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Guo-Qiang Zhang

Publications and source records attributed to Guo-Qiang Zhang.

At least 19 recordsLinked to original sources

Discrete Linear Ensemble Logic

We study the discrete point-based fragment of Ensemble Logic $\EL(\Nat)$ over the natural numbers, a logic combining displacement $φ_u$, bounded metric modalities $\boldBox_t$ and $\mdiamond_t$ with additive bounds, Boolean connectives, and first-order quantification over $\Nat$. Motivated by the need for a unified symbolic layer for biomedical knowledge with temporal, spatial, genomic, and multimodal metric content, we develop the foundational discrete theory of the formalism. We give syntax and semantics, and prove a forward embedding of $\EL(\Nat)$ over a finite proposition set $\mathcal{P}$ into first-order monadic Presburger arithmetic $\FO(\Nat,<,+;\mathcal{P})$. This embedding yields the analytical upper bounds, while a reduction from nondeterministic two-counter machines with recurring control states proves that satisfiability is $Σ^1_1$-complete and validity is dually $Π^1_1$-complete. Expressively, $\EL(\Nat)$ strictly extends the star-free $ω$-languages and is incomparable with the $ω$-regular languages: it defines the non-$ω$-regular counting language $\{a^mb^mc^md^m\mid m\geq 1\}\cdotΣ^ω$, whereas a delimited parity language remains outside the logic by classical Presburger-arithmetic lower bounds. On the proof-theoretic side, we present a sound Hilbert system $\HEL$ and establish completeness relative to monadic Presburger validity as oracle, noting that completeness relative to plain Presburger arithmetic is impossible.

cs.LO

Scaling Up Formal Representation of Clinical Trial Protocols in Ensemble Logic Using LLMs: A Preliminary Study

The reliance on unstructured free text for documenting clinical trial protocols creates a significant barrier to automated reasoning, cohort discovery, and trial simulation. The lack of formal structure obscures critical temporal phenotypes, such as dynamic eligibility criteria and event timing constraints. Although Temporal Ensemble Logic (TEL) offers an expressive framework for modeling these elements, manual encoding remains a prohibitive bottleneck. We introduce the CT-TEL workflow: a scalable pipeline leveraging Large Language Models (LLMs) to translate narrative clinical protocols into TEL formulas. We applied CT-TEL to generate logical models for 23 real-world trials from ClinicalTrials.gov. We evaluated translation fidelity via a back-translation approach, using LLMs to convert TEL formulas back into natural language and measuring semantic similarity against source texts. The resulting semantic retention suggests that LLMs may offer a pathway for mapping informal protocols to computable logic, providing preliminary evidence toward scalable clinical trial emulation within the emerging "Symbolic Biomedicine" paradigm championed by the corresponding author.

cs.LO

Ensemble Logic for Symbolic Representation of Sleep Medicine Guidelines

The American Academy of Sleep Medicine (AASM) Manual is the clinical standard for polysomnography (PSG) scoring, but its narrative rules can admit multiple reasonable interpretations, contributing to inter-scorer variability and implementation differences across studies and software systems. We present a formal framework for translating sleep-scoring rules into Rational Ensemble Logic (QEL), a dense-time (i.e., a continuous, rational-valued timeline rather than discrete steps) formalism that combines first-order quantification with metric temporal operators. Using an extraction-and-compilation procedure, we identified 18 unique atomic propositions and derived 12 final specifications corresponding to clinically scoreable AASM events. Back-translation of QEL specifications into clinician-facing language retained high semantic fidelity to the original scoring narratives (embedding cosine similarity: 79.3, 95% CI: 79.0--79.7) despite low lexical overlap (ROUGE-L: 18.3, 95 CI: 17.6--18.9). Formalization also clarifies latent ambiguities, including implicit physiological latencies and overlapping exclusions. This framework yields executable, rigorous rule specifications for computational phenotyping, more consistent implementation across datasets, and standardized open-source PSG analysis. This work is a part of the "Symbolic Biomedicine" program championed by the corresponding author.

cs.LO

A Logic-based Temporal Cohort Discovery Engine: Algorithms, Indices, and Experimental Results on the National Sleep Research Resource

Large sleep-study repositories contain rich time-stamped physiological annotations, but cohort discovery is still commonly implemented as ad hoc scripts or scalar-index filters. We present a logic-based temporal cohort discovery engine that brings formal semantics, model checking, specialized indexing, and empirical evaluation into a unified biomedical informatics framework. We adopt Rational Ensemble Logic (QEL) as a dense-time formal foundation for sleep-data querying and represent each annotated polysomnogram as a Biomedical Event Structure Temporal Model (BEST), a finite mapping from event labels to non-overlapping rational interval ensembles. Cohort discovery is formulated as model checking of QEL formulas over BEST databases. We organize common sleep-research requirements into three reusable temporal query patterns: single-event retrieval, dual-event temporal pattern matching, and event data extraction. The prototype cohort discovery engine was implemented in Python with in-memory and MongoDB-backed execution modes and evaluated on synthetic interval datasets containing up to 90 million intervals and on real-world National Sleep Research Resource annotations from the Cleveland Children's Sleep and Health Study (CCSHS) containing 515 subjects, 202,587 intervals, 23 event labels. 2DFC constructs indexes in linear space and linear build time, reducing build time at 90 million intervals from 11,549 s with RTFC and 23,902 seconds with 2DRT to 3,655 seconds. On CCSHS, cohort-selection queries executed at sub-second latency at native scale and under 45 seconds at 1,000 times scale. This work is a part of the Symbolic Biomedicine program championed by the corresponding author.

cs.DB

Digital Twins Need Feedback

Digital twins are too often described as realistic simulations, anatomical avatars, dashboards, or data mirrors. Those artifacts can be useful, but they miss the defining property of a digital twin: bidirectional feedback between a physical counterpart and a virtual counterpart. The physical system continuously updates the virtual one; the virtual system informs actions that change measurement, intervention, operation, or governance in the physical world. We propose such a bidirectional feedback as the organizing principle for digital twins and apply it to a nested, multi-scale hierarchy of biological and social organization, in which lower-level units combine into higher-level systems, producing desirable properties at each level, from cells and tissues to organs, individuals, organizations, and population at large. Neuroinformatics is a stress test for this view because brain health, dementia, epilepsy, and other neurological diseases require the integration of cells, circuits, behavior, care pathways, and the translation of discovery to practice. Examples from epilepsy care and consortium-scale brain-cell atlas production show that digital twinning is not merely multi-scale modeling. It is a rich, multidisciplinary paradigm of computing for designing, governing, and driving feedback loops that turn data into accountable action.

cs.LO

Superradiant phase transition in cavity magnonics via Floquet engineering

We propose a scheme to engineer the superradiant phase transition (SPT) in cavity magnonics by periodically modulating the frequency of the magnon mode. The studied system is composed of a yttrium iron garnet (YIG) sphere positioned inside a microwave cavity, where magnons in the YIG sphere are strongly coupled to microwave photons. Under the Floquet drive, the effective frequencies of both the cavity and magnon modes can be readily controlled via the frequency and strength of Floquet field. This tunability allows the cavity magnonic system to support a rich steady-state phase diagram, featuring parity-symmetric, parity-symmetry-broken, bistable, and unstable phases. With the increase of Floquet-field strength, the system exhibit a discontinuous phase transition from the parity-symmetric phase to the parity-symmetry-broken phase at a critical threshold, accompanied by an abrupt jump of the magnon occupation from zero to a finite value. Upon further increase of Floquet-field strength, the magnon occupation declines continuously from a nonzero value back to zero, corresponding to a second-order phase transition that restores the parity-symmetric phase. Additionally, fluctuations in magnon number during the SPT process are examined. Our work establishes an alternative route to engineer the cavity-magnon SPT without relying on microwave parametric drive.

quant-ph

Nonreciprocal superradiant quantum phase transition induced by the magnon Kerr effect

Recently, proposals for realizing a nonreciprocal superradiant quantum phase transition (SQPT) have been put forward, based on either nonreciprocal interactions between two spin ensembles or the Sagnac-Fizeau shift in a spinning cavity. However, experimental implementation of such a nonreciprocal SQPT remains challenging. This motivates the search for new mechanisms capable of producing a nonreciprocal SQPT. Here, we propose an alternative approach to realize a nonreciprocal SQPT, induced by the magnon Kerr effect (MKE), in a cavity magnonic system, where magnons in a yttrium iron garnet (YIG) sphere are coupled to cavity photons. The MKE coefficient is positive ($K>0$) when the bias magnetic field is aligned along the crystallographic axis [100], but negative ($K<0$) when aligned along the axis [110]. We show that the steady-state phase diagram for $K > 0$ differs markedly from that for $K < 0$. This contrast is the origin of the nonreciprocal SQPT. By further studying the steady-state magnon occupation and its fluctuations versus the parametric drive strength, we demonstrate that the SQPT becomes nonreciprocal, characterized by distinct critical thresholds for $K > 0$ and $K < 0$. Moreover, we introduce a bidirectional contrast ratio to quantify this nonreciprocal behavior. Our work provides a new mechanism for realizing the nonreciprocal SQPT, with potential applications in designing nonreciprocal quantum devices.

quant-ph

AD-CDO: A Lightweight Ontology for Representing Eligibility Criteria in Alzheimer's Disease Clinical Trials

Objective This study introduces the Alzheimer's Disease Common Data Element Ontology for Clinical Trials (AD-CDO), a lightweight, semantically enriched ontology designed to represent and standardize key eligibility criteria concepts in Alzheimer's disease (AD) clinical trials. Materials and Methods We extracted high-frequency concepts from more than 1,500 AD clinical trials on ClinicalTrials.gov and organized them into seven semantic categories: Disease, Medication, Diagnostic Test, Procedure, Social Determinants of Health, Rating Criteria, and Fertility. Each concept was annotated with standard biomedical vocabularies, including the UMLS, OMOP Standardized Vocabularies, DrugBank, NDC, and NLM VSAC value sets. To balance coverage and manageability, we applied the Jenks Natural Breaks method to identify an optimal set of representative concepts. Results The optimized AD-CDO achieved over 63% coverage of extracted trial concepts while maintaining interpretability and compactness. The ontology effectively captured the most frequent and clinically meaningful entities used in AD eligibility criteria. We demonstrated AD-CDO's practical utility through two use cases: (a) an ontology-driven trial simulation system for formal modeling and virtual execution of clinical trials, and (b) an entity normalization task mapping raw clinical text to ontology-aligned terms, enabling consistency and integration with EHR data. Discussion AD-CDO bridges the gap between broad biomedical ontologies and task-specific trial modeling needs. It supports multiple downstream applications, including phenotyping algorithm development, cohort identification, and structured data integration. Conclusion By harmonizing essential eligibility entities and aligning them with standardized vocabularies, AD-CDO provides a versatile foundation for ontology-driven AD clinical trial research.

cs.CL

Third-order exceptional surface in a pseudo-Hermitian superconducting circuit

Compared with an isolated exceptional point, exceptional surfaces in non-Hermitian systems are more robust against environment noises, fabrication errors, and experimental uncertainties. Thanks to this, exceptional surfaces can be applied to enhance the sensitivity of sensors and develop new quantum techniques. Over the past few years, several works have been devoted to studying high-order exceptional surfaces. However, they are restricted to non-Hermitian systems without pseudo-Hermiticity. To date, research on high-order exceptional surfaces in pseudo-Hermitian systems still remains an untouched area. In this work, we propose a pseudo-Hermitian superconducting circuit, which consists of three circularly-coupled superconducting cavities with the balanced gain and loss. We then study the third-order exceptional surface in the proposed circuit. By investigating the eigenvalues, we find that in the parameter space, all third-order exceptional points of the circuit form a third-order exceptional line in the parity-time-symmetric case. When the parity-time-symmetric condition is extended to pseudo-Hermitian conditions, we find more third-order exceptional points, which constitute a third-order exceptional surface in the parameter space. The proposed scheme is universal and can be applied to explore third-order exceptional surfaces in other physical systems, such as optomechanical systems, cavity-magnon systems, and photonic micro-ring systems. This work is of fundamental interest in quantum mechanics and opens a way for studying high-order exceptional surfaces in pseudo-Hermitian systems.

quant-ph

Nonreciprocal quantum phase transition in cavity magnonics

We investigate the nonreciprocal quantum phase transition in a cavity magnonic system driven by a parametric field, where an yttrium iron garnet (YIG) sphere is placed in a spinning microwave resonator. The system exhibits a rich phase diagram due to both magnon Kerr nonlinearity in YIG and parametric drive on the resonator. Especially, Sagnac-Fizeau shift caused by the spinning of the resonator brings about a significant modification in the critical driving strengths for second- and first-order quantum phase transitions, which means that the highly controllable quantum phase can be realized by the spinning speed of the resonator. More importantly, based on the difference in the detunings of the counterclockwise and clockwise modes induced by spinning direction of the resonator, we show that the phase transition in this system is nonreciprocal, that is, the quantum phase transition occurs when the cavity is driven in one direction but not the other. Our work offers an alternative path to engineer and design nonreciprocal magnonic devices.

quant-ph

Macroscopic entanglement of three magnon modes in three cavities via optical parametric amplifier

We propose a scheme to generate bipartite and tripartite entanglements of three magnon modes in a three-cavity system using a nonlinear optical parametric amplifier (OPA). The three magnon modes in three YIG spheres are respectively placed inside three cavities near the maximum magnetic fields of the cavities and coupled to cavity modes via linear magnetic dipole interaction. Additionally, linear coupling interaction exists between two cavities. Using experimentally feasible parameters, we demonstrate that OPA can prepare the three magnon modes in a steady-state entangled state, bipartite and tripartite entanglements increase with the nonlinear interaction strength of OPA. An alternative approach to enhance quantum entanglement involves multiplexed OPA inputs. By employing individual OPA for each cavity, we observe a significant improvement in entanglement generation. All the entanglements are robust against bath temperature.

quant-ph

Improved ion bunch quality of conical target irradiated by ultra-intense and ultra-short laser

We conduct particle-in-cell simulations to estimate the effects of circularly and linearly polarized SEL 100 PW lasers on flat Th targets with thicknesses of 50 nm, 100 nm and 250 nm, as well as easy to manufacture conical Th targets with angularity either on the left or right. As the thickness of the three types of targets increases and under the same polarized laser, the average energy, maximum energy and energy conversion efficiency of Th ions decrease as it is well-known, and except for the circularly polarized laser hit on the conical target with angularity on the left, the Th ion beam emittance also decreases, while its beam intensity increases conversely. The linearly polarized laser, compared to the circularly polarized laser with the same laser intensity, exhibits higher beam intensity, beam emittance and energy conversion efficiency for the same type and thickness of Th target. The conical Th target with angularity on the left and intermediate thickness, compared to the flat target and conical target with angularity on the right of the same thickness, possesses both higher ion average energy up to 7 GeV and virtually the same beam intensity up to 0.8 MA under the linearly polarized laser. The results lead us to an easier way of controlling laser-accelerated high-quality heavy ion beam by switching to an optimal laser-target configuration scheme, which may enable the synthesis of superheavy nuclei in a high-temperature and high-density extreme plasma environment in astronuclear physics.

physics.plasm-ph

Cavity magnon-polariton interface for strong spin-spin coupling

Strong coupling between single qubits is crucial for quantum information science and quantum computation. However, it is still challenged, especially for single solid-state qubit. Here, we propose a hybrid quantum system, consisting of a coplanar waveguide (CPW) resonator weakly coupled to a single nitrogen-vacancy spin in diamond and a yttrium-iron-garnet (YIG) nanosphere holding Kerr magnons, to realize strong long-distance spin-spin coupling. With a strong driving field on magnons, the Kerr effect can squeeze magnons, and {thus the coupling between the CPW resonator and the sequeezed magnons is exponentially enhanced}, which produces two cavity-magnon polaritons, i.e., the high-frequency polariton (HP) and low-frequency polariton (LP). When the enhanced cavity-magnon coupling {approaches} the critical value (i.e., the frequency of the LP becomes zero), the spin is fully decoupled from the HP, while the coupling between the spin and the LP is significantly improved. In the dispersive regime, a strong spin-spin coupling mediated by the LP is achieved with accessible parameters. Our proposal indicates that the critical cavity-magnon polarition is a potential interface to realize strong spin-spin coupling and manipulates remote solid spins.

quant-ph

Mechanical dynamics around higher-order exceptional point in magno-optomechanics

We theoretically study diverse exceptional points (EPs) in an experimentally feasible magno-optomechanics consisting of an optomechanical subsystem coupled to a magnomechanical subsystem via physically direct contact. By adiabatically eliminating both the cavity and the Kittel mode, dissipative and parity-time symmetric exceptional points can be observed. When only the cavity mode is eliminated, a second (third) -order pseudo-Hermitian EP emerges for nondegenerate (degenerate) mechanical modes. The distinct dynamical behavior of two mechanical modes around these EPs are further studied. Our proposal provides a promising way to engineer diverse EPs and quantify non-Hermitian phase transition with exceptional dynamical behavior in magno-optomechanics.

quant-ph

Temporal Ensemble Logic

We introduce Temporal Ensemble Logic (TEL), a monadic, first-order modal logic for linear-time temporal reasoning. TEL includes primitive temporal constructs such as ``always up to $t$ time later'' ($\Box_t$), ``sometimes before $t$ time in the future'' ($\Diamond_t$), and ``$t$-time later'' $φ_t$. TEL has been motivated from the requirement for rigor and reproducibility for cohort specification and discovery in clinical and population health research, to fill a gap in formalizing temporal reasoning in biomedicine. Existing logical frameworks such as linear temporal logic are too restrictive to express temporal and sequential properties in biomedicine, or too permissive in semantic constructs, such as in Halpern-Shoham logic, to serve this purpose. In this paper, we first introduce TEL in a general set up, with discrete and dense time as special cases. We then focus on the theoretical development of discrete TEL on the temporal domain of positive integers $\mathbb{N}^+$, denoted as ${\rm TEL}_{\mathbb{N}^+}$. ${\rm TEL}_{\mathbb{N}^+}$ is strictly more expressive than the standard monadic second order logic, characterized by Büchi automata. We present its formal semantics, a proof system, and provide a proof for the undecidability of the satisfiability of ${\rm TEL}_{\mathbb{N}^+}$. We also include initial results on expressiveness and decidability fragments for ${\rm TEL}_{\mathbb{N}^+}$, followed by application outlook and discussions.

cs.LO

Generating Bell states and $N$-partite $W$ states of long-distance qubits in superconducting waveguide QED

We show how to generate Bell states and $N$-partite $W$ states of long-distance superconducting (SC) qubits in a SC waveguide quantum electrodynamical (QED) system, where SC qubits are coupled to an open microwave transmission line. In the two-qubit case, the Bell state of two long-distance qubits can be a dark state of the system by choosing appropriate system parameters. If one proper microwave pulse drives one of two qubits, the two qubits will evolve from their ground states to a Bell state. Further, we extend this scheme to the multi-qubit case. We show that $W$ states of $N$ long-distance qubits can also be generated. Because both the Bell and $W$ states are decoupled from the waveguide (i.e., dark states of the system), they are steady and have very long lifetimes in the ideal case without decoherence of qubits. In contrast to the ideal case, the presence of decoherence of qubits limits the lifetimes of the Bell and $W$ states. Our study provides a novel scheme for generating Bell states and $N$-partite $W$ states in SC waveguide QED, which can be used to entangle long-distance nodes in waveguide quantum networks.

quant-ph

Quantum simulation of Hofstadter butterfly with synthetic gauge fields on two-dimensional superconducting-qubit lattices

Motivated by recent realizations of two-dimensional (2D) superconducting-qubit lattices, we propose a protocol to simulate Hofstadter butterfly with synthetic gauge fields in superconducting circuits. Based on the existing 2D superconducting-qubit lattices, we construct a generalized Hofstadter model on zigzag lattices, which has a fractal energy spectrum similar to the original Hofstadter butterfly. By periodically modulating the resonant frequencies of qubits, we engineer a synthetic gauge field to mimic the generalized Hofstadter Hamiltonian. A spectroscopic method is used to demonstrate the Hofstadter butterfly from the time evolutions of experimental observables. We numerically simulate the dynamics of the system with realistic parameters, and the results show a butterfly spectrum clearly. Our proposal provides a promising way to realize the Hofstadter butterfly on the latest 2D superconducting-qubit lattices and will stimulate the quantum simulation of novel properties induced by magnetic fields in superconducting circuits.

quant-ph

Optomechanical-interface-induced strong spin-magnon coupling

Strong long-distance spin-magnon coupling is essential for solid-state quantum information processing and single qubit manipulation. Here, we propose an approach to realize strong spin-magnon coupling in a hybrid optomechanical cavity-spin-magnon system, where the optomechanical system, consisting of two cavities coupled to a common high-frequency mechanical resonator, acts as quantum interface. By eliminating the mechanical mode, a position-position coupling and two-mode squeezing of two cavities are induced. In the squeezing presentation, the spin-photon, magnon-photon and photon-photon coupling strengths are exponentially amplified, thus lower- and upper-branch polaritons (LBP and UBP) are generated by strongly coupled squeezed modes of two cavities. Utilizing the critical property of the LBP, the coupling between the spin qubit (magnon) and LBP is greatly enhanced, while the coupling between the spin qubit (magnon) and UBP is fully suppressed. In the dispersive regime, strong and tunable spin-magnon coupling is induced by the virtual LBP, allowing quantum state exchange between them. Our proposal provides a promising platform to construct magnon-based hybrid systems and realize solid-state quantum information processing with optomechanical interfaces.

quant-ph