arXiv subjects

Hang Zhang

Publications and source records attributed to Hang Zhang.

At least 253 records · Page 14Linked to original sources

arXiv2015

Computational modeling to elucidate molecular mechanisms of epigenetic memory

q-bio.MN↗

arXiv2015

Length Dependent Thermal Conductivity Measurements Yield Phonon Mean Free Path Spectra in Nanostructures

Thermal conductivity measurements over variable lengths on nanostructures such as nanowires provide important information about the mean free paths (MFPs) of the phonons responsible for heat conduction. However, nearly all of these measurements have been interpreted using an average MFP even though phonons in many crystals possess a broad MFP spectrum. Here, we present a reconstruction method to obtain MFP spectra of nanostructures from variable-length thermal conductivity measurements. Using this method, we investigate recently reported length-dependent thermal conductivity measurements on SiGe alloy nanowires and suspended graphene ribbons. We find that the recent measurements on graphene imply that 70 % of the heat in graphene is carried by phonons with MFPs longer than 1 micron.

cond-mat.mes-hall↗

arXiv2015

The Best Nanoparticle Size Distribution for Minimum Thermal Conductivity

Which sizes of nanoparticles embedded in a crystalline solid yield the lowest thermal conductivity? Nanoparticles have long been demonstrated to reduce the thermal conductivity of crystals by scattering phonons, but most previous works assumed the nanoparticles to have a single size. Here, we use optimization methods to show that the best nanoparticle size distribution to scatter the broad thermal phonon spectrum is not a similarly broad distribution but rather several discrete peaks at well-chosen nanoparticle radii. For SiGe, the best size distribution yields a thermal conductivity below that of amorphous silicon. Further, we demonstrate that a simplified distribution yields nearly the same low thermal conductivity and can be readily fabricated. Our work provides important insights into how to manipulate the full spectrum of phonons and will guide the design of more efficient thermoelectric materials.

cond-mat.mtrl-sci↗

arXiv2015

Reflectance Hashing for Material Recognition

We introduce a novel method for using reflectance to identify materials. Reflectance offers a unique signature of the material but is challenging to measure and use for recognizing materials due to its high-dimensionality. In this work, one-shot reflectance is captured using a unique optical camera measuring {\it reflectance disks} where the pixel coordinates correspond to surface viewing angles. The reflectance has class-specific stucture and angular gradients computed in this reflectance space reveal the material class. These reflectance disks encode discriminative information for efficient and accurate material recognition. We introduce a framework called reflectance hashing that models the reflectance disks with dictionary learning and binary hashing. We demonstrate the effectiveness of reflectance hashing for material recognition with a number of real-world materials.

cs.CV↗

arXiv2015

Handling Mobility in Dense Networks

Network densification is one of key technologies in future networks to significantly increase network capacity. The gain obtained by network densification for fixed terminals have been studied and proved. However for mobility users, there are a number of issues, such as more frequent handover, packet loss due to high mobility, interference management and so on. The conventional solutions are to handover high speed mobiles to macro base stations or multicast traffic to multiple base stations. These solutions fail to exploit the capacity of dense networks and overuse the backhaul capacity. In this paper we propose a set of solutions to systematically solve the technical challenges of mobile dense networks. We introduce network architecture together with data transmission protocols to support mobile users. A software-defined protocol (SDP) concept is presented so that combinations of transport protocols and physical layer functions can be optimized and triggered on demand. Our solutions can significantly boost performance of dense networks and simplify the packet handling process. Importantly, the gain brought by network densification to fixed users can also be achieved for mobile users.

cs.NI↗

arXiv2014

Statistical Mechanics Model for the Dynamics of Collective Epigenetic Histone Modification

Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.

q-bio.GN↗

arXiv2013

Min Flow Rate Maximization for Software Defined Radio Access Networks

We consider a heterogeneous network (HetNet) of base stations (BSs) connected via a backhaul network of routers and wired/wireless links with limited capacity. The optimal provision of such networks requires proper resource allocation across the radio access links in conjunction with appropriate traffic engineering within the backhaul network. In this paper we propose an efficient algorithm for joint resource allocation across the wireless links and the flow control within the backhaul network. The proposed algorithm, which maximizes the minimum rate among all the users and/or flows, is based on a decomposition approach that leverages both the Alternating Direction Method of Multipliers (ADMM) and the weighted-MMSE (WMMSE) algorithm. We show that this algorithm is easily parallelizable and converges globally to a stationary solution of the joint optimization problem. The proposed algorithm can also be extended to deal with per-flow quality of service constraint, or to networks with multi-antenna nodes.

cs.IT↗

arXiv2013

Transport in Suspended Monolayer and Bilayer Graphene Under Strain: A New Platform for Material Studies

We develop two types of graphene devices based on nanoelectromechanical systems (NEMS), that allows transport measurement in the presence of in situ strain modulation. Different mobility and conductance responses to strain were observed for single layer and bilayer samples. These types of devices can be extended to other 2D membranes such as MoS2, providing transport, optical or other measurements with in situ strain.

cond-mat.mtrl-sci↗

arXiv2013

Organometallic Hexahapto Functionalization of Single Layer Graphene as a Route to High Mobility Graphene Devices

Organometallic hexahapto chromium metal complexation of single layer graphene, which involves constructive rehybridization of the graphene pi-system with the vacant chromium d orbital, leads to field effect devices which retain a high degree of the mobility with enhanced on-off ratio. This hexahapto mode of bonding between metal and graphene is quite distinct from the modification in electronic structure induced by conventional covalent sigma-bond formation with creation of sp3 carbon centers in graphene lattice and this chemistry is reversible.

cond-mat.mes-hall↗

arXiv2013

Coupled Reversible and Irreversible Bistable Switches Underlying TGF-β-induced Epithelial to Mesenchymal Transition

Epithelial to mesenchymal transition (EMT) plays important roles in embryonic development, tissue regeneration and cancer metastasis. While several feedback loops have been shown to regulate EMT, it remains elusive how they coordinately modulate EMT response to TGF-βtreatment. We construct a mathematical model for the core regulatory network controlling TGF-β-induced EMT. Through deterministic analyses and stochastic simulations, we show that EMT is a sequential two-step program that an epithelial cell first transits to partial EMT then to the mesenchymal state, depending on the strength and duration of TGF-βstimulation. Mechanistically the system is governed by coupled reversible and irreversible bistable switches. The SNAIL1/miR-34 double negative feedback loop is responsible for the reversible switch and regulates the initiation of EMT, while the ZEB/miR-200 feedback loop is accountable for the irreversible switch and controls the establishment of the mesenchymal state. Furthermore, an autocrine TGF-β/miR-200 feedback loop makes the second switch irreversible, modulating the maintenance of EMT. Such coupled bistable switches are robust to parameter variation and molecular noise. We provide a mechanistic explanation on multiple experimental observations. The model makes several explicit predictions on hysteretic dynamic behaviors, system response to pulsed stimulation and various perturbations, which can be straightforwardly tested.

q-bio.MN↗

arXiv2012

Global Epigenetic State Network Governs Cellular Pluripotent Reprogramming and Transdifferentiation

How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses? Furthermore how do cells of different phenotypes differentiate reproducibly from a single fertilized egg? These fundamental questions are closely related to a deeply rooted paradigm in developmental biology that cell differentiation is irreversible. Yet, recently a growing body of research suggests the possibility of cell reprogramming, which offers the potential for us to convert one type of cell into another. Despite the significance of quantitative understandings of cell reprogramming, theoretical efforts often suffer from the complexity of large circuits maintaining cell phenotypes coupled at many different epigenetic and gene regulation levels. To capture the global architecture of cell phenotypes, we propose an "epigenetic state network" approach that translates the classical concept of an epigenetic landscape into a simple-yet-predictive mathematical model. As a testing case, we apply the approach to the reprogramming of fibroblasts (FB) to cardiomyocytes (CM). The epigenetic state network for this case predicts three major pathways of reprogramming. One pathway goes by way of induced pluripotent stem cells (iPSC) and continues on to the normal pathway of cardiomyocyte differentiation. The other two pathways involve transdifferentiation (TD) either indirectly through cardiac progenitor (CP) cells or directly from fibroblast to cardiomyocyte. Numerous experimental observations support the predicted states and pathways.

q-bio.MN↗

arXiv2012

Visualizing Electrical Breakdown and ON/OFF States in Electrically Switchable Suspended Graphene Break Junctions

Narrow gaps are formed in suspended single to few layer graphene devices using a pulsed electrical breakdown technique. The conductance of the resulting devices can be programmed by the application of voltage pulses, with a voltage of 2.5V~4.5V corresponding to an ON pulse and voltages ~8V corresponding to OFF pulses. Electron microscope imaging of the devices shows that the graphene sheets typically remain suspended and that the device conductance tends to zero when the observed gap is large. The switching rate is strongly temperature dependent, which rules out a purely electromechanical switching mechanism. This observed switching in suspended graphene devices strongly suggests a switching mechanism via atomic movement and/or chemical rearrangement, and underscores the potential of all-carbon devices for integration with graphene electronics.

cond-mat.mes-hall↗

arXiv2012

Aryl Functionalization as a Route to Band Gap Engineering in Single Layer Graphene Devices

Chemical functionalization is a promising route to band gap engineering of graphene. We chemically grafted nitrophenyl groups onto exfoliated single-layer graphene sheets in the form of substrate-supported or free-standing films. Our transport measurements demonstrate that non-suspended functionalized graphene behaves as a granular metal, with variable range hopping transport and a mobility gap ~ 0.1 eV at low temperature. For suspended graphene that allows functionalization on both surfaces, we demonstrate tuning of its electronic properties from a granular metal to a gapped semiconductor, in which charge transport occurs via thermal activation over a gap ~ 80 meV. This non-invasive and scalable functionalization technique paves the way for CMOS-compatible band gap engineering of graphene electronic devices.

cond-mat.mes-hall↗

arXiv2010

Magnetoconductance Oscillations in High-Mobility Suspended Bilayer and Trilayer Graphene

We report pronounced magnetoconductance oscillations observed on suspended bilayer and trilayer graphene devices with mobilities up to 270,000 cm2/Vs. For bilayer devices, we observe conductance minima at all integer filling factors nu between 0 and -8, as well as a small plateau at ν=1/3. For trilayer devices, we observe features at nu=-1, -2, -3 and -4, and at ν~0.5 that persist to 4.5K at B=8T. All of these features persist for all accessible values of Vg and B, and could suggest the onset of symmetry breaking of the first few Landau (LL) levels and fractional quantum Hall states.

cond-mat.mes-hall↗

arXiv2010

Suspension and Measurement of Graphene and Bi2Se3 Atomic Membranes

Coupling high quality, suspended atomic membranes to specialized electrodes enables investigation of many novel phenomena, such as spin or Cooper pair transport in these two dimensional systems. However, many electrode materials are not stable in acids that are used to dissolve underlying substrates. Here we present a versatile and powerful multi-level lithographical technique to suspend atomic membranes, which can be applied to the vast majority of substrate, membrane and electrode materials. Using this technique, we fabricated suspended graphene devices with Al electrodes and mobility of 5500 cm^2/Vs. We also demonstrate, for the first time, fabrication and measurement of a free-standing thin Bi2Se3 membrane, which has low contact resistance to electrodes and a mobility of >~500 cm^2/Vs.

cond-mat.mes-hall↗

arXiv2009

Premature Switching in Graphene Josephson Transistors

We investigate electronic transport in single layer graphene coupled to superconducting electrodes. In these Josephson transistors, we observe significant suppression in the critical current Ic and large variation in the product IcRn in comparison to theoretic predictions in the ballistic limit. We show that the depression of Ic can be explained by premature switching in underdamped Josephson junctions described within the resistively and capacitively shunted junction (RCSJ) model. By considering the effect of premature switching and dissipation, the calculated gate dependence of product IcRn agrees with experimental data. Our discovery underscores the crucial role of thermal fluctuations in electronic transport in graphene Josephson transistors.

cond-mat.mes-hall↗

arXiv2009

Ripple Texturing of Suspended Graphene Atomic Membranes

Graphene is the nature's thinnest elastic membrane, with exceptional mechanical and electrical properties. We report the direct observation and creation of one-dimensional (1D) and 2D periodic ripples in suspended graphene sheets, using spontaneously and thermally induced longitudinal strains on patterned substrates, with control over their orientations and wavelengths. We also provide the first measurement of graphene's thermal expansion coefficient, which is anomalously large and negative, ~ -7x10^-6 K^-1 at 300K. Our work enables novel strain-based engineering of graphene devices.

cond-mat.mes-hall↗

arXiv2008

Wave Excitation in Disks Around Rotating Magnetic Stars

The accretion disk around a rotating magnetic star (neutron star, white dwarf or T Tauri star) is subjected to periodic vertical magnetic forces from the star, with the forcing frequency equal to the stellar spin frequency or twice the spin frequency. This gives rise bending waves in the disk that may influence the variabilities of the system. We study the excitation, propagation and dissipation of these waves using a hydrodynamical model coupled with a generic model description of the magnetic forces. The $m=1$ bending waves are excited at the Lindblad/vertical resonance, and propagate either to larger radii or inward toward the corotation resonance where dissipation takes place. While the resonant torque is negligible compared to the accretion torque, the wave nevertheless may reach appreciable amplitude and can cause or modulate flux variabilities from the system. We discuss applications of our result to the observed quasi-periodic oscillations from various systems, in particular neutron star low-mass X-ray binaries.

astro-ph↗