arXiv subjects

Hanwei Wang

Publications and source records attributed to Hanwei Wang.

5 recordsLinked to original sources

arXiv2026

DeepTCM1.0: A Multi-Expert AI Agent for Deciphering Mechanisms of Chinese Herbal Formulae Based on General Large Language Models

Background: Mechanistic elucidation of traditional Chinese medicine (TCM) compound formulas remains a central challenge in the modernization of TCM. Conventional approaches, including data mining and network pharmacology, are insufficient for achieving deep integration between classical TCM theory and modern scientific research. In addition, direct question-answering using general-purpose artificial intelligence large language models is limited by inadequate adaptation to TCM theoretical frameworks and susceptibility to reasoning hallucinations. Consequently, there is an urgent need to develop intelligent analytical methods aligned with the holistic principles of TCM. Objective: To establish a multi-expert intelligent agent framework integrating classical TCM theory with modern life sciences, thereby enabling systematic and interpretable mechanistic analysis of TCM compound formulas, with Guizhi Decoction serving as a representative validation case. Methods: The DeepTCM1.0 framework was constructed based on the general-purpose large language model DeepSeek V3.2. It adopts a three-tier collaborative architecture and a three-round iterative quality-control workflow, simulating the collaborative analytical process of 11 interdisciplinary intelligent agents. The framework was applied to the mechanistic interpretation of Guizhi Decoction from the dual perspectives of classical traditional Chinese medicine theory and modern scientific research. Framework performance was comprehensively evaluated through double-blind five-dimensional scoring, intraclass correlation coefficient (ICC) reliability testing, Mann-Whitney U tests, and effect size analysis. The evaluation employed four independent large language models as evaluators, each conducting five rounds of repeated scoring on five anonymized reports, resulting in a total of 100 independent scoring assessments.

cs.CL↗

arXiv2024

Plasmon-enhanced chiral absorption through electric dipole-electric quadrupole interaction

Enantioselective interactions of chiral molecules include distinct absorptions to opposite-handed circularly polarized light, known as chiral absorption. Traditionally, chiral absorption has been primarily attributed to electric dipole and magnetic dipole interaction with molecular chirality. However, this approach falls short for large molecules that support high-order multipolar components, such as electric quadrupole moment. Here, we introduce a theoretical model to study the chiral absorption of large molecules in the presence of plasmonic nanostructures. This model considers both electric dipole-magnetic dipole interaction and electric dipole-electric quadrupole interaction enhanced by a resonant structure. We numerically study such interactions of the chiral molecular solution in the vicinity of a nonchiral plasmonic nano-resonator. Our results show the distinct spectral information of the chiral media on- and off-resonance of the resonator.

physics.optics↗

arXiv2023

Metamaterial-Controlled Parity-Time Symmetry in Non-Hermitian Wireless Power Transfer Systems

Inductive wireless power transfer (WPT) systems can be effectively described as non-Hermitian systems using the coupled-mode theory. In these systems, parity-time (PT) symmetric states facilitate efficient power transfer. Traditionally, passive resonators have been used as relay devices in such systems to extend transmission distance; however, this approach may induce additional eigenstates with broken PT symmetry, particularly when specific spatial arrangements of the relay resonators, dependent on the positions of the transmitting (Tx) and receiving (Rx) resonators, are not maintained. This limitation hampers applications like free positioning WPT. To address this challenge, we introduce a multibody WPT system employing metamaterial controlled PT symmetry, which circumvents the constraints of physical arrangement. We utilize inverse design to configure the metamaterial, targeting a specific resonance mode that controls the effective coupling coefficients. Our approach ensures that a PT-symmetric state emerges when these coefficients, relating to the metamaterial and both the Tx and Rx resonators, are balanced. We confirm the stability of this state in a strong coupling regime, both theoretically and experimentally. Our experiments demonstrate the formation of PT-symmetric states governed by the metamaterial's resonant mode, achievable even with varying sizes and positions of the Tx and Rx in relation to the metamaterial. Moreover, we show that the PT symmetric state is attainable with different spatial configurations of the Rx resonator. This finding underscores our system's potential for free-positioning WPT, significantly broadening its applicability.

physics.app-ph↗

arXiv2023

Qi standard metasurface for free-positioning and multi-device supportive wireless power transfer

Free-positioning and multi-user supportive wireless power transfer systems represent the next-generation technology for wireless charging under the Qi standard. Traditional approaches employ multiple transmitting coils and multi-channel driving circuits with active control algorithms to achieve these goals. However, these traditional approaches are significantly limited by cost, weight, and heating due to their relatively low efficiency. Here, we demonstrate an innovative approach by using a metasurface to achieve free-positioning and multi-user compatibility. The metasurface works as a passive device to reform the magnetic field and enables high-efficiency free-positioning wireless power transfer with only a single transmitting coil. It shows up to 4.6 times improvement in efficiency. The metasurface also increases the coverage area from around 5 cm by 5 cm with over 40% efficiency to around 10 cm by 10 cm with over 70% efficiency. We further show that the system can support multiple receivers. Besides increasing the overall efficiency, we demonstrate tuning the power division between the multiple receivers, enabling compensation of receivers of different sizes to achieve their desired power.

physics.app-ph↗

arXiv2022

Understanding the Spatiotemporal Resolution of Near-Field Photoacoustics from Nanostructures

Understanding the mechanism of photoacoustic generation at the nano-scale is key to developing more efficient photoacoustic devices and agents. Unlike the far-field photoacoustic effect that has been well employed in imaging, the near-field profile leads to a complex wave-tissue interaction but is under-studied. Here we show that the spatiotemporal profile of the near-field photoacoustic waves can be shaped by laser pulses, anisotropy, and nanoparticle(s) spatial arrangement. Using a gold nanorod as an example, we discovered that the near-field photoacoustic amplitude in the short axis is ~75% stronger than the long axis, and the anisotropic spatial distribution converges to an isotropic spherical wave at ~50 nm away from the nanorod's surface. We further extend the model to asymmetric gold nanostructures by arranging isotropic nanospheres anisotropically with broken symmetry to achieve a precisely controlled near-field photoacoustic "focus" largely within an acoustic wavelength.

physics.bio-ph↗