Gwendal Ducloz | Searcharxiv

arXiv2026

A Congestion Parameter for Depth-First Graph Traversals

We explore a new graph parameter, the KLX number, which quantifies the minimum edge congestion of depth-first search (DFS) traversals of a given graph. Originally motivated by a problem in RNA nanostructure design, this parameter is also of independent theoretical interest. Informally, the KLX number of a graph is defined as the minimum, over all its DFS traversals, of the maximum number of back edges that are simultaneously open during the traversal. We provide full characterisations and linear-time recognition algorithms for graphs with KLX numbers 0, 1 and 2. We also relate KLX to tree-width, proving that any graph satisfies $\mathrm{TW} \le \mathrm{KLX}+1$. Furthermore, we show that the property $\mathrm{KLX} \le k$ is $\mathrm{MSO}_2$-expressible for every fixed $k$. Combined with the tree-width bound, this result implies that determining whether a graph has KLX number at most $k$ can be achieved in linear time for any constant $k$.

cs.DM↗

arXiv2025

Algorithmic hardness of the partition function for nucleic acid strands

To understand and engineer biological and artificial nucleic acid systems, algorithms are employed for prediction of secondary structures at thermodynamic equilibrium. Dynamic programming algorithms are used to compute the most favoured, or Minimum Free Energy (MFE), structure, and the Partition Function (PF), a tool for assigning a probability to any structure. However, in some situations, such as when there are large numbers of strands, or pseudoknoted systems, NP-hardness results show that such algorithms are unlikely, but only for MFE. Curiously, algorithmic hardness results were not shown for PF, leaving two open questions on the complexity of PF for multiple strands and single strands with pseudoknots. The challenge is that while the MFE problem cares only about one, or a few structures, PF is a summation over the entire secondary structure space, giving theorists the vibe that computing PF should not only be as hard as MFE, but should be even harder. We answer both questions. First, we show that computing PF is #P-hard for systems with an unbounded number of strands, answering a question of Condon Hajiaghayi, and Thachuk [DNA27]. Second, for even a single strand, but allowing pseudoknots, we find that PF is #P-hard. Our proof relies on a novel magnification trick that leads to a tightly-woven set of reductions between five key thermodynamic problems: MFE, PF, their decision versions, and #SSEL that counts structures of a given energy. Our reductions show these five problems are fundamentally related for any energy model amenable to magnification. That general classification clarifies the mathematical landscape of nucleic acid energy models and yields several open questions.

cs.CC↗