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Guojun Li

Publications and source records attributed to Guojun Li.

11 recordsLinked to original sources
arXiv2026

CellDETR: A Detection-Guided Framework for Scalable Cell Representation Learning from Histopathology Images

Recent advances in pathology foundation models have substantially improved patch and slide level representation learning from whole-slide images (WSIs).However, cell-level representations learning remain underexplored, limiting cell resolved interpretability, biological discovery, and clinical translation. We propose CellDETR, a detection-guided framework built on Deformable DETR for scalable cell representation learning from WSIs. By introducing location feature decoupling and box-constrained attention mechanism, CellDETR enables automated extraction of cell-level embeddings, and outperform existing state-of-the-art methods in supervised cell classification on PanNuke data. In addition, by incorporating contrastive learning design, we build a CellDETR-based pretraining model for scalable cell representation learning from unlabeled WSIs, which improves downstream cell classification performance. Furthermore, we show that after pretraining with Xenium spatial transcriptomics-derived cell annotations, CellDETR achieves accurate cross-dataset cell classification, demonstrating the transferability and biological relevance of the learned cell embeddings. Together, CellDETR provides a scalable route toward general cell-level representation learning framework for interpretable computational patholog

cs.CV↗
arXiv2025

COIVis: Eye-tracking-based Visual Exploration of Concept Learning in MOOC Videos

Massive Open Online Courses (MOOCs) make high-quality instruction accessible. However, the lack of face-to-face interaction makes it difficult for instructors to obtain feedback on learners' performance and provide more effective instructional guidance. Traditional analytical approaches, such as clickstream logs or quiz scores, capture only coarse-grained learning outcomes and offer limited insight into learners' moment-to-moment cognitive states. In this study, we propose COIVis, an eye tracking-based visual analytics system that supports concept-level exploration of learning processes in MOOC videos. COIVis first extracts course concepts from multimodal video content and aligns them with the temporal structure and screen space of the lecture, defining Concepts of Interest (COIs), which anchor abstract concepts to specific spatiotemporal regions. Learners' gaze trajectories are transformed into COI sequences, and five interpretable learner-state features -- Attention, Cognitive Load, Interest, Preference, and Synchronicity -- are computed at the COI level based on eye tracking metrics. Building on these representations, COIVis provides a narrative, multi-view visualization enabling instructors to move from cohort-level overviews to individual learning paths, quickly locate problematic concepts, and compare diverse learning strategies. We evaluate COIVis through two case studies and in-depth user-feedback interviews. The results demonstrate that COIVis effectively provides instructors with valuable insights into the consistency and anomalies of learners' learning patterns, thereby supporting timely and personalized interventions for learners and optimizing instructional design.

cs.HC↗
arXiv2025

First GNSS-deployed optical clock for local time scale upgrade

Precise time scale is the universal base for all measurements. Here we report the deployment of a compact and transportable optical clock to a timekeeping institution and steering an active hydrogen maser to generate an optical time scale, realizing the upgrade of the local time scale in the Global Navigation Satellite System. The optical clock was transported over 1200 km by express delivery and resume work as normal promptly, and its extremely high uptime of 93.6% in the half-year enabled us to precisely correct the frequency drift of hydrogen maser, ultimately achieving an unprecedented monthly instability of 4E-17. This steering experiment with a deployable optical clock marks a significant advancement, demonstrating that a timing accuracy below 100 ps per month can be achieved feasibly in various timekeeping institutions where hydrogen masers are typically employed as the primary contributor to timekeeping. In the future, mobile optical time scale based on such transportable optical clock can be deployed flexibly and rapidly, which is particularly important in scenarios lacking International Atomic Time reference.

physics.atom-ph↗
arXiv2025

Propulsive transitions and scaling relations of a heaving flexible foil in a cylinder wake

We numerically investigate the propulsive dynamics of a heaving flexible foil immersed in the wake of a stationary circular cylinder, focusing on the coupled effects of unsteady wake forcing, passive structural flexibility, and prescribed heaving kinematics. The analysis employs a high-fidelity fluid-structure interaction solver based on a partitioned variational formulation with a nonlinear iterative force correction scheme. Systematic simulations are conducted over a broad parameter space of dimensionless heaving amplitude and frequency at a Reynolds number of 3000. Five distinct response modes are identified, namely full-wake, semi-wake, full-wake-flexible, semi-wake-flexible, and vortex-flexible, based on propulsive transitions and associated flow features. An empirical boundary plane is discovered, separating regimes where the wake hinders lift performance (wake-dominated) from those where it enhances performance (flapping-dominated). Scaling relations for the force and power coefficients are formulated by decomposing the contributions of quasi-steady motion, added-mass effects, structural curvature, wake momentum deficit, and transverse flow gradients. At sufficiently large amplitude and frequency, a two-way lock-in emerges: the foil not only synchronizes with the cylinder shedding but also modulates it, accelerating the wake and enhancing lift.Flexibility is found to be detrimental in fully immersed wakes but beneficial in partial wakes, where it creates extra suction without much extra drag in the semi-wake-flexible mode. These findings elucidate the energy-saving and maneuverability strategies employed by biological propulsors and provide predictive guidelines for the design of bio-inspired energy harvesters and unmanned vehicles in disturbed flows.

physics.flu-dyn↗
arXiv2025

DFT+DMFT study on pressure-induced valence instability of CeCoSi

Rare-earth compounds RCoSi exhibit unique properties, with distinct structural behaviors depending on whether R is a light, middle or heavy rare-earth element. Among them, CeCoSi undergoes a structural phase transition under high pressure, with the phase transition pressure increasing as temperature rises. Some experimental studies suggest that the transition is closely related to the behavior of Ce-4f electrons. In this work, we systematically studied the evolution of the electronic structure of CeCoSi with temperature and pressure. First, we used the DFT+DMFT to calculate the energy-volume curve of CeCoSi, which was in good agreement with the experimental results and far superior to the DFT method. Next, we studied the electronic structure of CeCoSi under different pressures and temperatures using DFT+DMFT. Our results show that CeCoSi is a Kondo metal with hybridization of Ce-4f and Co-3d. As pressure increases, the renormalization factor Z of Ce-4f5/2 increases, the occupancy number of Ce-4f electrons decreases, and CeCoSi transitions to a mixed-valence state at ~5.5 GPa in 100 K. The pressure of the quantum phase transition PQ is slightly higher than the experimentally observed structural phase transition pressure PS, and the PQ increases with increasing temperature, which is consistent with the behavior of PS in experiment. In addition, the hybridization strength of Ce-4f in the mixed-valence state is significantly greater than in the Kondo metal state. Our results suggest that the valence instability of Ce-4f is the cause of the structural phase transition. As pressure increases, Ce-4f electrons delocalize and CeCoSi transitions to mixed-valence state. This valence instability may cause redistribution of electron density, thus inducing a structural phase transition. Our work reveals the cause of the structural phase transition of CeCoSi under high pressure.

cond-mat.str-el↗
arXiv2023

Coupled dynamics of steady jet flow control for flexible membrane wings

We present a steady jet flow-based flow control of flexible membrane wings for an adaptive and efficient motion of bat-inspired drones in complex flight environments. A body-fitted variational computational aeroelastic framework is adopted for the modeling of fluid-structure interactions. High-momentum jet flows are injected from the leading edge and transported to the wake flows to alter the aerodynamic performance and the membrane vibration. The phase diagrams of the coupled fluid-membrane dynamics are constructed in the parameter space of the angle of attack and the jet momentum coefficient. The coupled dynamical effect of active jet flow control on the membrane performance is systematically explored. While the results indicate that the current active flow control strategy performs well at low angles of attack, the effectiveness degrades at high angles of attack with large flow separation. To understand the coupling mechanism, the variations of the vortex patterns at different jet momentum coefficients are examined by the proper orthogonal decomposition modes in the Eulerian view and the fluid transport process is studied by the coherent flow structures in the Lagrange description. Two scaling relations that quantitatively connect the membrane deformation with the aerodynamic loads presented in our previous work are verified even when active jet flow control is applied. A unifying feedback loop that reveals the fluid-membrane coupling mechanism is proposed. This feedback loop provides useful guidance for designing optimal active flow control strategies and enhancing flight capabilities. These findings can facilitate the development of next-generation bio-inspired drones that incorporate smart sensing and intelligent control.

physics.flu-dyn↗
arXiv2023

Unsteady aeroelastic characterization and scaling relations of flexible membrane wings

We present a numerical study to characterize nonlinear unsteady aeroelastic interactions of two-dimensional flexible wings at high angles of attack. The coupled fluid-flexible wing system is solved by a body-fitted variational aeroelastic solver based on the fully-coupled Navier-Stokes and nonlinear structural equations. Using the coupled fluid-structure analysis, this study is aimed to provide physical insight and correlations for the aeroelastic behavior of flexible wings in the parameter space of the angle of attack and the aeroelastic number. The phase diagrams of the aerodynamic performance are established to obtain the envelope curves of the optimal performance and determine the transition line of the drag variation. The effects of the angle of attack and the aeroelastic number on the aeroelastic behaviors are systematically examined. The time-averaged membrane deformation is positively correlated with a non-dimensional number, the so-called Weber number. A new scaling relation is proposed based on the dynamic equilibrium between the aerodynamic force fluctuation and the combined inertia-elastic fluctuation. The unsteady aerodynamic force can be adjusted by manipulating the membrane vibration, the mass ratio, the Strouhal number and the aeroelastic number. The numerical investigations provide design guidelines and have the potential to enhance the maneuverability and flight agility of micro air vehicles with flexible wing structures.

physics.flu-dyn↗
arXiv2021

Flow-excited membrane instability at moderate Reynolds numbers

In this paper, we study the fluid-structure interaction (FSI) of a three-dimensional (3D) flexible membrane immersed in an unsteady separated flow at moderate Reynolds numbers. We employ a body-conforming variational FSI solver based on the recently developed partitioned iterative scheme for the coupling of turbulent fluid flow with nonlinear structural dynamics. Of particular interest is to understand the flow-excited instability of a 3D flexible membrane as a function of the non-dimensional mass ratio, Reynolds number and aeroelastic number. For a wide range of the parameters, we examine two distinctive stability regimes of fluid-membrane interaction: deformed-steady state (DSS) and dynamic balance state (DBS). We propose stability phase diagrams to demarcate the DSS and DBS regimes for the parameter space of mass ratio vs. Reynolds number and mass ratio vs. aeroelastic number. Based on the aeroelastic mode analysis, we observe a frequency synchronization between the vortex shedding frequency and the membrane vibration frequency which leads to self-sustained vibrations in the dynamic balance state. To characterize the origin of the frequency lock-in, we derive an approximate analytical formula for the nonlinear natural frequency by considering the added mass effect and employing a large deflection theory for a simply supported rectangular membrane. Through our systematic high-fidelity numerical investigation, we find that the onset of the membrane vibration and the mode transition has a dependence on the frequency lock-in between the natural frequency of the tensioned membrane and the vortex shedding frequency or its harmonics. These findings on the fluid-elastic instability of membranes have implications for the design and development of control strategies for membrane wing-based unmanned systems and drones.

physics.flu-dyn↗
arXiv2021

A high-fidelity numerical study on the propulsive performance of pitching flexible plates

In this paper, we numerically investigate the propulsive performance of three-dimensional pitching flexible plates with varying flexibility and trailing edge shapes. To eliminate the effect of other geometric parameters, only the trailing edge angle is varied from 45° (concave), 90° (rectangular) to 135° (convex) while maintaining the constant area of the flexible plate. We examine the impact of the frequency ratio f* defined as the ratio of the natural frequency of the flexible plate to the actuated pitching frequency. Through our numerical simulations, we find that the global maximum mean thrust occurs near f*=1 corresponding to the resonance condition. However, the optimal propulsive efficiency is achieved around f*=1.54 instead of the resonance condition. While the convex plate with low and high bending stiffness values shows the best performance, the rectangular plate with moderate bending stiffness is the most efficient propulsion configuration. Through dynamic mode decomposition, we find that the passive deformation can help in redistributing the pressure gradient thus improving the efficiency and thrust production. A momentum-based thrust evaluation approach is adopted to link the instantaneous vortical structures with the time-dependent thrust. When the vortices detach from the trailing edge, the instantaneous thrust shows the largest values due to the strong momentum change and convection process. Moderate flexibility and convex shape help transfer momentum to the fluid, thereby improving thrust generation and promoting the transition from drag to thrust. The increase of the trailing edge angle can broaden the range of flexibility that produces positive mean thrust.

physics.flu-dyn↗
arXiv2018

A novel 3D variational aeroelastic framework for flexible multibody dynamics: Application to bat-like flapping dynamics

We present a novel three-dimensional (3D) variational aeroelastic framework for flapping wing with a flexible multibody system subjected to an external incompressible turbulent flow. The proposed aeroelastic framework consists of a three-dimensional fluid solver with delayed detached eddy simulation (DDES) and a nonlinear monolithic elastic structural solver for the flexible multibody system with constraints. Radial basis function (RBF) is applied in this framework to transfer the aerodynamic forces and structural displacements across the discrete non-matching interface meshes while satisfying a global energy conservation. The fluid equations are discretized using a stabilized Petrov-Galerkin method in space and the generalized-$α$ approach is employed to integrate the solution in time. The flexible multibody system is solved by using geometrically exact co-rotational finite element method and an energy decaying scheme is used to achieve numerical stability of the multibody solver with constraints. A nonlinear iterative force correction (NIFC) scheme is applied in a staggered partitioned iterative manner to maintain the numerical stability of aeroelastic coupling with strong added mass effect. An isotropic aluminum wing with flapping motion is simulated via the proposed aeroelastic framework and the accuracy of the coupled solution is validated with the available experimental data. We next study the robustness and reliability of the 3D flexible multibody aeroelastic framework for an anisotropic flapping wing flight involving battens and membranes with composite material and compare against the experimental results. Finally, we demonstrate the aeroelastic framework for a bat-like wing and examine the effects of flexibility on the flapping wing dynamics.

physics.flu-dyn↗