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Hanwen Liu

Publications and source records attributed to Hanwen Liu.

53 records · Page 3Linked to original sources

AI for Biomedicine in the Era of Large Language Models

The capabilities of AI for biomedicine span a wide spectrum, from the atomic level, where it solves partial differential equations for quantum systems, to the molecular level, predicting chemical or protein structures, and further extending to societal predictions like infectious disease outbreaks. Recent advancements in large language models, exemplified by models like ChatGPT, have showcased significant prowess in natural language tasks, such as translating languages, constructing chatbots, and answering questions. When we consider biomedical data, we observe a resemblance to natural language in terms of sequences: biomedical literature and health records presented as text, biological sequences or sequencing data arranged in sequences, or sensor data like brain signals as time series. The question arises: Can we harness the potential of recent large language models to drive biomedical knowledge discoveries? In this survey, we will explore the application of large language models to three crucial categories of biomedical data: 1) textual data, 2) biological sequences, and 3) brain signals. Furthermore, we will delve into large language model challenges in biomedical research, including ensuring trustworthiness, achieving personalization, and adapting to multi-modal data representation

cs.CL↗

On the positivity of Fourier transform of the stretched Gaußian function

The stretched Gaußian function $f(\mathbf{x})=\exp \left(-\|\mathbf{x}\|^s\right)$, as a real function defined on $\mathbb{R}^d$, has found numerous applications in mathematics and physics. For instance, to describe results from spectroscopy or inelastic scattering, the Fourier transform of the stretched Gaußian function is needed. For $s \in(0,2]$, we prove that the Fourier transform of $f(\mathbf{x})=\exp \left(-\|\mathbf{x}\|^s\right)$ is everywhere positive on $\mathbb{R}^d$.

math.CA↗

Topological conjugacy between Schneider's continued fraction map and a shift map on $\mathbb{Q}_p$

We prove that Schneider's continued fraction map is topologically conjugate to a shift map defined on $\mathbb{Q}_p$, and the topological conjugation $f\colon\mathbb{Q}_p \rightarrow \mathbb{Q}_p$ is an isometry such that $f(\mathbb{Q})=\mathbb{Z}[\frac{1}{p}]$. Furthermore, for $x \in \mathbb{Q}_p$ we proved that $x \in \mathbb{Q}$ if and only if $f(x) \in \mathbb{Z}[\frac{1}{p}]$.

math.DS↗

XAI-CLASS: Explanation-Enhanced Text Classification with Extremely Weak Supervision

Text classification aims to effectively categorize documents into pre-defined categories. Traditional methods for text classification often rely on large amounts of manually annotated training data, making the process time-consuming and labor-intensive. To address this issue, recent studies have focused on weakly-supervised and extremely weakly-supervised settings, which require minimal or no human annotation, respectively. In previous methods of weakly supervised text classification, pseudo-training data is generated by assigning pseudo-labels to documents based on their alignment (e.g., keyword matching) with specific classes. However, these methods ignore the importance of incorporating the explanations of the generated pseudo-labels, or saliency of individual words, as additional guidance during the text classification training process. To address this limitation, we propose XAI-CLASS, a novel explanation-enhanced extremely weakly-supervised text classification method that incorporates word saliency prediction as an auxiliary task. XAI-CLASS begins by employing a multi-round question-answering process to generate pseudo-training data that promotes the mutual enhancement of class labels and corresponding explanation word generation. This pseudo-training data is then used to train a multi-task framework that simultaneously learns both text classification and word saliency prediction. Extensive experiments on several weakly-supervised text classification datasets show that XAI-CLASS outperforms other weakly-supervised text classification methods significantly. Moreover, experiments demonstrate that XAI-CLASS enhances both model performance and explainability.

cs.CL↗

TableQAKit: A Comprehensive and Practical Toolkit for Table-based Question Answering

Table-based question answering (TableQA) is an important task in natural language processing, which requires comprehending tables and employing various reasoning ways to answer the questions. This paper introduces TableQAKit, the first comprehensive toolkit designed specifically for TableQA. The toolkit designs a unified platform that includes plentiful TableQA datasets and integrates popular methods of this task as well as large language models (LLMs). Users can add their datasets and methods according to the friendly interface. Also, pleasantly surprised using the modules in this toolkit achieves new SOTA on some datasets. Finally, \tableqakit{} also provides an LLM-based TableQA Benchmark for evaluating the role of LLMs in TableQA. TableQAKit is open-source with an interactive interface that includes visual operations, and comprehensive data for ease of use.

cs.CL↗

Rational Variant of Hartogs' Theorem on Separate Holomorphicity

Given an uncountable algebraically closed field $K$, we proved that if partially defined function $f\colon K \times \dots \times K \dashrightarrow K$ defined on a Zariski open subset of the $n$-fold Cartesian product $K \times \dots \times K$ is rational in each coordinate whilst other coordinates are held constant, then $f$ is itself a rational function in $n$-variables.

math.AG↗

Hausdorff Dimension and Lebesgue Measure of Codiagonal of Embedded Vector Bundles over Submanifolds in Euclidean Space

In this paper we study measure theoretical size of the image of naturally embedded vector bundles in $\mathbb{R}^{n} \times \mathbb{R}^{n}$ under the codiagonal morphism, i.e. $Δ_{*}$ in the category of finite dimensional $\mathbb{R}$-vector spaces. Under very weak smoothness condition we show that codiagonal of normal bundles always contain an open subset of the ambient space, and we give corresponding criterions for the tangent bundles. For any differentiable hypersurface we show that the codiagonal of its tangent bundle has non-empty interior, unless the hypersurface is contained in a hyperplane. Assuming further smoothness (e.g. twice differentiable) we show that union of any family of hyperplanes that covers the hypersurface has maximal possible Hausdorff dimension. We also define and study a notion of degeneracy of embedded $C^{1}$ vector bundles over a $C^{1}$ submanifold and show as a corollary that if the base manifold has at least one non-inflection point then codiagonal of any $C^{1}$ line bundle over it has positive Lebesgue measure. Finally we show that codiagonal of any line bundle over an $n$-dimensional ellipsoid or a convex curve has non-empty interior, and the same assertion also holds for any non-tangent line bundle over a hyperplane.

math.MG↗

Anchor-Based Spatio-Temporal Attention 3D Convolutional Networks for Dynamic 3D Point Cloud Sequences

With the rapid development of measurement technology, LiDAR and depth cameras are widely used in the perception of the 3D environment. Recent learning based methods for robot perception most focus on the image or video, but deep learning methods for dynamic 3D point cloud sequences are underexplored. Therefore, developing efficient and accurate perception method compatible with these advanced instruments is pivotal to autonomous driving and service robots. An Anchor-based Spatio-Temporal Attention 3D Convolution operation (ASTA3DConv) is proposed in this paper to process dynamic 3D point cloud sequences. The proposed convolution operation builds a regular receptive field around each point by setting several virtual anchors around each point. The features of neighborhood points are firstly aggregated to each anchor based on the spatio-temporal attention mechanism. Then, anchor-based 3D convolution is adopted to aggregate these anchors' features to the core points. The proposed method makes better use of the structured information within the local region and learns spatio-temporal embedding features from dynamic 3D point cloud sequences. Anchor-based Spatio-Temporal Attention 3D Convolutional Neural Networks (ASTA3DCNNs) are built for classification and segmentation tasks based on the proposed ASTA3DConv and evaluated on action recognition and semantic segmentation tasks. The experiments and ablation studies on MSRAction3D and Synthia datasets demonstrate the superior performance and effectiveness of our method for dynamic 3D point cloud sequences. Our method achieves the state-of-the-art performance among the methods with dynamic 3D point cloud sequences as input on MSRAction3D and Synthia datasets.

cs.CV↗

Back-Projection Pipeline

We propose a simple extension of residual networks that works simultaneously in multiple resolutions. Our network design is inspired by the iterative back-projection algorithm but seeks the more difficult task of learning how to enhance images. Compared to similar approaches, we propose a novel solution to make back-projections run in multiple resolutions by using a data pipeline workflow. Features are updated at multiple scales in each layer of the network. The update dynamic through these layers includes interactions between different resolutions in a way that is causal in scale, and it is represented by a system of ODEs, as opposed to a single ODE in the case of ResNets. The system can be used as a generic multi-resolution approach to enhance images. We test it on several challenging tasks with special focus on super-resolution and raindrop removal. Our results are competitive with state-of-the-arts and show a strong ability of our system to learn both global and local image features.

eess.IV↗

Multi-Grid Back-Projection Networks

Multi-Grid Back-Projection (MGBP) is a fully-convolutional network architecture that can learn to restore images and videos with upscaling artifacts. Using the same strategy of multi-grid partial differential equation (PDE) solvers this multiscale architecture scales computational complexity efficiently with increasing output resolutions. The basic processing block is inspired in the iterative back-projection (IBP) algorithm and constitutes a type of cross-scale residual block with feedback from low resolution references. The architecture performs in par with state-of-the-arts alternatives for regression targets that aim to recover an exact copy of a high resolution image or video from which only a downscale image is known. A perceptual quality target aims to create more realistic outputs by introducing artificial changes that can be different from a high resolution original content as long as they are consistent with the low resolution input. For this target we propose a strategy using noise inputs in different resolution scales to control the amount of artificial details generated in the output. The noise input controls the amount of innovation that the network uses to create artificial realistic details. The effectiveness of this strategy is shown in benchmarks and it is explained as a particular strategy to traverse the perception-distortion plane.

eess.IV↗

Introduction to a novel T2 relaxation analysis method SAME-ECOS: Spectrum Analysis for Multiple Exponentials via Experimental Condition Oriented Simulation

We propose a novel T2 relaxation data analysis method which we have named spectrum analysis for multiple exponentials via experimental condition oriented simulation (SAME-ECOS). SAME-ECOS, which was developed based on a combination of information theory and machine learning neural network algorithms, is tailored for different MR experimental conditions, decomposing multi-exponential decay data into T2 spectra, which had been considered an ill-posed problem using conventional fitting algorithms, including the commonly used non-negative least squares (NNLS) method. Our results demonstrated that, compared with NNLS, the simulation-derived SAME-ECOS model yields much more reliable T2 spectra in a dramatically shorter time, increasing the feasibility of multi-component T2 decay analysis in clinical settings.

physics.med-ph↗

MGBPv2: Scaling Up Multi-Grid Back-Projection Networks

Here, we describe our solution for the AIM-2019 Extreme Super-Resolution Challenge, where we won the 1st place in terms of perceptual quality (MOS) similar to the ground truth and achieved the 5th place in terms of high-fidelity (PSNR). To tackle this challenge, we introduce the second generation of MultiGrid BackProjection networks (MGBPv2) whose major modifications make the system scalable and more general than its predecessor. It combines the scalability of the multigrid algorithm and the performance of iterative backprojections. In its original form, MGBP is limited to a small number of parameters due to a strongly recursive structure. In MGBPv2, we make full use of the multigrid recursion from the beginning of the network; we allow different parameters in every module of the network; we simplify the main modules; and finally, we allow adjustments of the number of network features based on the scale of operation. For inference tasks, we introduce an overlapping patch approach to further allow processing of very large images (e.g. 8K). Our training strategies make use of a multiscale loss, combining distortion and/or perception losses on the output as well as downscaled output images. The final system can balance between high quality and high performance.

eess.IV↗

A Tour of Convolutional Networks Guided by Linear Interpreters

Convolutional networks are large linear systems divided into layers and connected by non-linear units. These units are the "articulations" that allow the network to adapt to the input. To understand how a network manages to solve a problem we must look at the articulated decisions in entirety. If we could capture the actions of non-linear units for a particular input, we would be able to replay the whole system back and forth as if it was always linear. It would also reveal the actions of non-linearities because the resulting linear system, a Linear Interpreter, depends on the input image. We introduce a hooking layer, called a LinearScope, which allows us to run the network and the linear interpreter in parallel. Its implementation is simple, flexible and efficient. From here we can make many curious inquiries: how do these linear systems look like? When the rows and columns of the transformation matrix are images, how do they look like? What type of basis do these linear transformations rely on? The answers depend on the problems presented, through which we take a tour to some popular architectures used for classification, super-resolution (SR) and image-to-image translation (I2I). For classification we observe that popular networks use a pixel-wise vote per class strategy and heavily rely on bias parameters. For SR and I2I we find that CNNs use wavelet-type basis similar to the human visual system. For I2I we reveal copy-move and template-creation strategies to generate outputs.

cs.CV↗

Multigrid Backprojection Super-Resolution and Deep Filter Visualization

We introduce a novel deep-learning architecture for image upscaling by large factors (e.g. 4x, 8x) based on examples of pristine high-resolution images. Our target is to reconstruct high-resolution images from their downscale versions. The proposed system performs a multi-level progressive upscaling, starting from small factors (2x) and updating for higher factors (4x and 8x). The system is recursive as it repeats the same procedure at each level. It is also residual since we use the network to update the outputs of a classic upscaler. The network residuals are improved by Iterative Back-Projections (IBP) computed in the features of a convolutional network. To work in multiple levels we extend the standard back-projection algorithm using a recursion analogous to Multi-Grid algorithms commonly used as solvers of large systems of linear equations. We finally show how the network can be interpreted as a standard upsampling-and-filter upscaler with a space-variant filter that adapts to the geometry. This approach allows us to visualize how the network learns to upscale. Finally, our system reaches state of the art quality for models with relatively few number of parameters.

eess.IV↗

Multi-Scale Recursive and Perception-Distortion Controllable Image Super-Resolution

We describe our solution for the PIRM Super-Resolution Challenge 2018 where we achieved the 2nd best perceptual quality for average RMSE<=16, 5th best for RMSE<=12.5, and 7th best for RMSE<=11.5. We modify a recently proposed Multi-Grid Back-Projection (MGBP) architecture to work as a generative system with an input parameter that can control the amount of artificial details in the output. We propose a discriminator for adversarial training with the following novel properties: it is multi-scale that resembles a progressive-GAN; it is recursive that balances the architecture of the generator; and it includes a new layer to capture significant statistics of natural images. Finally, we propose a training strategy that avoids conflicts between reconstruction and perceptual losses. Our configuration uses only 281k parameters and upscales each image of the competition in 0.2s in average.

eess.IV↗

Convolutional Networks with MuxOut Layers as Multi-rate Systems for Image Upscaling

We interpret convolutional networks as adaptive filters and combine them with so-called MuxOut layers to efficiently upscale low resolution images. We formalize this interpretation by deriving a linear and space-variant structure of a convolutional network when its activations are fixed. We introduce general purpose algorithms to analyze a network and show its overall filter effect for each given location. We use this analysis to evaluate two types of image upscalers: deterministic upscalers that target the recovery of details from original content; and second, a new generation of upscalers that can sample the distribution of upscale aliases (images that share the same downscale version) that look like real content.

cs.CV↗