffusion Priors for Out-of-Domain and Robust Pose Estimation

Pre-trained diffusion models provide rich latent features across U-Net levels and are emerging as powerful vision backbones. While prior works such as Marigold and Lotus repurpose diffusion priors for dense geometric perception tasks such as depth and surface normal estimation, their potential for cross-domain human pose estimation remains largely unexplored. Through a systematic analysis of latent features from different upsampling levels of the Stable Diffusion U-Net, we identify the levels that deliver the strongest robustness and cross-domain generalization for pose estimation. Building on these findings, we propose \textbf{SDPose}, which (i) extracts U-Net features from the selected upsampling blocks, (ii) fuses them with a lightweight feature aggregation module to form a robust representation, and (iii) jointly optimizes keypoint heatmap supervision with an auxiliary latent reconstruction loss to regularize training and preserve the pre-trained generative prior. To evaluate cross-domain generalization and robustness, we construct COCO-OOD, a COCO-based benchmark with four subsets: three style-transferred splits to assess domain shift, and one corruption split (noise, weather, digital artifacts, and blur) to test robustness. With a shorter fine-tuning schedule, SDPose achieves performance comparable to Sapiens on COCO, surpasses Sapiens-1B on COCO-WholeBody, and establishes new state-of-the-art results on HumanArt and COCO-OOD.

cs.CV↗
arXiv2025

De novo design of alpha-helical peptide amphiphiles repairing fragmented collagen type I via supramolecular co-assembly

The hierarchical triple-helix structure of collagen type I, Col I, is essential for extracellular matrix support and integrity. However, current reconstruction strategies face challenges such as chain mismatch, preventing proper fibril formation. Here, we report a supramolecular co-assembly strategy using a de novo-designed alpha-helical peptide amphiphile (APA) of just seven amino acids. The APA features a hydrophobic palmitic acid tail, which stabilizes the helical structure and promotes co-assembly upon interaction with complementary molecular structures. This minimal design enables selective recognition of fragmented collagen (FC), restoring triple-helix conformation and guiding fibre formation. We applied this mechanism to engineer FC-rich nanofat (NF) into a mechanically reinforced biomaterial. Integration of APA-NF with coaxial 3D printing enabled spatial control of structure and function. In a porcine model, this platform enhanced in situ vascularized adipose tissue regeneration. Our results demonstrate that hierarchical reconstruction of collagen via peptide-guided supramolecular assembly offers a promising strategy for soft tissue repair.

physics.chem-ph↗
arXiv2025

Planar fault-tolerant logical measurements with low qubit overhead

Fault-tolerant quantum computation critically depends on architectures uniting high encoding rates with physical implementability. Quantum low-density parity-check (qLDPC) codes, including bivariate bicycle (BB) codes, achieve dramatic reductions in qubit overhead, yet their logical operations remain a key challenge under planar hardware constraints. Here, we introduce code craft, a framework for designing fault-tolerant logical operations on planar BB codes within a translationally invariant, two-dimensional qubit lattice. By systematically deforming codes through local modifications-stretching, cutting, and painting-we enable the manipulation of logical qubits using strictly planar operations. We establish fault tolerance through numerical optimization of code distances and show that logical operations, including controlled-NOT gates, state transfers, and Pauli measurements, can be efficiently implemented within this framework to assemble an individually addressable logical qubit network. Universal quantum computation can then be realized by coupling just one BB-code logical qubit to a surface-code block. By combining the high encoding efficiency of qLDPC codes with geometric locality, our approach offers a practical and resource-efficient path to fault-tolerant quantum computation.

quant-ph↗
arXiv2025

Constant-Overhead Magic State Injection into qLDPC Codes with Error Independence Guarantees

Magic states are essential yet resource-intensive components for realizing universal fault-tolerant quantum computation. Preparing magic states within emerging quantum low-density parity-check (qLDPC) codes poses additional challenges, due to the complex encoding structures. Here, we introduce a generic and scalable method for magic state injection into arbitrarily selected logical qubits encoded using qLDPC codes. Our approach, based on parallelized code surgery, supports the injection from either physical qubits or low-distance logical qubits. For qLDPC code families with asymptotically constant encoding rates, the method achieves injection into $\Theta(k)$ logical qubits -- where $k$ denotes the logical qubit number of the code -- with only constant qubit overhead and a time complexity of $\tilde{O}(d^2)$, where $d$ is the code distance. A central contribution of this work is a rigorous proof that errors affecting the injected magic states remain independent throughout the procedure. This independence ensures the resilience of logical qubits against interactions with noisy ancillae and preserves the presumption of subsequent magic state distillation protocols. We further support our theoretical results with numerical validation through circuit-level simulations. These findings advance the feasibility of scalable, fault-tolerant universal quantum computing using qLDPC codes, offering a pathway to significantly reduced qubit resource requirements in magic state injection.

quant-ph↗
arXiv2024

Time-Efficient Logical Operations on Quantum Low-Density Parity Check Codes

We propose schemes capable of measuring an arbitrary set of commutative logical Pauli operators in time independent of the number of operators. The only condition is commutativity, a fundamental requirement for simultaneous measurements in quantum mechanics. Quantum low-density parity check (qLDPC) codes show great promise for realizing fault-tolerant quantum computing. They are particularly significant for early fault-tolerant technologies as they can encode many logical qubits using relatively few physical qubits. By achieving simultaneous measurements of logical operators, our approaches enable fully parallelized quantum computing, thus minimizing computation time. Our schemes are applicable to any qLDPC codes and maintain the low density of parity checks while measuring multiple logical operators simultaneously. These results enhance the feasibility of applying early fault-tolerant technologies to practical problems.

quant-ph↗
arXiv2023

Deep learning radiomics for assessment of gastroesophageal varices in people with compensated advanced chronic liver disease

Objective: Bleeding from gastroesophageal varices (GEV) is a medical emergency associated with high mortality. We aim to construct an artificial intelligence-based model of two-dimensional shear wave elastography (2D-SWE) of the liver and spleen to precisely assess the risk of GEV and high-risk gastroesophageal varices (HRV). Design: A prospective multicenter study was conducted in patients with compensated advanced chronic liver disease. 305 patients were enrolled from 12 hospitals, and finally 265 patients were included, with 1136 liver stiffness measurement (LSM) images and 1042 spleen stiffness measurement (SSM) images generated by 2D-SWE. We leveraged deep learning methods to uncover associations between image features and patient risk, and thus conducted models to predict GEV and HRV. Results: A multi-modality Deep Learning Risk Prediction model (DLRP) was constructed to assess GEV and HRV, based on LSM and SSM images, and clinical information. Validation analysis revealed that the AUCs of DLRP were 0.91 for GEV (95% CI 0.90 to 0.93, p < 0.05) and 0.88 for HRV (95% CI 0.86 to 0.89, p < 0.01), which were significantly and robustly better than canonical risk indicators, including the value of LSM and SSM. Moreover, DLPR was better than the model using individual parameters, including LSM and SSM images. In HRV prediction, the 2D-SWE images of SSM outperform LSM (p < 0.01). Conclusion: DLRP shows excellent performance in predicting GEV and HRV over canonical risk indicators LSM and SSM. Additionally, the 2D-SWE images of SSM provided more information for better accuracy in predicting HRV than the LSM.

q-bio.TO↗
arXiv2022

TOV: The Original Vision Model for Optical Remote Sensing Image Understanding via Self-supervised Learning

Do we on the right way for remote sensing image understanding (RSIU) by training models via supervised data-dependent and task-dependent way, instead of human vision in a label-free and task-independent way? We argue that a more desirable RSIU model should be trained with intrinsic structure from data rather that extrinsic human labels to realize generalizability across a wide range of RSIU tasks. According to this hypothesis, we proposed \textbf{T}he \textbf{O}riginal \textbf{V}ision model (TOV) in remote sensing filed. Trained by massive unlabeled optical data along a human-like self-supervised learning (SSL) path that is from general knowledge to specialized knowledge, TOV model can be easily adapted to various RSIU tasks, including scene classification, object detection, and semantic segmentation, and outperforms dominant ImageNet supervised pretrained method as well as two recently proposed SSL pretrained methods on majority of 12 publicly available benchmarks. Moreover, we analyze the influences of two key factors on the performance of building TOV model for RSIU, including the influence of using different data sampling methods and the selection of learning paths during self-supervised optimization. We believe that a general model which is trained by a label-free and task-independent way may be the next paradigm for RSIU and hope the insights distilled from this study can help to foster the development of an original vision model for RSIU.

cs.CV↗
arXiv2022

A Robust Multimodal Remote Sensing Image Registration Method and System Using Steerable Filters with First- and Second-order Gradients

Co-registration of multimodal remote sensing images is still an ongoing challenge because of nonlinear radiometric differences (NRD) and significant geometric distortions (e.g., scale and rotation changes) between these images. In this paper, a robust matching method based on the Steerable filters is proposed consisting of two critical steps. First, to address severe NRD, a novel structural descriptor named the Steerable Filters of first- and second-Order Channels (SFOC) is constructed, which combines the first- and second-order gradient information by using the steerable filters with a multi-scale strategy to depict more discriminative structure features of images. Then, a fast similarity measure is established called Fast Normalized Cross-Correlation (Fast-NCCSFOC), which employs the Fast Fourier Transform technique and the integral image to improve the matching efficiency. Furthermore, to achieve reliable registration performance, a coarse-to-fine multimodal registration system is designed consisting of two pivotal modules. The local coarse registration is first conducted by involving both detection of interest points (IPs) and local geometric correction, which effectively utilizes the prior georeferencing information of RS images to address global geometric distortions. In the fine registration stage, the proposed SFOC is used to resist significant NRD, and to detect control points between multimodal images by a template matching scheme. The performance of the proposed matching method has been evaluated with many different kinds of multimodal RS images. The results show its superior matching performance compared with the state-of-the-art methods. Moreover, the designed registration system also outperforms the popular commercial software in both registration accuracy and computational efficiency. Our system is available at https://github.com/yeyuanxin110.

cs.CV↗
arXiv2021

Global and Local Contrastive Self-Supervised Learning for Semantic Segmentation of HR Remote Sensing Images

Supervised learning for semantic segmentation requires a large number of labeled samples, which is difficult to obtain in the field of remote sensing. Self-supervised learning (SSL), can be used to solve such problems by pre-training a general model with a large number of unlabeled images and then fine-tuning it on a downstream task with very few labeled samples. Contrastive learning is a typical method of SSL that can learn general invariant features. However, most existing contrastive learning methods are designed for classification tasks to obtain an image-level representation, which may be suboptimal for semantic segmentation tasks requiring pixel-level discrimination. Therefore, we propose a global style and local matching contrastive learning network (GLCNet) for remote sensing image semantic segmentation. Specifically, 1) the global style contrastive learning module is used to better learn an image-level representation, as we consider that style features can better represent the overall image features. 2) The local features matching contrastive learning module is designed to learn representations of local regions, which is beneficial for semantic segmentation. The experimental results show that our method mostly outperforms SOTA self-supervised methods and the ImageNet pre-training method. Specifically, with 1\% annotation from the original dataset, our approach improves Kappa by 6\% on the ISPRS Potsdam dataset relative to the existing baseline. Moreover, our method outperforms supervised learning methods when there are some differences between the datasets of upstream tasks and downstream tasks. Since SSL could directly learn the essential characteristics of data from unlabeled data, which is easy to obtain in the remote sensing field, this may be of great significance for tasks such as global mapping. The source code is available at https://github.com/GeoX-Lab/G-RSIM.

cs.CV↗
arXiv2020

Harnessing Structures for Value-Based Planning and Reinforcement Learning

Value-based methods constitute a fundamental methodology in planning and deep reinforcement learning (RL). In this paper, we propose to exploit the underlying structures of the state-action value function, i.e., Q function, for both planning and deep RL. In particular, if the underlying system dynamics lead to some global structures of the Q function, one should be capable of inferring the function better by leveraging such structures. Specifically, we investigate the low-rank structure, which widely exists for big data matrices. We verify empirically the existence of low-rank Q functions in the context of control and deep RL tasks. As our key contribution, by leveraging Matrix Estimation (ME) techniques, we propose a general framework to exploit the underlying low-rank structure in Q functions. This leads to a more efficient planning procedure for classical control, and additionally, a simple scheme that can be applied to any value-based RL techniques to consistently achieve better performance on "low-rank" tasks. Extensive experiments on control tasks and Atari games confirm the efficacy of our approach. Code is available at https://github.com/YyzHarry/SV-RL.

cs.LG↗
arXiv2019

ME-Net: Towards Effective Adversarial Robustness with Matrix Estimation

Deep neural networks are vulnerable to adversarial attacks. The literature is rich with algorithms that can easily craft successful adversarial examples. In contrast, the performance of defense techniques still lags behind. This paper proposes ME-Net, a defense method that leverages matrix estimation (ME). In ME-Net, images are preprocessed using two steps: first pixels are randomly dropped from the image; then, the image is reconstructed using ME. We show that this process destroys the adversarial structure of the noise, while re-enforcing the global structure in the original image. Since humans typically rely on such global structures in classifying images, the process makes the network mode compatible with human perception. We conduct comprehensive experiments on prevailing benchmarks such as MNIST, CIFAR-10, SVHN, and Tiny-ImageNet. Comparing ME-Net with state-of-the-art defense mechanisms shows that ME-Net consistently outperforms prior techniques, improving robustness against both black-box and white-box attacks.

cs.LG↗
arXiv2013

Reconstruction from boundary measurements for less regular conductivities

In this paper, following Nachman's idea and Haberman and Tataru's idea, we reconstruct $C^1$ conductivity $γ$ or Lipchitz conductivity $γ$ with small enough value of $|\nabla logγ|$ in a Lipschitz domain $Ω$ from the Dirichlet-to-Neumann map $Λ_γ$. In the appendix the authors and R. M. Brown recover the gradient of a $C^1$-conductivity at the boundary of a Lipschitz domain from the Dirichlet-to-Neumann map $Λ_γ$.

math.AP↗
arXiv2012

Citation content analysis (cca): A framework for syntactic and semantic analysis of citation content

This paper proposes a new framework for Citation Content Analysis (CCA), for syntactic and semantic analysis of citation content that can be used to better analyze the rich sociocultural context of research behavior. The framework could be considered the next generation of citation analysis. This paper briefly reviews the history and features of content analysis in traditional social sciences, and its previous application in Library and Information Science. Based on critical discussion of the theoretical necessity of a new method as well as the limits of citation analysis, the nature and purposes of CCA are discussed, and potential procedures to conduct CCA, including principles to identify the reference scope, a two-dimensional (citing and cited) and two-modular (syntactic and semantic modules) codebook, are provided and described. Future works and implications are also suggested.

cs.DL↗
arXiv2012

Topic-Level Opinion Influence Model(TOIM): An Investigation Using Tencent Micro-Blogging

Mining user opinion from Micro-Blogging has been extensively studied on the most popular social networking sites such as Twitter and Facebook in the U.S., but few studies have been done on Micro-Blogging websites in other countries (e.g. China). In this paper, we analyze the social opinion influence on Tencent, one of the largest Micro-Blogging websites in China, endeavoring to unveil the behavior patterns of Chinese Micro-Blogging users. This paper proposes a Topic-Level Opinion Influence Model (TOIM) that simultaneously incorporates topic factor and social direct influence in a unified probabilistic framework. Based on TOIM, two topic level opinion influence propagation and aggregation algorithms are developed to consider the indirect influence: CP (Conservative Propagation) and NCP (None Conservative Propagation). Users' historical social interaction records are leveraged by TOIM to construct their progressive opinions and neighbors' opinion influence through a statistical learning process, which can be further utilized to predict users' future opinions on some specific topics. To evaluate and test this proposed model, an experiment was designed and a sub-dataset from Tencent Micro-Blogging was used. The experimental results show that TOIM outperforms baseline methods on predicting users' opinion. The applications of CP and NCP have no significant differences and could significantly improve recall and F1-measure of TOIM.

cs.SI↗