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Gustavo Carneiro

Publications and source records attributed to Gustavo Carneiro.

142 records · Page 8Linked to original sources

End-to-End Diagnosis and Segmentation Learning from Cardiac Magnetic Resonance Imaging

Cardiac magnetic resonance (CMR) is used extensively in the diagnosis and management of cardiovascular disease. Deep learning methods have proven to deliver segmentation results comparable to human experts in CMR imaging, but there have been no convincing results for the problem of end-to-end segmentation and diagnosis from CMR. This is in part due to a lack of sufficiently large datasets required to train robust diagnosis models. In this paper, we propose a learning method to train diagnosis models, where our approach is designed to work with relatively small datasets. In particular, the optimisation loss is based on multi-task learning that jointly trains for the tasks of segmentation and diagnosis classification. We hypothesize that segmentation has a regularizing effect on the learning of features relevant for diagnosis. Using the 100 training and 50 testing samples available from the Automated Cardiac Diagnosis Challenge (ACDC) dataset, which has a balanced distribution of 5 cardiac diagnoses, we observe a reduction of the classification error from 32% to 22%, and a faster convergence compared to a baseline without segmentation. To the best of our knowledge, this is the best diagnosis results from CMR using an end-to-end diagnosis and segmentation learning method.

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Approximate Fisher Information Matrix to Characterise the Training of Deep Neural Networks

In this paper, we introduce a novel methodology for characterising the performance of deep learning networks (ResNets and DenseNet) with respect to training convergence and generalisation as a function of mini-batch size and learning rate for image classification. This methodology is based on novel measurements derived from the eigenvalues of the approximate Fisher information matrix, which can be efficiently computed even for high capacity deep models. Our proposed measurements can help practitioners to monitor and control the training process (by actively tuning the mini-batch size and learning rate) to allow for good training convergence and generalisation. Furthermore, the proposed measurements also allow us to show that it is possible to optimise the training process with a new dynamic sampling training approach that continuously and automatically change the mini-batch size and learning rate during the training process. Finally, we show that the proposed dynamic sampling training approach has a faster training time and a competitive classification accuracy compared to the current state of the art.

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Multi-modal Cycle-consistent Generalized Zero-Shot Learning

In generalized zero shot learning (GZSL), the set of classes are split into seen and unseen classes, where training relies on the semantic features of the seen and unseen classes and the visual representations of only the seen classes, while testing uses the visual representations of the seen and unseen classes. Current methods address GZSL by learning a transformation from the visual to the semantic space, exploring the assumption that the distribution of classes in the semantic and visual spaces is relatively similar. Such methods tend to transform unseen testing visual representations into one of the seen classes' semantic features instead of the semantic features of the correct unseen class, resulting in low accuracy GZSL classification. Recently, generative adversarial networks (GAN) have been explored to synthesize visual representations of the unseen classes from their semantic features - the synthesized representations of the seen and unseen classes are then used to train the GZSL classifier. This approach has been shown to boost GZSL classification accuracy, however, there is no guarantee that synthetic visual representations can generate back their semantic feature in a multi-modal cycle-consistent manner. This constraint can result in synthetic visual representations that do not represent well their semantic features. In this paper, we propose the use of such constraint based on a new regularization for the GAN training that forces the generated visual features to reconstruct their original semantic features. Once our model is trained with this multi-modal cycle-consistent semantic compatibility, we can then synthesize more representative visual representations for the seen and, more importantly, for the unseen classes. Our proposed approach shows the best GZSL classification results in the field in several publicly available datasets.

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Bayesian Semantic Instance Segmentation in Open Set World

This paper addresses the semantic instance segmentation task in the open-set conditions, where input images can contain known and unknown object classes. The training process of existing semantic instance segmentation methods requires annotation masks for all object instances, which is expensive to acquire or even infeasible in some realistic scenarios, where the number of categories may increase boundlessly. In this paper, we present a novel open-set semantic instance segmentation approach capable of segmenting all known and unknown object classes in images, based on the output of an object detector trained on known object classes. We formulate the problem using a Bayesian framework, where the posterior distribution is approximated with a simulated annealing optimization equipped with an efficient image partition sampler. We show empirically that our method is competitive with state-of-the-art supervised methods on known classes, but also performs well on unknown classes when compared with unsupervised methods.

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Producing radiologist-quality reports for interpretable artificial intelligence

Current approaches to explaining the decisions of deep learning systems for medical tasks have focused on visualising the elements that have contributed to each decision. We argue that such approaches are not enough to "open the black box" of medical decision making systems because they are missing a key component that has been used as a standard communication tool between doctors for centuries: language. We propose a model-agnostic interpretability method that involves training a simple recurrent neural network model to produce descriptive sentences to clarify the decision of deep learning classifiers. We test our method on the task of detecting hip fractures from frontal pelvic x-rays. This process requires minimal additional labelling despite producing text containing elements that the original deep learning classification model was not specifically trained to detect. The experimental results show that: 1) the sentences produced by our method consistently contain the desired information, 2) the generated sentences are preferred by doctors compared to current tools that create saliency maps, and 3) the combination of visualisations and generated text is better than either alone.

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Detecting hip fractures with radiologist-level performance using deep neural networks

We developed an automated deep learning system to detect hip fractures from frontal pelvic x-rays, an important and common radiological task. Our system was trained on a decade of clinical x-rays (~53,000 studies) and can be applied to clinical data, automatically excluding inappropriate and technically unsatisfactory studies. We demonstrate diagnostic performance equivalent to a human radiologist and an area under the ROC curve of 0.994. Translated to clinical practice, such a system has the potential to increase the efficiency of diagnosis, reduce the need for expensive additional testing, expand access to expert level medical image interpretation, and improve overall patient outcomes.

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A Bayesian Data Augmentation Approach for Learning Deep Models

Data augmentation is an essential part of the training process applied to deep learning models. The motivation is that a robust training process for deep learning models depends on large annotated datasets, which are expensive to be acquired, stored and processed. Therefore a reasonable alternative is to be able to automatically generate new annotated training samples using a process known as data augmentation. The dominant data augmentation approach in the field assumes that new training samples can be obtained via random geometric or appearance transformations applied to annotated training samples, but this is a strong assumption because it is unclear if this is a reliable generative model for producing new training samples. In this paper, we provide a novel Bayesian formulation to data augmentation, where new annotated training points are treated as missing variables and generated based on the distribution learned from the training set. For learning, we introduce a theoretically sound algorithm --- generalised Monte Carlo expectation maximisation, and demonstrate one possible implementation via an extension of the Generative Adversarial Network (GAN). Classification results on MNIST, CIFAR-10 and CIFAR-100 show the better performance of our proposed method compared to the current dominant data augmentation approach mentioned above --- the results also show that our approach produces better classification results than similar GAN models.

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Smart Mining for Deep Metric Learning

To solve deep metric learning problems and producing feature embeddings, current methodologies will commonly use a triplet model to minimise the relative distance between samples from the same class and maximise the relative distance between samples from different classes. Though successful, the training convergence of this triplet model can be compromised by the fact that the vast majority of the training samples will produce gradients with magnitudes that are close to zero. This issue has motivated the development of methods that explore the global structure of the embedding and other methods that explore hard negative/positive mining. The effectiveness of such mining methods is often associated with intractable computational requirements. In this paper, we propose a novel deep metric learning method that combines the triplet model and the global structure of the embedding space. We rely on a smart mining procedure that produces effective training samples for a low computational cost. In addition, we propose an adaptive controller that automatically adjusts the smart mining hyper-parameters and speeds up the convergence of the training process. We show empirically that our proposed method allows for fast and more accurate training of triplet ConvNets than other competing mining methods. Additionally, we show that our method achieves new state-of-the-art embedding results for CUB-200-2011 and Cars196 datasets.

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Automated Detection of Individual Micro-calcifications from Mammograms using a Multi-stage Cascade Approach

In mammography, the efficacy of computer-aided detection methods depends, in part, on the robust localisation of micro-calcifications ($μ$C). Currently, the most effective methods are based on three steps: 1) detection of individual $μ$C candidates, 2) clustering of individual $μ$C candidates, and 3) classification of $μ$C clusters. Where the second step is motivated both to reduce the number of false positive detections from the first step and on the evidence that malignancy depends on a relatively large number of $μ$C detections within a certain area. In this paper, we propose a novel approach to $μ$C detection, consisting of the detection \emph{and} classification of individual $μ$C candidates, using shape and appearance features, using a cascade of boosting classifiers. The final step in our approach then clusters the remaining individual $μ$C candidates. The main advantage of this approach lies in its ability to reject a significant number of false positive $μ$C candidates compared to previously proposed methods. Specifically, on the INbreast dataset, we show that our approach has a true positive rate (TPR) for individual $μ$Cs of 40\% at one false positive per image (FPI) and a TPR of 80\% at 10 FPI. These results are significantly more accurate than the current state of the art, which has a TPR of less than 1\% at one FPI and a TPR of 10\% at 10 FPI. Our results are competitive with the state of the art at the subsequent stage of detecting clusters of $μ$Cs.

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Learning Local Image Descriptors with Deep Siamese and Triplet Convolutional Networks by Minimising Global Loss Functions

Recent innovations in training deep convolutional neural network (ConvNet) models have motivated the design of new methods to automatically learn local image descriptors. The latest deep ConvNets proposed for this task consist of a siamese network that is trained by penalising misclassification of pairs of local image patches. Current results from machine learning show that replacing this siamese by a triplet network can improve the classification accuracy in several problems, but this has yet to be demonstrated for local image descriptor learning. Moreover, current siamese and triplet networks have been trained with stochastic gradient descent that computes the gradient from individual pairs or triplets of local image patches, which can make them prone to overfitting. In this paper, we first propose the use of triplet networks for the problem of local image descriptor learning. Furthermore, we also propose the use of a global loss that minimises the overall classification error in the training set, which can improve the generalisation capability of the model. Using the UBC benchmark dataset for comparing local image descriptors, we show that the triplet network produces a more accurate embedding than the siamese network in terms of the UBC dataset errors. Moreover, we also demonstrate that a combination of the triplet and global losses produces the best embedding in the field, using this triplet network. Finally, we also show that the use of the central-surround siamese network trained with the global loss produces the best result of the field on the UBC dataset. Pre-trained models are available online at https://github.com/vijaykbg/deep-patchmatch

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Unsupervised CNN for Single View Depth Estimation: Geometry to the Rescue

A significant weakness of most current deep Convolutional Neural Networks is the need to train them using vast amounts of manu- ally labelled data. In this work we propose a unsupervised framework to learn a deep convolutional neural network for single view depth predic- tion, without requiring a pre-training stage or annotated ground truth depths. We achieve this by training the network in a manner analogous to an autoencoder. At training time we consider a pair of images, source and target, with small, known camera motion between the two such as a stereo pair. We train the convolutional encoder for the task of predicting the depth map for the source image. To do so, we explicitly generate an inverse warp of the target image using the predicted depth and known inter-view displacement, to reconstruct the source image; the photomet- ric error in the reconstruction is the reconstruction loss for the encoder. The acquisition of this training data is considerably simpler than for equivalent systems, requiring no manual annotation, nor calibration of depth sensor to camera. We show that our network trained on less than half of the KITTI dataset (without any further augmentation) gives com- parable performance to that of the state of art supervised methods for single view depth estimation.

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Automated 5-year Mortality Prediction using Deep Learning and Radiomics Features from Chest Computed Tomography

We propose new methods for the prediction of 5-year mortality in elderly individuals using chest computed tomography (CT). The methods consist of a classifier that performs this prediction using a set of features extracted from the CT image and segmentation maps of multiple anatomic structures. We explore two approaches: 1) a unified framework based on deep learning, where features and classifier are automatically learned in a single optimisation process; and 2) a multi-stage framework based on the design and selection/extraction of hand-crafted radiomics features, followed by the classifier learning process. Experimental results, based on a dataset of 48 annotated chest CTs, show that the deep learning model produces a mean 5-year mortality prediction accuracy of 68.5%, while radiomics produces a mean accuracy that varies between 56% to 66% (depending on the feature selection/extraction method and classifier). The successful development of the proposed models has the potential to make a profound impact in preventive and personalised healthcare.

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Competitive Multi-scale Convolution

In this paper, we introduce a new deep convolutional neural network (ConvNet) module that promotes competition among a set of multi-scale convolutional filters. This new module is inspired by the inception module, where we replace the original collaborative pooling stage (consisting of a concatenation of the multi-scale filter outputs) by a competitive pooling represented by a maxout activation unit. This extension has the following two objectives: 1) the selection of the maximum response among the multi-scale filters prevents filter co-adaptation and allows the formation of multiple sub-networks within the same model, which has been shown to facilitate the training of complex learning problems; and 2) the maxout unit reduces the dimensionality of the outputs from the multi-scale filters. We show that the use of our proposed module in typical deep ConvNets produces classification results that are either better than or comparable to the state of the art on the following benchmark datasets: MNIST, CIFAR-10, CIFAR-100 and SVHN.

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On the Importance of Normalisation Layers in Deep Learning with Piecewise Linear Activation Units

Deep feedforward neural networks with piecewise linear activations are currently producing the state-of-the-art results in several public datasets. The combination of deep learning models and piecewise linear activation functions allows for the estimation of exponentially complex functions with the use of a large number of subnetworks specialized in the classification of similar input examples. During the training process, these subnetworks avoid overfitting with an implicit regularization scheme based on the fact that they must share their parameters with other subnetworks. Using this framework, we have made an empirical observation that can improve even more the performance of such models. We notice that these models assume a balanced initial distribution of data points with respect to the domain of the piecewise linear activation function. If that assumption is violated, then the piecewise linear activation units can degenerate into purely linear activation units, which can result in a significant reduction of their capacity to learn complex functions. Furthermore, as the number of model layers increases, this unbalanced initial distribution makes the model ill-conditioned. Therefore, we propose the introduction of batch normalisation units into deep feedforward neural networks with piecewise linear activations, which drives a more balanced use of these activation units, where each region of the activation function is trained with a relatively large proportion of training samples. Also, this batch normalisation promotes the pre-conditioning of very deep learning models. We show that by introducing maxout and batch normalisation units to the network in network model results in a model that produces classification results that are better than or comparable to the current state of the art in CIFAR-10, CIFAR-100, MNIST, and SVHN datasets.

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Robust Optimization for Deep Regression

Convolutional Neural Networks (ConvNets) have successfully contributed to improve the accuracy of regression-based methods for computer vision tasks such as human pose estimation, landmark localization, and object detection. The network optimization has been usually performed with L2 loss and without considering the impact of outliers on the training process, where an outlier in this context is defined by a sample estimation that lies at an abnormal distance from the other training sample estimations in the objective space. In this work, we propose a regression model with ConvNets that achieves robustness to such outliers by minimizing Tukey's biweight function, an M-estimator robust to outliers, as the loss function for the ConvNet. In addition to the robust loss, we introduce a coarse-to-fine model, which processes input images of progressively higher resolutions for improving the accuracy of the regressed values. In our experiments, we demonstrate faster convergence and better generalization of our robust loss function for the tasks of human pose estimation and age estimation from face images. We also show that the combination of the robust loss function with the coarse-to-fine model produces comparable or better results than current state-of-the-art approaches in four publicly available human pose estimation datasets.

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Deep Structured learning for mass segmentation from Mammograms

In this paper, we present a novel method for the segmentation of breast masses from mammograms exploring structured and deep learning. Specifically, using structured support vector machine (SSVM), we formulate a model that combines different types of potential functions, including one that classifies image regions using deep learning. Our main goal with this work is to show the accuracy and efficiency improvements that these relatively new techniques can provide for the segmentation of breast masses from mammograms. We also propose an easily reproducible quantitative analysis to as- sess the performance of breast mass segmentation methodologies based on widely accepted accuracy and running time measurements on public datasets, which will facilitate further comparisons for this segmentation problem. In particular, we use two publicly available datasets (DDSM-BCRP and INbreast) and propose the computa- tion of the running time taken for the methodology to produce a mass segmentation given an input image and the use of the Dice index to quantitatively measure the segmentation accuracy. For both databases, we show that our proposed methodology produces competitive results in terms of accuracy and running time.

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