arXiv subjects

Guoyou Qin

Publications and source records attributed to Guoyou Qin.

3 recordsLinked to original sources

arXiv2023

A Direct Approach to Simultaneous Tests of Superiority and Noninferiority with Multiple Endpoints

Simultaneous tests of superiority and non-inferiority hypotheses on multiple endpoints are often performed in clinical trials to demonstrate that a new treatment is superior over a control on at least one endpoint and non-inferior on the remaining endpoints. Existing methods tackle this problem by testing the superiority and non-inferiority hypotheses separately and control the Type I error rate each at $α$ level. In this paper we propose a unified approach to testing the superiority and non-inferiority hypotheses simultaneously. The proposed approach is based on the UI-IU test and the least favorable configurations of the combined superiority and non-inferiority hypotheses, which leads to the solution of an adjusted significance level $α'$ for marginal tests that controls the overall Type I error rate at pre-defined $α$. Simulations show that the proposed approach maintains a higher power than existing methods in the settings under investigation. Since the adjusted significance level $α'$ is obtained by controlling the Type I error rate at $α$, one can easily construct the exact $(1 - α)\%$ simultaneous confidence intervals for treatment effects on all endpoints. The proposed approach is illustrated with two real examples.

stat.ME↗

arXiv2023

Quantile regression outcome-adaptive lasso: variable selection for causal quantile treatment effect estimation

Quantile treatment effects (QTEs) can characterize the potentially heterogeneous causal effect of a treatment on different points of the entire outcome distribution. Propensity score (PS) methods are commonly employed for estimating QTEs in non-randomized studies. Empirical and theoretical studies have shown that insufficient and unnecessary adjustment for covariates in PS models can lead to bias and efficiency loss in estimating treatment effects. Striking a balance between bias and efficiency through variable selection is a crucial concern in casual inference. It is essential to acknowledge that the covariates related treatment and outcome may vary across different quantiles of the outcome distribution. However, previous studies have overlooked to adjust for different covariates separately in the PS models when estimating different QTEs. In this article, we proposed the quantile regression outcome-adaptive lasso (QROAL) method to select covariates that can provide unbiased and efficient estimates of QTEs. A distinctive feature of our proposed method is the utilization of linear quantile regression models for constructing penalty weights, enabling covariate selection in PS models separately when estimating different QTEs. We conducted simulation studies to show the superiority of our proposed method over the outcome-adaptive lasso (OAL) method in variable selection. Moreover, the proposed method exhibited favorable performance compared to the OAL method in terms of root mean square error in a range of settings, including both homogeneous and heterogeneous scenarios. Additionally, we applied the QROAL method to datasets from the China Health and Retirement Longitudinal Study (CHARLS) to explore the impact of smoking status on the severity of depression symptoms.

stat.ME↗

arXiv2022

Empirical likelihood inference for longitudinal data with covariate measurement errors: An application to the LEAN study

Measurement errors usually arise during the longitudinal data collection process. Ignoring the effects of measurement errors will lead to invalid estimates. The Lifestyle Education for Activity and Nutrition (LEAN) study was designed to assess the effectiveness of intervention for enhancing weight loss over nine months. The covariates systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at baseline, month 4, and month 9. At each assessment time, there were two replicate measurements for SBP and DBP. The replicate measurement errors of SBP follow different distributions, as does DBP. To account for the distributional difference of replicate measurement errors, a new method for analyzing longitudinal data with replicate covariate measurement errors is developed based on the empirical likelihood method. The asymptotic properties of the proposed estimator are established under some regularity conditions. The confidence region for the parameters of interest can be constructed based on the chi-squared approximation without estimating the covariance matrix. Additionally, the proposed empirical likelihood estimator is asymptotically more efficient than the estimator of Lin et al. (2018). Extensive simulations demonstrate that the proposed method can eliminate the effects of measurement errors in the covariate and has a high estimation efficiency. The proposed method indicates the significant effect of the intervention on BMI in the LEAN study.

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