arXiv subjects

Hao Chen

Publications and source records attributed to Hao Chen.

At least 487 records · Page 27Linked to original sources

arXiv2025

Solutions for Mitotic Figure Detection and Atypical Classification in MIDOG 2025

Deep learning has driven significant advances in mitotic figure analysis within computational pathology. In this paper, we present our approach to the Mitosis Domain Generalization (MIDOG) 2025 Challenge, which consists of two distinct tasks, i.e., mitotic figure detection and atypical mitosis classification. For the mitotic figure detection task, we propose a two-stage detection-classification framework that first localizes candidate mitotic figures and subsequently refines the predictions using a dedicated classification module. For the atypical mitosis classification task, we employ an ensemble strategy that integrates predictions from multiple state-of-the-art deep learning architectures to improve robustness and accuracy. Extensive experiments demonstrate the effectiveness of our proposed methods across both tasks.

eess.IV↗

arXiv2025

Newly observed $κ$(2600) and the highly excited states of the $K_0^{*}$ family

We conducted a study using the modified Godfrey-Isgur quark model and quark pair creation model to investigate the spectrum and two-body strong decays of the newly discovered $κ$(2600) resonance by the LHCb collaboration. Our analysis revealed that this {resonance} can be assigned as the fourth radial excitation within the $0^{+}$ light strange meson family. Furthermore, we predicted additional radial excitations in this meson family and systematically discussed their spectra, decay behaviors, and branching ratios. These results provide critical guidance for future to identify their signatures in experiments.

hep-ph↗

arXiv2025

Large-scale Multi-sequence Pretraining for Generalizable MRI Analysis in Versatile Clinical Applications

Multi-sequence Magnetic Resonance Imaging (MRI) offers remarkable versatility, enabling the distinct visualization of different tissue types. Nevertheless, the inherent heterogeneity among MRI sequences poses significant challenges to the generalization capability of deep learning models. These challenges undermine model performance when faced with varying acquisition parameters, thereby severely restricting their clinical utility. In this study, we present PRISM, a foundation model PRe-trained with large-scale multI-Sequence MRI. We collected a total of 64 datasets from both public and private sources, encompassing a wide range of whole-body anatomical structures, with scans spanning diverse MRI sequences. Among them, 336,476 volumetric MRI scans from 34 datasets (8 public and 26 private) were curated to construct the largest multi-organ multi-sequence MRI pretraining corpus to date. We propose a novel pretraining paradigm that disentangles anatomically invariant features from sequence-specific variations in MRI, while preserving high-level semantic representations. We established a benchmark comprising 44 downstream tasks, including disease diagnosis, image segmentation, registration, progression prediction, and report generation. These tasks were evaluated on 32 public datasets and 5 private cohorts. PRISM consistently outperformed both non-pretrained models and existing foundation models, achieving first-rank results in 39 out of 44 downstream benchmarks with statistical significance improvements. These results underscore its ability to learn robust and generalizable representations across unseen data acquired under diverse MRI protocols. PRISM provides a scalable framework for multi-sequence MRI analysis, thereby enhancing the translational potential of AI in radiology. It delivers consistent performance across diverse imaging protocols, reinforcing its clinical applicability.

eess.IV↗

arXiv2025

DIDS: Domain Impact-aware Data Sampling for Large Language Model Training

Large language models (LLMs) are commonly trained on multi-domain datasets, where domain sampling strategies significantly impact model performance due to varying domain importance across downstream tasks. Existing approaches for optimizing domain-level sampling strategies struggle with maintaining intra-domain consistency and accurately measuring domain impact. In this paper, we present Domain Impact-aware Data Sampling (DIDS). To ensure intra-domain consistency, a gradient clustering algorithm is proposed to group training data based on their learning effects, where a proxy language model and dimensionality reduction are employed to reduce computational overhead. To accurately measure domain impact, we develop a Fisher Information Matrix (FIM) guided metric that quantifies how domain-specific parameter updates affect the model's output distributions on downstream tasks, with theoretical guarantees. Furthermore, to determine optimal sampling ratios, DIDS combines both the FIM-guided domain impact assessment and loss learning trajectories that indicate domain-specific potential, while accounting for diminishing marginal returns. Extensive experiments demonstrate that DIDS achieves 3.4% higher average performance while maintaining comparable training efficiency. The code is available at https://github.com/shiweijiezero/DIDS.

cs.CL↗

arXiv2025

CYCLE-INSTRUCT: Fully Seed-Free Instruction Tuning via Dual Self-Training and Cycle Consistency

Instruction tuning is vital for aligning large language models (LLMs) with human intent, but current methods typically rely on costly human-annotated seed data or powerful external teacher models. While instruction back-translation techniques reduce this dependency, they remain fundamentally tethered to an initial seed set, which limits full automation, introduces biases, and can lead to inefficient use of unlabeled corpora. In this paper, we propose Cycle-Instruct, a novel framework that achieves fully seed-free instruction tuning. Inspired by cycle consistency, Cycle-Instruct employs a dual self-training loop where two models-an answer generator and a question generator-are bootstrapped solely from raw, unlabeled text. These models mutually supervise each other by reconstructing original text segments from their counterpart's generated pseudo-labels, effectively learning from the intrinsic structure of the data without any human-provided seeds. We demonstrate Cycle-Instruct's efficacy across four diverse data tracks, including general instruction-following, domain-specific tasks, dialogue logs, and plain text. Our extensive experiments show that Cycle-Instruct not only outperforms seed-driven back-translation baselines but also achieves performance comparable to strongly supervised methods.

cs.CL↗

arXiv2025

Thermodynamics of the Reissner-Nordström black hole with quintessence matter on the EGUP framework

In this paper, we investigate the quantum correction on thermodynamics of the Reissner-Nordström black hole in the presence of the quintessence matter associated with dark energy. To this end, the modified Hawking temperature, heat capacity, and entropy functions of the black hole are derived. { Investigation reveals that the modified uncertainty principles and normalization factor $α$ restrict the lower bound value of horizon radius to affect the Hawking temperature and the parameter $η_{0}$ have a non-negligible effect on the heat capacity threshold.} {Furthermore}, the correction of entropy does not depend on the quintessence matter. It is also examined the equation of state associated with the pressure and the volume in this framework. In addition, we employ graphical methods to compare and discuss the findings within the generalized uncertainty principle (GUP) and extended uncertainty principle (EUP).

gr-qc↗

arXiv2025

Multi-perspective monitoring of wildlife and human activities from camera traps and drones with deep learning models

Wildlife and human activities are key components of landscape systems. Understanding their spatial distribution is essential for evaluating human wildlife interactions and informing effective conservation planning. Multiperspective monitoring of wildlife and human activities by combining camera traps and drone imagery. Capturing the spatial patterns of their distributions, which allows the identification of the overlap of their activity zones and the assessment of the degree of human wildlife conflict. The study was conducted in Chitwan National Park (CNP), Nepal, and adjacent regions. Images collected by visible and nearinfrared camera traps and thermal infrared drones from February to July 2022 were processed to create training and testing datasets, which were used to build deep learning models to automatic identify wildlife and human activities. Drone collected thermal imagery was used for detecting targets to provide a multiple monitoring perspective. Spatial pattern analysis was performed to identify animal and resident activity hotspots and delineation potential human wildlife conflict zones. Among the deep learning models tested, YOLOv11s achieved the highest performance with a precision of 96.2%, recall of 92.3%, mAP50 of 96.7%, and mAP50 of 81.3%, making it the most effective for detecting objects in camera trap imagery. Drone based thermal imagery, analyzed with an enhanced Faster RCNN model, added a complementary aerial viewpoint for camera trap detections. Spatial pattern analysis identified clear hotspots for both wildlife and human activities and their overlapping patterns within certain areas in the CNP and buffer zones indicating potential conflict. This study reveals human wildlife conflicts within the conserved landscape. Integrating multiperspective monitoring with automated object detection enhances wildlife surveillance and landscape management.

cs.CV↗

arXiv2025

Tinker: Diffusion's Gift to 3D--Multi-View Consistent Editing From Sparse Inputs without Per-Scene Optimization

We introduce Tinker, a versatile framework for high-fidelity 3D editing that operates in both one-shot and few-shot regimes without any per-scene finetuning. Unlike prior techniques that demand extensive per-scene optimization to ensure multi-view consistency or to produce dozens of consistent edited input views, Tinker delivers robust, multi-view consistent edits from as few as one or two images. This capability stems from repurposing pretrained diffusion models, which unlocks their latent 3D awareness. To drive research in this space, we curate the first large-scale multi-view editing dataset and data pipeline, spanning diverse scenes and styles. Building on this dataset, we develop our framework capable of generating multi-view consistent edited views without per-scene training, which consists of two novel components: (1) Referring multi-view editor: Enables precise, reference-driven edits that remain coherent across all viewpoints. (2) Any-view-to-video synthesizer: Leverages spatial-temporal priors from video diffusion to perform high-quality scene completion and novel-view generation even from sparse inputs. Through extensive experiments, Tinker significantly reduces the barrier to generalizable 3D content creation, achieving state-of-the-art performance on editing, novel-view synthesis, and rendering enhancement tasks. We believe that Tinker represents a key step towards truly scalable, zero-shot 3D editing. Project webpage: https://aim-uofa.github.io/Tinker

cs.CV↗

arXiv2025

Segment Anything in Pathology Images with Natural Language

Pathology image segmentation is crucial in computational pathology for analyzing histological features relevant to cancer diagnosis and prognosis. However, current methods face major challenges in clinical applications due to limited annotated data and restricted category definitions. To address these limitations, we propose PathSegmentor, the first text-prompted segmentation foundation model designed specifically for pathology images. We also introduce PathSeg, the largest and most comprehensive dataset for pathology segmentation, built from 21 public sources and containing 275k image-mask-label triples across 160 diverse categories. With PathSegmentor, users can perform semantic segmentation using natural language prompts, eliminating the need for laborious spatial inputs such as points or boxes. Extensive experiments demonstrate that PathSegmentor outperforms specialized models with higher accuracy and broader applicability, while maintaining a compact architecture. It significantly surpasses existing spatial- and text-prompted models by 0.145 and 0.429 in overall Dice scores, respectively, showing strong robustness in segmenting complex structures and generalizing to external datasets. Moreover, PathSegmentor's outputs enhance the interpretability of diagnostic models through feature importance estimation and imaging biomarker discovery, offering pathologists evidence-based support for clinical decision-making. This work advances the development of explainable AI in precision oncology.

cs.CV↗

arXiv2025

A Versatile Pathology Co-pilot via Reasoning Enhanced Multimodal Large Language Model

Multimodal large language models (MLLMs) have emerged as powerful tools for computational pathology, offering unprecedented opportunities to integrate pathological images with language context for comprehensive diagnostic analysis. These models hold particular promise for automating complex tasks that traditionally require expert interpretation of pathologists. However, current MLLM approaches in pathology demonstrate significantly constrained reasoning capabilities, primarily due to their reliance on expensive chain-of-thought annotations. Additionally, existing methods remain limited to simplex application of visual question answering (VQA) at the region-of-interest (ROI) level, failing to address the full spectrum of diagnostic needs such as ROI classification, detection, segmentation, whole-slide-image (WSI) classification and VQA in clinical practice. In this study, we present SmartPath-R1, a versatile MLLM capable of simultaneously addressing both ROI-level and WSI-level tasks while demonstrating robust pathological reasoning capability. Our framework combines scale-dependent supervised fine-tuning and task-aware reinforcement fine-tuning, which circumvents the requirement for chain-of-thought supervision by leveraging the intrinsic knowledge within MLLM. Furthermore, SmartPath-R1 integrates multiscale and multitask analysis through a mixture-of-experts mechanism, enabling dynamic processing for diverse tasks. We curate a large-scale dataset comprising 2.3M ROI samples and 188K WSI samples for training and evaluation. Extensive experiments across 72 tasks validate the effectiveness and superiority of the proposed approach. This work represents a significant step toward developing versatile, reasoning-enhanced AI systems for precision pathology.

eess.IV↗

arXiv2025

Framework for Modeling and Optimization of On-Orbit Servicing Operations under Demand Uncertainties

This paper develops a framework that models and optimizes the operations of complex on-orbit servicing infrastructures involving one or more servicers and orbital depots to provide multiple types of services to a fleet of geostationary satellites. The proposed method extends the state-of-the-art space logistics technique by addressing the unique challenges in on-orbit servicing applications, and integrate it with the Rolling Horizon decision making approach. The space logistics technique enables modeling of the on-orbit servicing logistical operations as a Mixed-Integer Linear Program whose optimal solutions can efficiently be found. The Rolling Horizon approach enables the assessment of the long-term value of an on-orbit servicing infrastructure by accounting for the uncertain service needs that arise over time among the geostationary satellites. Two case studies successfully demonstrate the effectiveness of the framework for (1) short-term operational scheduling and (2) long-term strategic decision making for on-orbit servicing architectures under diverse market conditions.

math.OC↗

arXiv2025

On-Orbit Servicing Optimization Framework with High- and Low-Thrust Propulsion Tradeoff

This paper proposes an on-orbit servicing logistics optimization framework that is capable of performing the short-term operational scheduling and long-term strategic planning of sustainable servicing infrastructures that involve high-thrust, low-thrust, and/or multimodal servicers supported by orbital depots. The proposed framework generalizes the state-of-the-art on-orbit servicing logistics optimization method by incorporating user-defined trajectory models and optimizing the logistics operations with the propulsion technology and trajectory tradeoff in consideration. Mixed-Integer Linear Programming is leveraged to find the optimal operations of the servicers over a given period, while the Rolling Horizon approach is used to consider a long time horizon accounting for the uncertainties in service demand. Several analyses are carried out to demonstrate the value of the proposed framework in automatically trading off the high- and low-thrust propulsion systems for both short-term operational scheduling and long-term strategic planning of on-orbit servicing infrastructures.

math.OC↗

arXiv2025

Beyond Zero Initialization: Investigating the Impact of Non-Zero Initialization on LoRA Fine-Tuning Dynamics

Low-rank adaptation (LoRA) is a widely used parameter-efficient fine-tuning method. In standard LoRA layers, one of the matrices, $A$ or $B$, is initialized to zero, ensuring that fine-tuning starts from the pretrained model. However, there is no theoretical support for this practice. In this paper, we investigate the impact of non-zero initialization on LoRA's fine-tuning dynamics from an infinite-width perspective. Our analysis reveals that, compared to zero initialization, simultaneously initializing $A$ and $B$ to non-zero values improves LoRA's robustness to suboptimal learning rates, particularly smaller ones. Further analysis indicates that although the non-zero initialization of $AB$ introduces random noise into the pretrained weight, it generally does not affect fine-tuning performance. In other words, fine-tuning does not need to strictly start from the pretrained model. The validity of our findings is confirmed through extensive experiments across various models and datasets. The code is available at https://github.com/Leopold1423/non_zero_lora-icml25.

cs.LG↗

arXiv2025

Inference performance evaluation for LLMs on edge devices with a novel benchmarking framework and metric

With the significant success achieved by large language models (LLMs) like LLaMA, edge computing-based LLM inference services for mobile and PC are in high demand for data privacy. However, different edge platforms have different hardware characteristics and the large demand for memory capacity and bandwidth makes it very challenging to deploy and benchmark LLMs on edge devices. In this paper, we introduce a benchmarking tool named ELIB (edge LLM inference benchmarking) to evaluate LLM inference performance of different edge platforms, and propose a novel metric named MBU to indicate the percentage of the theoretically efficient use of available memory bandwidth for a specific model running on edge hardware to optimize memory usage. We deploy ELIB on three edge platforms and benchmark using five quantized models to optimize MBU in combination with other metrics such as FLOPS, throughput, latency and accuracy. And we analyze the results to derive the key factors, constraints, unpredictability in optimizing MBU that can guide deploying LLMs on more edge platforms.

cs.PF↗

arXiv2025

A Dual Quaternion Control Law for Formation Control of Multiple 3-D Rigid Bodies

This paper studies the integrated position and attitude control problem for multi-agent systems of 3D rigid bodies. While the state-of-the-art method in [Olfati-Saber and Murray, 2004] established the theoretical foundation for rigid-body formation control, it requires all agents to asymptotically converge to identical positions and attitudes, limiting its applicability in scenarios where distinct desired relative configurations must be maintained. In this paper, we develop a novel dual-quaternion-based framework that generalizes this paradigm. By introducing a unit dual quaternion directed graph (UDQDG) representation, we derive a new control law through the corresponding Laplacian matrix, enabling simultaneous position and attitude coordination while naturally accommodating directed interaction topologies. Leveraging the recent advances in UDQDG spectral theory, we prove global asymptotic convergence to desired relative configurations modulo a right-multiplicative constant and establish an R-linear convergence rate determined by the second smallest eigenvalue of the UDQDG Laplacian. A projected iteration method is proposed to compute the iterative states. Finally, the proposed solution is verified by several numerical experiments.

math.OC↗

arXiv2025

Application of Physics-Informed Neural Networks in Removing Telescope Beam Effects

This study introduces {\tt{PI-AstroDeconv}}, a physics-informed semi-supervised learning method specifically designed for removing beam effects in astronomical telescope observation systems. The method utilizes an encoder-decoder network architecture and combines the telescope's point spread function or beam as prior information, while integrating fast Fourier transform accelerated convolution techniques into the deep learning network. This enables effective removal of beam effects from astronomical observation images. {\tt{PI-AstroDeconv}} can handle multiple PSFs or beams, tolerate imprecise measurements to some extent, and significantly improve the efficiency and accuracy of image deconvolution. Therefore, this architecture is particularly suitable for astronomical data processing that does not rely on annotated data. To validate the reliability of the architecture, we used the SKA Science Data Challenge 3a datasets and compared it with the $\tt{CLEAN}$ deconvolution method at the 21-cm power spectrum level. The results demonstrate that our algorithm not only restores details and reduces blurriness in celestial images at the pixel level but also more accurately recovers the true neutral hydrogen power spectrum at the power spectrum level.

astro-ph.IM↗

arXiv2025

A Chain of Diagnosis Framework for Accurate and Explainable Radiology Report Generation

Despite the progress of radiology report generation (RRG), existing works face two challenges: 1) The performances in clinical efficacy are unsatisfactory, especially for lesion attributes description; 2) the generated text lacks explainability, making it difficult for radiologists to trust the results. To address the challenges, we focus on a trustworthy RRG model, which not only generates accurate descriptions of abnormalities, but also provides basis of its predictions. To this end, we propose a framework named chain of diagnosis (CoD), which maintains a chain of diagnostic process for clinically accurate and explainable RRG. It first generates question-answer (QA) pairs via diagnostic conversation to extract key findings, then prompts a large language model with QA diagnoses for accurate generation. To enhance explainability, a diagnosis grounding module is designed to match QA diagnoses and generated sentences, where the diagnoses act as a reference. Moreover, a lesion grounding module is designed to locate abnormalities in the image, further improving the working efficiency of radiologists. To facilitate label-efficient training, we propose an omni-supervised learning strategy with clinical consistency to leverage various types of annotations from different datasets. Our efforts lead to 1) an omni-labeled RRG dataset with QA pairs and lesion boxes; 2) a evaluation tool for assessing the accuracy of reports in describing lesion location and severity; 3) extensive experiments to demonstrate the effectiveness of CoD, where it outperforms both specialist and generalist models consistently on two RRG benchmarks and shows promising explainability by accurately grounding generated sentences to QA diagnoses and images.

cs.CV↗

arXiv2025

AmbiGraph-Eval: Can LLMs Effectively Handle Ambiguous Graph Queries?

Large Language Models (LLMs) have recently demonstrated strong capabilities in translating natural language into database queries, especially when dealing with complex graph-structured data. However, real-world queries often contain inherent ambiguities, and the interconnected nature of graph structures can amplify these challenges, leading to unintended or incorrect query results. To systematically evaluate LLMs on this front, we propose a taxonomy of graph-query ambiguities, comprising three primary types: Attribute Ambiguity, Relationship Ambiguity, and Attribute-Relationship Ambiguity, each subdivided into Same-Entity and Cross-Entity scenarios. We introduce AmbiGraph-Eval, a novel benchmark of real-world ambiguous queries paired with expert-verified graph query answers. Evaluating 9 representative LLMs shows that even top models struggle with ambiguous graph queries. Our findings reveal a critical gap in ambiguity handling and motivate future work on specialized resolution techniques.

cs.DB↗