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Hao Chen

Publications and source records attributed to Hao Chen.

At least 649 records · Page 36Linked to original sources

RAG-DDR: Optimizing Retrieval-Augmented Generation Using Differentiable Data Rewards

Retrieval-Augmented Generation (RAG) has proven its effectiveness in mitigating hallucinations in Large Language Models (LLMs) by retrieving knowledge from external resources. To adapt LLMs for the RAG systems, current approaches use instruction tuning to optimize LLMs, improving their ability to utilize retrieved knowledge. This supervised fine-tuning (SFT) approach focuses on equipping LLMs to handle diverse RAG tasks using different instructions. However, it trains RAG modules to overfit training signals and overlooks the varying data preferences among agents within the RAG system. In this paper, we propose a Differentiable Data Rewards (DDR) method, which end-to-end trains RAG systems by aligning data preferences between different RAG modules. DDR works by collecting the rewards to optimize each agent in the RAG system with the rollout method, which prompts agents to sample some potential responses as perturbations, evaluates the impact of these perturbations on the whole RAG system, and subsequently optimizes the agent to produce outputs that improve the performance of the RAG system. Our experiments on various knowledge-intensive tasks demonstrate that DDR significantly outperforms the SFT method, particularly for LLMs with smaller-scale parameters that depend more on the retrieved knowledge. Additionally, DDR exhibits a stronger capability to align the data preference between RAG modules. The DDR method makes the generation module more effective in extracting key information from documents and mitigating conflicts between parametric memory and external knowledge. All codes are available at https://github.com/OpenMatch/RAG-DDR.

cs.CL↗

Diffusion-based Virtual Staining from Polarimetric Mueller Matrix Imaging

Polarization, as a new optical imaging tool, has been explored to assist in the diagnosis of pathology. Moreover, converting the polarimetric Mueller Matrix (MM) to standardized stained images becomes a promising approach to help pathologists interpret the results. However, existing methods for polarization-based virtual staining are still in the early stage, and the diffusion-based model, which has shown great potential in enhancing the fidelity of the generated images, has not been studied yet. In this paper, a Regulated Bridge Diffusion Model (RBDM) for polarization-based virtual staining is proposed. RBDM utilizes the bidirectional bridge diffusion process to learn the mapping from polarization images to other modalities such as H\&E and fluorescence. And to demonstrate the effectiveness of our model, we conduct the experiment on our manually collected dataset, which consists of 18,000 paired polarization, fluorescence and H\&E images, due to the unavailability of the public dataset. The experiment results show that our model greatly outperforms other benchmark methods. Our dataset and code will be released upon acceptance.

eess.IV↗

SEKI: Self-Evolution and Knowledge Inspiration based Neural Architecture Search via Large Language Models

We introduce SEKI, a novel large language model (LLM)-based neural architecture search (NAS) method. Inspired by the chain-of-thought (CoT) paradigm in modern LLMs, SEKI operates in two key stages: self-evolution and knowledge distillation. In the self-evolution stage, LLMs initially lack sufficient reference examples, so we implement an iterative refinement mechanism that enhances architectures based on performance feedback. Over time, this process accumulates a repository of high-performance architectures. In the knowledge distillation stage, LLMs analyze common patterns among these architectures to generate new, optimized designs. Combining these two stages, SEKI greatly leverages the capacity of LLMs on NAS and without requiring any domain-specific data. Experimental results show that SEKI achieves state-of-the-art (SOTA) performance across various datasets and search spaces while requiring only 0.05 GPU-days, outperforming existing methods in both efficiency and accuracy. Furthermore, SEKI demonstrates strong generalization capabilities, achieving SOTA-competitive results across multiple tasks.

cs.CL↗

Revisiting Convolution Architecture in the Realm of DNA Foundation Models

In recent years, a variety of methods based on Transformer and state space model (SSM) architectures have been proposed, advancing foundational DNA language models. However, there is a lack of comparison between these recent approaches and the classical architecture convolutional networks (CNNs) on foundation model benchmarks. This raises the question: are CNNs truly being surpassed by these recent approaches based on transformer and SSM architectures? In this paper, we develop a simple but well-designed CNN-based method termed ConvNova. ConvNova identifies and proposes three effective designs: 1) dilated convolutions, 2) gated convolutions, and 3) a dual-branch framework for gating mechanisms. Through extensive empirical experiments, we demonstrate that ConvNova significantly outperforms recent methods on more than half of the tasks across several foundation model benchmarks. For example, in histone-related tasks, ConvNova exceeds the second-best method by an average of 5.8%, while generally utilizing fewer parameters and enabling faster computation. In addition, the experiments observed findings that may be related to biological characteristics. This indicates that CNNs are still a strong competitor compared to Transformers and SSMs. We anticipate that this work will spark renewed interest in CNN-based methods for DNA foundation models.

cs.LG↗

FilterLLM: Text-To-Distribution LLM for Billion-Scale Cold-Start Recommendation

Large Language Model (LLM)-based cold-start recommendation systems continue to face significant computational challenges in billion-scale scenarios, as they follow a "Text-to-Judgment" paradigm. This approach processes user-item content pairs as input and evaluates each pair iteratively. To maintain efficiency, existing methods rely on pre-filtering a small candidate pool of user-item pairs. However, this severely limits the inferential capabilities of LLMs by reducing their scope to only a few hundred pre-filtered candidates. To overcome this limitation, we propose a novel "Text-to-Distribution" paradigm, which predicts an item's interaction probability distribution for the entire user set in a single inference. Specifically, we present FilterLLM, a framework that extends the next-word prediction capabilities of LLMs to billion-scale filtering tasks. FilterLLM first introduces a tailored distribution prediction and cold-start framework. Next, FilterLLM incorporates an efficient user-vocabulary structure to train and store the embeddings of billion-scale users. Finally, we detail the training objectives for both distribution prediction and user-vocabulary construction. The proposed framework has been deployed on the Alibaba platform, where it has been serving cold-start recommendations for two months, processing over one billion cold items. Extensive experiments demonstrate that FilterLLM significantly outperforms state-of-the-art methods in cold-start recommendation tasks, achieving over 30 times higher efficiency. Furthermore, an online A/B test validates its effectiveness in billion-scale recommendation systems.

cs.IR↗

FreeTumor: Large-Scale Generative Tumor Synthesis in Computed Tomography Images for Improving Tumor Recognition

Tumor is a leading cause of death worldwide, with an estimated 10 million deaths attributed to tumor-related diseases every year. AI-driven tumor recognition unlocks new possibilities for more precise and intelligent tumor screening and diagnosis. However, the progress is heavily hampered by the scarcity of annotated datasets, which demands extensive annotation efforts by radiologists. To tackle this challenge, we introduce FreeTumor, an innovative Generative AI (GAI) framework to enable large-scale tumor synthesis for mitigating data scarcity. Specifically, FreeTumor effectively leverages a combination of limited labeled data and large-scale unlabeled data for tumor synthesis training. Unleashing the power of large-scale data, FreeTumor is capable of synthesizing a large number of realistic tumors on images for augmenting training datasets. To this end, we create the largest training dataset for tumor synthesis and recognition by curating 161,310 publicly available Computed Tomography (CT) volumes from 33 sources, with only 2.3% containing annotated tumors. To validate the fidelity of synthetic tumors, we engaged 13 board-certified radiologists in a Visual Turing Test to discern between synthetic and real tumors. Rigorous clinician evaluation validates the high quality of our synthetic tumors, as they achieved only 51.1% sensitivity and 60.8% accuracy in distinguishing our synthetic tumors from real ones. Through high-quality tumor synthesis, FreeTumor scales up the recognition training datasets by over 40 times, showcasing a notable superiority over state-of-the-art AI methods including various synthesis methods and foundation models. These findings indicate promising prospects of FreeTumor in clinical applications, potentially advancing tumor treatments and improving the survival rates of patients.

eess.IV↗

MedIAnomaly: A comparative study of anomaly detection in medical images

Anomaly detection (AD) aims at detecting abnormal samples that deviate from the expected normal patterns. Generally, it can be trained merely on normal data, without a requirement for abnormal samples, and thereby plays an important role in rare disease recognition and health screening in the medical domain. Despite the emergence of numerous methods for medical AD, the lack of a fair and comprehensive evaluation causes ambiguous conclusions and hinders the development of this field. To address this problem, this paper builds a benchmark with unified comparison. Seven medical datasets with five image modalities, including chest X-rays, brain MRIs, retinal fundus images, dermatoscopic images, and histopathology images, are curated for extensive evaluation. Thirty typical AD methods, including reconstruction and self-supervised learning-based methods, are involved in comparison of image-level anomaly classification and pixel-level anomaly segmentation. Furthermore, for the first time, we systematically investigate the effect of key components in existing methods, revealing unresolved challenges and potential future directions. The datasets and code are available at https://github.com/caiyu6666/MedIAnomaly.

cs.CV↗

Logistics Analysis for Lunar Post-Mission Disposal

As human activities on the Moon expand through initiatives like NASA's Artemis program, the need for sustainable post-mission disposal strategies becomes critical to maintaining the lunar environment. This paper analyzes the logistics and environmental implications of waste products generated by In-Situ Resource Utilization technologies employed in oxygen production on the Moon. The study examines the inputs, generation of products, and the resulting byproducts from Molten Regolith Electrolysis, Soil/Water Extraction, and Direct Water Electrolysis systems. These technologies yield varied byproducts, including slag, metals and volatiles, each presenting unique challenges for disposal and recycling. The analysis assesses the economic and ecological impacts of In-Situ Resource Utilization activities on lunar operations using a multi-commodity flow model adapted from cislunar logistics frameworks. The results inform that ISRU-enabled missions achieve a significant threefold cost reduction. However, the management of byproducts remains a critical challenge, demanding innovative solutions to address their impact and support scalable and sustainable lunar exploration.

math.OC↗

On the robustness of multimodal language model towards distractions

Although vision-language models (VLMs) have achieved significant success in various applications such as visual question answering, their resilience to prompt variations remains an under-explored area. Understanding how distractions affect VLMs is crucial for improving their real-world applicability, as inputs could have noisy and irrelevant information in many practical scenarios. This paper aims to assess the robustness of VLMs against both visual and textual distractions in the context of science question answering. Built on the ScienceQA dataset, we developed a new benchmark that introduces distractions in both the visual and textual contexts to evaluate the reasoning capacity of VLMs amid these distractions. Our findings reveal that most-of-the-art VLMs, including GPT-4, are vulnerable to various types of distractions, experiencing noticeable degradation in reasoning capabilities when confronted with distractions. Notably, models such as InternVL2 demonstrate a higher degree of robustness to these distractions. We also found that models exhibit greater sensitivity to textual distractions than visual ones. Additionally, we explored various mitigation strategies, such as prompt engineering, to counteract the impact of distractions. While these strategies improved solution accuracy, our analysis shows that there remain significant opportunities for improvement.

cs.CV↗

Generalizable Cervical Cancer Screening via Large-scale Pretraining and Test-Time Adaptation

Cervical cancer is a leading malignancy in female reproductive system. While AI-assisted cytology offers a cost-effective and non-invasive screening solution, current systems struggle with generalizability in complex clinical scenarios. To address this issue, we introduced Smart-CCS, a generalizable Cervical Cancer Screening paradigm based on pretraining and adaptation to create robust and generalizable screening systems. To develop and validate Smart-CCS, we first curated a large-scale, multi-center dataset named CCS-127K, which comprises a total of 127,471 cervical cytology whole-slide images collected from 48 medical centers. By leveraging large-scale self-supervised pretraining, our CCS models are equipped with strong generalization capability, potentially generalizing across diverse scenarios. Then, we incorporated test-time adaptation to specifically optimize the trained CCS model for complex clinical settings, which adapts and refines predictions, improving real-world applicability. We conducted large-scale system evaluation among various cohorts. In retrospective cohorts, Smart-CCS achieved an overall area under the curve (AUC) value of 0.965 and sensitivity of 0.913 for cancer screening on 11 internal test datasets. In external testing, system performance maintained high at 0.950 AUC across 6 independent test datasets. In prospective cohorts, our Smart-CCS achieved AUCs of 0.947, 0.924, and 0.986 in three prospective centers, respectively. Moreover, the system demonstrated superior sensitivity in diagnosing cervical cancer, confirming the accuracy of our cancer screening results by using histology findings for validation. Interpretability analysis with cell and slide predictions further indicated that the system's decision-making aligns with clinical practice. Smart-CCS represents a significant advancement in cancer screening across diverse clinical contexts.

q-bio.QM↗

Adaptive Grasping of Moving Objects in Dense Clutter via Global-to-Local Detection and Static-to-Dynamic Planning

Robotic grasping is facing a variety of real-world uncertainties caused by non-static object states, unknown object properties, and cluttered object arrangements. The difficulty of grasping increases with the presence of more uncertainties, where commonly used learning-based approaches struggle to perform consistently across varying conditions. In this study, we integrate the idea of similarity matching to tackle the challenge of grasping novel objects that are simultaneously in motion and densely cluttered using a single RGBD camera, where multiple uncertainties coexist. We achieve this by shifting visual detection from global to local states and operating grasp planning from static to dynamic scenes. Notably, we introduce optimization methods to enhance planning efficiency for this time-sensitive task. Our proposed system can adapt to various object types, arrangements and movement speeds without the need for extensive training, as demonstrated by real-world experiments. Videos are available at https://youtu.be/sdC50dx-xp8?si=27oVr4dhG0rqN_tT.

cs.RO↗

Satellite Observations Guided Diffusion Model for Accurate Meteorological States at Arbitrary Resolution

Accurate acquisition of surface meteorological conditions at arbitrary locations holds significant importance for weather forecasting and climate simulation. Due to the fact that meteorological states derived from satellite observations are often provided in the form of low-resolution grid fields, the direct application of spatial interpolation to obtain meteorological states for specific locations often results in significant discrepancies when compared to actual observations. Existing downscaling methods for acquiring meteorological state information at higher resolutions commonly overlook the correlation with satellite observations. To bridge the gap, we propose Satellite-observations Guided Diffusion Model (SGD), a conditional diffusion model pre-trained on ERA5 reanalysis data with satellite observations (GridSat) as conditions, which is employed for sampling downscaled meteorological states through a zero-shot guided sampling strategy and patch-based methods. During the training process, we propose to fuse the information from GridSat satellite observations into ERA5 maps via the attention mechanism, enabling SGD to generate atmospheric states that align more accurately with actual conditions. In the sampling, we employed optimizable convolutional kernels to simulate the upscale process, thereby generating high-resolution ERA5 maps using low-resolution ERA5 maps as well as observations from weather stations as guidance. Moreover, our devised patch-based method promotes SGD to generate meteorological states at arbitrary resolutions. Experiments demonstrate SGD fulfills accurate meteorological states downscaling to 6.25km.

cs.LG↗

BLEND: Behavior-guided Neural Population Dynamics Modeling via Privileged Knowledge Distillation

Modeling the nonlinear dynamics of neuronal populations represents a key pursuit in computational neuroscience. Recent research has increasingly focused on jointly modeling neural activity and behavior to unravel their interconnections. Despite significant efforts, these approaches often necessitate either intricate model designs or oversimplified assumptions. Given the frequent absence of perfectly paired neural-behavioral datasets in real-world scenarios when deploying these models, a critical yet understudied research question emerges: how to develop a model that performs well using only neural activity as input at inference, while benefiting from the insights gained from behavioral signals during training? To this end, we propose BLEND, the behavior-guided neural population dynamics modeling framework via privileged knowledge distillation. By considering behavior as privileged information, we train a teacher model that takes both behavior observations (privileged features) and neural activities (regular features) as inputs. A student model is then distilled using only neural activity. Unlike existing methods, our framework is model-agnostic and avoids making strong assumptions about the relationship between behavior and neural activity. This allows BLEND to enhance existing neural dynamics modeling architectures without developing specialized models from scratch. Extensive experiments across neural population activity modeling and transcriptomic neuron identity prediction tasks demonstrate strong capabilities of BLEND, reporting over 50% improvement in behavioral decoding and over 15% improvement in transcriptomic neuron identity prediction after behavior-guided distillation. Furthermore, we empirically explore various behavior-guided distillation strategies within the BLEND framework and present a comprehensive analysis of effectiveness and implications for model performance.

cs.NE↗

PICBench: Benchmarking LLMs for Photonic Integrated Circuits Design

While large language models (LLMs) have shown remarkable potential in automating various tasks in digital chip design, the field of Photonic Integrated Circuits (PICs)-a promising solution to advanced chip designs-remains relatively unexplored in this context. The design of PICs is time-consuming and prone to errors due to the extensive and repetitive nature of code involved in photonic chip design. In this paper, we introduce PICBench, the first benchmarking and evaluation framework specifically designed to automate PIC design generation using LLMs, where the generated output takes the form of a netlist. Our benchmark consists of dozens of meticulously crafted PIC design problems, spanning from fundamental device designs to more complex circuit-level designs. It automatically evaluates both the syntax and functionality of generated PIC designs by comparing simulation outputs with expert-written solutions, leveraging an open-source simulator. We evaluate a range of existing LLMs, while also conducting comparative tests on various prompt engineering techniques to enhance LLM performance in automated PIC design. The results reveal the challenges and potential of LLMs in the PIC design domain, offering insights into the key areas that require further research and development to optimize automation in this field. Our benchmark and evaluation code is available at https://github.com/PICDA/PICBench.

cs.LG↗

On Fairness of Unified Multimodal Large Language Model for Image Generation

Unified multimodal large language models (U-MLLMs) have demonstrated impressive performance in visual understanding and generation in an end-to-end pipeline. Compared with generation-only models (e.g., Stable Diffusion), U-MLLMs may raise new questions about bias in their outputs, which can be affected by their unified capabilities. This gap is particularly concerning given the under-explored risk of propagating harmful stereotypes. In this paper, we benchmark the latest U-MLLMs and find that most exhibit significant demographic biases, such as gender and race bias. To better understand and mitigate this issue, we propose a locate-then-fix strategy, where we audit and show how the individual model component is affected by bias. Our analysis shows that bias originates primarily from the language model. More interestingly, we observe a "partial alignment" phenomenon in U-MLLMs, where understanding bias appears minimal, but generation bias remains substantial. Thus, we propose a novel balanced preference model to balance the demographic distribution with synthetic data. Experiments demonstrate that our approach reduces demographic bias while preserving semantic fidelity. We hope our findings underscore the need for more holistic interpretation and debiasing strategies of U-MLLMs in the future.

cs.CL↗

HERA: Improving Long Document Summarization using Large Language Models with Context Packaging and Reordering

Despite the rapid growth of context length of large language models (LLMs) , LLMs still perform poorly in long document summarization. An important reason for this is that relevant information about an event is scattered throughout long documents, and the messy narrative order impairs the accurate understanding and utilization of LLMs for long documents. To address these issues, we propose a novel summary generation framework, called HERA. Specifically, we first segment a long document by its semantic structure and retrieve text segments about the same event, and finally reorder them to form the input context. We evaluate our approach on two long document summarization datasets. The experimental results show that HERA outperforms foundation models in ROUGE, BERTScore and faithfulness metrics, while HERA does not require additional fine-tuning and resources.

cs.CL↗

FedDAG: Federated Domain Adversarial Generation Towards Generalizable Medical Image Analysis

Federated domain generalization aims to train a global model from multiple source domains and ensure its generalization ability to unseen target domains. Due to the target domain being with unknown domain shifts, attempting to approximate these gaps by source domains may be the key to improving model generalization capability. Existing works mainly focus on sharing and recombining local domain-specific attributes to increase data diversity and simulate potential domain shifts. However, these methods may be insufficient since only the local attribute recombination can be hard to touch the out-of-distribution of global data. In this paper, we propose a simple-yet-efficient framework named Federated Domain Adversarial Generation (FedDAG). It aims to simulate the domain shift and improve the model generalization by adversarially generating novel domains different from local and global source domains. Specifically, it generates novel-style images by maximizing the instance-level feature discrepancy between original and generated images and trains a generalizable task model by minimizing their feature discrepancy. Further, we observed that FedDAG could cause different performance improvements for local models. It may be due to inherent data isolation and heterogeneity among clients, exacerbating the imbalance in their generalization contributions to the global model. Ignoring this imbalance can lead the global model's generalization ability to be sub-optimal, further limiting the novel domain generation procedure. Thus, to mitigate this imbalance, FedDAG hierarchically aggregates local models at the within-client and across-client levels by using the sharpness concept to evaluate client model generalization contributions. Extensive experiments across four medical benchmarks demonstrate FedDAG's ability to enhance generalization in federated medical scenarios.

cs.CV↗

Kolmogorov Arnold Neural Interpolator for Downscaling and Correcting Meteorological Fields from In-Situ Observations

Obtaining accurate weather forecasts at station locations is a critical challenge due to systematic biases arising from the mismatch between multi-scale, continuous atmospheric characteristic and their discrete, gridded representations. Previous works have primarily focused on modeling gridded meteorological data, inherently neglecting the off-grid, continuous nature of atmospheric states and leaving such biases unresolved. To address this, we propose the Kolmogorov Arnold Neural Interpolator (KANI), a novel framework that redefines meteorological field representation as continuous neural functions derived from discretized grids. Grounded in the Kolmogorov Arnold theorem, KANI captures the inherent continuity of atmospheric states and leverages sparse in-situ observations to correct these biases systematically. Furthermore, KANI introduces an innovative zero-shot downscaling capability, guided by high-resolution topographic textures without requiring high-resolution meteorological fields for supervision. Experimental results across three sub-regions of the continental United States indicate that KANI achieves an accuracy improvement of 40.28% for temperature and 67.41% for wind speed, highlighting its significant improvement over traditional interpolation methods. This enables continuous neural representation of meteorological variables through neural networks, transcending the limitations of conventional grid-based representations.

cs.CV↗