SearcharxivSearch

arXiv subjects

Hafiz Khan

Publications and source records attributed to Hafiz Khan.

3 recordsLinked to original sources

Functional Random Forest with Adaptive Cost-Sensitive Splitting for Imbalanced Functional Data Classification

Classification of functional data where observations are curves or trajectories poses unique challenges, particularly under severe class imbalance. Traditional Random Forest algorithms, while robust for tabular data, often fail to capture the intrinsic structure of functional observations and struggle with minority class detection. This paper introduces Functional Random Forest with Adaptive Cost-Sensitive Splitting (FRF-ACS), a novel ensemble framework designed for imbalanced functional data classification. The proposed method leverages basis expansions and Functional Principal Component Analysis (FPCA) to represent curves efficiently, enabling trees to operate on low dimensional functional features. To address imbalance, we incorporate a dynamic cost sensitive splitting criterion that adjusts class weights locally at each node, combined with a hybrid sampling strategy integrating functional SMOTE and weighted bootstrapping. Additionally, curve specific similarity metrics replace traditional Euclidean measures to preserve functional characteristics during leaf assignment. Extensive experiments on synthetic and real world datasets including biomedical signals and sensor trajectories demonstrate that FRF-ACS significantly improves minority class recall and overall predictive performance compared to existing functional classifiers and imbalance handling techniques. This work provides a scalable, interpretable solution for high dimensional functional data analysis in domains where minority class detection is critical.

stat.ML

Deep Learning Approaches with Explainable AI for Differentiating Alzheimer Disease and Mild Cognitive Impairment

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we propose a hybrid deep learning ensemble framework for Alzheimer Disease classification using structural magnetic resonance imaging. Gray and white matter slices are used as inputs to three pretrained convolutional neural networks such as ResNet50, NASNet, and MobileNet, each fine tuned through an end to end process. To further enhance performance, we incorporate a stacked ensemble learning strategy with a meta learner and weighted averaging to optimally combine the base models. Evaluated on the Alzheimer Disease Neuroimaging Initiative dataset, the proposed method achieves state of the art accuracy of 99.21% for Alzheimer Disease vs. Mild Cognitive Impairment and 91.0% for Mild Cognitive Impairment vs. Normal Controls, outperforming conventional transfer learning and baseline ensemble methods. To improve interpretability in image based diagnostics, we integrate Explainable AI techniques by Gradient weighted Class Activation, which generates heatmaps and attribution maps that highlight critical regions in gray and white matter slices, revealing structural biomarkers that influence model decisions. These results highlight the frameworks potential for robust and scalable clinical decision support in neurodegenerative disease diagnostics.

eess.IV

An Ontology-driven Treatment Article Retrieval System for Precision Oncology

This paper presents an ontology-driven treatment article retrieval system developed and experimented using the data and ground truths provided by the TREC 2017 precision medicine track. The key aspects of our system include: meaningful integration of various disease, gene, and drug name ontologies, training of a novel perceptron model for article relevance labeling, a ranking module that considers additional factors such as journal impact and article publication year, and comprehensive query matching rules. Experimental results demonstrate that our proposed system considerably outperforms the results of the best participating system of the TREC 2017 precision medicine challenge.

cs.IR