arXiv subjects

Hakan Ceylan

Publications and source records attributed to Hakan Ceylan.

4 recordsLinked to original sources

arXiv2026

Contrast-Free Autonomous Navigation of Untethered Endovascular Microrobots Using Single-Plane Fluoroscopy

Reliable three-dimensional (3D) navigation of magnetically actuated untethered microrobots remains a major barrier to clinical translation. X-ray fluoroscopy is the standard real-time imaging modality for endovascular procedures, but single-plane fluoroscopy provides only a two-dimensional (2D) projection, eliminating depth information and complicating autonomous navigation. Recovering this information through biplane imaging or repeated contrast-enhanced angiography increases procedural complexity, radiation exposure, or contrast burden. Here, we introduce VISTA (Virtual Integration for Spatial Tracking and Autonomy), a digital twin framework enabling contrast-free autonomous navigation under single-plane fluoroscopy. VISTA reconstructs vascular anatomy as a 3D digital twin, discretizes the vessel centerline into navigation milestones, and assigns the detected 2D robot position to the nearest projected milestone. Consecutive milestones define the local vessel orientation used to generate magnetic actuation commands, converting single-plane fluoroscopic observations into topology-constrained navigation states without requiring contrast injection during navigation. VISTA is demonstrated across anatomically distinct vascular phantoms under continuous flow and within the inferior vena cava of a live rat in vivo. Compared with conventional fluoroscopic human-in-the-loop control, VISTA reduced navigation time by up to 62%, corrective actuation commands by up to 98%, and radiation exposure by up to 57%. These results establish VISTA as a digital twin-guided framework for contrast-free autonomous navigation of untethered endovascular microrobots using widely available single-plane fluoroscopy.

cs.RO↗

arXiv2025

Translating Milli/Microrobots with A Value-Centered Readiness Framework

Untethered mobile milli/microrobots hold transformative potential for interventional medicine by enabling more precise and entirely non-invasive diagnosis and therapy. Realizing this promise requires bridging the gap between groundbreaking laboratory demonstrations and successful clinical integration. Despite remarkable technical progress over the past two decades, most millirobots and microrobots remain confined to laboratory proof-of-concept demonstrations, with limited real-world feasibility. In this Review, we identify key factors that slow translation from bench to bedside, focusing on the disconnect between technical innovation and real-world application. We argue that the long-term impact and sustainability of the field depend on aligning development with unmet medical needs, ensuring applied feasibility, and integrating seamlessly into existing clinical workflows, which are essential pillars for delivering meaningful patient outcomes. To support this shift, we introduce a strategic milli/microrobot Technology Readiness Level framework (mTRL), which maps system development from initial conceptualization to clinical adoption through clearly defined milestones and their associated stepwise activities. The mTRL model provides a structured gauge of technological maturity, a common language for cross-disciplinary collaboration and actionable guidance to accelerate translational development toward new, safer and more efficient interventions.

cs.RO↗

arXiv2025

Optimization of Epsilon-Greedy Exploration

Modern recommendation systems rely on exploration to learn user preferences for new items, typically implementing uniform exploration policies (e.g., epsilon-greedy) due to their simplicity and compatibility with machine learning (ML) personalization models. Within these systems, a crucial consideration is the rate of exploration - what fraction of user traffic should receive random item recommendations and how this should evolve over time. While various heuristics exist for navigating the resulting exploration-exploitation tradeoff, selecting optimal exploration rates is complicated by practical constraints including batched updates, time-varying user traffic, short time horizons, and minimum exploration requirements. In this work, we propose a principled framework for determining the exploration schedule based on directly minimizing Bayesian regret through stochastic gradient descent (SGD), allowing for dynamic exploration rate adjustment via Model-Predictive Control (MPC). Through extensive experiments with recommendation datasets, we demonstrate that variations in the batch size across periods significantly influence the optimal exploration strategy. Our optimization methods automatically calibrate exploration to the specific problem setting, consistently matching or outperforming the best heuristic for each setting.

cs.LG↗

arXiv2024

X-ray Fluoroscopy Guided Localization and Steering of Medical Microrobots through Virtual Enhancement

In developing medical interventions using untethered milli- and microrobots, ensuring safety and effectiveness relies on robust methods for detection, real-time tracking, and precise localization within the body. However, the inherent non-transparency of the human body poses a significant obstacle, limiting robot detection primarily to specialized imaging systems such as X-ray fluoroscopy, which often lack crucial anatomical details. Consequently, the robot operator (human or machine) would encounter severe challenges in accurately determining the location of the robot and steering its motion. This study explores the feasibility of circumventing this challenge by creating a simulation environment that contains the precise digital replica (virtual twin) of a model microrobot operational workspace. Synchronizing coordinate systems between the virtual and real worlds and continuously integrating microrobot position data from the image stream into the virtual twin allows the microrobot operator to control navigation in the virtual world. We validate this concept by demonstrating the tracking and steering of a mobile magnetic robot in confined phantoms with high temporal resolution (< 100 ms, with an average of ~20 ms) visual feedback. Additionally, our object detection-based localization approach offers the potential to reduce overall patient exposure to X-ray doses during continuous microrobot tracking without compromising tracking accuracy. Ultimately, we address a critical gap in developing image-guided remote interventions with untethered medical microrobots, particularly for near-future applications in animal models and human patients.

cs.RO↗