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Haleh Alimohamadi

Publications and source records attributed to Haleh Alimohamadi.

4 recordsLinked to original sources

World State Generator

Language agents solve complex tasks through plans and actions. A single step the world refuses puts the goal out of reach, and what the agent does next decides the task. Prompted planners fail at exactly this point, rewriting the refused step in new words, meeting the same refusal, and burning the attempt budget without moving. They fail because the plan was never tied to the world, so a refusal has nothing in the plan to attach to. A world is where a task runs, and it has its own rules, its own admissible actions, and its own constraints. We build synthetic worlds across 7 domains and extract training data from them. A program enforces each world's rules and grades its goal, and every world is admitted only if its goal is reachable from its initial state. Agents run inside and leave verified failures paired with repairs that carried the run to a state the world certified, a record of about 226K trajectories. On this record we train the World State Generator, a model that writes a plan as checkable states of the world and keeps that plan aligned with the world it runs in. That alignment is what a plan written in language lacks, since the world it runs in has physical limits, logical dependencies, and required orders the language never states, and the plan encounters these rules only when a state fails. WSG takes that failure as the rule the world has stated and rewrites the remaining states to obey it, so the plan bends to the world as the run goes on. Across 7 public benchmarks, WSG raises end-to-end success for two open models near 30B parameters over prompting and brings to the level of proprietary model.

cs.AI↗

Membrane Tension Governs Particle Wrapping-Unwrapping Transitions and Stalling

Membrane wrapping controls nanoparticle uptake during endocytosis, whereas the reverse process of membrane unwrapping accompanies particle expulsion and membrane fusion events. Existing theoretical descriptions typically focus on adhesion and bending energies within the particle membrane contact region and often neglect the deformation energy of the membrane outside the contact zone. This approximation is valid only in the limit of vanishing membrane tension, where the non contact membrane assumes a catenoid like configuration with negligible bending energy. However, at finite tension the deformation of the non contact membrane becomes a dominant energetic contribution. Here we show that this tension dependent non contact energy governs the progression of particle wrapping. By analysing the variation of the total membrane energy with wrapping degree, we uncover a competition between particle adhesion, membrane tension and particle size that determines whether wrapping proceeds, stalls, or reverses into spontaneous unwrapping. This framework reveals a stalling boundary separating regimes of particle uptake and expulsion. To capture the non contact deformation efficiently, we derive a compact phenomenological approximation that accurately reproduces the full numerical solution of the membrane shape. The resulting energetic map provides a unified physical description of particle wrapping and unwrapping, with implications for endocytosis, membrane fusion, and nanoparticle design.

physics.bio-ph↗

Spiking Hyperdimensional Network: Neuromorphic Models Integrated with Memory-Inspired Framework

Recently, brain-inspired computing models have shown great potential to outperform today's deep learning solutions in terms of robustness and energy efficiency. Particularly, Spiking Neural Networks (SNNs) and HyperDimensional Computing (HDC) have shown promising results in enabling efficient and robust cognitive learning. Despite the success, these two brain-inspired models have different strengths. While SNN mimics the physical properties of the human brain, HDC models the brain on a more abstract and functional level. Their design philosophies demonstrate complementary patterns that motivate their combination. With the help of the classical psychological model on memory, we propose SpikeHD, the first framework that fundamentally combines Spiking neural network and hyperdimensional computing. SpikeHD generates a scalable and strong cognitive learning system that better mimics brain functionality. SpikeHD exploits spiking neural networks to extract low-level features by preserving the spatial and temporal correlation of raw event-based spike data. Then, it utilizes HDC to operate over SNN output by mapping the signal into high-dimensional space, learning the abstract information, and classifying the data. Our extensive evaluation on a set of benchmark classification problems shows that SpikeHD provides the following benefit compared to SNN architecture: (1) significantly enhance learning capability by exploiting two-stage information processing, (2) enables substantial robustness to noise and failure, and (3) reduces the network size and required parameters to learn complex information.

cs.NE↗

The role of traction in membrane curvature generation

Curvature in biological membranes can be generated by a variety of different molecular mechanisms such as protein scaffolding, lipid or protein asymmetry, cytoskeletal forces, etc. These mechanisms have the net effect of generating stresses on the bilayer that are translated into distinct final shapes of the membrane. We propose reversing this input-output relationship by using the shape of a curved membrane to infer physical quantities like the magnitude of the applied forces acting on the bilayer. To do this, we calculate the normal and tangential tractions along the membrane using the known material properties of the membrane along with its shape. These tractions are a quantitative measure of the response of the membrane to external forces or sources of spontaneous curvature. We demonstrate the utility of this approach first by showing that the magnitude of applied force can be inferred from the shape of the membrane alone in both simulations and experiments of membrane tubulation. Next, we show that membrane budding by local differences in spontaneous curvature is driven purely by the generation of traction in the radial direction and the emergence of an effective line tension at the boundary of these regions. Finally, we show that performing this calculation on images of phase-separated giant vesicles yields a line tension similar to experimentally determined values.

physics.bio-ph↗