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Hannah Scott

Publications and source records attributed to Hannah Scott.

5 recordsLinked to original sources

A novel method to separate circadian from non-circadian masking effects in order to enhance daily circadian timing and amplitude estimation from core body temperature

Circadian disruption contributes to adverse effects on sleep, performance, and health. One accepted method to track continuous daily changes in circadian timing is to measure core body temperature (CBT), and establish daily, circadian-related CBT minimum time (Tmin). This method typically applies cosine-model fits to measured CBT data, which may not adequately account for substantial wake metabolic activity and sleep effects on CBT that confound and mask circadian effects, and thus estimates of the circadian-related Tmin. This study introduced a novel physiology-grounded analytic approach to separate circadian from non-circadian effects on CBT, which we compared against traditional cosine-based methods. The dataset comprised 33 healthy participants attending a 39-hour in-laboratory study with an initial overnight sleep followed by an extended wake period. CBT data were collected at 30-second intervals via ingestible capsules. Our design captured CBT during both the baseline sleep period and during extended wake period (without sleep) and allowed us to model the influence of circadian and non-circadian effects of sleep, wake, and activity on CBT using physiology-guided generalized additive models. Model fits and estimated Tmin inferred from extended wake without sleep were compared with traditional cosine-based models fits. Compared to the traditional cosine model, the new model exhibited superior fits to CBT (Pearson R 0.90 [95%CI; [0.83 - 0.96] versus 0.81 [0.55-0.93]). The difference between estimated vs measured circadian Tmin, derived from the day without sleep, was better fit with our method (0.2 [-0.5,0.3] hours) versus previous methods (1.4 [1.1 to 1.7] hours). This new method provides superior demasking of non-circadian influences compared to traditional cosine methods, including the removal of a sleep-related bias towards an earlier estimate of circadian Tmin.

q-bio.QM

Noise limits on two-photon interferometric sensing

When a photon interferes with itself while traversing a Mach-Zehnder inteferometer, the output port where it emerges is influenced by the phase difference between the interferometer arms. This allows for highly precise estimation of the path length difference (delay) but is extremely sensitive to phase noise. By contrast, a delay between the arms of the two-photon Hong-Ou-Mandel interferometer directly affects the relative indistinguishability of the photon pair, affecting the rate of recorded coincidences. This likewise allows for delay estimation; notably less precise but with the advantage of being less sensitive to perturbations of the photons' phase. Focusing on two-photon input states, we here investigate to what degree of noise Mach-Zehnder interferometry retains its edge over Hong-Ou-Mandel interferometry. We also explore the competing benefits of different two-photon inputs for a Mach-Zehnder interferometer, and under what parameter regimes each input performs best.

quant-ph

Beyond coincidence: using all the data in Hong-Ou-Mandel interferometry

The Hong-Ou-Mandel effect provides a mechanism to determine the distinguishability of a photon pair by measuring the bunching rates of two photons interfering at a beam splitter. Of particular interest is the distinguishability in time, which can be used to probe a time delay. Photon detectors themselves give some timing information, however--while that resolution may dwarf that of an interferometric technique--typical analyses reduce the interference to a binary event, neglecting temporal information in the detector. By modelling detectors with number and temporal resolution we demonstrate a greater precision than coincidence rates or temporal data alone afford. Moreover, the additional information can allow simultaneous estimation of a time delay alongside calibration parameters, opening up the possibility of calibration-free protocols and approaching the precision of the quantum Cram\'er-Rao bound.

quant-ph

Agile and versatile quantum communication: signatures and secrets

Agile cryptography allows for a resource-efficient swap of a cryptographic core in case the security of an underlying classical cryptographic algorithm becomes compromised. Conversely, versatile cryptography allows the user to switch the cryptographic task without requiring any knowledge of its inner workings. In this paper, we suggest how these related principles can be applied to the field of quantum cryptography by explicitly demonstrating two quantum cryptographic protocols, quantum digital signatures (QDS) and quantum secret sharing (QSS), on the same hardware sender and receiver platform. Crucially, the protocols differ only in their classical post-processing. The system is also suitable for quantum key distribution (QKD) and is highly compatible with deployed telecommunication infrastructures, since it uses standard quadrature phase shift keying (QPSK) encoding and heterodyne detection. For the first time, QDS protocols are modified to allow for postselection at the receiver, enhancing protocol performance. The cryptographic primitives QDS and QSS are inherently multipartite and we prove that they are secure not only when a player internal to the task is dishonest, but also when (external) eavesdropping on the quantum channel is allowed. In our first proof-of-principle demonstration of an agile and versatile quantum communication system, the quantum states were distributed at GHz rates. This allows for a one-bit message to be securely signed using our QDS protocols in less than 0.05 ms over a 2 km fiber link and in less than 0.2~s over a 20 km fiber link. To our knowledge, this also marks the first demonstration of a continuous-variable direct QSS protocol.

quant-ph

Continuous-variable quantum digital signatures over insecure channels

Digital signatures ensure the integrity of a classical message and the authenticity of its sender. Despite their far-reaching use in modern communication, currently used signature schemes rely on computational assumptions and will be rendered insecure by a quantum computer. We present a quantum digital signatures (QDS) scheme whose security is instead based on the impossibility of perfectly and deterministically distinguishing between quantum states. Our continuous-variable (CV) scheme relies on phase measurement of a distributed alphabet of coherent states, and allows for secure message authentication against a quantum adversary performing collective beamsplitter and entangling-cloner attacks. Crucially, for the first time in the CV setting we allow for an eavesdropper on the quantum channels and yet retain shorter signature lengths than previous protocols with no eavesdropper. This opens up the possibility to implement CV QDS alongside existing CV quantum key distribution (QKD) platforms with minimal modification.

quant-ph