arXiv subjects

Hamed Almohammadi

Publications and source records attributed to Hamed Almohammadi.

3 recordsLinked to original sources

arXiv2026

Biomedical active matter: Emergence and breakdown of collective functionalities

Living systems are made of active materials with microscopic components that work together to perform macroscopic biological tasks. The breakdown of these collective functionalities leads to diseases, which, conversely, could be treated by exploiting self-organization in healthcare technologies. Here, we review recent advances in this rapidly growing field of biomedical active matter. The main themes are (1) collective self-assembly and spatiotemporal coordination; (2) collective motion, transport, and navigation; (3) collective sensing, signaling, and communication; and (4) collective adaptation, evolution, and learning. We discuss these emerging processes in a wide range of systems, including protein folding, biomolecular condensates, cytoskeleton dynamics, intracellular flows, bacterial biofilms, quorum sensing, cilia synchronization, wound healing, biolocomotion, neurons, endocrine signalling, and cardiovascular flow networks. For each, we highlight medical conditions associated with reduced collective functionality and how they may be treated using microrobotic swarms, bioinspired metamaterials, diagnostics, lab-on-chip devices, organoids, and other active and adaptive matter innovations.

physics.bio-ph↗

arXiv2022

Disentangling kinetics from thermodynamics in heterogeneous colloidal systems

Nucleation and growth (N&G) - the emergence of a new phase within an initially homogeneous one - is one of the most important physical phenomena by which gas-liquid, liquid-liquid and solid-liquid phase separation takes place. Accordingly, thermodynamics sets the asymptotic boundaries towards which the system must evolve, while kinetics tries to cope with it by imposing the transport rates at which phase separation is realized. In all heterogeneous colloidal systems observed in nature, the composition, shape, structure and ultimately physical properties result from the trade-off between thermodynamics and kinetics. In this work we demonstrate, by carefully selecting colloidal systems and controlling phase separation in microfluidic devices, that it becomes possible to go beyond N&G, disentangling kinetics effects from thermodynamics in composition, structure and physical properties of the final system. Using amyloid fibril and cellulose nanocrystal filamentous colloids for which the binodal curve defining the two-phase region in the phase diagram is given by two separate vertical lines, we extrude a solution set at one thermodynamic branch inside the other branch, realizing nematic or cholesteric droplets where the composition is set by thermodynamics, while the structure and morphology are defined by dynamic flow parameters. We demonstrate that departing from the N&G paradigm unveils new physical phenomena, such as orders of magnitude shorter timescales, a wider phase diagram and internal cholesteric structures that are not observable via conventional LLPS. We also show that by co-dispersing plasmonic gold nanoparticles within colloidal liquid crystalline droplets, our approach enables on-demand fabrication of multicomponent heterogeneous liquid crystals, enhancing their potential, and introducing original fundamental and technological directions in multicomponent structured fluids.

cond-mat.soft↗

arXiv2020

Flow-induced order-order transitions in amyloid fibril liquid crystalline tactoids

Understanding and controlling the director field configuration, shape, and orientation in nematic and cholesteric liquid crystals is of fundamental importance in several branches of science. Liquid crystalline droplets, also known as tactoids, which spontaneously form by nucleation and growth within the biphasic region of the phase diagram where isotropic and nematic phases coexist, challenge our current understanding of liquid crystals under confinement, due to the influence of anisotropic surface boundaries at vanishingly small interfacial tension and are mostly studied under quiescent, quasi-equilibrium conditions. Here, we show that different classes of amyloid fibril nematic and cholesteric tactoids undergo out-of-equilibrium order-order transitions by flow-induced deformations of their shape. The tactoids align under extensional flow and undergo extreme deformation into highly elongated oblate shapes, allowing the cholesteric pitch to decrease as an inverse power law of the tactoids aspect ratio. Energy functional theory and experimental measurements are combined to rationalize the critical elongation ratio above which the director-field configuration of tactoids transforms from bipolar and uniaxial cholesteric to homogenous and to debate on the thermodynamic nature of these transitions. Our findings suggest new opportunities in designing self-assembled liquid crystalline materials where structural and dynamical properties may be tuned by non-equilibrium phase transitions.

cond-mat.soft↗